Clinical Protocols

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  Subject Areas on Research

  • 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. 
  • 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. 
  • A GPS for finding the route to transplantation for the sensitized patient. 
  • A New Protocol for Anticoagulation With Tirofiban During Flow Diversion. 
  • A Quality Improvement Project to Increase Adherence to a Pain, Agitation, and Delirium Protocol in the Intensive Care Unit. 
  • A Respiratory Therapist-Driven Asthma Pathway Reduced Hospital Length of Stay in the Pediatric Intensive Care Unit. 
  • A Standard Set of Outcome Measures for the Comprehensive Appraisal of Cleft Care. 
  • A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. The XOMA Sepsis Study Group. 
  • A controlled clinical trial of angiotensin-converting enzyme inhibition in type I diabetic nephropathy: study design and patient characteristics. The Collaborative Study Group. 
  • A daily skincare regimen with a unique ceramide and filaggrin formulation rapidly improves chronic xerosis, pruritus, and quality of life in older adults. 
  • A double-blind, vehicle-controlled study evaluating masoprocol cream in the treatment of actinic keratoses on the head and neck. 
  • A greater analgesia, sedation, delirium order set quality score is associated with a decreased duration of mechanical ventilation in cardiovascular surgery patients. 
  • A literature review of studies evaluating gluteus maximus and gluteus medius activation during rehabilitation exercises. 
  • A phase I trial of human gamma interferon transduced autologous tumor cells in patients with disseminated malignant melanoma. 
  • A pilot study testing the effect of different levels of financial incentives on weight loss among overweight employees. 
  • A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults. 
  • A quality improvement process for implementing the Texas algorithm for schizophrenia in Ohio. 
  • A randomized controlled trial comparing two vaso-occlusive episode (VOE) protocols in sickle cell disease (SCD). 
  • A randomized trial of protocol-based care for early septic shock. 
  • A response adaptive randomization platform trial for efficient evaluation of Ebola virus treatments: A model for pandemic response. 
  • A round-robin gamma stereotactic radiosurgery dosimetry interinstitution comparison of calibration protocols. 
  • A systematic review of antibiotic use and infection in breast reconstruction: what is the evidence? 
  • A telephonic mindfulness-based intervention for persons with sickle cell disease: study protocol for a randomized controlled trial. 
  • AMBITION-cm: intermittent high dose AmBisome on a high dose fluconazole backbone for cryptococcal meningitis induction therapy in sub-Saharan Africa: study protocol for a randomized controlled trial. 
  • Abbreviated screening protocol for breast MRI: a feasibility study. 
  • Acceptability of second-step treatments to depressed outpatients: a STAR*D report. 
  • Active surveillance for prostate cancer: can we modernize contemporary protocols to improve patient selection and outcomes in the focal therapy era? 
  • Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. 
  • Adaptation of a postoperative handoff communication process for children with heart disease: a quantitative study. 
  • Adenocarcinoma of the liver without a detectable primary. 
  • Adherence to Enhanced Recovery Protocols in NSQIP and Association With Colectomy Outcomes. 
  • Adherence to ventilator-associated pneumonia bundle and incidence of ventilator-associated pneumonia in the surgical intensive care unit. 
  • Advantages of Bayesian monitoring methods in deciding whether and when to stop a clinical trial: an example of a neonatal cooling trial. 
  • Algorithms for optimizing the treatment of depression: making the right decision at the right time. 
  • Allocating Resources Across the Life Span During COVID-19-Integrating Neonates and Children Into Crisis Standards of Care Protocols. 
  • Amendment to Clinical Research Project. Project 90-C-195. April 1, 1993. Treatment of severe combined immunodeficiency disease (SCID) due to adenosine deaminase deficiency with autologous lymphocytes transduced with a human ADA gene. 
  • An Asthma Protocol Improved Adherence to Evidence-Based Guidelines for Pediatric Subjects With Status Asthmaticus in the Emergency Department. 
  • An analysis of the Association of Society of Chest Pain Centers Accreditation to American College of Cardiology/American Heart Association non-ST-segment elevation myocardial infarction guideline adherence. 
  • An economic analysis of an aggressive diagnostic strategy with single photon emission computed tomography myocardial perfusion imaging and early exercise stress testing in emergency department patients who present with chest pain but nondiagnostic electrocardiograms: Results from a randomized trial. 
  • An evidence-based clinical protocol for diagnosis of acute appendicitis decreased the use of computed tomography in children. 
  • An innovative pay-for-performance (P4P) strategy for improving malaria management in rural Kenya: protocol for a cluster randomized controlled trial. 
  • Approach to epilepsy in children. 
  • Are surgeons' preferences for instrumentation related to patient outcomes? A randomized clinical trial of two implants for idiopathic scoliosis. 
  • Asian age-related macular degeneration phenotyping study: rationale, design and protocol of a prospective cohort study. 
  • Assessing the effect of Measurement-Based Care depression treatment on HIV medication adherence and health outcomes: rationale and design of the SLAM DUNC Study. 
  • Assessment of chiropractic treatment for active duty, U.S. military personnel with low back pain: study protocol for a randomized controlled trial. 
  • Autologous stem cell transplantation for autoimmune diseases: issues in protocol development. 
  • Background and rationale for the sequenced treatment alternatives to relieve depression (STAR*D) study. 
  • Barriers to and facilitators of clinical practice guideline use in nursing homes. 
  • Baseline Predictors of Low-Density Lipoprotein Cholesterol and Systolic Blood Pressure Goal Attainment After 1 Year in the ISCHEMIA Trial. 
  • Benign prostatic hyperplasia: diagnosis and treatment. Benign Prostatic Hyperplasia Guideline Panel. Agency for Health Care Policy and Research. 
  • Blood Products in the Management of Abnormal Placentation. 
  • Building health system capacity to improve maternal and newborn care: a pilot leadership program for frontline staff at a tertiary hospital in Ghana. 
  • CAMERA2 - combination antibiotic therapy for methicillin-resistant Staphylococcus aureus infection: study protocol for a randomised controlled trial. 
  • COMParative Early Treatment Effectiveness between physical therapy and usual care for low back pain (COMPETE): study protocol for a randomized controlled trial. 
  • CONNECT for quality: protocol of a cluster randomized controlled trial to improve fall prevention in nursing homes. 
  • CT utilization: the emergency department perspective. 
  • Can we make postoperative patient handovers safer? A systematic review of the literature. 
  • Canadian Association for Immunization Research and Evaluation (CAIRE) guidelines for industry-sponsored clinical trial and epidemiology contract research. 
  • Central nervous system cancers. 
  • Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans for Juvenile Idiopathic Arthritis-Associated and Idiopathic Chronic Anterior Uveitis. 
  • Clinical judgment and therapeutic decision making. 
  • Clinical results for patients with major depressive disorder in the Texas Medication Algorithm Project. 
  • Clinical trials in children with Down syndrome: issues from a cognitive research perspective. 
  • Clinical trials registration. 
  • Clinical-trial agreements between medical schools and industry. 
  • Cluster analyses of pain patients' responses to the SCL-90R. 
  • Coadministration of zidovudine and interleukin-2 increases absolute CD4 cells in subjects with Walter Reed stage 2 human immunodeficiency virus infection: results of ACTG protocol 042. 
  • Cognitive behavioral control of arthritis pain. 
  • Colchicine effectiveness in symptom and inflammation modification in knee osteoarthritis (COLKOA): study protocol for a randomized controlled trial. 
  • Collaborative Care for Older Adults with low back pain by family medicine physicians and doctors of chiropractic (COCOA): study protocol for a randomized controlled trial. 
  • Community care of corneal ulcers. 
  • Comparing office-based and ambulatory blood pressure monitoring in clinical trials. 
  • Comparing the effectiveness of selective laser trabeculoplasty with topical medication as initial treatment (the Glaucoma Initial Treatment Study): study protocol for a randomised controlled trial. 
  • Comparison of Radiation Doses and Best-Practice Use for Myocardial Perfusion Imaging in US and Non-US Laboratories: Findings From the IAEA (International Atomic Energy Agency) Nuclear Cardiology Protocols Study. 
  • Complementary roles of open and hybrid approaches to thoracoabdominal aortic aneurysm repair. 
  • Consensus guidelines in the treatment of major depressive disorder. 
  • Consensus recommendations for a standardized Brain Tumor Imaging Protocol in clinical trials. 
  • Contemporary therapy of acute ST-elevation myocardial infarction. 
  • Coronavirus disease 2019: Implications of emerging infections for transplantation. 
  • Cost of Medical Care of Patients with Advanced Serious Illness in Singapore (COMPASS): prospective cohort study protocol. 
  • Cost-effectiveness as an outcome in randomized clinical trials. 
  • Craniosacral therapy for migraine: protocol development for an exploratory controlled clinical trial. 
  • Creating Clinical Research Protocols in Advanced Practice: Part I, Identifying the Fit and the Aim. 
  • Creating Clinical Research Protocols in Advanced Practice: Part II, Operational Steps to Improve Project Feasibility. 
  • Creating Clinical Research Protocols in Advanced Practice: Part III, Building Blocks of Study Design. 
  • Creating Clinical Research Protocols in Advanced Practice: Part IV, Designing Research to Fit Practice. 
  • Current and future preparative regimens for bone marrow transplantation in thalassemia. 
  • Current worldwide nuclear cardiology practices and radiation exposure: results from the 65 country IAEA Nuclear Cardiology Protocols Cross-Sectional Study (INCAPS). 
  • Daily bone alignment with limited repeat CT correction rivals daily ultrasound alignment for prostate radiotherapy. 
  • Deciding to terminate treatment: a practical guide for physicians. 
  • Deflazacort in Duchenne muscular dystrophy: a comparison of two different protocols. 
  • Department of Health and Human Services National Institutes of Health Recombinant DNA Advisory Committee. Minutes of meeting March 8-10, 2000. 
  • Departures from the protocol during conduct of a clinical trial: a pattern from the data record consistent with a learning curve. 
  • Design and Methodological Considerations of the Centers for Disease Control and Prevention Urologic and Renal Protocol for the Newborn and Young Child with Spina Bifida. 
  • Design and rationale for RE-VERSE AD: A phase 3 study of idarucizumab, a specific reversal agent for dabigatran. 
  • Design and rationale for the life after stopping tyrosine kinase inhibitors (LAST) study, a prospective, single-group longitudinal study in patients with chronic myeloid leukemia. 
  • Design and rationale of the B-lines lung ultrasound guided emergency department management of acute heart failure (BLUSHED-AHF) pilot trial. 
  • Designing and implementing a comparative effectiveness study of two strategies for delivering high quality CHD prevention: methods and participant characteristics for the Heart to Health study. 
  • Designing effective drug and device development programs for hospitalized heart failure: a proposal for pretrial registries. 
  • Detection of micrometastases in peritoneal washings of pancreatic cancer patients by the reverse transcriptase polymerase chain reaction. 
  • Determining the Association Between End-of-Life Care Resources and Patient Outcomes in Pennsylvania ICUs. 
  • Development and Implementation of a Perioperative Blood Glucose Monitoring Protocol for Patients Undergoing Spinal Surgery. 
  • Development of Team Action Projects in Surgery (TAPS): a multilevel team-based approach to teaching quality improvement. 
  • Development of a Clinical Decision Aid for Chiropractic Management of Common Conditions Causing Low Back Pain in Veterans: Results of a Consensus Process. 
  • Development of a manualized protocol of massage therapy for clinical trials in osteoarthritis. 
  • Development of a protocol for allogeneic marrow transplantation for severe systemic sclerosis: paradigm for autoimmune disease. 
  • Distribution of feeding styles after pyloromyotomy among pediatric surgical training programs in North America. 
  • Do clinical decision-support reminders for medical providers improve isoniazid preventative therapy prescription rates among HIV-positive adults? Study protocol for a randomized controlled trial. 
  • Does the use of a prescriptive clinical prediction rule increase the likelihood of applying inappropriate treatments? A survey using clinical vignettes. 
  • Dose reduction in paediatric MDCT: general principles. 
  • Driving biology: The effect of standardized wound management on wound biomarker profiles. 
  • Drug compliance in adolescents: assessing and managing modifiable risk factors. 
  • Dual-energy CT workflow: multi-institutional consensus on standardization of abdominopelvic MDCT protocols. 
  • Early and late changes in left ventricular systolic performance after percutaneous aortic balloon valvuloplasty. 
  • Early predictors of massive transfusion in patients sustaining torso gunshot wounds in a civilian level I trauma center. 
  • Economics methods in Cochrane systematic reviews of health promotion and public health related interventions. 
  • Effect of Diagnosis on Outcomes in the Setting of Enhanced Recovery Protocols. 
  • Effect of dosing time of angiotensin II receptor blockade titrated by self-measured blood pressure recordings on cardiorenal protection in hypertensives: the Japan Morning Surge-Target Organ Protection (J-TOP) study. 
  • Effective dose and dose-length product in CT. 
  • Effects of Adding an Internet-Based Pain Coping Skills Training Protocol to a Standardized Education and Exercise Program for People With Persistent Hip Pain (HOPE Trial): Randomized Controlled Trial Protocol. 
  • Effects of nurse-managed protocols in the outpatient management of adults with chronic conditions: a systematic review and meta-analysis. 
  • Effects of time, dose, and inversion time for acute myocardial infarct size measurements based on magnetic resonance imaging-delayed contrast enhancement. 
  • Effects of varenicline and cognitive bias modification on neural response to smoking-related cues: study protocol for a randomized controlled study. 
  • End of study transition from study drug to open-label vitamin K antagonist therapy: the ROCKET AF experience. 
  • Enhanced Recovery After Surgery Protocols: Rationale and Components. 
  • Enhancing Recovery in Coronary Heart Disease (ENRICHD) study intervention: rationale and design. 
  • Estimating the likelihood of severe coronary artery disease. 
  • Ethical dilemma in continuing a zidovudine-placebo trial in symptomatic human immunodeficiency virus infection. 
  • Evaluation of a discharge education protocol for pediatric patients with gastrostomy tubes. 
  • Evaluation of ischemic heart disease. 
  • Evaluation of patient effective dose of neurovascular imaging protocols for C-arm cone-beam CT. 
  • Evaluation of the clinical efficacy of embryo cryopreservation. 
  • Experience with protocol biopsies after solitary pancreas transplantation. 
  • Exploring Emergency Department Provider Experiences With and Perceptions of Weight-Based Versus Individualized Vaso-Occlusive Treatment Protocols in Sickle Cell Disease. 
  • External validation of an ED protocol for reflex urine culture cancelation. 
  • FDA-Catalyst-Using FDA's Sentinel Initiative for large-scale pragmatic randomized trials: Approach and lessons learned during the planning phase of the first trial. 
  • Factors associated with the use of cognitive aids in operating room crises: a cross-sectional study of US hospitals and ambulatory surgical centers. 
  • Far beyond informed consent. US research institutions keep close watch on OPRR's suspensions. 
  • Feasibility of allogeneic hematopoietic stem cell transplantation for autoimmune disease: position statement from a National Institute of Allergy and Infectious Diseases and National Cancer Institute-Sponsored International Workshop, Bethesda, MD, March 12 and 13, 2005. 
  • Fewer medications for in vitro fertilization can be better: thinking outside the box. 
  • Flexible dosing schedules for continuation electroconvulsive therapy. 
  • Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome*. 
  • Gallstone extracorporeal shock-wave lithotripsy: time and treatment considerations. 
  • Gentamicin sponge for infection prophylaxis in colorectal surgery. 
  • Glucose control in hospitalized patients. 
  • Goal-directed or goal-misdirected - how should we interpret the literature? 
  • Golden Hour Protocol for Preterm Infants: A Quality Improvement Project. 
  • Gradient shimming during magnetic resonance imaging of the liver: comparison of a standard protocol versus a novel reduced protocol. 
  • Group interventions for co-morbid insomnia and osteoarthritis pain in primary care: the lifestyles cluster randomized trial design. 
  • Guidelines for the Management of Pediatric Severe Traumatic Brain Injury, Third Edition: Update of the Brain Trauma Foundation Guidelines, Executive Summary. 
  • Hemicraniectomy and durotomy upon deterioration from infarction-related swelling trial: randomized pilot clinical trial. 
  • Hodgkin disease: clinical utility of CT in initial staging and treatment. 
  • Hospital infection control, seat belts and the national debt. 
  • How can we optimize the processes of care for acute coronary syndromes to improve outcomes? 
  • Hypertension Improvement Project (HIP): study protocol and implementation challenges. 
  • Hypertension and diabetes and the Fosinopril versus Amlodipine Cardiovascular Events Trial (FACET). More ammunition against surrogate end points. 
  • Image noise and dose performance across a clinical population: Patient size adaptation as a metric of CT performance. 
  • Imaging Protocols in Clinical Studies in Advanced Age-Related Macular Degeneration: Recommendations from Classification of Atrophy Consensus Meetings. 
  • Imaging the renal lesion with dual-energy multidetector CT and multi-energy applications in clinical practice: what can it truly do for you? 
  • Immunotherapy for malignant melanoma with a tumor cell vaccine. 
  • Impact of a provider job aid intervention on injectable contraceptive continuation in South Africa. 
  • Impact of a statewide ST-segment-elevation myocardial infarction regionalization program on treatment times for women, minorities, and the elderly. 
  • Impact of advance care planning on the care of patients with heart failure: study protocol for a randomized controlled trial. 
  • Impact of delayed lymphoscintigraphy for sentinel lymphnode biopsy for breast cancer. 
  • Impact of rate-modulated pacing on quality of life and exercise capacity--evidence from the Advanced Elements of Pacing Randomized Controlled Trial (ADEPT). 
  • Implementation of a Hydrotherapy Protocol to Improve Postpartum Pain Management. 
  • Implementation of an Obstructive Sleep Apnea Protocol in the Postanesthesia Care Unit for Patients Undergoing Spinal Fusion Surgery. 
  • Implementation of antibiotic rotation protocol improves antibiotic susceptibility profile in a surgical intensive care unit. 
  • Implementing a Weaning Protocol for Cardiac Surgery Patients Using Simulation: A Quality Improvement Project. 
  • Implementing standardized substance use disorder screening in primary care. 
  • Implementing the protocol of a pilot randomized controlled trial for the recovery-oriented intervention to people with psychoses in two Latin American cities. 
  • Improved analgesia, sedation, and delirium protocol associated with decreased duration of delirium and mechanical ventilation. 
  • Improvements in early mortality and coagulopathy are sustained better in patients with blunt trauma after institution of a massive transfusion protocol in a civilian level I trauma center. 
  • Improving Nursing Home Care through Feedback On PerfoRMance Data (INFORM): Protocol for a cluster-randomized trial. 
  • Improving the Efficiency of Care for Pediatric Patients Hospitalized With Asthma. 
  • Integration of musculoskeletal physical therapy care in the patient-centred medical home (IMPaC): protocol for a single-site randomised clinical trial. 
  • Interdisciplinary Care Model Independently Decreases Use of Critical Care Services After Corrective Surgery for Adult Degenerative Scoliosis. 
  • Internet-mediated physiotherapy and pain coping skills training for people with persistent knee pain (IMPACT - knee pain): a randomised controlled trial protocol. 
  • Interpreting the Results of Intention-to-Treat, Per-Protocol, and As-Treated Analyses of Clinical Trials. 
  • Is there a learning curve associated with the use of remifentanil? 
  • Isolated Ocular Motor Nerve Palsies. 
  • Late-onset ornithine transcarbamylase deficiency in male patients. 
  • Logistical challenges and design considerations for studies using acute anterior cruciate ligament injury as a potential model for early posttraumatic osteoarthritis. 
  • Long-term safety and efficacy of a once-daily regimen of emtricitabine, didanosine, and efavirenz in HIV-infected, therapy-naive children and adolescents: Pediatric AIDS Clinical Trials Group Protocol P1021. 
  • Loop ileostomy closure at an ambulatory surgery facility: a safe and cost-effective alternative to routine hospitalization. 
  • Management of Pediatric Severe Traumatic Brain Injury: 2019 Consensus and Guidelines-Based Algorithm for First and Second Tier Therapies. 
  • Management of rocuronium neuromuscular block using a protocol for qualitative monitoring and reversal with neostigmine. 
  • Massive transfusion: blood component ratios. 
  • Medication treatment for the severely and persistently mentally ill: the Texas Medication Algorithm Project. 
  • Metaanalysis and review of heart failure disease management randomized controlled clinical trials. 
  • Methodological challenges in constructing effective treatment sequences for chronic psychiatric disorders. 
  • Monitoring versus interim analysis of clinical trials: a perspective from the pharmaceutical industry. 
  • Multimodal Pain Management for Major Joint Replacement Surgery. 
  • Multisystem Inflammatory Syndrome in Children: Survey of Protocols for Early Hospital Evaluation and Management. 
  • National Institute of Mental Health Collaborative Multimodal Treatment Study of Children with ADHD (the MTA). Design challenges and choices. 
  • Negative trials in nephrology: what can we learn? 
  • Nonoperative management of non-small cell lung cancer: the current cancer and leukemia group B experience. 
  • Nutrition therapy for the critically ill surgical patient: we need to do better! 
  • Optimizing linkage and retention to hypertension care in rural Kenya (LARK hypertension study): study protocol for a randomized controlled trial. 
  • Optimizing the use of thrombolytics in ST-segment elevation myocardial infarction. 
  • Optimizing veteran-centered prostate cancer survivorship care: study protocol for a randomized controlled trial. 
  • Oral Iron Therapy for Heart Failure With Reduced Ejection Fraction: Design and Rationale for Oral Iron Repletion Effects on Oxygen Uptake in Heart Failure. 
  • Oral Multimodal Analgesia for Total Joint Arthroplasty. 
  • Oral cleft prevention program (OCPP). 
  • Out-of-hospital stroke screen accuracy in a state with an emergency medical services protocol for routing patients to acute stroke centers. 
  • Pancreatography and the surgical management of pseudocysts. 
  • Patient and provider interventions for managing osteoarthritis in primary care: protocols for two randomized controlled trials. 
  • Patients Receiving Integrative Medicine Effectiveness Registry (PRIMIER) of the BraveNet practice-based research network: study protocol. 
  • Patterns and sites of failure in cervix cancer treated in the U.S.A. in 1978. 
  • Patterns of etanercept use in juvenile idiopathic arthritis in the Childhood Arthritis and Rheumatology Research Alliance Registry. 
  • Pelvic inflammatory disease: findings during inpatient treatment of clinically severe, laparoscopy-documented disease. 
  • Performance of Consultative Palliative Care Model in Achieving Quality Metrics in the ICU. 
  • Perioperative blood transfusion and blood conservation in cardiac surgery: the Society of Thoracic Surgeons and The Society of Cardiovascular Anesthesiologists clinical practice guideline. 
  • Planning, delivery, and quality assurance of intensity-modulated radiotherapy using dynamic multileaf collimator: a strategy for large-scale implementation for the treatment of carcinoma of the prostate. 
  • Poststroke treatment: lost in translation. 
  • Predictors of pulmonary toxicity in limited stage small cell lung cancer patients treated with induction chemotherapy followed by concurrent platinum-based chemotherapy and 70 Gy daily radiotherapy: CALGB 30904. 
  • Preoperative and postoperative chemoradiation strategies in patients treated with pancreaticoduodenectomy for adenocarcinoma of the pancreas. 
  • Preoperative optimization for patients undergoing elective spine surgery. 
  • Preparing for Total Power Failure in the Operating Room. 
  • Prevention of sudden death in patients with coronary artery disease: the Multicenter Unsustained Tachycardia Trial (MUSTT). 
  • Progress against childhood cancer: the Pediatric Oncology Group experience. 
  • Prospective treatment of urea cycle disorders. 
  • Prothrombin Complex Concentrates for Bleeding in the Perioperative Setting. 
  • Protocol for the examination of specimens from patients with primary non-small cell carcinoma, small cell carcinoma, or carcinoid tumor of the lung. 
  • Protocol of a randomized controlled trial of culturally sensitive interventions to improve African Americans' and non-African Americans' early, shared, and informed consideration of live kidney transplantation: the Talking About Live Kidney Donation (TALK) Study. 
  • Protocol versus ad libitum feeds after laparoscopic pyloromyotomy: a prospective randomized trial. 
  • Protocolized Care for Early Septic Shock (ProCESS) statistical analysis plan. 
  • Protocolized approach to the management of congenital diaphragmatic hernia: benefits of reducing variability in care. 
  • Protocols for the initial treatment of moderately severe juvenile dermatomyositis: results of a Children's Arthritis and Rheumatology Research Alliance Consensus Conference. 
  • Provider attitudes toward clinical protocols in obstetrics. 
  • Psychiatric sequelae of traumatic brain injury: a case report. 
  • Psychometric properties of the Social Phobia Inventory (SPIN). New self-rating scale. 
  • Public disclosure of clinical research. 
  • Quality Improvement in 3D Imaging. 
  • RSNA Clinical Trials Methodology Workshop. 
  • RTOG quality assurance guidelines for clinical trials using hyperthermia administered by ultrasound. 
  • RTOG quality assurance guidelines for clinical trials using hyperthermia for deep-seated malignancy. 
  • Racial variations in treatment and outcomes of black and white patients with high-risk non-ST-elevation acute coronary syndromes: insights from CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the ACC/AHA Guidelines?). 
  • Radiation dose from contemporary cardiothoracic multidetector CT protocols with an anthropomorphic female phantom: implications for cancer induction. 
  • Radiation dose to the female breast from 16-MDCT body protocols. 
  • Radiosurgery, cost-effectiveness, gold standards, the scientific method, cavalier cowboys, and the cost of hope. 
  • Randomized clinical trial of an emergency department observation syncope protocol versus routine inpatient admission. 
  • Rationale and design of a cluster-randomized multifaceted intervention trial to improve stroke care quality in China: The GOLDEN BRIDGE-Acute Ischemic Stroke. 
  • Rationale and design of a randomized controlled trial of allogeneic mesenchymal stem cells in patients with nonischemic cardiomyopathy. 
  • Rationale and design of a secondary prevention trial of increasing serum high-density lipoprotein cholesterol and reducing triglycerides in patients with clinically manifest atherosclerotic heart disease (the Bezafibrate Infarction Prevention Trial). 
  • Rationale and design of the Children's Oncology Group (COG) study ALTE1621: a randomized, placebo-controlled trial to determine if low-dose carvedilol can prevent anthracycline-related left ventricular remodeling in childhood cancer survivors at high risk for developing heart failure. 
  • Rationale and strategies for implementing community-based transfer protocols for primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction. 
  • Rationale for the diabetic retinopathy clinical research network treatment protocol for center-involved diabetic macular edema. 
  • Rationale, design, and protocol for the prevention of low back pain in the military (POLM) trial (NCT00373009). 
  • Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): study protocol for a randomized controlled trial. 
  • Reduced length of hospital stay in colorectal surgery after implementation of an enhanced recovery protocol. 
  • Rehabilitation of an Adolescent Equestrian Athlete With a History of Multiple Concussions: A Case Report Describing an Adapted Return-to-Sport Protocol. 
  • Relationship between clinical trial site enrollment with participant characteristics, protocol completion, and outcomes: insights from the EVEREST (Efficacy of Vasopressin Antagonism in Heart Failure: Outcome Study with Tolvaptan) trial. 
  • Reperfusion strategies for acute myocardial infarction in the elderly: benefits and risks. 
  • Reply. 
  • Reply: Specifics of Dose Modification in ARISTOTLE. 
  • Research design features and patient characteristics associated with the outcome of antidepressant clinical trials. 
  • Respiratory controversies in the critical care setting. Conference summary. 
  • Results of a North American survey of rapid-sequence MRI utilization to evaluate cerebral ventricles in children. 
  • Review: in adult outpatients, nurse-managed protocols improve hemoglobin A1c levels and blood pressure. 
  • Revisiting the Role of Aspirin for the Primary Prevention of Cardiovascular Disease. 
  • Risk stratification in chest pain patients undergoing nuclear stress testing: the Erlanger Stress Score. 
  • Roles of mental health professionals in multidisciplinary medically supervised treatment programs for obesity. 
  • SPIRIT 2013 statement: defining standard protocol items for clinical trials. 
  • STAR*D: revising conventional wisdom. 
  • Sepsis Resuscitation in Resource-Limited Settings. 
  • Sequenced treatment alternatives to relieve depression (STAR*D): rationale and design. 
  • Sequential psychological and pharmacological therapies for comorbid and primary insomnia: study protocol for a randomized controlled trial. 
  • Single-centre, triple-blinded, randomised, 1-year, parallel-group, superiority study to compare the effects of Roux-en-Y gastric bypass and sleeve gastrectomy on remission of type 2 diabetes and β-cell function in subjects with morbid obesity: a protocol for the Obesity surgery in Tønsberg (Oseberg) study. 
  • Siyaphambili protocol: An evaluation of randomized, nurse-led adaptive HIV treatment interventions for cisgender female sex workers living with HIV in Durban, South Africa. 
  • Sources of hospital-level variation in major bleeding among patients with non-st-segment elevation myocardial infarction: a report from the National Cardiovascular Data Registry (NCDR). 
  • Standardized Team-Based Care for Cardiogenic Shock. 
  • Standardized cardiovascular magnetic resonance imaging (CMR) protocols: 2020 update. 
  • Statistical Evaluation of Clinical Trials Under COVID-19 Pandemic. 
  • Statistical inference for clinical trials with binary responses when there is a shift in patient population. 
  • Statistical models of acute mountain sickness. 
  • Stimulant reduction intervention using dosed exercise (STRIDE) - CTN 0037: study protocol for a randomized controlled trial. 
  • Study protocol for patient response to spinal manipulation - a prospective observational clinical trial on physiological and patient-centered outcomes in patients with chronic low back pain. 
  • Study protocol, sample characteristics, and loss to follow-up: the OPPERA prospective cohort study. 
  • Study protocol: Couples Partnering for Lipid Enhancing Strategies (CouPLES) - a randomized, controlled trial. 
  • Study protocol: the Adherence and Intensification of Medications (AIM) study--a cluster randomized controlled effectiveness study. 
  • Suicide risk protocols: addressing the needs of high risk youths identified through suicide prevention efforts and in clinical settings. 
  • Surgical malpractice: myths and realities. 
  • Tailoring cognitive-behavioral treatment for cancer pain. 
  • Targeting the kidney in acute heart failure: can old drugs provide new benefit? Renal Optimization Strategies Evaluation in Acute Heart Failure (ROSE AHF) trial. 
  • Teaching neuraxial anesthesia techniques for obstetric care in a Ghanaian referral hospital: achievements and obstacles. 
  • Telephone-based goal management training for adults with mild traumatic brain injury: study protocol for a randomized controlled trial. 
  • Texas Medication Algorithm Project: definitions, rationale, and methods to develop medication algorithms. 
  • The American Heart Association's principles for comparative effectiveness research: a policy statement from the American Heart Association. 
  • The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study protocol: a cross-sectional, lifespan, multidisciplinary examination of healthy cognitive ageing. 
  • The Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans: Toward Comparative Effectiveness in the Pediatric Rheumatic Diseases. 
  • The Design of a Randomized Trial of Vaginal Surgery for Uterovaginal Prolapse: Vaginal Hysterectomy With Native Tissue Vault Suspension Versus Mesh Hysteropexy Suspension (The Study of Uterine Prolapse Procedures Randomized Trial). 
  • The Emergency Department Sickle Cell Assessment of Needs and Strengths (ED-SCANS): reliability and validity. 
  • The Legal Ethics of Pediatric Research 
  • The Lifespan Human Connectome Project in Development: A large-scale study of brain connectivity development in 5-21 year olds. 
  • The National Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) project: schizophrenia trial design and protocol development. 
  • The Treatment for Adolescents With Depression Study (TADS): long-term effectiveness and safety outcomes. 
  • The Vitek analyser for routine bacterial identification and susceptibility testing: protocols, problems, and pitfalls. 
  • The case for practical clinical trials in psychiatry. 
  • The duration of zidovudine benefit in persons with asymptomatic HIV infection. Prolonged evaluation of protocol 019 of the AIDS Clinical Trials Group. 
  • The effect of CYP2C19 gene polymorphisms on the pharmacokinetics and pharmacodynamics of prasugrel 5-mg, prasugrel 10-mg and clopidogrel 75-mg in patients with coronary artery disease. 
  • The effect of chiropractic treatment on the reaction and response times of special operation forces military personnel: study protocol for a randomized controlled trial. 
  • The effectiveness of the peer delivered Thinking Healthy Plus (THPP+) Programme for maternal depression and child socio-emotional development in Pakistan: study protocol for a three-year cluster randomized controlled trial. 
  • The future of perioperative therapy in advanced renal cell carcinoma: how can we PROSPER? 
  • The impact of a massive transfusion protocol (1:1:1) on major hepatic injuries: does it increase abdominal wall closure rates? 
  • The impact of emergency department structure and care processes in delivering care for non-ST-segment elevation acute coronary syndromes. 
  • The impact of patient self-testing of prothrombin time for managing anticoagulation: rationale and design of VA Cooperative Study #481--the Home INR Study (THINRS). 
  • The implementation and efficacy of the Northwestern High Risk Spine Protocol. 
  • The management of fractures with soft-tissue disruptions. 
  • The role of intravenous acetaminophen in multimodal pain protocols for perioperative orthopedic patients. 
  • The timing and influence of MRI on the management of patients with cervical facet dislocations remains highly variable: a survey of members of the Spine Trauma Study Group. 
  • The treatment of chronic depression, part 1: study design and rationale for evaluating the comparative efficacy of sertraline and imipramine as acute, crossover, continuation, and maintenance phase therapies. 
  • The use of high-fidelity human patient simulation as an evaluative tool in the development of clinical research protocols and procedures. 
  • There Is Limited and Inconsistent Reporting of Postoperative Rehabilitation for Femoroacetabular Impingement Syndrome: A Scoping Review of 169 Studies. 
  • Thyroid hormone use during cardiac transplant organ procurement. 
  • Time from convulsive status epilepticus onset to anticonvulsant administration in children. 
  • Tissue expansion of the lower limb: complications in a cohort of 103 cases. 
  • Tissue plasminogen activator for acute ischemic stroke. 
  • Titrating Oxygen Requirements During Exercise: Evaluation of a Standardized Single Walk Test Protocol. 
  • Tool for evaluating research implementation challenges: a sense-making protocol for addressing implementation challenges in complex research settings. 
  • Toward individualized post-electroconvulsive therapy care: piloting the Symptom-Titrated, Algorithm-Based Longitudinal ECT (STABLE) intervention. 
  • Translational development strategy for magnetic seizure therapy. 
  • Treatment algorithm use to optimize management of symptomatic patients with a history of mania. 
  • Triaging Primary Care Patients Referred for Chest Pain to Specialist Cardiology Centres: Efficacy of an Optimised Protocol. 
  • Trial to Incentivise Adherence for Diabetes (TRIAD): study protocol for a randomised controlled trial. 
  • Understanding the costs of better tuberculosis diagnostics. 
  • Uptake of enhanced recovery practices by SAGES members: a survey. 
  • Usability Testing of a Sick-Day Protocol in CKD. 
  • Using a modified nominal group technique to elicit director of nursing input for an osteoporosis intervention. 
  • Using decision lists to construct interpretable and parsimonious treatment regimes. 
  • Using digital health to facilitate compliance with standardized pediatric cancer treatment guidelines in Tanzania: protocol for an early-stage effectiveness-implementation hybrid study. 
  • Vagal nerve stimulator infection: a lead-salvage protocol. 
  • Venous ulcers. 
  • Vestibular rehabilitation strategies in Meniere's disease. 
  • Veteran Response to Dosage in Chiropractic Therapy (VERDICT): Study Protocol of a Pragmatic Randomized Trial for Chronic Low Back Pain. 
  • Worldwide Organization of Neurocritical Care: Results from the PRINCE Study Part 1. 
  • Yoga for persistent pain: new findings and directions for an ancient practice. 
  • [Intraportal injection of specific monoclonal antibody in nude mice with liver metastasis]. 
  • {I}ndependent but coordinated trials: insights from the practice-based {O}pportunities for {W}eight {R}eduction {T}rials {C}ollaborative {R}esearch {G}roup 
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  Keywords of People

  • Alexander, John Hunter Peel, Professor of Medicine, Medicine, Cardiology
  • Anderson, Ruth A., Professor Emerita in the School of Nursing, School of Nursing
  • Barbeito, Atilio, Associate Professor of Anesthesiology, Anesthesiology
  • Clendaniel, Richard Alan, Assistant Professor in Orthopaedic Surgery, Head and Neck Surgery & Communication Sciences
  • Granger, Christopher Bull, Professor of Medicine, School of Nursing
  • McConnell, Eleanor Schildwachter, Associate Professor in the School of Nursing, School of Nursing
  • Mentz, Robert John, Associate Professor of Medicine, Medicine, Cardiology
  • Muhlbaier, Lawrence H., Associate Professor Emeritus of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
  • O'Connor, Christopher Michael, Richard Sean Stack, M.D. Distinguished Professor, Medicine, Clinical Pharmacology
  • O'Daniel, Jennifer Colleen, Assistant Professor of Radiation Oncology, Radiation Oncology
  • Patil, Sunita, Assoc Dir, Research Operations, Duke Clinical & Translational Science Institute
  • Shaw, Ryan, Associate Professor in the School of Nursing, Duke Innovation & Entrepreneurship
  • Taekman, Jeffrey Marc, Professor Emeritus of Anesthesiology, Anesthesiology, Neuroanesthesia
  • Yancy Jr., William Samuel, Professor of Medicine, Medicine, General Internal Medicine