Chromosomes

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  Subject Areas on Research

  • A Chromosome-level Genome Assembly of the Highly Heterozygous Sea Urchin Echinometra sp. EZ Reveals Adaptation in the Regulatory Regions of Stress Response Genes. 
  • A chromosome-level reference genome and pangenome for barn swallow population genomics. 
  • A comparison of the genes coding for canonical TRP channels and their M, V and P relatives. 
  • A cytogenetic comparison of the responses of mouse and human peripheral blood lymphocytes to 60Co gamma radiation. 
  • A micro-spreading improvement for spermatogenic chromosomes from Triatominae (Hemiptera-Reduviidae). 
  • A multimember kinesin gene family in Drosophila. 
  • A new emu genome illuminates the evolution of genome configuration and nuclear architecture of avian chromosomes. 
  • A physical map of the mouse genome. 
  • A recombinational portrait of the Drosophila pseudoobscura genome. 
  • A remarkable career in science-Joseph G. Gall. 
  • A sampling of methods to study chromosome and genome structure and function. 
  • A unique role of the DNA fragmentation factor in maintaining genomic stability. 
  • Acquisition and processing of a conditional dicentric chromosome in Saccharomyces cerevisiae. 
  • An improved germline genome assembly for the sea lamprey Petromyzon marinus illuminates the evolution of germline-specific chromosomes. 
  • Anastral spindle assembly: a mathematical model. 
  • Anticentromere antibody. Clinical Correlations and association with favorable prognosis in patients with scleroderma variants. 
  • Antiretroviral therapy effects on genetic and morphologic end points in lymphocytes and sperm of men with human immunodeficiency virus infection. 
  • Assembly pathway of the anastral Drosophila oocyte meiosis I spindle. 
  • Association between family history of cancer and mutagen sensitivity in upper aerodigestive tract cancer patients. 
  • Atypical chromosome 22q11.2 deletions are complex rearrangements and have different mechanistic origins. 
  • Cell-enhanced dissolution of carcinogenic lead chromate particles: the role of individual dissolution products in clastogenesis. 
  • Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer. 
  • Centromere identity in Drosophila is not determined in vivo by replication timing. 
  • Centromere round-up at the heterochromatin corral. 
  • Centromere scission drives chromosome shuffling and reproductive isolation. 
  • Centrosome and spindle function of the Drosophila Ncd microtubule motor visualized in live embryos using Ncd-GFP fusion proteins. 
  • Chromatin conformation of yeast centromeres 
  • Chromium(III) picolinate produces chromosome damage in Chinese hamster ovary cells. 
  • Chromosome 1q21.2 and additional loci influence risk of spontaneous coronary artery dissection and myocardial infarction. 
  • Chromosome breakage in Drosophila melanogaster induced by a monofunctional alkylating agent (EMS). 
  • Chromosome end-to-end associations and telomerase activity during cancer progression in human cells after treatment with alpha-particles simulating radon progeny. 
  • Chromosome mutation tests for mutagenesis in Drosophila melanogaster. A report of the U.S. Environmental Protection Agency Gene-Tox Program. 
  • Chromosome rearrangements and aneuploidy in yeast strains lacking both Tel1p and Mec1p reflect deficiencies in two different mechanisms. 
  • Chromosome segregation. Programmed to stay together. 
  • Chromosome-Level Reference Genomes for Two Strains of Caenorhabditis briggsae: An Improved Platform for Comparative Genomics. 
  • Chromosome-Specific Human Herpesvirus 6 Integration and Hematologic Malignancies. 
  • Chromosomes with high gene density are preferentially repaired in human cells. 
  • Clinical Practice Guidelines for the Immunological Management of Chromosome 22q11.2 Deletion Syndrome and Other Defects in Thymic Development. 
  • Cloning, characterization, and chromosomal localization of rec1.3, a member of the G-protein-coupled receptor family highly expressed in brain. 
  • Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution. 
  • Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus. 
  • Computational approaches for inferring 3D conformations of chromatin from chromosome conformation capture data. 
  • Concerning the mechanism of FSH action: rapid stimulation of testicular synthesis of nuclear RNA. 
  • Condensin and cohesin display different arm conformations with characteristic hinge angles. 
  • Conditional dicentric chromosomes in yeast. 
  • Conserved organization of centromeric chromatin in flies and humans. 
  • Control of gene expression and assembly of chromosomal subdomains by chromatin regulators with antagonistic functions. 
  • Convergent evolution of chromosomal sex-determining regions in the animal and fungal kingdoms. 
  • Coordination of DNA ends during double-strand-break repair in bacteriophage T4. 
  • Coordination of replication and transcription along a Drosophila chromosome. 
  • Crossover interference on nucleolus organizing region-bearing chromosomes in Arabidopsis. 
  • Cytogenetic changes induced by 1-(N1-methylhydrazinomethyl)-N-isopropyl benzamide in Ehrlich ascites tumor cells. 
  • DEK over-expression promotes mitotic defects and micronucleus formation. 
  • DNA content and chromosomes in permanent cultured cell lines derived from malignant human gliomas. 
  • Dancing genomes: fungal nuclear positioning. 
  • Dense sampling of ethnic groups within African countries reveals fine-scale genetic structure and extensive historical admixture. 
  • Differential apoptosis-inducing effect of quercetin and its glycosides in human promyeloleukemic HL-60 cells by alternative activation of the caspase 3 cascade. 
  • Differential staining of actin in metaphase spindles with 7-nitrobenz-2-oxa-1,3-diazole-phallacidin and fluorescent DNase: is actin involved in chromosomal movement? 
  • Distribution of RNA polymerase on Drosophila polytene chromosomes as studied by indirect immunofluorescence. 
  • Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis. 
  • Effects of inversions on within- and between-species recombination and divergence. 
  • Essential light chain of Drosophila nonmuscle myosin II. 
  • Evaluation of the spindle apparatus of in-vitro matured human oocytes following cryopreservation. 
  • Evidence that myosin does not contribute to force production in chromosome movement. 
  • Evolutionary biology: Genes to make new species. 
  • Expanding studies of chromosome structure and function in the era of T2T genomics. 
  • Expansions and contractions of the genetic map relative to the physical map of yeast chromosome III. 
  • False gene and chromosome losses in genome assemblies caused by GC content variation and repeats. 
  • Fiber autoradiography of replicating yeast DNA. 
  • Function of the hydrophilic carboxyl terminus of type II DNA topoisomerase from Drosophila melanogaster. II. In vivo studies. 
  • Functional ecdysone receptor is the product of EcR and Ultraspiracle genes. 
  • Functional epialleles at an endogenous human centromere. 
  • Functional organization of polytene chromosomes. 
  • Gene transposition as a cause of hybrid sterility in Drosophila. 
  • Generation of a Mouse Full-length Balancer with Versatile Cassette-shuttling Selection Strategy. 
  • Genetic analysis demonstrates a direct link between rho signaling and nonmuscle myosin function during Drosophila morphogenesis. 
  • Genetic analysis of susceptibility to Chlamydia trachomatis in mouse. 
  • Genetic control of chromosome length in yeast. 
  • Genetic manipulation of centromere function. 
  • Genetic mapping of the beta-arrestin 1 and 2 genes on mouse chromosomes 7 and 11 respectively. 
  • Genetics of Alzheimer's disease. 
  • Genome accessibility is widely preserved and locally modulated during mitosis. 
  • Genome-wide scan for adult onset primary open angle glaucoma. 
  • HL A typing, mixed leukocyte reactivity, and skin graft survival in a family with a recombinant at the HL-1 chromosomal region (major transplantation region). 
  • Haploidy and androgenesis in Drosophila. 
  • Heat-shock-specific phosphorylation and transcriptional activity of RNA polymerase II. 
  • Histone gene clusters of the newt notophthalmus are separated by long tracts of satellite DNA. 
  • Histone genes are located at the sphere loci of newt lampbrush chromosomes. 
  • Homothallic conversions of yeast mating-type genes occur by intrachromosomal recombination. 
  • How cells get the right chromosomes. 
  • Human Centromeres Produce Chromosome-Specific and Array-Specific Alpha Satellite Transcripts that Are Complexed with CENP-A and CENP-C. 
  • Human chromosomes with shorter telomeres and large heterochromatin regions have a higher frequency of acquired somatic cell aneuploidy. 
  • Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype. 
  • Identification and utilization of arbitrary correlations in models of recombination signal sequences. 
  • Identification of yeast mutants with altered telomere structure. 
  • Identifying Key Genetic Regions for Cell Sheet Morphogenesis on Chromosome 2L Using a Drosophila Deficiency Screen in Dorsal Closure. 
  • Immunofluorescence localization of an adducin-like protein in the chromosomes of mouse oocytes. 
  • Improved adenoviral vectors for gene therapy of Duchenne muscular dystrophy. 
  • Induction of internucleosomal DNA fragmentation by carcinogenic chromate: relationship to DNA damage, genotoxicity, and inhibition of macromolecular synthesis. 
  • Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs. 
  • Initiation of replication at a mammalian chromosomal origin. 
  • Interphase cohesin regulation ensures mitotic fidelity after genome reduplication. 
  • Interrogating the Roles of Mutation-Selection Balance, Heterozygote Advantage, and Linked Selection in Maintaining Recessive Lethal Variation in Natural Populations. 
  • Interrupter sequences that are widely distributed in the Drosophila genome. 
  • Intrachromosomal gene conversion and the maintenance of sequence homogeneity among repeated genes. 
  • Intrachromosomal gene conversion in yeast. 
  • Intraspecific variation in symbiont genomes: bottlenecks and the aphid-buchnera association. 
  • Inversions shape the divergence of Drosophila pseudoobscura and Drosophila persimilis on multiple timescales. 
  • Is there left-handed DNA at the ends of yeast chromosomes? 
  • Lattice animal model of chromosome organization 
  • Localization of RNA polymerase in polytene chromosomes of Drosophila melanogaster. 
  • Localizing Post-Admixture Adaptive Variants with Object Detection on Ancestry-Painted Chromosomes. 
  • Location of the gene involving the small eye mutation on mouse chromosome 2 suggests homology with human aniridia 2 (AN2). 
  • Locus-specific variation in phosphorylation state of RNA polymerase II in vivo: correlations with gene activity and transcript processing. 
  • Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote. 
  • Mediation of meiotic and early mitotic chromosome segregation in Drosophila by a protein related to kinesin. 
  • Meiotic recombination within the centromere of a yeast chromosome. 
  • Meiotic sister chromatid recombination. 
  • Microtubule motors in spindle and chromosome motility. 
  • Mitotic phosphatase activity is required for MCC maintenance during the spindle checkpoint. 
  • Mitotic recombination within the centromere of a yeast chromosome. 
  • Molecular and genetic characterization of a radiation-induced structural rearrangement in mouse chromosome 2 causing mutations at the limb deformity and agouti loci. 
  • Molecular genetics of yeast. 
  • Morphological and biochemical properties of a new human breast cancer cell line. 
  • Mutagen sensitivity in upper aerodigestive tract cancer: a case-control analysis. 
  • Mutants of the microtubule motor protein, nonclaret disjunctional, affect spindle structure and chromosome movement in meiosis and mitosis. 
  • New murine cell line derived from a spontaneous lung tumor induces paraneoplastic syndromes. 
  • Novel Insights into Chromosome Evolution in Birds, Archosaurs, and Reptiles. 
  • Patterns of chromosomal alterations in breast ductal carcinoma in situ. 
  • Patterns of heteroduplex formation associated with the initiation of meiotic recombination in the yeast Saccharomyces cerevisiae. 
  • Phosphorylation dependence of the initiation of productive transcription of Balbiani ring 2 genes in living cells. 
  • Polytene chromosomal maps of 11 Drosophila species: the order of genomic scaffolds inferred from genetic and physical maps. 
  • Population Selection and Sequencing of Caenorhabditis elegans Wild Isolates Identifies a Region on Chromosome III Affecting Starvation Resistance. 
  • Prenatal diagnosis using deletion studies in Duchenne muscular dystrophy. 
  • Properties of prostatic cultures transformed by SV40. 
  • Quantification of DNA cleavage specificity in Hi-C experiments. 
  • RNA polymerase B (or II) in heat induced puffs of Drosophila polytene chromosomes. 
  • Radiation-induced genomic instability: radiation quality and dose response. 
  • Reference genome and demographic history of the most endangered marine mammal, the vaquita. 
  • Remarkably little variation in proteins encoded by the Y chromosome's single-copy genes, implying effective purifying selection. 
  • Replication of yeast chromosomal DNA. 
  • Reprogramming after chromosome transfer into mouse blastomeres. 
  • Retrotransposons Are the Major Contributors to the Expansion of the Drosophila ananassae Muller F Element. 
  • SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development. 
  • Satellite DNA is transcribed on lampbrush chromosomes. 
  • Sedimentation properties of yeast chromosomal DNA. 
  • Separation of chromosomes of Cryptococcus neoformans by pulsed field gel electrophoresis. 
  • Separation of meiotic and mitotic effects of claret non-disjunctional on chromosome segregation in Drosophila. 
  • Simple Mendelian inheritance of the reiterated ribosomal DNA of yeast. 
  • Size and structure of yeast chromosomal DNA. 
  • Somatic uniparental disomy of Chromosome 16p in hemimegalencephaly. 
  • Some properties of a DNA-unwinding protein unique to lymphocytes from chronic lymphocytic leukemia. 
  • Sparrows and supergenes: Ecological epigenetics in action. 
  • Stability of Drosophila chromosomes to radioactive decay of incorporated phosphorus-32. 
  • Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes. 
  • Stepping-stone spatial structure causes slow decay of linkage disequilibrium and shifts the site frequency spectrum. 
  • Structural analysis of a yeast centromere. 
  • Synaptonemal complex complement of man in spreads of spermatocytes, with details of the sex chromosome pair. 
  • TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene. 
  • Tension on chromosomes increases the number of kinetochore microtubules but only within limits. 
  • The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae. 
  • The Drosophila claret segregation protein is a minus-end directed motor molecule. 
  • The G72/G30 gene complex and cognitive abnormalities in schizophrenia. 
  • The Time Scale of Recombination Rate Evolution in Great Apes. 
  • The bacteriophage T4 insertion/substitution vector system. A method for introducing site-specific mutations into the virus chromosome. 
  • The claret locus in Drosophila encodes products required for eyecolor and for meiotic chromosome segregation. 
  • The forkhead transcription factor FoxI1 remains bound to condensed mitotic chromosomes and stably remodels chromatin structure. 
  • The genetics of hybrid male sterility between the allopatric species pair Drosophila persimilis and D. pseudoobscura bogotana: dominant sterility alleles in collinear autosomal regions. 
  • The genetics of speciation by reinforcement. 
  • The new year for chromosome research: a change of guard amidst a shifting scientific landscape and global pandemic. 
  • The relation of germ line mosaicism to somatic mosaicism in Drosophila. 
  • The structure of a primitive kinetochore. 
  • The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. 
  • Trisomy of rat chromosome 1 associated with mesothelial cell transformation. 
  • Type I elements mediate replication fork pausing at conserved upstream sites in the Tetrahymena thermophila ribosomal DNA minichromosome. 
  • Ultra high-risk PFA ependymoma is characterized by loss of chromosome 6q. 
  • Unusual DNA sequences associated with the ends of yeast chromosomes. 
  • Unusual chromosome architecture and behaviour at an HSR. 
  • Virus-infected avian cell lines established in vitro. 
  • Visualization of replication initiation and elongation in Drosophila. 
  • Wrestling with Chromosomes: The Roles of SUMO During Meiosis. 
  • Yeast chromosomal DNA: size, structure, and replication. 
  • pYAC-RC, a yeast artificial chromosome vector for cloning DNA cut with infrequently cutting restriction endonucleases. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Schmid, Amy K., David M. Goodner Associate Professor, Duke Science & Society
  • Shinohara, Mari L., Professor of Integrative Immunobiology, Cell Biology
  • Sullivan, Beth Ann, Professor of Molecular Genetics and Microbiology, Duke Science & Society
  • Yildirim, Eda, Assistant Professor of Cell Biology, Cell Biology