Cilia

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  Subject Areas on Research

  • A Mec17-Myosin II Effector Axis Coordinates Microtubule Acetylation and Actin Dynamics to Control Primary Cilium Biogenesis. 
  • A beta-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination. 
  • A complex of distal appendage-associated kinases linked to human disease regulates ciliary trafficking and stability. 
  • A novel role for primary cilia in airway remodeling. 
  • A proteomic analysis of human cilia: identification of novel components. 
  • A3 adenosine and CB1 receptors activate a PKC-sensitive Cl- current in human nonpigmented ciliary epithelial cells via a G beta gamma-coupled MAPK signaling pathway. 
  • Activation by odorants of a multistate cation channel from olfactory cilia. 
  • Ankyrin-G promotes cyclic nucleotide-gated channel transport to rod photoreceptor sensory cilia. 
  • Axonal Odorant Receptors Mediate Axon Targeting. 
  • Beta-arrestin-mediated localization of smoothened to the primary cilium. 
  • Broken detailed balance at mesoscopic scales in active biological systems. 
  • Cilia loss sensitizes cells to transformation by activating the mevalonate pathway. 
  • Cilia proteins are biomarkers of altered flow in the vasculature. 
  • Ciliated epithelial cell lifespan in the mouse trachea and lung. 
  • Contribution of hedgehog signaling to the establishment of left-right asymmetry in the sea urchin. 
  • Development of a tracheal implant xenograft model to expose human bronchial epithelial cells to toxic gases. 
  • Discordant organ laterality in monozygotic twins with primary ciliary dyskinesia. 
  • Disrupting the ciliary gradient of active Arl3 affects rod photoreceptor nuclear migration. 
  • Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells. 
  • Flagellar motility requires the cAMP-dependent phosphorylation of a heat-stable NP-40-soluble 56 kd protein, axokinin. 
  • Gene expression and larval evolution: changing roles of distal-less and orthodenticle in echinoderm larvae. 
  • Hedgehog signaling requires motile cilia in the sea urchin. 
  • Human myelomeningocele risk and ultra-rare deleterious variants in genes associated with cilium, WNT-signaling, ECM, cytoskeleton and cell migration. 
  • IL-6/STAT3 promotes regeneration of airway ciliated cells from basal stem cells. 
  • In Vivo Profiling of Individual Multiciliated Cells during Acute Influenza A Virus Infection. 
  • Integrin-β1 is required for the renal cystogenesis caused by ciliary defects. 
  • Intracellular and extracellular forces drive primary cilia movement. 
  • Knocking out lca5 in zebrafish causes cone-rod dystrophy due to impaired outer segment protein trafficking. 
  • Loss of Arf4 causes severe degeneration of the exocrine pancreas but not cystic kidney disease or retinal degeneration. 
  • Lung development and repair: contribution of the ciliated lineage. 
  • Multiple ciliary localization signals control INPP5E ciliary targeting. 
  • Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. 
  • Olfactory desensitization requires membrane targeting of receptor kinase mediated by beta gamma-subunits of heterotrimeric G proteins. 
  • PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia. 
  • Parent stem cells can serve as niches for their daughter cells. 
  • Photoreceptor Discs: Built Like Ectosomes. 
  • Photoreceptor discs form through peripherin-dependent suppression of ciliary ectosome release. 
  • Presence and indirect immunofluorescent localization of calmodulin in Paramecium tetraurelia. 
  • Primary Cilia Signaling Shapes the Development of Interneuronal Connectivity. 
  • Primary cilia and the reciprocal activation of AKT and SMAD2/3 regulate stretch-induced autophagy in trabecular meshwork cells. 
  • Primary cilia attenuate hedgehog signalling in neoplastic chondrocytes. 
  • Proteomic Analysis of Primary Human Airway Epithelial Cells Exposed to the Respiratory Toxicant Diacetyl. 
  • RPGR isoforms in photoreceptor connecting cilia and the transitional zone of motile cilia. 
  • Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1. 
  • Roles for microtubules in the proliferative and differentiated cells of stratified epithelia. 
  • Scanning electron microscopic study of the airways in normal children and in patients with cystic fibrosis and other lung diseases. 
  • Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli. 
  • Sonic-hedgehog-mediated proliferation requires the localization of PKA to the cilium base. 
  • Spinocerebellar ataxia type 11-associated alleles of Ttbk2 dominantly interfere with ciliogenesis and cilium stability. 
  • TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone. 
  • TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells. 
  • TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons. 
  • TTBK2 controls cilium stability by regulating distinct modules of centrosomal proteins. 
  • The WAVE complex drives the morphogenesis of the photoreceptor outer segment cilium. 
  • The actin nucleator Cordon-bleu is required for development of motile cilia in zebrafish. 
  • The prevalence of abnormal cilia in normal pediatric lungs. 
  • The primary cilium as a Hedgehog signal transduction machine. 
  • The primary cilium: a signalling centre during vertebrate development. 
  • The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis. 
  • ZCCHC8, the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturation. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute