Chromosomes, Human, Pair 17

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  Subject Areas on Research

  • "Cannibalistic" phagocytosis in acute megakaryoblastic leukemia (AML M7) with t(10;17)(p15;q22). 
  • A 90 kb DNA deletion associated with neurofibromatosis type 1. 
  • A chromosome jump crosses a translocation breakpoint in the von Recklinghausen neurofibromatosis region. 
  • A compound nucleotide repeat in the neurofibromatosis (NF1) gene. 
  • A deletion unit on chromosome 17q in epithelial ovarian tumors distal to the familial breast/ovarian cancer locus. 
  • A highly polymorphic cDNA probe in the NF1 gene. 
  • A human protein related to yeast Cdc6p. 
  • A novel Alzheimer disease locus located near the gene encoding tau protein. 
  • A novel long and unstable CAG/CTG trinucleotide repeat on chromosome 17q. 
  • A polymorphic cDNA probe on chromosome 17q11.2 located within the NF1 gene [D17S376]. 
  • A promoter sequence variant of ZNF750 is linked with familial psoriasis. 
  • A refined genetic map of the region of chromosome 17 surrounding the von Recklinghausen neurofibromatosis (NF1) gene. 
  • A region of interstitial 17q25 allelic loss in ovarian tumors coincides with a defined region of loss in breast tumors. 
  • AURKA amplification, chromosome instability, and centrosome abnormality in human pancreatic carcinoma cells. 
  • Absence of truncating BRIP1 mutations in chromosome 17q-linked hereditary prostate cancer families. 
  • Acquired genomic copy number aberrations and survival in adult acute myelogenous leukemia. 
  • Age-related maculopathy: a genomewide scan with continued evidence of susceptibility loci within the 1q31, 10q26, and 17q25 regions. 
  • Alterations of the TP53 gene in human gliomas. 
  • An EcoRI RFLP in the 5' region of the human NF1 gene. 
  • Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease. 
  • BRCA1 maps proximal to D17S579 on chromosome 17q21 by genetic analysis. 
  • BRCA1 mutations in primary breast and ovarian carcinomas. 
  • Characterization of chromosome 17 abnormalities in medulloblastomas. 
  • Chromosome 17q12 variants contribute to risk of early-onset prostate cancer. 
  • Chromosome 17q22-q24 and multiple sclerosis genetic susceptibility. American-French Multiple Sclerosis Genetic Group. 
  • Chromosome breakpoint at 17q11.2 and insertion of DNA from three different chromosomes in a glioblastoma with exceptional glial fibrillary acidic protein expression. 
  • Clarification of subtle reciprocal rearrangements using fluorescence in situ hybridization. 
  • Combined genome-wide scan for prostate cancer susceptibility genes. 
  • Common variation in the BRCA1 gene and prostate cancer risk. 
  • Complete genomic screen in Parkinson disease: evidence for multiple genes. 
  • Comprehensive biomarker and genomic analysis identifies p53 status as the major determinant of response to MDM2 inhibitors in chronic lymphocytic leukemia. 
  • Copy Number Loss of 17q22 Is Associated with Enzalutamide Resistance and Poor Prognosis in Metastatic Castration-Resistant Prostate Cancer. 
  • Cytogenetic and molecular analysis of an unusual case of acute promyelocytic leukemia with a t(15;17;17)(q22;q23;q21). 
  • Cytogenetic assignment and physical mapping of the human DGKE gene to chromosome 17q22. 
  • Detection of frequent allelic loss on proximal chromosome 17q in sporadic breast carcinoma using microsatellite length polymorphisms. 
  • Development of a prognostic model for overall survival in multiple myeloma using the Connect® MM Patient Registry. 
  • Distinct functions of two isoforms of a homeobox gene, BP1 and DLX7, in the regulation of the beta-globin gene. 
  • Elevated frequency of microsatellite mutations in TK6 human lymphoblast clones selected for mutations at the thymidine kinase locus. 
  • Evidence for coincident mutations in human lymphoblast clones selected for functional loss of a thymidine kinase gene. 
  • Fine-mapping the putative chromosome 17q21-22 prostate cancer susceptibility gene to a 10 cM region based on linkage analysis. 
  • Flanking markers for the gene causing von Recklinghausen neurofibromatosis (NF1). 
  • Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53. 
  • Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. 
  • GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21. 
  • Genetic analysis of eight breast-ovarian cancer families with suspected BRCA1 mutations. 
  • Genetic changes in human adrenocortical carcinomas. 
  • Genetic linkage mapping of chromosome 17 markers and neurofibromatosis type I. 
  • Genetic linkage of von Recklinghausen neurofibromatosis to the nerve growth factor receptor gene. 
  • Genetic linkage studies of chromosome 17 RFLPs in von Recklinghausen neurofibromatosis (NF1). 
  • Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21. 
  • Genome-wide scan for prostate cancer susceptibility genes using families from the University of Michigan prostate cancer genetics project finds evidence for linkage on chromosome 17 near BRCA1. 
  • Genomic variation within alpha satellite DNA influences centromere location on human chromosomes with metastable epialleles. 
  • Germline mutations in HOXB13 and prostate-cancer risk. 
  • Human centromere repositioning within euchromatin after partial chromosome deletion. 
  • Human ovarian cancer of the surface epithelium. 
  • Hypoglossal neuropathy in hereditary neuropathy with liability to pressure palsy. 
  • Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms. 
  • Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31. 
  • Identification of a novel germline SPOP mutation in a family with hereditary prostate cancer. 
  • In vitro polymerization of tau protein monitored by laser light scattering: method and application to the study of FTDP-17 mutants. 
  • Infrequent p53 gene mutations in medulloblastomas. 
  • Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family. 
  • Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture. 
  • Linkage analysis in von Recklinghausen neurofibromatosis (NF1) with DNA markers for chromosome 17. 
  • Linkage and association with the NOS2A locus on chromosome 17q11 in multiple sclerosis. 
  • Linkage disequilibrium and haplotype tagging polymorphisms in the Tau H1 haplotype. 
  • Linkage of Charcot-Marie-Tooth neuropathy type 1a to chromosome 17. 
  • Linkage of frontotemporal dementia to chromosome 17: clinical and neuropathological characterization of phenotype. 
  • Localization of Charcot-Marie-Tooth disease type 1a (CMT1A) to chromosome 17p11.2. 
  • Localization of the VHR phosphatase gene and its analysis as a candidate for BRCA1. 
  • Loss of heterozygosity of the putative prostate cancer susceptibility gene HPC2/ELAC2 is uncommon in sporadic and familial prostate cancer. 
  • Loss of heterozygosity on chromosome 17q11-21 in cancers of women who have both breast and ovarian cancer. 
  • Mapping of psoriasis to 17q terminus. 
  • Molecular analysis of the JAZF1-JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms. 
  • Molecular and cytogenetic characterization of a novel rearrangement involving chromosomes 9, 12, and 17 resulting in ETV6 (TEL) and ABL fusion. 
  • Molecular characterization and localization of the human MAFG gene. 
  • Molecular mechanisms of spontaneous and induced loss of heterozygosity in human cells in vitro. 
  • Mutation analysis of the THRA1 gene in breast cancer: deletion/fusion of the gene to a novel sequence on 17q in the BT474 cell line. 
  • Neuropathological features of frontotemporal dementia and parkinsonism linked to chromosome 17q21-22 (FTDP-17): Duke Family 1684. 
  • New locus for autosomal dominant high myopia maps to the long arm of chromosome 17. 
  • Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23. 
  • Outcomes of front-line ibrutinib treated CLL patients excluded from landmark clinical trial. 
  • PSORS2 is due to mutations in CARD14. 
  • Phylogenetic implications of the superfast myosin in extraocular muscles. 
  • Prognostic implications of chromosome 17p deletions in human medulloblastomas. 
  • Progression of basal cell carcinoma through loss of chromosome 9q and inactivation of a single p53 allele. 
  • Prohibitin mutations are uncommon in prostate cancer families linked to chromosome 17q. 
  • Prostate cancer metastasis-suppressor genes: a current perspective. 
  • Response of malignant scalp dermatofibrosarcoma to presurgical targeted growth factor inhibition. 
  • Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor. 
  • Ring chromosome 17: phenotype variation by deletion size. 
  • Role of BRCA1 mutation screening in the management of familial ovarian cancer. 
  • Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines. 
  • Sequencing and analysis of genomic fragments from the NF1 locus. 
  • Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis. 
  • Somatic mutations in the BRCA1 gene in sporadic ovarian tumours. 
  • Structure, chromosome location, and expression of the human gamma-actin gene: differential evolution, location, and expression of the cytoskeletal beta- and gamma-actin genes. 
  • Targeted sequencing in chromosome 17q linkage region identifies familial glioma candidates in the Gliogene Consortium. 
  • The case of the gray optic disc! 
  • The evolutionary dynamics of alpha-satellite. 
  • The gene for a novel epidermal antigen maps near the neurofibromatosis 1 gene. 
  • The human extraocular muscle myosin heavy chain gene (MYH13) maps to the cluster of fast and developmental myosin genes on chromosome 17. 
  • The tau N279K exon 10 splicing mutation recapitulates frontotemporal dementia and parkinsonism linked to chromosome 17 tauopathy in a mouse model. 
  • Truncating BRCA1 mutations are uncommon in a cohort of hereditary prostate cancer families with evidence of linkage to 17q markers. 
  • Type 1 neurofibromatosis gene: correction. 
  • Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms. 
  • Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. 
  • cDNA cloning of the type 1 neurofibromatosis gene: complete sequence of the NF1 gene product. 
  • cDNA sequence and genomic structure of EV12B, a gene lying within an intron of the neurofibromatosis type 1 gene. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology