Cholinesterase Inhibitors
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Subject Areas on Research
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A mechanism-based complementary screening approach for the amelioration and reversal of neurobehavioral teratogenicity.
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A randomized, placebo-controlled study of the efficacy and safety of sertraline in the treatment of the behavioral manifestations of Alzheimer's disease in outpatients treated with donepezil.
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Advances in pharmacotherapy for decline of memory and cognition in patients with Alzheimer's disease.
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Advances in the diagnosis of neuromuscular junction disorders.
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Alpha7 nicotinic acetylcholine receptors targeted by cholinergic developmental neurotoxicants: nicotine and chlorpyrifos.
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Alterations in serotonin transporter expression in brain regions of rats exposed neonatally to chlorpyrifos.
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Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cells.
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An unsubstantiated conclusion.
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Autoimmune disorders of neuromuscular transmission.
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Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity.
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Benzo[a]pyrene impairs neurodifferentiation in PC12 cells.
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Beyond Thiamine: Treatment for Cognitive Impairment in Korsakoff's Syndrome.
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Biological evaluation of some biphenyl analogs of acetyl-seco-hemicholinium No. 3.
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Biological evaluation of some norphenyl analogs of hemicholinium No. 3 and acetyl-seco-hemicholinium No. 3.
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Biological evaluation of some terphenyl analogs of hemicholinium No. 3.
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Biosensor system for continuous monitoring of organophosphate aerosols.
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Cellular mechanisms for developmental toxicity of chlorpyrifos: targeting the adenylyl cyclase signaling cascade.
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Characterization of procaine metabolism as probe for the butyrylcholinesterase enzyme investigation by simultaneous determination of procaine and its metabolite using capillary electrophoresis with electrochemiluminescence detection.
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Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: critical stages targeting differentiation in PC12 cells.
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Chlorpyrifos exposure during a critical neonatal period elicits gender-selective deficits in the development of coordination skills and locomotor activity.
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Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood.
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Cholinergic Stimulation Improves Oxidative Stress and Inflammation in Experimental Myocardial Infarction.
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Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates.
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Cholinergic therapy for Down's syndrome.
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Cholinesterase inhibitors and Pisa syndrome: a pharmacovigilance study.
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Cholinesterase inhibitors as adjunctive therapy in patients with schizophrenia and schizoaffective disorder: a review and meta-analysis of the literature.
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Clinical and radiological characteristics of early versus late mild cognitive impairment in patients with comorbid depressive disorder.
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Co-exposure to pyridostigmine bromide, DEET, and/or permethrin causes sensorimotor deficit and alterations in brain acetylcholinesterase activity.
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Combination drug therapy for Alzheimer's disease: what is evidence-based, and what is not?
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Combination therapy for early Alzheimer's disease: what are we waiting for?
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Comparative cardiovascular safety of dementia medications: a cross-national study.
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Comparative properties of channel catfish (Ictalurus punctatus) and blue crab (Callinectes sapidus) acetylcholinesterases.
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Critical periods for the role of oxidative stress in the developmental neurotoxicity of chlorpyrifos and terbutaline, alone or in combination.
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Current and future treatments for cognitive deficits in dementia.
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Defining meaningful change in Alzheimer's disease trials: the donepezil experience.
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Dementia assessment and management.
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Dementia assessment and management.
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Design of the efficacy of prednisone in the treatment of ocular myasthenia (EPITOME) trial.
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Developmental chlorpyrifos effects on hatchling zebrafish swimming behavior.
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Developmental cholinotoxicants: nicotine and chlorpyrifos.
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Developmental diazinon neurotoxicity in rats: later effects on emotional response.
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Developmental exposure to organophosphates triggers transcriptional changes in genes associated with Parkinson's disease in vitro and in vivo.
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Developmental neurotoxic effects of chlorpyrifos on acetylcholine and serotonin pathways in an avian model.
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Developmental neurotoxicity of chlorpyrifos modeled in vitro: comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cells.
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Developmental neurotoxicity of chlorpyrifos: delayed targeting of DNA synthesis after repeated administration.
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Developmental neurotoxicity of low dose diazinon exposure of neonatal rats: effects on serotonin systems in adolescence and adulthood.
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Developmental neurotoxicity of organophosphates targets cell cycle and apoptosis, revealed by transcriptional profiles in vivo and in vitro.
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Developmental neurotoxicity of parathion: progressive effects on serotonergic systems in adolescence and adulthood.
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Diazinon and parathion diverge in their effects on development of noradrenergic systems.
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Differential acetylcholinesterase inhibition of chlorpyrifos, diazinon and parathion in larval zebrafish.
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Difficult behaviors in long-term care patients with dementia.
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Difficult behaviors in long-term care patients with dementia.
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Does this patient have myasthenia gravis?
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Donepezil Treatment in Patients With Depression and Cognitive Impairment on Stable Antidepressant Treatment: A Randomized Controlled Trial.
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Donepezil effects on language in children with Down syndrome: results of the first 22-week pilot clinical trial.
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Donepezil for Down's syndrome.
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Donepezil for the treatment of language deficits in adults with Down syndrome: a preliminary 24-week open trial.
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Donepezil for treatment of cognitive dysfunction in children with Down syndrome aged 10-17.
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Donepezil treatment of older adults with cognitive impairment and depression (DOTCODE study): clinical rationale and design.
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Donepezil use in Down syndrome.
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Early biochemical detection of delayed neurotoxicity resulting from developmental exposure to chloropyrifos.
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Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: the InDDEx study.
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Effect of sulfur substitution for the noncarbonyl oxygen in hemicholinium-3 and acetyl-seco-hemicholinium-3. Synthesis, biological activity, and structure-toxicity relationships.
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Effective management of sarin exposure: simulation case scenario.
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Effects of Food and Drug Administration-approved medications for Alzheimer's disease on clinical progression.
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Effects of physostigmine on rat brain acetylcholine, acetylcholinesterase and conditioned pole jumping.
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Efficacy and safety of donepezil in patients with schizophrenia or schizoaffective disorder: significant placebo/practice effects in a 12-week, randomized, double-blind, placebo-controlled trial.
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Efficacy of prednisone for the treatment of ocular myasthenia (EPITOME): A randomized, controlled trial.
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Emerging pharmacotherapy for cancer patients with cognitive dysfunction.
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Exposure of neonatal rats to parathion elicits sex-selective impairment of acetylcholine systems in brain regions during adolescence and adulthood.
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Gene expression profiles of the rat brain both immediately and 3 months following acute sarin exposure.
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Geriatric depression and cognitive impairment.
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Ginkgo and memory.
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Imbalances emerge in cardiac autonomic cell signaling after neonatal exposure to terbutaline or chlorpyrifos, alone or in combination.
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Immunosuppressive therapies in myasthenia gravis.
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Impact of ¹⁸F-florbetapir PET imaging of β-amyloid neuritic plaque density on clinical decision-making.
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In utero exposure to nicotine and chlorpyrifos alone, and in combination produces persistent sensorimotor deficits and Purkinje neuron loss in the cerebellum of adult offspring rats.
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Increasing uptake and bioactivation with development positively modulate diazinon toxicity in early life stage medaka (Oryzias latipes).
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Induction of urinary excretion of 3-nitrotyrosine, a marker of oxidative stress, following administration of pyridostigmine bromide, DEET (N,N-diethyl-m-toluamide) and permethrin, alone and in combination in rats.
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Interventions for mild cognitive impairment and Alzheimer disease: new strategies, new hope.
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Is oxidative stress involved in the developmental neurotoxicity of chlorpyrifos?
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Lambert-Eaton myasthenic syndrome (LEMS). Clinical and electrodiagnostic features and response to therapy in 59 patients.
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Myasthenia gravis and pregnancy.
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Neonatal chlorpyrifos administration elicits deficits in immune function in adulthood: a neural effect?
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Neonatal chlorpyrifos exposure alters synaptic development and neuronal activity in cholinergic and catecholaminergic pathways.
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Neonatal chlorpyrifos exposure targets multiple proteins governing the hepatic adenylyl cyclase signaling cascade: implications for neurotoxicity.
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Neonatal exposure to low doses of diazinon: long-term effects on neural cell development and acetylcholine systems.
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Neonatal exposure to parathion alters lipid metabolism in adulthood: Interactions with dietary fat intake and implications for neurodevelopmental deficits.
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Neurotransmitter Imbalance in the Brain and Alzheimer's Disease Pathology.
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Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos.
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Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon, and diazinon.
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Ontogenic expression of acetylcholinesterase activity in trachealis of young swine.
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Organophosphate exposure during a critical developmental stage reprograms adenylyl cyclase signaling in PC12 cells.
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Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition.
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Organophosphate-induced acetylcholinesterase inhibition and embryonic retinal cell necrosis in vivo in the teleost (Oryzias latipes).
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Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos.
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Patterns of Dementia Treatment and Frank Prescribing Errors in Older Adults With Parkinson Disease.
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Perinatal diazinon exposure compromises the development of acetylcholine and serotonin systems.
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Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinon.
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Position statement of the American Association for Geriatric Psychiatry regarding principles of care for patients with dementia resulting from Alzheimer disease.
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Preferential cerebrospinal fluid acetylcholinesterase inhibition by rivastigmine in humans.
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Preliminary study of the safety and efficacy of donepezil hydrochloride in children with Down syndrome: a clinical report series.
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Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations.
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Preoperative preparation of patients with myasthenia gravis forestalls postoperative respiratory complications after thymectomy.
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Pyridostigmine bromide intake during the Persian Gulf War is not associated with postwar handgrip strength.
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Quantitative morphological assessment reveals neuronal and glial deficits in hippocampus after a brief subtoxic exposure to chlorpyrifos in neonatal rats.
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Randomized, placebo-controlled trial of the effects of donepezil on neuronal markers and hippocampal volumes in Alzheimer's disease.
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Response to the letter of Hanley et al. ([1999] Teratology 59:323-324), concerning the article by Roy et al. ([1998] Teratology 58:62-68)
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Rosiglitazone monotherapy in mild-to-moderate Alzheimer's disease: results from a randomized, double-blind, placebo-controlled phase III study.
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Safety and efficacy of rivastigmine in adolescents with Down syndrome: a preliminary 20-week, open-label study.
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Screening for Adverse Drug Reactions in Dementia Patients on Cholinesterase Inhibitor Therapy.
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Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine, and divalent nickel.
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Sensorimotor deficit and cholinergic changes following coexposure with pyridostigmine bromide and sarin in rats.
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Steroid treatment for myasthenia gravis: steroids have an important role.
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Structure-activity relationships of noreperidine congeners on cholinesterase systems in vitro and analgesia in vivo.
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Supportive approaches for Alzheimer disease.
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Targeting of neurotrophic factors, their receptors, and signaling pathways in the developmental neurotoxicity of organophosphates in vivo and in vitro.
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Testicular germ-cell apoptosis in stressed rats following combined exposure to pyridostigmine bromide, N,N-diethyl m-toluamide (DEET), and permethrin.
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The effect of chlorothiazide on neurally mediated contraction of rabbit bronchial smooth muscle.
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The effect of cholinesterase inhibitors of SFEMG in myasthenia gravis.
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The inhibitory effect of metoclopramide on plasma cholinesterase activity.
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The treatment of patients with myasthenia gravis.
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Transcriptional profiles for glutamate transporters reveal differences between organophosphates but similarities with unrelated neurotoxicants.
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Treating cognitive deficits in multiple sclerosis: are we there yet?
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Update on Alzheimer's disease. Promising advances in detection and treatment.
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Use of neostigmine in the management of acute postoperative pain and labour pain: a review.
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What constitutes clinical evidence for neuroprotection in Alzheimer disease: support for the cholinesterase inhibitors?
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When should functional neuroimaging techniques be used in the diagnosis and management of Alzheimer's dementia? A decision analysis.
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[Cholinergic regulation of the sea urchin embryonic and larval development].
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Keywords of People