Chromosome Banding

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  Subject Areas on Research

  • A de novo direct duplication of 16q22.1 --> q23.1 in a boy with midface hypoplasia and mental retardation. 
  • A patient with duplication (7)(p22.1pter) characterized by array-CGH. 
  • Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts. 
  • Amplified C lambda and c-abl genes are on the same marker chromosome in K562 leukemia cells. 
  • An 18-locus linkage map of the pericentromeric region of the human X chromosome: genetic framework for mapping X-linked disorders. 
  • An Xp; Yq translocation causing a novel contiguous gene syndrome in brothers with generalized epilepsy, ichthyosis, and attention deficits. 
  • Assignment of hexokinase types 1,2,3 (Hk1,2,3) and glucokinase (Gck) to rat chromosome band 20q11, 4q34, 17q12 and 14q21 respectively, by in situ hybridization. 
  • Assignment of the beta-subunit of rod photoreceptor cGMP phosphodiesterase gene PDEB (homolog of the mouse rd gene) to human chromosome 4p16. 
  • Assignment of the human glycogen debrancher gene to chromosome 1p21. 
  • Assignment of the human slow skeletal troponin T gene to 19q13.4 using somatic cell hybrids and fluorescence in situ hybridization analysis. 
  • Characterization of chromosome 17 abnormalities in medulloblastomas. 
  • Chromosomal characteristics of childhood brain tumors. 
  • Chromosomal composition of four permanent cultured cell lines derived from human gliomas. 
  • Chromosomal composition of malignant human gliomas through serial subcutaneous transplantation in athymic mice. 
  • Chromosomal localization and catalytic properties of the recombinant alpha subunit of human lymphocyte methionine adenosyltransferase. 
  • Chromosomal localization of human glutamate receptor genes. 
  • Chromosomal organization of adrenergic receptor genes. 
  • Chromosomal progression of malignant human gliomas from biopsy to establishment as permanent lines in vitro. 
  • Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. 
  • De novo partial duplication of chromosome 7p in a male with autistic disorder. 
  • Deletions in Xq26.3-q27.3 including FMR1 result in a severe phenotype in a male and variable phenotypes in females depending upon the X inactivation pattern. 
  • Establishment and characterization of a human prostatic carcinoma cell line (PC-3). 
  • Evidence for coincident mutations in human lymphoblast clones selected for functional loss of a thymidine kinase gene. 
  • Familial tandem duplication of bands q31.1 to q32.3 on chromosome 4 with mild phenotypic effect. 
  • Gene order on the short arm of human chromosome 11: regional assignment of the LDH A gene distal to catalase in two translocations. 
  • Genetic mapping of dinucleotide repeat polymorphisms and von Hippel-Lindau disease on chromosome 3p25-26. 
  • Hereditary renal cell carcinoma in the rat associated with nonrandom loss of chromosomes 5 and 6. 
  • Homozygous deletion on chromosome 9p and loss of heterozygosity on 9q, 6p, and 6q in primary human small cell lung cancer. 
  • In situ hybridization and translocation breakpoint mapping. I. Nonidentical 22q11 breakpoints for the t(9;22) of CML and the t(8;22) of Burkitt lymphoma. 
  • Intrachromosomal triplication of 2q11.2-q21 in a severely malformed infant: case report and review of triplications and their possible mechanism. 
  • Isolation of a murine copper transporter gene, tissue specific expression and functional complementation of a yeast copper transport mutant. 
  • Localization of the cDNA for an alpha 1-adrenergic receptor subtype (ADRA1D) to chromosome band 20p13. 
  • Microduplication 22q11.2, an emerging syndrome: clinical, cytogenetic, and molecular analysis of thirteen patients. 
  • Molecular and genetic characterization of a radiation-induced structural rearrangement in mouse chromosome 2 causing mutations at the limb deformity and agouti loci. 
  • Molecular cytogenetic analysis of the bladder carcinoma cell line BK-10 by spectral karyotyping. 
  • Patterns of the early, gross chromosomal changes in malignant human gliomas. 
  • Recombination of 4p16 DNA markers in an unusual family with Huntington disease. 
  • Regional localization of the human genes for S-adenosylhomocysteine hydrolase (cen----q131) and adenosine deaminase (q131----qter) on chromosome 20. 
  • Structural chromosomal abnormalities in human medulloblastoma. 
  • Subtelomeric deletions of chromosome 6p: molecular and cytogenetic characterization of three new cases with phenotypic overlap with Ritscher-Schinzel (3C) syndrome. 
  • The gene encoding the glutamate receptor subunit GluR5 is located on human chromosome 21q21.1-22.1 in the vicinity of the gene for familial amyotrophic lateral sclerosis. 
  • The gene that encodes the human CD20 (B1) differentiation antigen is located on chromosome 11 near the t(11;14)(q13;q32) translocation site. 
  • The murine Hox-2 cluster of homeo box containing genes maps distal on chromosome 11 near the tail-short (Ts) locus. 
  • The sequence of the human genome. 
  • Tumorigenic suppression of a human cutaneous squamous cell carcinoma cell line in the nude mouse skin graft assay. 
  • Unbalanced translocation 46,XY,-15,+der(22)t(15;22)(q13;q11)pat: case report and review of the literature. 
  • cDNA cloning and chromosomal localization of the human beta-adrenergic receptor kinase.