Coenzymes

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  Subject Areas on Research

  • A molybdopterin-free form of xanthine oxidase. 
  • A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease. 
  • A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A. 
  • A sulfurtransferase is required in the transfer of cysteine sulfur in the in vitro synthesis of molybdopterin from precursor Z in Escherichia coli. 
  • Absence of hepatic molybdenum cofactor: an inborn error of metabolism leading to a combined deficiency of sulphite oxidase and xanthine dehydrogenase. 
  • Allosteric cooperation in a de novo-designed two-domain protein. 
  • An HPLC assay for detection of elevated urinary S-sulphocysteine, a metabolic marker of sulphite oxidase deficiency. 
  • An active site tyrosine influences the ability of the dimethyl sulfoxide reductase family of molybdopterin enzymes to reduce S-oxides. 
  • Assay and detection of the molybdenum cofactor. 
  • Assembly and disassembly of DNA polymerase holoenzyme. 
  • Biosynthesis and processing of the molybdenum cofactors. 
  • C-C bond forming radical SAM enzymes involved in the construction of carbon skeletons of cofactors and natural products. 
  • C-Terminal glycine-gated radical initiation by GTP 3',8-cyclase in the molybdenum cofactor biosynthesis. 
  • COQ2 nephropathy: a newly described inherited mitochondriopathy with primary renal involvement. 
  • Characterization of Escherichia coli MoeB and its involvement in the activation of molybdopterin synthase for the biosynthesis of the molybdenum cofactor. 
  • Characterization of molybdenum cofactor from Escherichia coli. 
  • Characterization of the molybdenum cofactor of sulfite oxidase, xanthine, oxidase, and nitrate reductase. Identification of a pteridine as a structural component. 
  • Chemistry and biology of the molybdenum cofactor. 
  • Chemistry and biology of the molybdenum cofactors. 
  • Clamp subunit dissociation dictates bacteriophage T4 DNA polymerase holoenzyme disassembly. 
  • Coenzyme Q10 protects ischemic myocardium in an open-chest swine model. 
  • Coenzyme Q10: a review of its promise as a neuroprotectant. 
  • Concurrent administration of coenzyme Q10 and alpha-tocopherol improves learning in aged mice. 
  • Could coenzyme Q10 affect hemostasis by inhibiting platelet vitronectin (CD51/CD61) receptor? 
  • Crystal structure of DMSO reductase: redox-linked changes in molybdopterin coordination. 
  • Crystal structure of the gephyrin-related molybdenum cofactor biosynthesis protein MogA from Escherichia coli. 
  • Defective molybdopterin biosynthesis: clinical heterogeneity associated with molybdenum cofactor deficiency. 
  • Dietary coenzyme Q10 supplementation alters platelet size and inhibits human vitronectin (CD51/CD61) receptor expression. 
  • Dissecting the order of bacteriophage T4 DNA polymerase holoenzyme assembly. 
  • Effect of sulphanilamide on formation of sterols in Saccharomyces cerevisiae and Neurospora crassa. 
  • Escherichia coli MoeA and MogA. Function in metal incorporation step of molybdenum cofactor biosynthesis. 
  • Further insights into quinone cofactor biogenesis: probing the role of mauG in methylamine dehydrogenase tryptophan tryptophylquinone formation. 
  • Hemostatic changes after dietary coenzyme Q10 supplementation in swine. 
  • How an enzyme binds the C1 carrier tetrahydromethanopterin. Structure of the tetrahydromethanopterin-dependent formaldehyde-activating enzyme (Fae) from Methylobacterium extorquens AM1. 
  • Human molybdenum cofactor deficiency. 
  • Identification of a cyclic nucleotide as a cryptic intermediate in molybdenum cofactor biosynthesis. 
  • Identification of a molybdopterin-containing molybdenum cofactor in xanthine dehydrogenase from Pseudomonas aeruginosa. 
  • Identification of molybdopterin as the organic component of the tungsten cofactor in four enzymes from hyperthermophilic Archaea. 
  • In vitro incorporation of nascent molybdenum cofactor into human sulfite oxidase. 
  • In vitro reconstitution of nitrate reductase activity of the Neurospora crassa mutant nit-1: specific incorporation of molybdopterin. 
  • In vitro synthesis of molybdopterin from precursor Z using purified converting factor. Role of protein-bound sulfur in formation of the dithiolene. 
  • In vitro system for molybdopterin biosynthesis. 
  • Inborn errors of molybdenum metabolism: combined deficiencies of sulfite oxidase and xanthine dehydrogenase in a patient lacking the molybdenum cofactor. 
  • Investigation of the early steps of molybdopterin biosynthesis in Escherichia coli through the use of in vivo labeling studies. 
  • Involvement of chlA, E, M, and N loci in Escherichia coli molybdopterin biosynthesis. 
  • Kinetics of thermal unfolding of phenylalanine hydroxylase variants containing different metal cofactors (FeII, CoII, and ZnII) and their isokinetic relationship. 
  • Lessons From the Studies of a CC Bond Forming Radical SAM Enzyme in Molybdenum Cofactor Biosynthesis. 
  • Mechanism of pyranopterin ring formation in molybdenum cofactor biosynthesis. 
  • Mechanistic Investigation of cPMP Synthase in Molybdenum Cofactor Biosynthesis Using an Uncleavable Substrate Analogue. 
  • Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis. 
  • Mechanistic studies of human molybdopterin synthase reaction and characterization of mutants identified in group B patients of molybdenum cofactor deficiency. 
  • Molecular cloning of rat liver sulfite oxidase. Expression of a eukaryotic Mo-pterin-containing enzyme in Escherichia coli. 
  • Molybdenum cofactor biosynthesis in Escherichia coli mod and mog mutants. 
  • Molybdenum cofactor biosynthesis in Escherichia coli. Requirement of the chlB gene product for the formation of molybdopterin guanine dinucleotide. 
  • Molybdenum cofactor deficiency associated with Dandy-Walker malformation. 
  • Molybdopterin biosynthesis in man. Properties of the converting factor in liver tissue from a molybdenum cofactor deficient patient. 
  • Molybdopterin from molybdenum and tungsten enzymes. 
  • Molybdopterin guanine dinucleotide: a modified form of molybdopterin identified in the molybdenum cofactor of dimethyl sulfoxide reductase from Rhodobacter sphaeroides forma specialis denitrificans. 
  • Molybdopterin in carbon monoxide oxidase from carboxydotrophic bacteria. 
  • Molybdopterin synthase mutations in a mild case of molybdenum cofactor deficiency. 
  • Molybdopterin--problems and perspectives. 
  • Novel aspects of the biochemistry of the molybdenum cofactor. 
  • Organization of enzyme concentration across the metabolic network in cancer cells. 
  • Oxidation of molybdopterin in sulfite oxidase by ferricyanide. Effect on electron transfer activities. 
  • Prenatal diagnosis of molybdenum cofactor deficiency by assay of sulphite oxidase activity in chorionic villus samples. 
  • Proposed nomenclature for the genes involved in molybdenum metabolism in Escherichia coli and Salmonella typhimurium. 
  • Radical Breakthroughs in Natural Product and Cofactor Biosynthesis. 
  • Re-design of Rhodobacter sphaeroides dimethyl sulfoxide reductase. Enhancement of adenosine N1-oxide reductase activity. 
  • Requirement of helix P2.2 and nucleotide G1 for positioning the cleavage site and cofactor of the glmS ribozyme. 
  • Resonance Raman spectroscopic characterization of the molybdopterin active site of DMSO reductase. 
  • Specific incorporation of molybdopterin in xanthine dehydrogenase of Pseudomonas aeruginosa. 
  • Structural and metabolic relationship between the molybdenum cofactor and urothione. 
  • Structural characterization of a molybdopterin precursor. 
  • The Roles of β-Oxidation and Cofactor Homeostasis in Peroxisome Distribution and Function in Arabidopsis thaliana. 
  • The biosynthesis of molybdopterin in Escherichia coli. Purification and characterization of the converting factor. 
  • The mechanism of discrimination between oxidized and reduced coenzyme in the aldehyde dehydrogenase domain of Aldh1l1. 
  • The mechanisms of inactivation of sulfite oxidase by periodate and arsenite. 
  • The pterin component of the molybdenum cofactor. Structural characterization of two fluorescent derivatives. 
  • The pterin molybdenum cofactors. 
  • The pterin of the molybdenum cofactor. 
  • The relationship of Mo, molybdopterin, and the cyanolyzable sulfur in the Mo cofactor. 
  • The role of FeS clusters for molybdenum cofactor biosynthesis and molybdoenzymes in bacteria. 
  • The state of reduction of molybdopterin in xanthine oxidase and sulfite oxidase. 
  • The structure of a molybdopterin precursor. Characterization of a stable, oxidized derivative. 
  • The structure of formylmethanofuran: tetrahydromethanopterin formyltransferase in complex with its coenzymes. 
  • The structure of the molybdenum cofactor. Characterization of di-(carboxamidomethyl)molybdopterin from sulfite oxidase and xanthine oxidase. 
  • Thermodynamic analysis of subunit interactions in Escherichia coli molybdopterin synthase. 
  • Two proteins encoded at the chlA locus constitute the converting factor of Escherichia coli chlA1.