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Subject Areas on Research
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A Sephadex dialysis method of determining small molecule-macromolecule binding constants.
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A chemotactic factor for mononuclear leukocytes.
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A kinetic study of the binding of an ADP fluorescent analog to mitochondrial ATPase.
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A monoclonal IgM with antibodylike specificity for phospholipids in a patient with lymphoma.
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A neutrophil chemotatic factor derived from C'5 upon interaction of guinea pig serum with endotoxin.
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A novel N-acetylglucosaminidase from neonatal rat enterocytes.
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A structural comparison of tryptic fragments of three types of intermediate filaments.
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ACTH-receptor interaction in the adrenal: a model for the initial step in the action of hormones that stimulate adenyl cyclase.
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Activation of beef heart mitochondrial adenosine triphosphatase by 2,4-dinitrophenol.
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Aggregation of rabbit muscle phosphofructokinase.
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Agonist-induced increase in apparent beta-adrenergic receptor size.
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An analysis of type-C retrovirus polypeptides and their associations in the virion.
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An equilibrium binding study of the interaction of aspartate transcarbamylase with cytidine 5'-triphosphate and adenosine 5'-triphosphate.
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An improved method for the isolation of human serum retinol binding protein (S-RBP).
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Antigen-presenting cell lines internalize peptide antigens via fluid-phase endocytosis.
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Application of a modified 203Hg binding assay for metallothionein.
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Assay of G-protein beta gamma-subunit complex by catalytic support of ADP-ribosylation of Go alpha.
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Assembly of microtubules from preformed, ring-shaped protofilaments and 6-S tubulin.
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Association of viral reverse transcriptase with an enzyme degrading the RNA moiety of RNA-DNA hybrids.
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Atrial natriuretic peptide increases urodilatin in the circulation.
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Bacteriophage T7 Deoxyribonucleic acid replication in vitro. A protein of Escherichia coli required for bacteriophage T7 DNA polymerase activity.
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Binding kinetics of superantigen with TCR and MHC class II.
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Bioassay of plasma cholecystokinin in rats: effects of food, trypsin inhibitor, and alcohol.
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Biochemical and immunological properties of dog brain isorenin.
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Biochemical properties of oncornavirus polypeptides.
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Biological activity of complement in vivo. Role of C5 in the accumulation of polymorphonuclear leukocytes in inflammatory exudates.
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Both heptad repeats of human respiratory syncytial virus fusion protein are potent inhibitors of viral fusion.
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Bovine mitochondrial initiation and elongation factors.
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Calmodulin mediates Ca2+ sensitivity of sodium channels.
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Cathepsin B1. A lysosomal enzyme that degrades native collagen.
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Chaperone-like activity of alpha-crystallin. The effect of NADPH on its interaction with zeta-crystallin.
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Characterization and structure of the manganese-responsive transcriptional regulator ScaR.
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Characterization of Escherichia coli MoeB and its involvement in the activation of molybdopterin synthase for the biosynthesis of the molybdenum cofactor.
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Characterization of a B lymphoblastoid cell line mutant that secretes HLA-A2.
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Characterization of chemotactic activity produced in vivo by a cell-mediated immune reaction in the guinea pig.
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Characterization of molybdenum cofactor from Escherichia coli.
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Characterization of precipitating antibodies to ruminant serum and milk proteins in humans with selective IgA deficiency.
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Clearance and binding of native and defucosylated lactoferrin.
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Combined antibody-high-performance liquid chromatography approach to assess prohormone processing.
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Comparison of the intestinal and serum antibody response in patients with dermatitis herpetiformis.
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Complement-mediated vasoconstriction and graft rejection.
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Comprehensive two-dimensional high-performance liquid chromatography for the isolation of overexpressed proteins and proteome mapping.
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Control of phenylalanine hydroxylase synthesis in tissue culture by serum and insulin.
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Copper-chelatin: isolation from various eucaryotic sources.
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Corneal organ cultures in tyrosinemia release chemotactic factors.
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Crosstalk between bacterial chemotaxis signal transduction proteins and regulators of transcription of the Ntr regulon: evidence that nitrogen assimilation and chemotaxis are controlled by a common phosphotransfer mechanism.
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Cyclic adenosine 3':5'-monophosphate-dependent protein kinase.
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Cytochemistry of sex steroid receptors: a critique.
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De novo design of a single-chain diphenylporphyrin metalloprotein.
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Depression of murine macrophage accumulation by low-molecular-weight derived from spontaneous mammary carcinomas.
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Development of a YIGSR-peptide-modified polyurethaneurea to enhance endothelialization.
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Development of a radioimmunoassay for fetal antigen 2.
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Directed differentiation and neurite extension of mouse embryonic stem cell on aligned poly(lactide) nanofibers functionalized with YIGSR peptide.
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Distribution of lead-203 in human peripheral blood in vitro.
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Dysregulation of proteoglycan production by intrahepatic biliary epithelial cells bearing defective (delta-f508) cystic fibrosis transmembrane conductance regulator.
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Effect of heme and non-heme ligands on subunit dissociation of normal and carboxypeptidase-digested hemoglobin. Gel filtration and flash photolysis studies.
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Effector mechanisms of cytolytically activated macrophages. II. Secretion of a cytolytic factor by activated macrophages and its relationship to secreted neutral proteases.
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Electron microscopy and hydrodynamic properties of factor XIII subunits.
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Electron microscopy studies of alpha 2-macroglobulin subunit association after limited reduction with dithiothreitol.
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Enzymatic joining of polynucleotides. XI. Reversal of Escherichia coli deoxyribonucleic acid ligase reaction.
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Equilibrium binding of nucleotides to beef heart mitochondrial adenosine triphosphatase.
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Evidence for polymorphonuclear-leucocyte-derived proteinases in arthritic cartilage.
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Fat digestion in patients with bile acid malabsorption but minimal steatorrhea.
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Functional differences in the multiple hemocyanins of the horseshoe crab, Limulus polyphemus L.
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Functional properties of hemoglobin Pôrto Alegre (alpha2A beta2 9Ser leads to Cys) and the reactivity of its extra cysteinyl residue.
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Further characterization of a factor from endotoxin-treated serum which releases histamine and heparin from mast cells.
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GRP94/gp96 elicits ERK activation in murine macrophages. A role for endotoxin contamination in NF-kappa B activation and nitric oxide production.
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Glycine metabolism. I. Properties of the system catalyzing the exchange of bicarbonate with the carboxyl group of glycine in Peptococcus glycinophilus.
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Hemocyanin of the chambered nautilus: structure-function relationships.
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Hemoglobin of the electric Atlantic torpedo, Torpedo nobiliana: a cooperative hemoglobin without Bohr effects.
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Heterogeneity of somatostatin like immunoreactivity (SLI) in extracts of porcine, canine and human pancreas.
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Human leukemia antigens: partial isolation and characterization.
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Humoral mediators of chemotaxis of mononuclear leukocytes.
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Identification and initial characterization of translational initiation factor 2 from bovine mitochondria.
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Identification of a molybdopterin-containing molybdenum cofactor in xanthine dehydrogenase from Pseudomonas aeruginosa.
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Identification of monomeric alpha-macroglobulin proteinase inhibitors in birds, reptiles, amphibians and mammals, and purification and characterization of a monomeric alpha-macroglobulin proteinase inhibitor from the American bullfrog Rana catesbeiana.
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Identification of the cardiac beta-adrenergic receptor protein: solubilization and purification by affinity chromatography.
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Identification of the ral and rac1 gene products, low molecular mass GTP-binding proteins from human platelets.
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Immunoaffinity chromatography of canine high-molecular-weight renin: partial purification and characterization.
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Immunological properties of avian oncornavirus polypeptides.
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Immunological studies on eluates from human renal allografts.
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In situ analysis of protein chromatography and column efficiency using magnetic resonance imaging.
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In vitro modulation of macrophage tumoricidal activity: partial characterization of a macrophage-activating factor(s) in supernatants of NaIO4-treated peritoneal cells.
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Inhibition of platelet-derived growth factor-BB-induced fibroblast proliferation by plasmin-activated alpha 2-macroglobulin is mediated via an alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein-dependent mechanism.
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Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides.
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Insulin activates a novel adipocyte mitogen-activated protein kinase kinase kinase that shows rapid phasic kinetics and is distinct from c-Raf.
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Interacting fidelity defects in the replicative DNA polymerase of bacteriophage RB69.
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Interaction of calcium and lead in human erythrocytes.
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Isolation and characterization of the Escherichia coli mutL gene product.
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Isolation and characterization of viridin, a new 65 kDa antifungal protein from the mould Trichoderma viride.
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Isolation and purification of cellular retinol binding protein (CRBP) from goat mammary gland.
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Isolation and regulation of the protein kinase inhibitor and the calcium-dependent cyclic nucleotide phosphodiesterase regulator in the Sertoli cell-enriched testis.
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Isolation of proteins by gel filtration in 6M guanidinium chloride: application to RNA tumor viruses.
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Isolation, purification and characterization of an iron-binding protein from the horseshoe crab (Limulus polyphemus).
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Length Specificity and Polymerization Mechanism of (1,3)-β-d-Glucan Synthase in Fungal Cell Wall Biosynthesis.
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Lipoprotein (a): purification and kinetic analysis.
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Lipoprotein a inhibits streptokinase-mediated activation of human plasminogen.
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Localization of RNA tumor virus polypeptides. I. Isolation of further virus substructures.
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Macrophage accumulation in mice is inhibited by low molecular weight products from murine leukemia viruses.
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Mapping tertiary interactions in protein folding reactions: a novel mass spectrometry- and chemical synthesis-based approach.
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Measurement of 25-hydroxyvitamin D 1-alpha-hydroxylase activity in mammalian kidney.
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Mechanism of action of cholera toxin and the mobile receptor theory of hormone receptor-adenylate cyclase interactions.
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Mechanism of insulin incorporation into alpha 2-macroglobulin: implications for the study of peptide and growth factor binding.
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Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.
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Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis.
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Microemulsions of cholesteryl oleate and dimyristoylphosphatidylcholine: a model for cholesteryl ester rich very low density lipoproteins.
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Monomeric yeast frataxin is an iron-binding protein.
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Multiphasic effect of morphine on the release of substance P from rat trigeminal nucleus slices.
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Multiple chromatographic forms of the formylpeptide chemoattractant receptor and their relationship to GTP-binding proteins.
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NADPH-dependent oxygen reductase activity in pulmonary macrophages.
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Neutral proteinase of rabbit skin: an enzyme capable of degrading skin protein and inducing an inflammatory response.
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Norepinephrine: dissociation of -receptor binding from adenylate cyclase activation in solubilized myocardium.
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Nuclease activity in a fragment of bacteriophage T4 deoxyribonucleic acid polymerase induced by the amber mutant am B22.
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Oligonucleotides produced by digestion of bakers' yeast serine transfer ribonucleic acid with specific nucleases.
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Overproduction of alpha chains provides a proton-insensitive component to the bluefish hemoglobin system.
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Partial purification of the cyanide-resistant alternative oxidase of skunk cabbage (Symplocarpus foetidus) mitochondria.
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Physical and chemical properties of rabbit muscle phosphofructokinase cross-linked with dimethyl suberimidate.
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Polymerization of hemoglobins of mouse and man: structural basis.
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Polypeptides of mammalian oncornaviruses. I. Isolation and serological analysis polypeptides from murine and feline C-type viruses.
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Polypeptides of mammalian oncornaviruses. II Characterization of murine leukemia virus polypeptide (p 15) bearing interspecies reactivity.
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Preparation of high molecular weight invertebrate hemoglobins.
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Preparative solvent partition chromatography of butyrylated cyclic AMP analogues.
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Prespliceosome and spliceosome isolation and analysis.
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Progressive Rod-Cone Degeneration (PRCD) Protein Requires N-Terminal S-Acylation and Rhodopsin Binding for Photoreceptor Outer Segment Localization and Maintaining Intracellular Stability.
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Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit.
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Proteomic analysis of mitotic RNA polymerase II reveals novel interactors and association with proteins dysfunctional in disease.
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Purification and characterization of a "half-molecule" alpha 2-macroglobulin from the southern grass frog: absence of binding to the mammalian alpha 2-macroglobulin receptor.
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Purification and characterization of a 60-kDa protein from oat, formerly known as a TCP1-related chaperone.
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Purification and characterization of a lecithin-D(-)- -hydroxybutyrate dehydrogenase complex.
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Purification and characterization of one-chain and two-chain renins from mouse submandibular gland.
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Purification and characterization of papain-solubilized HLA antigens from human platelets.
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Purification and characterization of the beta-adrenergic receptor kinase.
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Purification and initial characterization of a putative blue light-regulated phosphodiesterase from Escherichia coli.
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Purification and properties of sulfite oxidase from chicken liver. Presence of molybdenum in sulfite oxidase from diverse sources.
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Purification and properties of sulfite oxidase from human liver.
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Purification and some properties of Cd-binding protein from rat liver.
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Purification of G protein beta gamma from bovine brain.
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Purification of a 12,020-dalton protein that enhances the activation of mitogen-activated protein (MAP) kinase by MAP kinase kinase.
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Purification of a distinct placental lactogen receptor, a new member of the growth hormone/prolactin receptor family.
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Purification of a naturally produced, low molecular weight organic factor that reversibly blocks encystment of Blastocladiella emersonii zoospores.
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Purification of brain analogs of red blood cell membrane skeletal proteins: ankyrin, protein 4.1 (synapsin), spectrin, and spectrin subunits.
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Purification of glycopeptides of human plasma proteins by high-performance liquid chromatography.
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Purification of hexabrachion (tenascin) from cell culture conditioned medium, and separation from a cell adhesion factor.
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Purification, characterization, and structural elucidation of the active moiety of the previously called "suppressor activating factor (SAF)".
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Quantification of mouse macrophage chemotaxis in vitro: role of C5 for the production of chemotactic activity.
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Rac1, a low-molecular-mass GTP-binding-protein with high intrinsic GTPase activity and distinct biochemical properties.
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Radioimmunoassay of plasma estradiol during the breeding cycle of ring doves (Streptopelia risoria).
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Rapid degradation of puromycyl peptides in hepatoma cells and reticulocytes.
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Rapid shotgun cloning utilizing the two base recognition endonuclease CviJI.
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Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. 3. The Escherichia coli hemoflavoprotein: catalytic parameters and the sequence of electron flow.
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Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. IV. The Escherichia coli hemoflavoprotein: subunit structure and dissociation into hemoprotein and flavoprotein components.
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Regional localization of a glioma-associated antigen defined by monoclonal antibody 81C6 in vivo: kinetics and implications for diagnosis and therapy.
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Regulation of E2A activities by histone acetyltransferases in B lymphocyte development.
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Regulation of cyclin D1/Cdk4 complexes by calcium/calmodulin-dependent protein kinase I.
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Release of ubiquitin-charged Cdc34-S - Ub from the RING domain is essential for ubiquitination of the SCF(Cdc4)-bound substrate Sic1.
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Renaturation and partial peptide sequencing of mitogen-activated protein kinase (MAP kinase) activator from rabbit skeletal muscle.
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Reversible binding of platelet-derived growth factor-AA, -AB, and -BB isoforms to a similar site on the "slow" and "fast" conformations of alpha 2-macroglobulin.
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Role of aggregated human growth hormone (hGH) in development of antibodies to hGH.
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Secreted extracellular domains of macrophage scavenger receptors form elongated trimers which specifically bind crocidolite asbestos.
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Sel-association of glucagon. Equilibrium studies.
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Separation and quantitation of serum constituents associated with calcium by gel filtration.
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Separation of two thyrotropin binding components from porcine thyroid tissue by affinity chromatography: characterization of high and low affinity sites.
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Serum IgD and IgE concentrations in immunodeficiency diseases.
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Siroheme and sirohydrochlorin. The basis for a new type of porphyrin-related prosthetic group common to both assimilatory and dissimilatory sulfite reductases.
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Solubilization and partial isolation of human melanoma tumor-associated antigens.
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Somatostatin-like immunoactivity and biological activity is present in Tetrahymena pyriformis, a ciliated protozoan.
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Strain variation in composition and molecular size of the capsular polysaccharide of Cryptococcus neoformans serotype A.
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Structural and Biochemical Characterization of the Francisella tularensis Pathogenicity Regulator, Macrophage Locus Protein A (MglA).
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Structural characteristics of the desmin protofilament.
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Studies of the copper and heme cofactors of pseudomonad L-tryptophan-2,3-dioxygenase by electron paramagnetic resonance spectroscopy.
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Studies on photosystem I. I. Relationship of plastocyanin, cytochrome f and P700.
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Substructure of human von Willebrand factor.
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Subunit structure of fragment D from fibrinogen and cross-linked fibrin.
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Synaptic vesicle membrane proteins interact to form a multimeric complex.
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Synthesis and secretion of gamma-globulin by lymph node cells. VI. Characteristics of the structure of immunoglobulin A and its pattern of secretion by appendix cell suspensions.
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Synthesis of Modular Brush Polymer-Protein Hybrids Using Diazotransfer and Copper Click Chemistry.
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Synthesis, characterization, and functionalization of gold nanoparticles for cancer imaging.
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The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity.
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The beta-phosphoro[35S]thioate analogue of UDP-Glc is efficiently utilized by the glucose phosphotransferase and is relatively resistant to hydrolytic degradation.
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The double-stranded RNA binding protein 76:NF45 heterodimer inhibits translation initiation at the rhinovirus type 2 internal ribosome entry site.
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The effect of plasmin on the subunit structure of human fibrin.
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The effect of plasmin on the subunit structure of human fibrinogen.
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The hemoglobin of the crossopterygian fish, Latimeria chalumnae (Smith). Subunit structure and oxygen equilibria.
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The integrity of a cholesterol-binding pocket in Niemann-Pick C2 protein is necessary to control lysosome cholesterol levels.
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The mammalian beta 2-adrenergic receptor: purification and characterization.
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The materials engineering of temperature-sensitive liposomes.
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The membrane attachment protein for spectrin is associated with band 3 in human erythrocyte membranes.
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The structure and assembly of microtubules.
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The subunit structure of normal and hemophilic factor VIII.
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The synthesis and secretion of gamma-globulin by lymph node cells. V. The dissociation of the microsome-antibody complex with enzymatically and chemically altered gamma-globulins.
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Three peptides from the atrial natriuretic factor prohormone amino terminus lower blood pressure and produce diuresis, natriuresis, and/or kaliuresis in humans.
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Thrittene, homologous with somatostatin-28((1-13)), is a novel peptide in mammalian gut and circulation.
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Trimethoprim resistance in Haemophilus influenzae is due to altered dihydrofolate reductase(s).
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Urinary metabolities of harmine in the rat and their inhibition of monoamine oxidase.
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Use of Sepharose 4B for preparative scale fractionation of eukaryotic messenger RNA's.
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Use of gel filtration in the preparation of biological fluids for magnetic resonance spectroscopy.
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Use of gel filtration to examine the distribution of calcium among serum proteins.
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[Synthesis of human proinsulin in Escherichia coli cells].
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zeta-Crystallin is a major protein in the lens of Camelus dromedarius.
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