Cinnamates
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Subject Areas on Research
- A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death.
- A prochelator with a modular masking group featuring hydrogen peroxide activation with concurrent fluorescent reporting.
- A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.
- Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor.
- Comparative analyses of mechanistic differences among antiestrogens.
- Definition of functionally important mechanistic differences among selective estrogen receptor down-regulators.
- Dissection of the molecular mechanism of action of GW5638, a novel estrogen receptor ligand, provides insights into the role of estrogen receptor in bone.
- Effects of novel ethacrynic acid derivatives on human trabecular meshwork cell shape, actin cytoskeletal organization, and transcellular fluid flow.
- Effects of the new ethacrynic acid derivative SA9000 on intraocular pressure in cats and monkeys.
- Effects of the new ethacrynic acid oxime derivative SA12590 on intraocular pressure in cats and monkeys.
- Enhancer-blocking activity within the DNase I hypersensitive site 2 to 6 region between the TCR alpha and Dad1 genes.
- Evaluation of p-amidinophenyl esters as potential antithrombotic agents.
- Eyedrops containing SA9000 prodrugs result in sustained reductions in intraocular pressure in rabbits.
- ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells.
- MECHANISM OF ENZYME CATALYSIS.
- Nontoxic irreversible inhibitors of factors IXa, Xa, and thrombin: potential therapeutic agents for the in vivo regulation of thrombin generation and activity.
- PERK (Protein Kinase RNA-Like ER Kinase) Branch of the Unfolded Protein Response Confers Neuroprotection in Ischemic Stroke by Suppressing Protein Synthesis.
- Quantitative comparison of the inhibitory effects of GW5638 and tamoxifen on angiogenesis in the cornea pocket assay.
- Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis.
- Structural basis for an unexpected mode of SERM-mediated ER antagonism.
- Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative.
- Targeting phosphorylation of eukaryotic initiation factor-2α to treat human disease.
- Transfection of a human cytochrome P-450 gene into the human lymphoblastoid cell line, AHH-1, and use of the recombinant cell line in gene mutation assays.
- Tyrosine phosphorylation in human neutrophil.
- p-Amidino esters as irreversible inhibitors of factors IXa and Xa and thrombin.
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Keywords of People
- McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology