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Subject Areas on Research
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A CNS catecholaminergic cell line expresses voltage-gated currents.
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A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone.
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A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat.
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A threshold for central T cell tolerance to an inducible serum protein
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A visual assay to monitor purification of cell surface antigens reacting with monoclonal antibodies.
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Acquisition of a side population fraction augments malignant phenotype in ovarian cancer.
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Activation of human B lymphocytes. XIII. Characterization of multiple populations of naturally occurring immunoregulatory cells of polyclonally induced in vitro human B cell function.
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Acute myeloblastic leukemia in paroxysmal nocturnal hemoglobinuria. Evidence of evolution from the abnormal paroxysmal nocturnal hemoglobinuria clone.
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Acute myeloid leukaemia with maturation demonstrates persistent disease with prominent megakaryoblastic differentiation 16 days following induction chemotherapy: an intra-myeloid lineage switch mediated by chemotherapy-induced clonal selection.
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Aedes albopictus cells resistant to adenosine because of a defect in nucleoside transport.
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Aggressive fibromatosis (desmoid tumor) is a monoclonal disorder.
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Allo-Specific Humoral Responses: New Methods for Screening Donor-Specific Antibody and Characterization of HLA-Specific Memory B Cells.
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Aluminum-induced DNA synthesis in osteoblasts: mediation by a G-protein coupled cation sensing mechanism.
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Analysis of clones derived from human CD7+CD4-CD8-CD3- thymocytes.
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Analysis of factors associated with the tumorigenic potential of 12 tumor clones derived from a single rat colon adenocarcinoma.
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Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation.
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Anti-self HLA may be clonally expressed.
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Apoptosis and P53 induction in human lung fibroblasts exposed to chromium (VI): effect of ascorbate and tocopherol.
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Apoptosis rate can be accelerated or decelerated by overexpression or reduction of the level of elongation factor-1 alpha.
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Application of in vivo and in vitro pharmacokinetics for physiologically relevant drug exposure in a human tumor clonogenic cell assay.
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Astrocyte cytolysis by MHC class II-specific mouse T cell clones.
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Basic fibroblast growth factor downregulates Bcl-2 and promotes apoptosis in MCF-7 human breast cancer cells.
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Basis for resistance to 3-deazaaristeromycin, an inhibitor of S-adenosylhomocysteine hydrolase, in human B-lymphoblasts.
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Cell interactions modulate embryonal carcinoma cell differentiation into parietal or visceral endoderm.
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Centrifugal migration of mesenchymal cells in embryonic lung.
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Characterization of a B lymphoblastoid cell line mutant that secretes HLA-A2.
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Characterization of a monoclonal antibody (4F2) that binds to human monocytes and to a subset of activated lymphocytes.
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Characterization of a monoclonal antibody (5E9) that defines a human cell surface antigen of cell activation.
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Characterization of a monoclonal antibody that defines an immunoregulatory T cell subset for immunoglobulin synthesis in humans.
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Circulating PIG-A mutant T lymphocytes in healthy adults and patients with bone marrow failure syndromes.
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Circulating mutational portrait of cancer: manifestation of aggressive clonal events in both early and late stages.
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Clonal Analysis of the Neonatal Mouse Heart using Nearest Neighbor Modeling.
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Clonal analysis of human anti-V3 monoclonal antibodies selected by a V3 tetramer.
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Clonal contributions of small numbers of retrovirally marked hematopoietic stem cells engrafted in unirradiated neonatal W/Wv mice.
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Clonal evolution in t(14;18)-positive follicular lymphoma, evidence for multiple common pathways, and frequent parallel clonal evolution.
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Clonal expansion and decreased occurrence of peripheral blood gamma delta T cells of the V delta 2J delta 3 lineage in multiple sclerosis patients.
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Clonal expansion of CD8+ BV8 T lymphocytes in bone marrow characterizes thymoma-associated B lymphopenia.
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Clonal origin of epithelial ovarian carcinoma: analysis by loss of heterozygosity, p53 mutation, and X-chromosome inactivation.
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Clonal persistence and evolution during a decade of recurrent melanoma.
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Clonality of combined tumors.
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Clonally dominant cardiomyocytes direct heart morphogenesis.
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Cloned endothelium derived from autoimmune vascular disease retain structural and functional characteristics of normal endothelial cells.
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Cloning efficiency of cultured human tumor cell lines measured with the use of a Coulter particle counter.
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Cloning of B cells from autoimmune MRL-lpr/lpr and MRL.xid mice.
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Cloning of mitogen- and antigen-reactive B lymphocytes on filter paper disks: phenotypic and genotypic analysis of B cell colonies.
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Cloning of murine splenic T lymphocytes and natural killer (NK) cells on filter paper discs: detection of a novel NK/T phenotype.
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Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus.
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Commentary: Comparison of current flow cytometry methods for monoclonal B cell lymphocytosis detection.
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Competition of hydrophobic peptides, cytotoxic drugs, and chemosensitizers on a common P-glycoprotein pharmacophore as revealed by its ATPase activity.
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Complete DiGeorge syndrome: development of rash, lymphadenopathy, and oligoclonal T cells in 5 cases.
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Composite lymphoma of mycosis fungoides and cutaneous small B-cell lymphoma in a 73-year-old male patient.
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Concurrent classical Hodgkin lymphoma and plasmablastic lymphoma in a patient with chronic lymphocytic leukemia/small lymphocytic lymphoma treated with fludarabine: a dimorphic presentation of iatrogenic immunodeficiency-associated lymphoproliferative disorder with evidence suggestive of multiclonal transformability of B cells by Epstein-Barr virus.
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Cultured glomerular mesangial cells contain renin: influence of calcium and isoproterenol.
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Cytogenetic heterogeneity negatively impacts outcomes in patients with acute myeloid leukemia.
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Cytoprotection by somatostatin of normal and malignant clonogenic cells against the in vitro cytotoxicity of bischloroethylnitrosourea (BCNU).
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Degenerate TCR recognition and dual DR2 restriction of autoreactive T cells: implications for the initiation of the autoimmune response in multiple sclerosis.
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Demonstration of complex antigenic heterogeneity in a human glioma cell line and eight derived clones by specific monoclonal antibodies.
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Demonstration that mutation of the type II transforming growth factor beta receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells.
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Detailed analysis of cytomegalovirus (CMV)-specific T cells expanded for adoptive immunotherapy of CMV infection following allogeneic stem cell transplantation for malignant disease.
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Detection of clonal lymphoid receptor gene rearrangements in langerhans cell histiocytosis.
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Diagnostic and clinical considerations in concomitant bone marrow involvement by plasma cell myeloma and chronic lymphocytic leukemia/monoclonal B-cell lymphocytosis: a series of 15 cases and review of literature.
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Differential regulation of cAMP by endogenous versus transfected formylpeptide chemoattractant receptors: implications for Gi-coupled receptor signaling.
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Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases.
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Direct correlation between DNA repair capacity and metastatic potential of K-1735 murine melanoma cells.
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Does thalidomide affect IL-2 response and production?
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Donor cell-derived leukemias/myelodysplastic neoplasms in allogeneic hematopoietic stem cell transplant recipients: a clinicopathologic study of 10 cases and a comprehensive review of the literature.
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Effect of inhibitors of proteolytic enzymes on the growth of normal and polyoma transformed BHK cells.
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Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors.
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Effects of nitrogen mustard and splenectomy on mouse bone marrow colony formation in vitro.
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Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow.
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Elevated frequency of microsatellite mutations in TK6 human lymphoblast clones selected for mutations at the thymidine kinase locus.
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Elevation of cAMP is required for down-regulation, but not agonist-induced desensitization, of endogenous dopamine D1 receptors in opossum kidney cells. Studies in cells that stably express a rat cAMP phosphodiesterase (rPDE3) cDNA.
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Endovascular infections caused by methicillin-resistant Staphylococcus aureus are linked to clonal complex-specific alterations in binding and invasion domains of fibronectin-binding protein A as well as the occurrence of fnbB.
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Establishment and characterization of conditionally immortalized cells from the mouse urogenital ridge.
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Evidence for cellular heterogeneity in primary cultures of human orbital fibroblasts.
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Evidence for coincident mutations in human lymphoblast clones selected for functional loss of a thymidine kinase gene.
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Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infection.
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Evidence for susceptibility of intrathymic T-cell precursors and their progeny carrying T-cell antigen receptor phenotypes TCR alpha beta + and TCR gamma delta + to human immunodeficiency virus infection: a mechanism for CD4+ (T4) lymphocyte depletion.
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Evidence of sexual recombination among Cryptococcus neoformans serotype A isolates in sub-Saharan Africa.
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Expression of transforming growth factor beta (TGFbeta) type III receptor restores autocrine TGFbeta1 activity in human breast cancer MCF-7 cells.
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Expression profiling of a transformed thymocyte cell line undergoing maturation in vitro identifies multiple genes involved in positive selection.
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Generation of Dhx9-deficient clones in T-cell development with a mitotic recombination technique.
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Genetic changes in contralateral bronchioloalveolar carcinomas of the lung.
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Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells.
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Glimpse of natural selection of long-lived T-cell clones in healthy life.
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HIV-1 GP120-mediated immune suppression and lymphocyte destruction in the absence of viral infection.
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HIV-1 Nef induces proliferation and anchorage-independent growth in podocytes.
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Heterogeneity in the hormonal responsiveness of clones derived from the 13762NF rat mammary tumor.
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Histiocytic sarcoma arising in indolent small B-cell lymphoma: report of two cases with molecular/genetic evidence suggestive of a 'transdifferentiation' during the clonal evolution.
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Histiocytic/dendritic cell transformation of B-cell neoplasms: pathologic evidence of lineage conversion in differentiated hematolymphoid malignancies.
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Human histocompatibility antigen mutants immunoselected in vitro. Biochemical analysis of a mutant which synthesizes an altered HLA-A2 heavy chain.
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Human lymphocyte antigens: production of a monoclonal antibody that defines functional thymus-derived lymphocyte subsets.
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IL-10 induces regulatory T cell apoptosis by up-regulation of the membrane form of TNF-alpha.
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Identification of novel Runx2 targets in osteoblasts: cell type-specific BMP-dependent regulation of Tram2.
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Idiotypic regulation by isologous monoclonal anti-idiotope antibodies.
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Ig VH hypermutation is absent in the germinal centers of aged mice.
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Immortalized hypothalamic gonadotropin-releasing hormone neurons.
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Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques.
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Immunogenetics shows that not all MBL are equal: the larger the clone, the more similar to CLL.
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In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers.
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In vitro versus in vivo correlations of chemosensitivity of human medulloblastoma.
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Inducers of Friend leukaemic cell differentiation in vitro--effects of in vivo administration.
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Induction of autologous mixed lymphocyte culture responses by myelin basic protein-reactive T cell clones.
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Induction of polyclonal prostate cancer-specific CTL using dendritic cells transfected with amplified tumor RNA.
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Initiation of antiretroviral therapy during primary HIV-1 infection induces rapid stabilization of the T-cell receptor beta chain repertoire and reduces the level of T-cell oligoclonality.
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Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin.
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Intraclonal generation of antibody mutants in germinal centres.
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Intratumor heterogeneity in evolutionary models of tumor progression.
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Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion.
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Kinetics of TCR use in response to repeated epitope-specific immunization.
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Locus-specific somatic hypermutation in germinal centre T cells.
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Low- and high-LET radiation drives clonal expansion of lung progenitor cells in vivo.
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Major expansion of CD8+ T cells with a predominant V beta usage during the primary immune response to HIV.
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Massively parallel quantification of phenotypic heterogeneity in single-cell drug responses.
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Metabolism of pro-luteinizing hormone-releasing hormone in immortalized hypothalamic neurons.
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Mice lacking Bmp6 function.
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Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.
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Minimal barriers to invasion during human colorectal tumor growth.
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Mismatch repair deficiency in phenotypically normal human cells.
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Modified MHC restriction of donor-origin T cells in humans with severe combined immunodeficiency transplanted with haploidentical bone marrow stem cells.
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Modulation of CD45 tyrosine phosphatase activity by antigen.
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Modulation of the transformed and neoplastic phenotype of rat fibroblasts by MHC-I gene expression.
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Molecular characteristics of mantle cell lymphoma presenting with clonal plasma cell component.
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Molecular characterization of anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. Differences from spontaneous anti-DNA in the content and location of VH CDR3 arginines.
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Molecular detection of circulating Sezary cells in patients with mycosis fungoides: could it predict future development of secondary Sezary syndrome? A single-institution experience.
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Molecular mechanisms of spontaneous and induced loss of heterozygosity in human cells in vitro.
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Monoclonal B cell lymphocytosis: clinical and population perspectives.
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Monoclonal antibodies binding renal renin.
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Monolayer absorption of human cytotoxic T cells: evidence for clonality.
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Morphological characterization of immortalized hypothalamic neurons synthesizing luteinizing hormone-releasing hormone.
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Multicolor mapping of the cardiomyocyte proliferation dynamics that construct the atrium.
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Multilocus sequence typing suggests the chytrid pathogen of amphibians is a recently emerged clone.
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NK and LAK susceptibility varies inversely with target cell MHC class I antigen expression in a rat epithelial tumour system.
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Novel type of proliferating lymphoplasmacytoid cell with a characteristic spotted immunofluorescence pattern.
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Oligoclonal CD8 lymphocytes from persons with asymptomatic human immunodeficiency virus (HIV) type 1 infection inhibit HIV-1 replication.
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Optimization and characterization of the capillary human tumor clonogenic cell assay.
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Pathogenesis of hemangioma.
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Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling.
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Persistence and selection of an expanded B-cell clone in the setting of rituximab therapy for Sjögren's syndrome.
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Pharmacologic purging of malignant T cells from human bone marrow using 9-beta-D-arabinofuranosylguanine.
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Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung.
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Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans.
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Potential associations between severity of infection and the presence of virulence-associated genes in clinical strains of Staphylococcus aureus.
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Presence of clonal chromosome abnormalities in virtually all cases of acute lymphoblastic leukemia.
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Primary intraocular T-cell-rich large B-cell lymphoma.
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Production of monoclonal antibodies reacting with peripheral blood mononuclear cell surface differentiation antigens.
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Progressive immunoglobulin gene mutations in chronic lymphocytic leukemia: evidence for antigen-driven intraclonal diversification.
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Proteins of purified Epstein-Barr virus.
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Questionable relevance of gamma delta T lymphocytes in renal cell carcinoma.
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Rapid method for permanent slide preparation of colonies in soft agar cultures.
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Rapid selection of tetracycline-controlled inducible cell lines using a green fluorescent-transactivator fusion protein.
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Reciprocal expansions of idiotypic and anti-idiotypic clones following antigen stimulation.
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Recognition and lysis of human melanoma by a CD3+, CD4+, CD8- T-cell clone restricted by HLA-A2.
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Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development.
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Reduced thymic output, increased spontaneous apoptosis and oligoclonal B cells in polyethylene glycol-adenosine deaminase-treated patients.
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Regulation of 2',5'-oligoadenylate synthetase gene expression by interferons and platelet-derived growth factor.
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Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition.
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Retinoic acid modulation of alpha(1-->2) fucosyltransferase activity and sensitivity of tumor cells to LAK-mediated cytotoxicity.
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Reversion from deficiency of galactose-1-phosphate uridylytransferase (GALT) in an SV40-transformed human fibroblast line.
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Revertants and partial transformants of rat fibroblasts infected with Fujinami sarcoma virus.
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Role for hedgehog signaling in hepatic stellate cell activation and viability.
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Sequence complexity of nuclear and cytoplasmic ribonucleic acids from clonal neurotumor cell lines and brain sections of the rat.
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Sequential development of chronic myelogenous leukemia and primary myelofibrosis in a patient with history of large B-cell lymphoma treated with radiotherapy and chemotherapy: two myeloid neoplasms with distinct genotypic profiles suggestive of biclonality in a single individual.
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Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma.
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Specific blockers of myoblast fusion inhibit a soluble and not the membrane-associated metalloendoprotease in myoblasts.
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Specificity, cross-reactivity, and affinity of 125I-labeled antiglioma antibodies for monolayers of cultured glioma cells.
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Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes.
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Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replication.
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Status of activation of circulating vaccine-elicited CD8+ T cells.
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Stimulation of clonal tumor cell growth in vitro by inhibiting the serum polyamine oxidase activity.
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Stochastic pairing of heavy-chain and kappa light-chain variable gene families occurs in polyclonally activated B cells.
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Studies on the reproductive and cell-converting abilities of avian sarcoma viruses.
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Study of the ability of phenacetin, acetaminophen, and aspirin to induce cytotoxicity, mutation, and morphological transformation in C3H/10T1/2 clone 8 mouse embryo cells.
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T cell repertoire development in humans with SCID after nonablative allogeneic marrow transplantation.
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T-cell prolymphocytic leukemia in a 63-year-old female with a pre-existing T-cell large granular lymphocytic leukemia: metachronous T-cell leukemias with discordant subset restrictions (CD4 versus CD8) and distinct clonal identities.
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T-cell receptors of human suppressor cells.
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Targeted Elimination of Immunodominant B Cells Drives the Germinal Center Reaction toward Subdominant Epitopes.
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Tepoxalin enhances the activity of an antioxidant, pyrrolidine dithiocarbamate, in attenuating tumor necrosis factor alpha-induced apoptosis in WEHI 164 cells.
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The B-cell repertoire for autoantibodies: frequency of precursor cells for anti-DNA antibodies.
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The Drosophila hindgut lacks constitutively active adult stem cells but proliferates in response to tissue damage.
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The PIG-A mutation and absence of glycosylphosphatidylinositol-linked proteins do not confer resistance to apoptosis in paroxysmal nocturnal hemoglobinuria.
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The isoforms of phospholipase C-gamma are differentially used by distinct human NK activating receptors.
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The role of CD4-Lck in T-cell receptor antagonism: evidence for negative signaling.
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Tracing Tumor Evolution in Sarcoma Reveals Clonal Origin of Advanced Metastasis.
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Transformation of follicular lymphoma to precursor B-cell lymphoblastic lymphoma with c-myc gene rearrangement as a critical event.
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Tumor stem cell cloning in agar-containing capillaries.
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Two forms of the T-cell receptor gamma protein found on peripheral blood cytotoxic T lymphocytes.
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Use of recombinant adenovirus for metabolic engineering of mammalian cells.
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Utilizing cell–matrix interactions to modulate gene transfer to stem cells inside hyaluronic acid hydrogels
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V region gene analysis of anti-Sm hybridomas from MRL/Mp-lpr/lpr mice.
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Vaccination establishes clonal relatives of germinal center T cells in the blood of humans.
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Wnt proteins synergize to activate β-catenin signaling.
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p53 Regulates Progenitor Cell Quiescence and Differentiation in the Airway.
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p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene.
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Keywords of People
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Ferrari, Guido,
Professor in Surgery,
Molecular Genetics and Microbiology
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Hogan, Brigid L. M.,
George Barth Geller Distinguished Professor for Research in Molecular Biology,
Cell Biology
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Krangel, Michael S.,
George Barth Geller Distinguished Professor of Immunology,
Immunology
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Luftig, Micah Alan,
Associate Professor of Molecular Genetics and Microbiology,
Immunology
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Stoecker, Maggie Marie,
Assistant Professor of Pathology,
Pathology
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Weinhold, Kent James,
Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery,
Immunology
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Zennadi, Rahima,
Associate Professor in Medicine,
Pathology