Clone Cells

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  Subject Areas on Research

  • A CNS catecholaminergic cell line expresses voltage-gated currents. 
  • A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone. 
  • A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat. 
  • A threshold for central T cell tolerance to an inducible serum protein. 
  • A visual assay to monitor purification of cell surface antigens reacting with monoclonal antibodies. 
  • Acquisition of a side population fraction augments malignant phenotype in ovarian cancer. 
  • Activation of human B lymphocytes. XIII. Characterization of multiple populations of naturally occurring immunoregulatory cells of polyclonally induced in vitro human B cell function. 
  • Acute myeloblastic leukemia in paroxysmal nocturnal hemoglobinuria. Evidence of evolution from the abnormal paroxysmal nocturnal hemoglobinuria clone. 
  • Acute myeloid leukaemia with maturation demonstrates persistent disease with prominent megakaryoblastic differentiation 16 days following induction chemotherapy: an intra-myeloid lineage switch mediated by chemotherapy-induced clonal selection. 
  • Aedes albopictus cells resistant to adenosine because of a defect in nucleoside transport. 
  • Aggressive fibromatosis (desmoid tumor) is a monoclonal disorder. 
  • Aluminum-induced DNA synthesis in osteoblasts: mediation by a G-protein coupled cation sensing mechanism. 
  • Analysis of clones derived from human CD7+CD4-CD8-CD3- thymocytes. 
  • Analysis of factors associated with the tumorigenic potential of 12 tumor clones derived from a single rat colon adenocarcinoma. 
  • Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. 
  • Anti-self HLA may be clonally expressed. 
  • Apoptosis and P53 induction in human lung fibroblasts exposed to chromium (VI): effect of ascorbate and tocopherol. 
  • Apoptosis rate can be accelerated or decelerated by overexpression or reduction of the level of elongation factor-1 alpha. 
  • Application of in vivo and in vitro pharmacokinetics for physiologically relevant drug exposure in a human tumor clonogenic cell assay. 
  • Astrocyte cytolysis by MHC class II-specific mouse T cell clones. 
  • Basic fibroblast growth factor downregulates Bcl-2 and promotes apoptosis in MCF-7 human breast cancer cells. 
  • Basis for resistance to 3-deazaaristeromycin, an inhibitor of S-adenosylhomocysteine hydrolase, in human B-lymphoblasts. 
  • Cell interactions modulate embryonal carcinoma cell differentiation into parietal or visceral endoderm. 
  • Centrifugal migration of mesenchymal cells in embryonic lung. 
  • Characterization of a B lymphoblastoid cell line mutant that secretes HLA-A2. 
  • Characterization of a monoclonal antibody (4F2) that binds to human monocytes and to a subset of activated lymphocytes. 
  • Characterization of a monoclonal antibody (5E9) that defines a human cell surface antigen of cell activation. 
  • Characterization of a monoclonal antibody that defines an immunoregulatory T cell subset for immunoglobulin synthesis in humans. 
  • Characterization of monolayer and organ cultures of cloned and enriched lymphohematopoietic stroma cell populations. 
  • Circulating PIG-A mutant T lymphocytes in healthy adults and patients with bone marrow failure syndromes. 
  • Circulating mutational portrait of cancer: manifestation of aggressive clonal events in both early and late stages. 
  • Clonal Analysis of the Neonatal Mouse Heart using Nearest Neighbor Modeling. 
  • Clonal analysis of human anti-V3 monoclonal antibodies selected by a V3 tetramer. 
  • Clonal contributions of small numbers of retrovirally marked hematopoietic stem cells engrafted in unirradiated neonatal W/Wv mice. 
  • Clonal expansion and decreased occurrence of peripheral blood gamma delta T cells of the V delta 2J delta 3 lineage in multiple sclerosis patients. 
  • Clonal expansion of CD8+ BV8 T lymphocytes in bone marrow characterizes thymoma-associated B lymphopenia. 
  • Clonal origin of epithelial ovarian carcinoma: analysis by loss of heterozygosity, p53 mutation, and X-chromosome inactivation. 
  • Clonal persistence and evolution during a decade of recurrent melanoma. 
  • Clonality analysis of multifocal papillary thyroid carcinoma by using genetic profiles. 
  • Clonally dominant cardiomyocytes direct heart morphogenesis. 
  • Cloned endothelium derived from autoimmune vascular disease retain structural and functional characteristics of normal endothelial cells. 
  • Cloning efficiency of cultured human tumor cell lines measured with the use of a Coulter particle counter. 
  • Cloning of B cells from autoimmune MRL-lpr/lpr and MRL.xid mice. 
  • Cloning of mitogen- and antigen-reactive B lymphocytes on filter paper disks: phenotypic and genotypic analysis of B cell colonies. 
  • Cloning of murine splenic T lymphocytes and natural killer (NK) cells on filter paper discs: detection of a novel NK/T phenotype. 
  • Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter. 
  • Clustered cancer cells show a distinct adhesion behavior from single cell form under physiological shear conditions. 
  • Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. 
  • Commentary: Comparison of current flow cytometry methods for monoclonal B cell lymphocytosis detection. 
  • Competition of hydrophobic peptides, cytotoxic drugs, and chemosensitizers on a common P-glycoprotein pharmacophore as revealed by its ATPase activity. 
  • Complete DiGeorge syndrome: development of rash, lymphadenopathy, and oligoclonal T cells in 5 cases. 
  • Composite lymphoma of mycosis fungoides and cutaneous small B-cell lymphoma in a 73-year-old male patient. 
  • Concurrent classical Hodgkin lymphoma and plasmablastic lymphoma in a patient with chronic lymphocytic leukemia/small lymphocytic lymphoma treated with fludarabine: a dimorphic presentation of iatrogenic immunodeficiency-associated lymphoproliferative disorder with evidence suggestive of multiclonal transformability of B cells by Epstein-Barr virus. 
  • Cultured glomerular mesangial cells contain renin: influence of calcium and isoproterenol. 
  • Cytogenetic heterogeneity negatively impacts outcomes in patients with acute myeloid leukemia. 
  • Cytoprotection by somatostatin of normal and malignant clonogenic cells against the in vitro cytotoxicity of bischloroethylnitrosourea (BCNU). 
  • Degenerate TCR recognition and dual DR2 restriction of autoreactive T cells: implications for the initiation of the autoimmune response in multiple sclerosis. 
  • Demonstration of complex antigenic heterogeneity in a human glioma cell line and eight derived clones by specific monoclonal antibodies. 
  • Demonstration that mutation of the type II transforming growth factor beta receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells. 
  • Detailed analysis of cytomegalovirus (CMV)-specific T cells expanded for adoptive immunotherapy of CMV infection following allogeneic stem cell transplantation for malignant disease. 
  • Detection of clonal lymphoid receptor gene rearrangements in langerhans cell histiocytosis. 
  • Diagnostic and clinical considerations in concomitant bone marrow involvement by plasma cell myeloma and chronic lymphocytic leukemia/monoclonal B-cell lymphocytosis: a series of 15 cases and review of literature. 
  • Differential regulation of cAMP by endogenous versus transfected formylpeptide chemoattractant receptors: implications for Gi-coupled receptor signaling. 
  • Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases. 
  • Direct correlation between DNA repair capacity and metastatic potential of K-1735 murine melanoma cells. 
  • Does thalidomide affect IL-2 response and production? 
  • Donor cell-derived leukemias/myelodysplastic neoplasms in allogeneic hematopoietic stem cell transplant recipients: a clinicopathologic study of 10 cases and a comprehensive review of the literature. 
  • Effect of inhibitors of proteolytic enzymes on the growth of normal and polyoma transformed BHK cells. 
  • Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors. 
  • Effects of nitrogen mustard and splenectomy on mouse bone marrow colony formation in vitro. 
  • Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. 
  • Elevated frequency of microsatellite mutations in TK6 human lymphoblast clones selected for mutations at the thymidine kinase locus. 
  • Elevation of cAMP is required for down-regulation, but not agonist-induced desensitization, of endogenous dopamine D1 receptors in opossum kidney cells. Studies in cells that stably express a rat cAMP phosphodiesterase (rPDE3) cDNA. 
  • Endovascular infections caused by methicillin-resistant Staphylococcus aureus are linked to clonal complex-specific alterations in binding and invasion domains of fibronectin-binding protein A as well as the occurrence of fnbB. 
  • Establishment and characterization of conditionally immortalized cells from the mouse urogenital ridge. 
  • Evidence for cellular heterogeneity in primary cultures of human orbital fibroblasts. 
  • Evidence for coincident mutations in human lymphoblast clones selected for functional loss of a thymidine kinase gene. 
  • Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infection. 
  • Evidence for susceptibility of intrathymic T-cell precursors and their progeny carrying T-cell antigen receptor phenotypes TCR alpha beta + and TCR gamma delta + to human immunodeficiency virus infection: a mechanism for CD4+ (T4) lymphocyte depletion. 
  • Evidence of sexual recombination among Cryptococcus neoformans serotype A isolates in sub-Saharan Africa. 
  • Expression of transforming growth factor beta (TGFbeta) type III receptor restores autocrine TGFbeta1 activity in human breast cancer MCF-7 cells. 
  • Expression profiling of a transformed thymocyte cell line undergoing maturation in vitro identifies multiple genes involved in positive selection. 
  • Fine mapping two distinct antigenic sites on simian virus 40 (SV40) T antigen reactive with SV40-specific cytotoxic T-cell clones by using SV40 deletion mutants. 
  • Generation of Dhx9-deficient clones in T-cell development with a mitotic recombination technique. 
  • Genetic changes in contralateral bronchioloalveolar carcinomas of the lung. 
  • Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells. 
  • Glimpse of natural selection of long-lived T-cell clones in healthy life. 
  • HIV-1 GP120-mediated immune suppression and lymphocyte destruction in the absence of viral infection. 
  • HIV-1 Nef induces proliferation and anchorage-independent growth in podocytes. 
  • Heterogeneity in the hormonal responsiveness of clones derived from the 13762NF rat mammary tumor. 
  • Histiocytic sarcoma arising in indolent small B-cell lymphoma: report of two cases with molecular/genetic evidence suggestive of a 'transdifferentiation' during the clonal evolution. 
  • Histiocytic/dendritic cell transformation of B-cell neoplasms: pathologic evidence of lineage conversion in differentiated hematolymphoid malignancies. 
  • Human histocompatibility antigen mutants immunoselected in vitro. Biochemical analysis of a mutant which synthesizes an altered HLA-A2 heavy chain. 
  • Human lymphocyte antigens: production of a monoclonal antibody that defines functional thymus-derived lymphocyte subsets. 
  • IL-10 induces regulatory T cell apoptosis by up-regulation of the membrane form of TNF-alpha. 
  • Identification of novel Runx2 targets in osteoblasts: cell type-specific BMP-dependent regulation of Tram2. 
  • Idiotypic regulation by isologous monoclonal anti-idiotope antibodies. 
  • Ig VH hypermutation is absent in the germinal centers of aged mice. 
  • Immortalized hypothalamic gonadotropin-releasing hormone neurons. 
  • Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques. 
  • Immunogenetics shows that not all MBL are equal: the larger the clone, the more similar to CLL. 
  • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers. 
  • In vitro versus in vivo correlations of chemosensitivity of human medulloblastoma. 
  • Inducers of Friend leukaemic cell differentiation in vitro--effects of in vivo administration. 
  • Induction of autologous mixed lymphocyte culture responses by myelin basic protein-reactive T cell clones. 
  • Induction of polyclonal prostate cancer-specific CTL using dendritic cells transfected with amplified tumor RNA. 
  • Initiation of antiretroviral therapy during primary HIV-1 infection induces rapid stabilization of the T-cell receptor beta chain repertoire and reduces the level of T-cell oligoclonality. 
  • Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin. 
  • Intraclonal generation of antibody mutants in germinal centres. 
  • Intratumor heterogeneity in evolutionary models of tumor progression. 
  • Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion. 
  • Kinetics of TCR use in response to repeated epitope-specific immunization. 
  • Localization of an immunorecessive epitope on SV40 T antigen by H-2Db-restricted cytotoxic T-lymphocyte clones and a synthetic peptide. 
  • Locus-specific somatic hypermutation in germinal centre T cells. 
  • Low- and high-LET radiation drives clonal expansion of lung progenitor cells in vivo. 
  • Major expansion of CD8+ T cells with a predominant V beta usage during the primary immune response to HIV. 
  • Metabolism of pro-luteinizing hormone-releasing hormone in immortalized hypothalamic neurons. 
  • Mice lacking Bmp6 function. 
  • Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide. 
  • Minimal barriers to invasion during human colorectal tumor growth. 
  • Mismatch repair deficiency in phenotypically normal human cells. 
  • Modified MHC restriction of donor-origin T cells in humans with severe combined immunodeficiency transplanted with haploidentical bone marrow stem cells. 
  • Modulation of CD45 tyrosine phosphatase activity by antigen. 
  • Modulation of the transformed and neoplastic phenotype of rat fibroblasts by MHC-I gene expression. 
  • Molecular characteristics of mantle cell lymphoma presenting with clonal plasma cell component. 
  • Molecular characterization of anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. Differences from spontaneous anti-DNA in the content and location of VH CDR3 arginines. 
  • Molecular detection of circulating Sezary cells in patients with mycosis fungoides: could it predict future development of secondary Sezary syndrome? A single-institution experience. 
  • Molecular mechanisms of spontaneous and induced loss of heterozygosity in human cells in vitro. 
  • Monoclonal B cell lymphocytosis: clinical and population perspectives. 
  • Monoclonal antibodies binding renal renin. 
  • Monolayer absorption of human cytotoxic T cells: evidence for clonality. 
  • Morphological characterization of immortalized hypothalamic neurons synthesizing luteinizing hormone-releasing hormone. 
  • Multicolor mapping of the cardiomyocyte proliferation dynamics that construct the atrium. 
  • Multilocus sequence typing suggests the chytrid pathogen of amphibians is a recently emerged clone. 
  • NK and LAK susceptibility varies inversely with target cell MHC class I antigen expression in a rat epithelial tumour system. 
  • Novel type of proliferating lymphoplasmacytoid cell with a characteristic spotted immunofluorescence pattern. 
  • Oligoclonal CD8 lymphocytes from persons with asymptomatic human immunodeficiency virus (HIV) type 1 infection inhibit HIV-1 replication. 
  • Optimization and characterization of the capillary human tumor clonogenic cell assay. 
  • Pathogenesis of hemangioma. 
  • Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling. 
  • Persistence and selection of an expanded B-cell clone in the setting of rituximab therapy for Sjögren's syndrome. 
  • Pharmacologic purging of malignant T cells from human bone marrow using 9-beta-D-arabinofuranosylguanine. 
  • Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung. 
  • Potential associations between severity of infection and the presence of virulence-associated genes in clinical strains of Staphylococcus aureus. 
  • Presence of clonal chromosome abnormalities in virtually all cases of acute lymphoblastic leukemia. 
  • Primary intraocular T-cell-rich large B-cell lymphoma. 
  • Production of monoclonal antibodies reacting with peripheral blood mononuclear cell surface differentiation antigens. 
  • Progressive immunoglobulin gene mutations in chronic lymphocytic leukemia: evidence for antigen-driven intraclonal diversification. 
  • Proteins of purified Epstein-Barr virus. 
  • Questionable relevance of gamma delta T lymphocytes in renal cell carcinoma. 
  • Rapid method for permanent slide preparation of colonies in soft agar cultures. 
  • Rapid selection of tetracycline-controlled inducible cell lines using a green fluorescent-transactivator fusion protein. 
  • Reciprocal expansions of idiotypic and anti-idiotypic clones following antigen stimulation. 
  • Recognition and lysis of human melanoma by a CD3+, CD4+, CD8- T-cell clone restricted by HLA-A2. 
  • Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development. 
  • Reduced thymic output, increased spontaneous apoptosis and oligoclonal B cells in polyethylene glycol-adenosine deaminase-treated patients. 
  • Regulation of 2',5'-oligoadenylate synthetase gene expression by interferons and platelet-derived growth factor. 
  • Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition. 
  • Retinoic acid modulation of alpha(1-->2) fucosyltransferase activity and sensitivity of tumor cells to LAK-mediated cytotoxicity. 
  • Reversion from deficiency of galactose-1-phosphate uridylytransferase (GALT) in an SV40-transformed human fibroblast line. 
  • Revertants and partial transformants of rat fibroblasts infected with Fujinami sarcoma virus. 
  • Role for hedgehog signaling in hepatic stellate cell activation and viability. 
  • Sequence complexity of nuclear and cytoplasmic ribonucleic acids from clonal neurotumor cell lines and brain sections of the rat. 
  • Sequential development of chronic myelogenous leukemia and primary myelofibrosis in a patient with history of large B-cell lymphoma treated with radiotherapy and chemotherapy: two myeloid neoplasms with distinct genotypic profiles suggestive of biclonality in a single individual. 
  • Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma. 
  • Specific blockers of myoblast fusion inhibit a soluble and not the membrane-associated metalloendoprotease in myoblasts. 
  • Specificity, cross-reactivity, and affinity of 125I-labeled antiglioma antibodies for monolayers of cultured glioma cells. 
  • Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes. 
  • Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replication. 
  • Status of activation of circulating vaccine-elicited CD8+ T cells. 
  • Stimulation of clonal tumor cell growth in vitro by inhibiting the serum polyamine oxidase activity. 
  • Stochastic pairing of heavy-chain and kappa light-chain variable gene families occurs in polyclonally activated B cells. 
  • Studies on the reproductive and cell-converting abilities of avian sarcoma viruses. 
  • Study of the ability of phenacetin, acetaminophen, and aspirin to induce cytotoxicity, mutation, and morphological transformation in C3H/10T1/2 clone 8 mouse embryo cells. 
  • T cell repertoire development in humans with SCID after nonablative allogeneic marrow transplantation. 
  • T-cell prolymphocytic leukemia in a 63-year-old female with a pre-existing T-cell large granular lymphocytic leukemia: metachronous T-cell leukemias with discordant subset restrictions (CD4 versus CD8) and distinct clonal identities. 
  • T-cell receptors of human suppressor cells. 
  • Targeted Elimination of Immunodominant B Cells Drives the Germinal Center Reaction toward Subdominant Epitopes. 
  • Tepoxalin enhances the activity of an antioxidant, pyrrolidine dithiocarbamate, in attenuating tumor necrosis factor alpha-induced apoptosis in WEHI 164 cells. 
  • The B-cell repertoire for autoantibodies: frequency of precursor cells for anti-DNA antibodies. 
  • The Drosophila hindgut lacks constitutively active adult stem cells but proliferates in response to tissue damage. 
  • The PIG-A mutation and absence of glycosylphosphatidylinositol-linked proteins do not confer resistance to apoptosis in paroxysmal nocturnal hemoglobinuria. 
  • The isoforms of phospholipase C-gamma are differentially used by distinct human NK activating receptors. 
  • The role of CD4-Lck in T-cell receptor antagonism: evidence for negative signaling. 
  • Tracing Tumor Evolution in Sarcoma Reveals Clonal Origin of Advanced Metastasis. 
  • Tumor stem cell cloning in agar-containing capillaries. 
  • Two forms of the T-cell receptor gamma protein found on peripheral blood cytotoxic T lymphocytes. 
  • Use of recombinant adenovirus for metabolic engineering of mammalian cells. 
  • Utilizing cell–matrix interactions to modulate gene transfer to stem cells inside hyaluronic acid hydrogels 
  • V region gene analysis of anti-Sm hybridomas from MRL/Mp-lpr/lpr mice. 
  • Vaccination establishes clonal relatives of germinal center T cells in the blood of humans. 
  • Wnt proteins synergize to activate β-catenin signaling. 
  • p53 Regulates Progenitor Cell Quiescence and Differentiation in the Airway. 
  • p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Ferrari, Guido, Professor in Surgery, Molecular Genetics and Microbiology
  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor for Research in Molecular Biology, Cell Biology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Immunology
  • Luftig, Micah Alan, Associate Professor of Molecular Genetics and Microbiology, Immunology
  • Stoecker, Maggie Marie, Assistant Professor of Pathology, Pathology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, in the School of Medicine, Immunology
  • Zennadi, Rahima, Associate Professor in Medicine, Pathology