Chromosomal Proteins, Non-Histone

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  Subject Areas on Research

  • A genetic memory initiates the epigenetic loop necessary to preserve centromere position. 
  • A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation. 
  • ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis. 
  • Analysis of Cdc6 function in the assembly of mammalian prereplication complexes. 
  • Autoantibodies to DEK oncoprotein in human inflammatory disease. 
  • Bacterial Growth Inhibition Screen (BGIS) identifies a loss-of-function mutant of the DEK oncogene, indicating DNA modulating activities of DEK in chromatin. 
  • Bacterial Growth Inhibition Screen (BGIS): harnessing recombinant protein toxicity for rapid and unbiased interrogation of protein function. 
  • Centromere round-up at the heterochromatin corral. 
  • Centromeres of human chromosomes. 
  • Characterization of neo-centromeres in marker chromosomes lacking detectable alpha-satellite DNA. 
  • Chromatin association of rad17 is required for an ataxia telangiectasia and rad-related kinase-mediated S-phase checkpoint in response to low-dose ultraviolet radiation. 
  • Chromatin conformation of yeast centromeres 
  • Cis-acting polymorphisms affect complex traits through modifications of microRNA regulation pathways. 
  • Cohesin, CTCF and lymphocyte antigen receptor locus rearrangement. 
  • Cohesin: it's not just for chromosomes anymore. 
  • Comprehensive analysis of the chromatin landscape in Drosophila melanogaster. 
  • Concise review: role of DEK in stem/progenitor cell biology. 
  • Condensin and cohesin display different arm conformations with characteristic hinge angles. 
  • Conserved organization of centromeric chromatin in flies and humans. 
  • Cornelia de Lange syndrome in diverse populations. 
  • DEK expression in Merkel cell carcinoma and small cell carcinoma. 
  • DEK expression in melanocytic lesions. 
  • DEK in the synovium of patients with juvenile idiopathic arthritis: characterization of DEK antibodies and posttranslational modification of the DEK autoantigen. 
  • DEK is a poly(ADP-ribose) acceptor in apoptosis and mediates resistance to genotoxic stress. 
  • DEK is required for homologous recombination repair of DNA breaks. 
  • DEK oncogene expression during normal hematopoiesis and in Acute Myeloid Leukemia (AML). 
  • DEK over-expression promotes mitotic defects and micronucleus formation. 
  • DEK proto-oncogene expression interferes with the normal epithelial differentiation program. 
  • DEK regulates hematopoietic stem engraftment and progenitor cell proliferation. 
  • DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions. 
  • Defining the genotypic and phenotypic spectrum of X-linked MSL3-related disorder. 
  • Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. 
  • Dicentric chromosomes: unique models to study centromere function and inactivation. 
  • Differential contribution of cis-regulatory elements to higher order chromatin structure and expression of the CFTR locus. 
  • Drosophila ORC localizes to open chromatin and marks sites of cohesin complex loading. 
  • Drosophila PIWI associates with chromatin and interacts directly with HP1a. 
  • Early Diverging Fungus Mucor circinelloides Lacks Centromeric Histone CENP-A and Displays a Mosaic of Point and Regional Centromeres. 
  • Effects of nickel(II) on nuclear protein binding to DNA in intact mammalian cells. 
  • Embryonal central nervous system neoplasms arising in infants and young children: a pediatric brain tumor consortium study. 
  • Epigenetic dynamics of centromeres and neocentromeres in Cryptococcus deuterogattii. 
  • Epigenomics of centromere assembly and function. 
  • Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. 
  • Exome-wide Sequencing Shows Low Mutation Rates and Identifies Novel Mutated Genes in Seminomas. 
  • Foreword: the centromere and kinetochore in creatures great and small. 
  • Functional domains of the ubiquitous chromatin protein DEK. 
  • Functional epialleles at an endogenous human centromere. 
  • Functional organization of polytene chromosomes. 
  • Gains and overexpression identify DEK and E2F3 as targets of chromosome 6p gains in retinoblastoma. 
  • Genomic size of CENP-A domain is proportional to total alpha satellite array size at human centromeres and expands in cancer cells. 
  • Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer. 
  • High-affinity interaction of poly(ADP-ribose) and the human DEK oncoprotein depends upon chain length. 
  • Histone H3K4 methylation keeps centromeres open for business. 
  • Human Centromeres Produce Chromosome-Specific and Array-Specific Alpha Satellite Transcripts that Are Complexed with CENP-A and CENP-C. 
  • Human Rad9 is required for the activation of S-phase checkpoint and the maintenance of chromosomal stability. 
  • Human centromere repositioning within euchromatin after partial chromosome deletion. 
  • Human centromeric chromatin is a dynamic chromosomal domain that can spread over noncentromeric DNA. 
  • Hypophosphorylation of the architectural chromatin protein DEK in death-receptor-induced apoptosis revealed by the isotope coded protein label proteomic platform. 
  • Identification of MeCP2 mutations in a series of females with autistic disorder. 
  • Identification of centromeric antigens in dicentric Robertsonian translocations: CENP-C and CENP-E are necessary components of functional centromeres. 
  • Immunolocalization of CENP-A suggests a distinct nucleosome structure at the inner kinetochore plate of active centromeres. 
  • Imprinted CDKN1C is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors. 
  • Initial testing of the CENP-E inhibitor GSK923295A by the pediatric preclinical testing program. 
  • Intercellular trafficking of the nuclear oncoprotein DEK. 
  • Interphase cohesin regulation ensures mitotic fidelity after genome reduplication. 
  • Interplay between SCARECROW, GA and LIKE HETEROCHROMATIN PROTEIN 1 in ground tissue patterning in the Arabidopsis root. 
  • Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. 
  • Long transposon-rich centromeres in an oomycete reveal divergence of centromere features in Stramenopila-Alveolata-Rhizaria lineages. 
  • Mechanism for G2 phase-specific nuclear export of the kinetochore protein CENP-F. 
  • Melanoma proliferation and chemoresistance controlled by the DEK oncogene. 
  • Microtubules accelerate the kinase activity of Aurora-B by a reduction in dimensionality. 
  • Molecular basis for a protein-mediated DNA-bridging mechanism that functions in condensation of the E. coli chromosome. 
  • Mutations in NCAPG2 Cause a Severe Neurodevelopmental Syndrome that Expands the Phenotypic Spectrum of Condensinopathies. 
  • Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton. 
  • Nonhistone chromosomal proteins of the developing rat testis. 
  • Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding. 
  • Phosphorylation by protein kinase CK2 changes the DNA binding properties of the human chromatin protein DEK. 
  • Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. 
  • Promoter methylation and silencing of the tissue factor pathway inhibitor-2 (TFPI-2), a gene encoding an inhibitor of matrix metalloproteinases in human glioma cells. 
  • Protein phosphatase 1 regulation by inhibitors and targeting subunits. 
  • Rapid detection of SMARCB1 sequence variation using high resolution melting. 
  • Regulation of mitotic chromosome cohesion by Haspin and Aurora B. 
  • Rhabdoid tumour: a malignancy of early childhood with variable primary site, histology and clinical behaviour. 
  • Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling. 
  • Sequence divergence of coiled coils--structural rods, myosin filament packing, and the extraordinary conservation of cohesins. 
  • Single-molecule FRET reveals multiscale chromatin dynamics modulated by HP1α. 
  • Solution NMR structure of the N-terminal domain of the human DEK protein. 
  • Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. 
  • Spatiotemporal regulation of Aurora B recruitment ensures release of cohesion during C. elegans oocyte meiosis. 
  • Stable dicentric X chromosomes with two functional centromeres. 
  • Stacking the DEK: from chromatin topology to cancer stem cells. 
  • Stem cell differentiation indicated by noninvasive photonic characterization and fractal analysis of subcellular architecture. 
  • Structures of archaeal DNA segregation machinery reveal bacterial and eukaryotic linkages. 
  • Studies on scaffold attachment sites and their relation to genome function. 
  • Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1. 
  • TEX11 is mutated in infertile men with azoospermia and regulates genome-wide recombination rates in mouse. 
  • Tau deficiency leads to the upregulation of BAF-57, a protein involved in neuron-specific gene repression. 
  • The ATM-dependent DNA damage signaling pathway. 
  • The DEK nuclear autoantigen is a secreted chemotactic factor. 
  • The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity. 
  • The DEK protein--an abundant and ubiquitous constituent of mammalian chromatin. 
  • The SAF-box domain of chromatin protein DEK. 
  • The coiled coils of cohesin are conserved in animals, but not in yeast. 
  • The human oncoprotein and chromatin architectural factor DEK counteracts DNA replication stress. 
  • The nuclear DEK interactome supports multi-functionality. 
  • The oncoprotein DEK affects the outcome of PARP1/2 inhibition during mild replication stress. 
  • The symmetrical structure of structural maintenance of chromosomes (SMC) and MukB proteins: long, antiparallel coiled coils, folded at a flexible hinge. 
  • The unique DEK oncoprotein in women's health: A potential novel biomarker. 
  • Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming. 
  • Variable Extent of Lineage-Specificity and Developmental Stage-Specificity of Cohesin and CCCTC-Binding Factor Binding Within the Immunoglobulin and T Cell Receptor Loci. 
  • Variegated aneuploidy in two siblings: phenotype, genotype, CENP-E analysis, and literature review. 
  • Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Gordan, Raluca Mihaela, Associate Professor in Biostatistics & Bioinformatics, Computer Science
  • Hartemink, Alexander J., Professor in the Department of Computer Science, Biology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
  • Sullivan, Beth Ann, Professor of Molecular Genetics and Microbiology, Duke Science & Society