Collagen

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  Subject Areas on Research

  • 3D Culture Facilitates VEGF-Stimulated Endothelial Differentiation of Adipose-Derived Stem Cells. 
  • 3D traction stresses activate protease-dependent invasion of cancer cells. 
  • A collagen-based nerve guide conduit for peripheral nerve repair: an electrophysiological study of nerve regeneration in rodents and nonhuman primates. 
  • A comparative histologic study of rapid three-dimensional zygomatic suture expansion osteogenesis. 
  • A cross sectional analysis of 5 different markers of collagen degradation in rheumatoid arthritis. 
  • A followup on transurethral collagen injection therapy for urinary incontinence. 
  • A micro-CT analysis of murine lung recruitment in bleomycin-induced lung injury. 
  • A novel bioreactor for combined magnetic resonance spectroscopy and optical imaging of metabolism in 3D cell cultures. 
  • A patient with Ehlers-Danlos syndrome type VI is homozygous for a premature termination codon in exon 14 of the lysyl hydroxylase 1 gene. 
  • A preliminary study of the fixation mechanism of collagen reaction with a polyepoxy fixative. 
  • A role of matrix metalloproteinase-8 in atherosclerosis. 
  • A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury. 
  • Accuracy of a collagen-plug biopsy site marking device deployed after stereotactic core needle breast biopsy. 
  • Acetylcholine promotes the proliferation and collagen gene expression of myofibroblastic hepatic stellate cells. 
  • Acidic fibroblast growth factor enhances peripheral nerve regeneration in vivo. 
  • Addition of platelet-rich plasma supports immune modulation and improved mechanical integrity in Alloderm mesh for ventral hernia repair in a rat model. 
  • Adverse alterations in bone metabolism are associated with lung infection in adults with cystic fibrosis. 
  • Adynamic Bone Decreases Bone Toughness During Aging by Affecting Mineral and Matrix. 
  • Aging of the skin: implications for cutaneous surgery. 
  • Altered posttranslational modifications of collagen in keloid. 
  • Altered wound healing in mice lacking a functional osteopontin gene (spp1). 
  • Alveolar septal structure in different species. 
  • Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors. 
  • An active role for basement membrane assembly and modification in tissue sculpting. 
  • An association of keratoconus and mitral valve prolapse. 
  • An immunoelectron microscope study of the aged human lens capsule. 
  • An ultrastructural analysis of collagen in tissue engineered arteries. 
  • Analysis of "old" proteins unmasks dynamic gradient of cartilage turnover in human limbs. 
  • Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells 
  • Angiotensin II stimulates canonical TGF-β signaling pathway through angiotensin type 1 receptor to induce granulation tissue contraction. 
  • Angiotensin type 2 receptor is expressed in murine atherosclerotic lesions and modulates lesion evolution. 
  • Anterior uveitis following collagen crosslinking in a patient with X-linked chronic granulomatous disease. 
  • Apoptosis in the cervix of pregnant rats in association with cervical softening. 
  • Application of hydrogels in heart valve tissue engineering. 
  • Ascorbic acid increases the severity of spontaneous knee osteoarthritis in a guinea pig model. 
  • Ascorbic acid modulates collagen type I gene expression by cells from an eye tissue--trabecular meshwork. 
  • Ascorbic acid specifically increases type I and type III procollagen messenger RNA levels in human skin fibroblast. 
  • Aspartic acid racemization reveals a high turnover state in knee compared with hip osteoarthritic cartilage. 
  • Assessment of liver fibrosis progression and regression by a serological collagen turnover profile. 
  • Assessment of primary hemostasis by PFA-100 analysis in a tertiary care center. 
  • Assessment of the utility of biomarkers of osteoarthritis in the guinea pig. 
  • Basic methods in histopathology of joint tissues. 
  • Beta-catenin and transforming growth factor beta have distinct roles regulating fibroblast cell motility and the induction of collagen lattice contraction. 
  • Biaxial Stretch Improves Elastic Fiber Maturation, Collagen Arrangement, and Mechanical Properties in Engineered Arteries 
  • Binding of human plasminogen to basement-membrane (type IV) collagen. 
  • Biochemical Pathways and Myometrial Cell Differentiation Leading to Nodule Formation Containing Collagen and Fibronectin. 
  • Biochemical and molecular homogeneity in the patellar tendon of the immature pig. 
  • Biocompatibility studies of functionalized regioregular poly(3-hexylthiophene) layers for sensing applications. 
  • Biological basis of bone formation, remodeling, and repair-part II: extracellular matrix. 
  • Biomimetic polydopamine-laced hydroxyapatite collagen material orients osteoclast behavior to an anti-resorptive pattern without compromising osteoclasts' coupling to osteoblasts. 
  • Bivalirudin and clopidogrel with and without eptifibatide for elective stenting: effects on platelet function, thrombelastographic indexes, and their relation to periprocedural infarction results of the CLEAR PLATELETS-2 (Clopidogrel with Eptifibatide to Arrest the Reactivity of Platelets) study. 
  • Bone sialoprotein-collagen interaction promotes hydroxyapatite nucleation. 
  • Bovine retinal explants cultured in collagen gels. A model system for the study of proliferative retinopathy. 
  • COL5A1: fine genetic mapping and exclusion as candidate gene in families with nail-patella syndrome, tuberous sclerosis 1, hereditary hemorrhagic telangiectasia, and Ehlers-Danlos Syndrome type II. 
  • Cancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma. 
  • Cardiac rupture after myocardial infarction: new insights from murine models. 
  • Cathepsin B1. A lysosomal enzyme that degrades native collagen. 
  • Cell adhesion peptides alter smooth muscle cell adhesion, proliferation, migration, and matrix protein synthesis on modified surfaces and in polymer scaffolds. 
  • Cell death and proliferation and its relation to collagen degradation in uterine involution of rat. 
  • Cell surface-associated proteins which bind native type IV collagen or gelatin. 
  • Cellular and connective tissue changes in alveolar septal walls in emphysema. 
  • Changes in dermal histomorphology following surgical weight loss versus diet-induced weight loss in the morbidly obese patient. 
  • Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254). 
  • Characterization complex collagen fiber architecture in knee joint using high-resolution diffusion imaging. 
  • Characterization of a partial cDNA for lysyl hydroxylase from human skin fibroblasts; lysyl hydroxylase mRNAs are regulated differently by minoxidil derivatives and hydralazine. 
  • Characterization of non-equilibrium nanoparticle adsorption on a model biological substrate. 
  • Characterization of prolidase activity using capillary electrophoresis with tris(2,2'-bipyridyl)ruthenium(II) electrochemiluminescence detection and application to evaluate collagen degradation in diabetes mellitus. 
  • Characterizing differences between MSCs and TM cells: Toward autologous stem cell therapies for the glaucomatous trabecular meshwork. 
  • Cholesterol-fed and casein-fed rabbit models of atherosclerosis. Part 2: Differing morphological severity of atherogenesis despite matched plasma cholesterol levels. 
  • Chondrocytic differentiation of human adipose-derived adult stem cells in elastin-like polypeptide. 
  • Chromosomal assignments of the genes coding for human types II, III, and IV collagen: a dispersed gene family. 
  • Chronic rejection of mouse kidney allografts. 
  • Cirrhosis regression is associated with improved clinical outcomes in patients with nonalcoholic steatohepatitis. 
  • Clinical studies of angiogenesis inhibitors: the University of Texas MD Anderson Center Trial of Human Endostatin. 
  • Clinical utility of the platelet function analyzer (PFA-100) for the assessment of the platelet status in patients with congestive heart failure (EPCOT trial). 
  • Clinicopathologic correlation of surgically removed macular hole opercula. 
  • Co-culture of primary pulmonary cells to model alveolar injury and translocation of proteins. 
  • Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2. 
  • Collagen changes in rat cervix in pregnancy--polarized light microscopic and electron microscopic studies. 
  • Collagen cross-linking in patients with urinary incontinence. 
  • Collagen fibril diameters in arteries of mice. A comparison of manual and computer-aided morphometric analyses. 
  • Collagen gene expression and mechanical properties of intervertebral disc cell-alginate cultures. 
  • Collagen implant for treating stress urinary incontinence in women with urethral hypermobility. 
  • Collagen injection for the treatment of incontinence after cystectomy and orthotopic neobladder reconstruction in women. 
  • Collagen shield delivery of tissue plasminogen activator: functional and pharmacokinetic studies of anterior segment delivery. 
  • Collagen, collagenase and clinicians. 
  • Collagen-related genes influence the glaucoma risk factor, central corneal thickness. 
  • Collagen-rich crystalloids in a scarred vascularized cornea. 
  • Collagenase: its physiological and pathological role. 
  • Collagenolytic activity of synovium in rheumatoid arthritis. 
  • Collagenolytic activity of the skin associated with neuromuscular diseases including amyotrophic lateral sclerosis. 
  • Collagens in ocular tissues. 
  • Collagens in the aged human macula. 
  • Collagens in the aged human macular sclera. 
  • Comparative epitope mapping of sera from United States (US) and Japanese patients with bullous pemphigoid (BP) to fusion proteins encoded by BPAG1. 
  • Comparison of aortic intima and inner media in young adult versus aging rats. Stereology in a polarized system. 
  • Comparison of native porcine skin and a dermal substitute using tensiometry and digital image speckle correlation. 
  • Comparison of pleural responses of rats and hamsters to subchronic inhalation of refractory ceramic fibers. 
  • Comparison of pulmonary and pleural responses of rats and hamsters to inhaled refractory ceramic fibers. 
  • Comparison of transurethral versus periurethral collagen injection in women with intrinsic sphincter deficiency. 
  • Comprehensive Endogenous Tagging of Basement Membrane Components Reveals Dynamic Movement within the Matrix Scaffolding. 
  • Conditions that promote primary human skeletal myoblast culture and muscle differentiation in vitro. 
  • Cooccurrence of collagenous colitis with seronegative spondyloarthropathy: report of a case and literature review. 
  • Corneal collagen crosslinking using riboflavin and ultraviolet-A light for keratoconus: one-year analysis using Scheimpflug imaging. 
  • Corneal crosslinking: Current protocols and clinical approach. 
  • Corneal endothelial cell abnormalities in an early stage of the iridocorneal endothelial syndrome. 
  • Correction for specimen movement after acquisition of element-specific electron microprobe images. 
  • Creutzfeldt-Jakob disease in a pregnant woman with an implanted dura mater graft. 
  • Cross-sectional relations of multiple biomarkers representing distinct biological pathways to plasma markers of collagen metabolism in the community. 
  • Crosslinked hyaluronic acid hydrogels: a strategy to functionalize and pattern 
  • Crystal structure of human type III collagen Gly991-Gly1032 cystine knot-containing peptide shows both 7/2 and 10/3 triple helical symmetries. 
  • DNA delivery from hyaluronic acid-collagen hydrogels via a substrate-mediated approach 
  • DNA methylation signatures reflect aging in patients with nonalcoholic steatohepatitis. 
  • Decellularized native and engineered arterial scaffolds for transplantation. 
  • Decreased expression of lysyl hydroxylase 2 (LH2) in skin fibroblasts from three Ehlers-Danlos patients does not result from mutations in either the coding or proximal promoter region of the LH2 gene. 
  • Decreased hernia recurrence using autologous platelet-rich plasma (PRP) with Strattice™ mesh in a rodent ventral hernia model. 
  • Degradation of collagen by a human granulocyte collagenolytic system. 
  • Depressed platelet status in an elderly patient with hemorrhagic stroke after thrombolysis for acute myocardial infarction. GUSTO-III Investigators. 
  • Development of biologic markers of response and assessment of antiangiogenic activity in a clinical trial of human recombinant endostatin. 
  • Different roles for matrix metalloproteinase-2 and matrix metalloproteinase-9 in the pathogenesis of cardiac allograft rejection. 
  • Differential collagen I gene expression in fetal fibroblasts. 
  • Differential effects of cytochalasin B on platelet release, aggregation and contractility: evidence against a contractile mechanism for the release of platelet granular contents. 
  • Differential regulation of the fibroblast growth factor (FGF) family by alpha(2)-macroglobulin: evidence for selective modulation of FGF-2-induced angiogenesis. 
  • Differential uptake of DNA–poly (ethylenimine) polyplexes in cells cultured on collagen and fibronectin surfaces 
  • Diffusional anisotropy in collagenous tissues: fluorescence imaging of continuous point photobleaching. 
  • Distinct function of estrogen receptor α in smooth muscle and fibroblast cells in prostate development. 
  • Distinct patterns of glycosylation of colligin, a collagen-binding glycoprotein, and SPARC (osteonectin), a secreted Ca2+-binding glycoprotein. Evidence for the localisation of colligin in the endoplasmic reticulum. 
  • Distribution of type VI collagen in human gliomas: comparison with fibronectin and glioma-mesenchymal matrix glycoprotein. 
  • Does lacrimal duct occlusion decrease intraocular pressure in patients refractory to medical treatment for glaucoma? A randomized, sham-controlled, crossover trial. 
  • Doxycycline alters collagen composition following ventral hernia repair. 
  • Dupuytren's fibroblast contractility by sphingosine-1-phosphate is mediated through non-muscle myosin II. 
  • Dynamic Glycosylation Governs the Vertebrate COPII Protein Trafficking Pathway. 
  • Early report of a randomized comparative clinical trial of Strattice™ reconstructive tissue matrix to lightweight synthetic mesh in the repair of inguinal hernias. 
  • Echinonectin: a new embryonic substrate adhesion protein. 
  • Effect of local hypothermia on early wound repair. 
  • Effect of magnesium sulphate infusion on ex vivo platelet aggregation in swine. 
  • Effect of surface topography on in vitro osteoblast function and mechanical performance of 3D printed titanium. 
  • Effects of Copper and Cross-Linking on the Extracellular Matrix of Tissue-Engineered Arteries. 
  • Effects of copper and cross-linking on the extracellular matrix of tissue-engineered arteries. 
  • Effects of growth hormone and IGF-I on cardiac hypertrophy and gene expression in mice. 
  • Effects of transdermal testosterone gel on bone turnover markers and bone mineral density in hypogonadal men. 
  • Effects of tumor microenvironment heterogeneity on nanoparticle disposition and efficacy in breast cancer tumor models. 
  • Electric field-mediated transport of plasmid DNA in tumor interstitium in vivo. 
  • Electrical properties of implant encapsulation tissue. 
  • Electromobility of plasmid DNA in tumor tissues during electric field-mediated gene delivery. 
  • Elevated levels of beta-catenin and fibronectin in three-dimensional collagen cultures of Dupuytren's disease cells are regulated by tension in vitro. 
  • Emerging paradigms in arterial thrombosis. 
  • Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix. 
  • Endoscopic collagen injection therapy in elderly women with type I stress urinary incontinence. 
  • Endoscopic injection of glutaraldehyde cross-linked collagen for the treatment of intrinsic sphincter deficiency in women. 
  • Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1. 
  • Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies. 
  • Entubulation repair with protein additives increases the maximum nerve gap distance successfully bridged with tubular prostheses. 
  • Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis. 
  • Epigenetic regulation of COL15A1 in smooth muscle cell replicative aging and atherosclerosis. 
  • Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling. 
  • Establishment of three-dimensional cultures of human pancreatic duct epithelial cells. 
  • Estrogen receptor beta protects against in vivo injury in RPE cells. 
  • Evaluation of collagen modification and surface properties of a bovine artery via polyepoxy compound fixation. 
  • Evaluation of dose-related effects of aspirin on platelet function: results from the Aspirin-Induced Platelet Effect (ASPECT) study. 
  • Evaluation of late outgrowth endothelial progenitor cell and umbilical vein endothelial cell responses to thromboresistant collagen-mimetic hydrogels. 
  • Evidence for locus heterogeneity in the Bethlem myopathy and linkage to 2q37. 
  • Evidence for preferential adhesion of ovarian epithelial carcinoma cells to type I collagen mediated by the alpha2beta1 integrin. 
  • Evidence of biomechanical and collagen heterogeneity in uterine fibroids. 
  • Evolution of load transfer between hydroxyapatite and collagen during creep deformation of bone. 
  • Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis. 
  • Extracellular matrix in aged human ciliary body: an immunoelectron microscope study. 
  • Extracellular matrix remodeling after balloon angioplasty injury in a rabbit model of restenosis. 
  • Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid. 
  • Fibrillar collagen and remodeling of dilated canine left ventricle. 
  • Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung. 
  • Further evidence of a decorin-collagen interaction in the disruption of cervical collagen fibers during rat gestation. 
  • Gastrulation in the sea urchin embryo requires the deposition of crosslinked collagen within the extracellular matrix. 
  • Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1a receptor. 
  • Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium. 
  • Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women. 
  • Gentamicin-collagen sponge for infection prophylaxis in colorectal surgery. 
  • HIV-1 infection stimulates T cell invasiveness and synthesis of the 92-kDa type IV collagenase. 
  • Heart regeneration in zebrafish. 
  • Heightened potency of human pluripotent stem cell lines created by transient BMP4 exposure. 
  • Heme oxygenase-1 (HO-1) inhibits postmyocardial infarct remodeling and restores ventricular function. 
  • Heterogeneity of platelet aggregation and major surface receptor expression in patients with acute myocardial infarction. 
  • Heterogeneous basis of the type VIB form of Ehlers-Danlos syndrome (EDS VIB) that is unrelated to decreased collagen lysyl hydroxylation. 
  • Histoarchitecture of the fibrillary matrix of human fetal posterior tibial tendons. 
  • Histologic Analysis of Porcine Dermal Graft Augmentation in Treatment of Rotator Cuff Tears. 
  • Human arteries engineered in vitro. 
  • Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration. 
  • Human glioma-mesenchymal extracellular matrix antigen defined by monoclonal antibody. 
  • Human granulocyte collagenase. 
  • Hyperreactive platelet phenotypes: relationship to altered serotonin transporter number, transport kinetics and intrinsic response to adrenergic co-stimulation. 
  • IFATS collection: Adipose-derived stromal cells improve the foreign body response. 
  • IgG antibodies from patients with bullous pemphigoid bind to localized epitopes on synthetic peptides encoded by bullous pemphigoid antigen cDNA. 
  • Imaging diamagnetic susceptibility of collagen in hepatic fibrosis using susceptibility tensor imaging. 
  • Immuno-electron labelling of matrix components in congenital hereditary endothelial dystrophy. 
  • Immunocytochemical localisation of collagens (I-V) in the human iris. 
  • Immunogold fine structural localization of extracellular matrix components in aged human cornea. I. Types I-IV collagen and laminin. 
  • Immunogold fine structural localization of extracellular matrix components in aged human cornea. II. Collagen types V and VI. 
  • Immunogold localization of type IV collagen and laminin in the aging human outflow system. 
  • Immunogold ultrastructural localization of collagens in the aged human outflow system. 
  • In Situ Fabrication and Perfusion of Tissue-Engineered Blood Vessel Microphysiological System. 
  • In vitro characteristics of Tenon's fibroblast lines derived from pediatric and adult eyes do not fully explain pediatric glaucoma surgery failure: a preliminary report. 
  • In vitro effects of recombinant activated factor VIIa (NovoSeven) on clopidogrel-induced platelet inhibition. 
  • In vitro inhibition of chick embryo lysyl hydroxylase by homogentisic acid. A proposed connective tissue defect in alkaptonuria. 
  • In vitro inhibition of collagen cross links by catechol analogs. 
  • In vitro synthesis of type IV procollagen. 
  • In vivo quantification of liver stiffness in a rat model of hepatic fibrosis with acoustic radiation force. 
  • In-Depth Characterization and Validation of Human Urine Metabolomes Reveal Novel Metabolic Signatures of Lower Urinary Tract Symptoms. 
  • Incorporation into Reichert's membrane of laminin-like extracellular proteins synthesized by parietal endoderm cells of the mouse embryo. 
  • Increased use of surgical energy promotes methicillin-resistant Staphylococcus aureus colonization in rabbits following open ventral hernia mesh repair. 
  • Induction of tenascin in rat lungs undergoing bleomycin-induced pulmonary fibrosis. 
  • Influence of oxygen tension on interleukin 1-induced peroxynitrite formation and matrix turnover in articular cartilage. 
  • Inhibition of lysyl hydroxylase by catechol analogs. 
  • Interaction of retinal glial cells with collagen matrices: implications for pathogenesis of cell-mediated vitreous traction. 
  • Intercellular adhesion molecule-1 and L-selectin regulate bleomycin-induced lung fibrosis. 
  • Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice. 
  • Intervertebral disc cells exhibit differences in gene expression in alginate and monolayer culture. 
  • In Vivo Effects of Long-Term Cigarette Smoke Exposure on Mammary Tissue in Mice. 
  • Is basal laminar deposit unique for age-related macular degeneration? 
  • Isolation of cDNA clones for basal lamina components: type IV procollagen. 
  • Juvenile arthritis and autoimmunity to type II collagen. 
  • Keratoconus. 
  • Kinetic study of collagen fixation with polyepoxy fixatives. 
  • Knockdown of the cell cycle inhibitor p21 enhances cartilage formation by induced pluripotent stem cells. 
  • LPA1 antagonist BMS-986020 changes collagen dynamics and exerts antifibrotic effects in vitro and in patients with idiopathic pulmonary fibrosis. 
  • Laser-assisted indocyanine green dye angiography accurately predicts the split-thickness graft timing of integra artificial dermis. 
  • Leukocyte-derived IL-10 reduces subepithelial fibrosis associated with chronically inhaled endotoxin. 
  • Ligament-derived matrix stimulates a ligamentous phenotype in human adipose-derived stem cells. 
  • Lineage restriction of human hepatic stem cells to mature fates is made efficient by tissue-specific biomatrix scaffolds. 
  • Long-term results of transurethral collagen injection in men with intrinsic sphincter deficiency. 
  • Longitudinal assessment of hepatitis C fibrosis progression by collagen and smooth muscle actin morphometry in comparison to serum markers. 
  • Loss of HDAC3 results in nonreceptive endometrium and female infertility. 
  • Loss of basal cells precedes bronchiolitis obliterans-like pathological changes in a murine model of chlorine gas inhalation. 
  • Loss of stiffness in collagen-rich uterine fibroids after digestion with purified collagenase Clostridium histolyticum. 
  • Magic angle effect on diffusion tensor imaging in ligament and brain. 
  • Magnetic resonance imaging of intramuscular myxoma with histological comparison and a review of the literature. 
  • Matrix Metalloproteinases and Glaucoma Treatment. 
  • Matrix metalloproteinase activity modulates tumor size, cell motility, and cell invasiveness in murine aggressive fibromatosis. 
  • Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines. 
  • Medulloblastoma cell-substrate interaction in vitro. 
  • Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. 
  • Methotrexate disposition, anti-folate activity and efficacy in the collagen-induced arthritis mouse model. 
  • MicroRNA-146a-5p Attenuates Fibrosis-related Molecules in Irradiated and TGF-beta1-Treated Human Hepatic Stellate Cells by Regulating PTPRA-SRC Signaling. 
  • MicroRNA-182 and microRNA-200a control G-protein subunit α-13 (GNA13) expression and cell invasion synergistically in prostate cancer cells. 
  • Missense mutation in a von Willebrand factor type A domain of the alpha 3(VI) collagen gene (COL6A3) in a family with Bethlem myopathy. 
  • Mitigation of hypertrophic scar contraction via an elastomeric biodegradable scaffold. 
  • Modeling dynamics in diseased cardiac tissue: Impact of model choice. 
  • Monkey median nerve repaired by nerve graft or collagen nerve guide tube. 
  • Morphology and ultrastructure of differentiating three-dimensional mammalian skeletal muscle in a collagen gel. 
  • Mutations in fam20b and xylt1 reveal that cartilage matrix controls timing of endochondral ossification by inhibiting chondrocyte maturation. 
  • Mutations near amino end of alpha1(I) collagen cause combined osteogenesis imperfecta/Ehlers-Danlos syndrome by interference with N-propeptide processing. 
  • Nature of Amorphous Hydrophilic Block Affects Self-Assembly of an Artificial Viral Coat Polypeptide. 
  • Near-infrared spectrometry of abdominal aortic aneurysm in the ApoE-/- mouse. 
  • Nitric oxide-generating polymers reduce platelet adhesion and smooth muscle cell proliferation. 
  • Nonlinear dependence of hydraulic conductivity on tissue deformation during intratumoral infusion. 
  • Nontoxic nerve guide tubes support neovascular growth in transected rat optic nerve. 
  • Norepinephrine induces hepatic fibrogenesis in leptin deficient ob/ob mice. 
  • Nutritional cirrhosis in rheusus monkeys: electron microscopy and histochemistry. 
  • Obesity alters the collagen organization and mechanical properties of murine cartilage. 
  • Onset and extent of platelet inhibition by clopidogrel loading in patients undergoing elective coronary stenting: the Plavix Reduction Of New Thrombus Occurrence (PRONTO) trial. 
  • Osteopontin deficiency ameliorates Alport pathology by preventing tubular metabolic deficits. 
  • Osteopontin-dependent CD44v6 expression and cell adhesion in HepG2 cells. 
  • Overexpression of extracellular superoxide dismutase protects mice from radiation-induced lung injury. 
  • P311 induces a TGF-beta1-independent, nonfibrogenic myofibroblast phenotype. 
  • Parathyroid hormone 1-34 enhances extracellular matrix deposition and organization during flexor tendon repair. 
  • Passive ventricular mechanics in tight-skin mice. 
  • Peripheral nerve repair with collagen conduits. 
  • Peripheral ulcerative keratitis due to systemic diseases. 
  • Persistence and survival of autologous muscle derived cells versus bovine collagen as potential treatment of stress urinary incontinence. 
  • Pharmacodynamic and pharmacokinetic study of chronic low-dose metronomic cyclophosphamide therapy in mice. 
  • Phase I study of recombinant human endostatin in patients with advanced solid tumors. 
  • Phosphatase and tensin homologue on chromosome 10 (PTEN) directs prostaglandin E2-mediated fibroblast responses via regulation of E prostanoid 2 receptor expression. 
  • Phosphorylation of Threonine 794 on Tie1 by Rac1/PAK1 Reveals a Novel Angiogenesis Regulatory Pathway. 
  • Platelet function measured by VerifyNow identifies generalized high platelet reactivity in aspirin treated patients. 
  • Platelet inhibition by low-dose aspirin is not influenced by body mass or weight. 
  • Polarization-resolved second-harmonic-generation optical coherence tomography in collagen. 
  • Polarized light propagation in corneal lamellae. 
  • Poly(lactide-co-ε-caprolactone) scaffold promotes equivalent tissue integration and supports skin grafts compared to a predicate collagen scaffold. 
  • Polymorphism of DNA sequence in the human pro alpha 2(I) collagen gene. 
  • Porphyrin-Based SOD Mimic MnTnBu OE -2-PyP5+ Inhibits Mechanisms of Aortic Valve Remodeling in Human and Murine Models of Aortic Valve Sclerosis. 
  • Potential treatment for clubfeet based on growth factor blockade. 
  • Prasugrel. 
  • Pretargeting and Bioorthogonal Click Chemistry-Mediated Endogenous Stem Cell Homing for Heart Repair. 
  • Prevalence and significance of inflammatory bowel disease-like morphologic features in collagenous and lymphocytic colitis. 
  • Progressive cardiac dysfunction and fibrosis in the cardiomyopathic hamster and effects of growth hormone and angiotensin-converting enzyme inhibition. 
  • Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes. 
  • Protamine reversal of heparin affects platelet aggregation and activated clotting time after cardiopulmonary bypass. 
  • Protease production by cultured microglia: substrate gel analysis and immobilized matrix degradation. 
  • Protection against chronic pancreatitis and pancreatic fibrosis in mice overexpressing pancreatic secretory trypsin inhibitor. 
  • RB-mediated tumor suppression of a lung cancer cell line is abrogated by an extract enriched in extracellular matrix. 
  • Rabbits immunized with a peptide encoded for by the 230-kD bullous pemphigoid antigen cDNA develop an enhanced inflammatory response to UVB irradiation: a potential animal model for bullous pemphigoid. 
  • Radiation-induced lung injury is mitigated by blockade of gastrin-releasing peptide. 
  • Radioprotection of lungs by amifostine is associated with reduction in profibrogenic cytokine activity. 
  • Recurrent abdominal laxity following interpositional human acellular dermal matrix. 
  • Regulation of lysyl oxidase mRNA in dermal fibroblasts from normal donors and patients with inherited connective tissue disorders. 
  • Regulation of plasminogen activation by components of the extracellular matrix. 
  • Reichert's membrane as a model for studying the biosynthesis and assembly of basement membrane components. 
  • Relationship between T1rho magnetic resonance imaging, synovial fluid biomarkers, and the biochemical and biomechanical properties of cartilage. 
  • Remodeling and reparation of the cardiovascular system. 
  • Repair response of the inner and outer regions of the porcine meniscus in vitro. 
  • Reshaping procedures for the surgical management of corneal ectasia. 
  • Retention of the native chondrocyte pericellular matrix results in significantly improved matrix production. 
  • RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork. 
  • Role for Nox1 NADPH oxidase in atherosclerosis. 
  • Role of granulocyte collagenase in collagen degradation. 
  • Role of plasminogen activator and of 92-KDa type IV collagenase in glioblastoma invasion using an in vitro matrigel model. 
  • Runx2/Cbfa1-genetically engineered skeletal myoblasts mineralize collagen scaffolds in vitro. 
  • SMAD3 deficiency promotes vessel wall remodeling, collagen fiber reorganization and leukocyte infiltration in an inflammatory abdominal aortic aneurysm mouse model. 
  • SU5416 delays wound healing through inhibition of TGF-beta 1 activation. 
  • Selective Enzymatic Digestion of Proteoglycans and Collagens Alters Cartilage T1rho and T2 Relaxation Times. 
  • Selective suppression of matrix metalloproteinase-9 in human glioblastoma cells by antisense gene transfer impairs glioblastoma cell invasion. 
  • Sequential changes in lung morphology during the repair of acute oxygen-induced lung injury in adult rats. 
  • Sequential clinical and histopathological changes in collagenous and lymphocytic colitis over time. 
  • Short-term calcitriol administration improves calcium homeostasis in adults with cystic fibrosis. 
  • Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer. 
  • Simtuzumab Is Ineffective for Patients With Bridging Fibrosis or Compensated Cirrhosis Caused by Nonalcoholic Steatohepatitis. 
  • Simtuzumab for Primary Sclerosing Cholangitis: Phase 2 Study Results With Insights on the Natural History of the Disease. 
  • Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice. 
  • Species variability in angiotensin receptor expression by cultured cardiac fibroblasts and the infarcted heart. 
  • Specific targeting of gene expression to a subset of human trabecular meshwork cells using the chitinase 3-like 1 promoter. 
  • Structural and elemental characterization of heart cells grown in a collagen matrix. 
  • Structural remodelling in heart failure: gelatinase induction. 
  • Study of the media's potential influence on prospective research participants' understanding of and motivations for participation in a high-profile phase I trial. 
  • Susceptibility of signal transducer and activator of transcription-1-deficient mice to pulmonary fibrogenesis. 
  • Susceptibility tensor imaging and tractography of collagen fibrils in the articular cartilage. 
  • Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice. 
  • Synergistic actions of hematopoietic and mesenchymal stem/progenitor cells in vascularizing bioengineered tissues. 
  • Synovial Fluid Profile at the Time of Anterior Cruciate Ligament Reconstruction and Its Association With Cartilage Matrix Composition 3 Years After Surgery. 
  • TRPV4-mediated calcium signaling in mesenchymal stem cells regulates aligned collagen matrix formation and vinculin tension. 
  • Targets to tackle--the pathophysiology of the disease. 
  • The 120-kDa soluble ectodomain of type XVII collagen is recognized by autoantibodies in patients with pemphigoid and linear IgA dermatosis. 
  • The DASH diet and sodium reduction improve markers of bone turnover and calcium metabolism in adults. 
  • The Ehlers-Danlos syndromes. 
  • The combination of novel low molecular weight inhibitors of RAF (LBT613) and target of rapamycin (RAD001) decreases glioma proliferation and invasion. 
  • The conundrum of cryptogenic cirrhosis: Adverse outcomes without treatment options. 
  • The crystal structure of a collagen-like polypeptide with 3(S)-hydroxyproline residues in the Xaa position forms a standard 7/2 collagen triple helix. 
  • The crystal structure of the collagen-like polypeptide (glycyl-4(R)-hydroxyprolyl-4(R)-hydroxyprolyl)9 at 1.55 A resolution shows up-puckering of the proline ring in the Xaa position. 
  • The cxc chemokine cCAF stimulates differentiation of fibroblasts into myofibroblasts and accelerates wound closure. 
  • The design of an industry-sponsored randomized controlled trial to compare synthetic mesh versus biologic mesh for inguinal hernia repair. 
  • The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. 
  • The effect of elinogrel on high platelet reactivity during dual antiplatelet therapy and the relation to CYP2C19*2 genotype: first experience in patients. 
  • The effect of nitric oxide surface flux on the foreign body response to subcutaneous implants. 
  • The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explants. 
  • The effects of intravenous doxycycline therapy for rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial. 
  • The incidence of enlarged chondrons in normal and osteoarthritic human cartilage and their relative matrix density. 
  • The influence of red wine or white wine intake on platelet function and viscoelastic property of blood in volunteers. 
  • The inhibition by interleukin 1 of MSC chondrogenesis and the development of biomechanical properties in biomimetic 3D woven PCL scaffolds. 
  • The mRNA and the activity of lysyl hydroxylase are up-regulated by the administration of ascorbate and hydralazine to human skin fibroblasts from a patient with Ehlers-Danlos syndrome type VI. 
  • The permeability of the outer layers of limbus and anterior sclera. 
  • The relationship of collagenolytic activity to stage of human colorectal carcinoma. 
  • The role of Smad3 in mediating mouse hepatic stellate cell activation. 
  • The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation. 
  • The structural proteins of normal and diseased human myocardium. 
  • The terminal ileum is affected in patients with lymphocytic or collagenous colitis. 
  • The ultrastructure of human limbal collagen. 
  • Three-dimensional direct writing of B35 neuronal cells. 
  • Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia. 
  • Time dependence of clopidogrel loading effect: platelet activation versus platelet aggregation. 
  • Tissue-specific expression and regulation of the alternatively-spliced forms of lysyl hydroxylase 2 (LH2) in human kidney cells and skin fibroblasts. 
  • Tissue-specific gene expression in mouse F9 embryonal carcinoma cells: type IV collagen. 
  • Tractography of Porcine Meniscus Microstructure Using High-Resolution Diffusion Magnetic Resonance Imaging. 
  • Transforming growth factor beta3 promotes fascial wound healing in a new animal model. 
  • Transforming growth factor-beta1 antisense treatment of rat vein grafts reduces the accumulation of collagen and increases the accumulation of h-caldesmon. 
  • Treating the chronic wound: A practical approach to the care of nonhealing wounds and wound care dressings. 
  • Treatment of rheumatoid arthritis with oral type II collagen. Results of a multicenter, double-blind, placebo-controlled trial. 
  • Tumor-infiltrating dendritic cell precursors recruited by a beta-defensin contribute to vasculogenesis under the influence of Vegf-A. 
  • Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression. 
  • Type IV collagen and laminin in Bruch's membrane and basal linear deposit in the human macula. 
  • USE OF TANNED COLLAGEN SPONGES IN THE TREATMENT OF LIVER INJURIES. 
  • Ultrastructural distribution of collagen types I-VI in aging human retinal vessels. 
  • Up-regulated expression of extracellular matrix remodeling genes in phagocytically challenged trabecular meshwork cells. 
  • Use of AlloDerm in type I tympanoplasty: a comparison with native tissue grafts. 
  • Use of Alloderm in the neurotologic setting. 
  • Use of Apligraf for a devascularized ulcer secondary to mastectomy and radiation. 
  • Utility of telomerase-pot1 fusion protein in vascular tissue engineering. 
  • Viscoelastic and failure properties of spine ligament collagen fascicles. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • O'Connor, Christopher Michael, Adjunct Professor in the Department of Medicine, Medicine, Clinical Pharmacology
  • Taylor, Gregory Alan, Professor in Medicine, Integrative Immunobiology