Coated Pits, Cell-Membrane

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  Subject Areas on Research

  • A central role for beta-arrestins and clathrin-coated vesicle-mediated endocytosis in beta2-adrenergic receptor resensitization. Differential regulation of receptor resensitization in two distinct cell types. 
  • A conserved clathrin assembly motif essential for synaptic vesicle endocytosis. 
  • A requirement for ankyrin binding to clathrin during coated pit budding. 
  • ARF1 regulates Nef-induced CD4 degradation. 
  • Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. 
  • An internalization signal in the simian immunodeficiency virus transmembrane protein cytoplasmic domain modulates expression of envelope glycoproteins on the cell surface. 
  • Biochemical and biophysical identification of cystic fibrosis transmembrane conductance regulator chloride channels as components of endocytic clathrin-coated vesicles. 
  • Clathrin phosphorylation is required for actin recruitment at sites of bacterial adhesion and internalization. 
  • Clathrin-coated vesicle assembly polypeptides: physical properties and reconstitution studies with brain membranes. 
  • Electric field-induced redistribution and postfield relaxation of low density lipoprotein receptors on cultured human fibroblasts. 
  • Internalization of recombinant tissue-type plasminogen activator by isolated rat hepatocytes is via coated pits. 
  • Morphologic demonstration of clathrin-coated pits in frog and turkey erythrocytes. 
  • Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development. 
  • Role of beta-arrestins in the intracellular trafficking of G-protein-coupled receptors. 
  • The alpha1a-adrenergic receptor occupies membrane rafts with its G protein effectors but internalizes via clathrin-coated pits. 
  • The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pits. 
  • Trafficking of apical proteins into clathrin-coated vesicles isolated from rat renal cortex. 
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  Keywords of People

  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute