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Subject Areas on Research
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A Mec17-Myosin II Effector Axis Coordinates Microtubule Acetylation and Actin Dynamics to Control Primary Cilium Biogenesis.
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A beta-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination.
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A complex of distal appendage-associated kinases linked to human disease regulates ciliary trafficking and stability.
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A novel role for primary cilia in airway remodeling.
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A proteomic analysis of human cilia: identification of novel components.
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A3 adenosine and CB1 receptors activate a PKC-sensitive Cl- current in human nonpigmented ciliary epithelial cells via a G beta gamma-coupled MAPK signaling pathway.
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Activation by odorants of a multistate cation channel from olfactory cilia.
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Ankyrin-G promotes cyclic nucleotide-gated channel transport to rod photoreceptor sensory cilia.
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Axonal Odorant Receptors Mediate Axon Targeting.
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Beta-arrestin-mediated localization of smoothened to the primary cilium.
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Broken detailed balance at mesoscopic scales in active biological systems.
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Cilia loss sensitizes cells to transformation by activating the mevalonate pathway.
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Cilia proteins are biomarkers of altered flow in the vasculature.
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Ciliated epithelial cell lifespan in the mouse trachea and lung.
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Contribution of hedgehog signaling to the establishment of left-right asymmetry in the sea urchin.
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Development of a tracheal implant xenograft model to expose human bronchial epithelial cells to toxic gases.
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Discordant organ laterality in monozygotic twins with primary ciliary dyskinesia.
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Disrupting the ciliary gradient of active Arl3 affects rod photoreceptor nuclear migration.
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Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells.
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Flagellar motility requires the cAMP-dependent phosphorylation of a heat-stable NP-40-soluble 56 kd protein, axokinin.
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Gene expression and larval evolution: changing roles of distal-less and orthodenticle in echinoderm larvae.
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Hedgehog signaling requires motile cilia in the sea urchin.
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Human myelomeningocele risk and ultra-rare deleterious variants in genes associated with cilium, WNT-signaling, ECM, cytoskeleton and cell migration.
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IL-6/STAT3 promotes regeneration of airway ciliated cells from basal stem cells.
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In Vivo Profiling of Individual Multiciliated Cells during Acute Influenza A Virus Infection.
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Integrin-β1 is required for the renal cystogenesis caused by ciliary defects.
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Intracellular and extracellular forces drive primary cilia movement.
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Knocking out lca5 in zebrafish causes cone-rod dystrophy due to impaired outer segment protein trafficking.
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Loss of Arf4 causes severe degeneration of the exocrine pancreas but not cystic kidney disease or retinal degeneration.
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Lung development and repair: contribution of the ciliated lineage.
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Multiple ciliary localization signals control INPP5E ciliary targeting.
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Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination.
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Olfactory desensitization requires membrane targeting of receptor kinase mediated by beta gamma-subunits of heterotrimeric G proteins.
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PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia.
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Parent stem cells can serve as niches for their daughter cells.
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Photoreceptor Discs: Built Like Ectosomes.
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Photoreceptor discs form through peripherin-dependent suppression of ciliary ectosome release.
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Presence and indirect immunofluorescent localization of calmodulin in Paramecium tetraurelia.
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Primary Cilia Signaling Shapes the Development of Interneuronal Connectivity.
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Primary cilia and the reciprocal activation of AKT and SMAD2/3 regulate stretch-induced autophagy in trabecular meshwork cells.
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Primary cilia attenuate hedgehog signalling in neoplastic chondrocytes.
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Proteomic Analysis of Primary Human Airway Epithelial Cells Exposed to the Respiratory Toxicant Diacetyl.
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RPGR isoforms in photoreceptor connecting cilia and the transitional zone of motile cilia.
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Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1.
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Roles for microtubules in the proliferative and differentiated cells of stratified epithelia.
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Scanning electron microscopic study of the airways in normal children and in patients with cystic fibrosis and other lung diseases.
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Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli.
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Sonic-hedgehog-mediated proliferation requires the localization of PKA to the cilium base.
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Spinocerebellar ataxia type 11-associated alleles of Ttbk2 dominantly interfere with ciliogenesis and cilium stability.
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TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone.
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TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells.
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TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons.
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TTBK2 controls cilium stability by regulating distinct modules of centrosomal proteins.
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The WAVE complex drives the morphogenesis of the photoreceptor outer segment cilium.
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The actin nucleator Cordon-bleu is required for development of motile cilia in zebrafish.
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The prevalence of abnormal cilia in normal pediatric lungs.
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The primary cilium as a Hedgehog signal transduction machine.
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The primary cilium: a signalling centre during vertebrate development.
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The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis.
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ZCCHC8, the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturation.
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Keywords of People