Colon

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  Subject Areas on Research

  • A High-Throughput Organoid Microinjection Platform to Study Gastrointestinal Microbiota and Luminal Physiology. 
  • A LGR5 reporter pig model closely resembles human intestine for improved study of stem cells in disease. 
  • A model of neural cross-talk and irritation in the pelvis: implications for the overlap of chronic pelvic pain disorders. 
  • A prospective comparison of a noninvasive cardiac output monitor versus esophageal Doppler monitor for goal-directed fluid therapy in colorectal surgery patients. 
  • A sensitive, specific radioisotope assay for L-glutamine-D-fructose-6-phosphate aminotransferase. 
  • APC promoter hypermethylation contributes to the loss of APC expression in colorectal cancers with allelic loss on 5q. 
  • Activation of ENS Circuits in Mouse Colon: Coordination in the Mouse Colonic Motor Complex as a Robust, Distributed Control System. 
  • Acute Surgical Decision-Making in Abdominal Trauma Is Not Altered by Race or Socioeconomic Status. 
  • Acute and chronic mesenteric ischemia. 
  • Alterations in colonic mucosal vessels in patients with cirrhosis and noncirrhotic portal hypertension. 
  • Alternative forms of urinary diversion after cystectomy. 
  • An intravital window to image the colon in real time. 
  • Analysis of air contrast barium enema, computed tomographic colonography, and colonoscopy: prospective comparison. 
  • Association 'Between Gabapentinoids on the Day of Colorectal Surgery and Adverse Postoperative Respiratory Outcomes. 
  • Automated flight path planning for virtual endoscopy. 
  • Bacterial gastroenteritis. 
  • Baseline Colonoscopy Findings Associated With 10-Year Outcomes in a Screening Cohort Undergoing Colonoscopy Surveillance. 
  • Bile salts stimulate glycoprotein release by guinea pig gallbladder in vitro. 
  • Biochemical and biophysical identification of cystic fibrosis transmembrane conductance regulator chloride channels as components of endocytic clathrin-coated vesicles. 
  • Bladder reconstruction in children. 
  • Blood vessels in ganglia in human esophagus might explain the higher frequency of megaesophagus compared with megacolon. 
  • Brincidofovir (CMX001) Toxicity Associated With Epithelial Apoptosis and Crypt Drop Out in a Hematopoietic Cell Transplant Patient: Challenges in Distinguishing Drug Toxicity From GVHD. 
  • Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro. 
  • Can the localization of primary colonic tumors be improved by staging CT without specific bowel preparation compared to optical colonoscopy? 
  • Cancer care quality measures: diagnosis and treatment of colorectal cancer. 
  • Characterization of basal pseudopod-like processes in ileal and colonic PYY cells. 
  • Characterization of the cystic fibrosis transmembrane conductance regulator in a colonocyte cell line. 
  • Clinical Practice Guidelines for Enhanced Recovery After Colon and Rectal Surgery From the American Society of Colon and Rectal Surgeons and the Society of American Gastrointestinal and Endoscopic Surgeons. 
  • Clinical challenges and images in GI. Invasive candidal enterocolitis. 
  • Clinical practice guidelines for enhanced recovery after colon and rectal surgery from the American Society of Colon and Rectal Surgeons and the Society of American Gastrointestinal and Endoscopic Surgeons. 
  • Clostridium difficile associated with pseudomembranous colitis. Occurrence in a 12-week-old infant without prior antibiotic therapy. 
  • Colonic "coloplasty": novel technique to enhance low colorectal or coloanal anastomosis. 
  • Colonic Diverticulitis in a 19-Year-Old Boy With Juvenile Idiopathic Arthritis: Surgical Implications of Chronic Immunosuppression. 
  • Colonic Epithelial-Derived Selenoprotein P Is the Source for Antioxidant-Mediated Protection in Colitis-Associated Cancer. 
  • Colonic duplication: another suspected diagnosis in a prenatal ultrasound with double bubble sign. 
  • Colonic irritation in the rat sensitizes urinary bladder afferents to mechanical and chemical stimuli: an afferent origin of pelvic organ cross-sensitization. 
  • Colonic necrosis is an adverse prognostic factor in pancreatic necrosis. 
  • Colonic nodular lymphoid hyperplasia in a child with antibody deficiency and near-normal immunoglobulins. 
  • Comparison of intestinal lengthening procedures for patients with short bowel syndrome. 
  • Comparison of staple and suture techniques for end-to-end anastomosis of the small colon in horses. 
  • Complications of enterocystoplasty. 
  • Control of colonic motility using electrical stimulation to modulate enteric neural activity. 
  • Convergence of bladder and colon sensory innervation occurs at the primary afferent level. 
  • Cooccurrence of collagenous colitis with seronegative spondyloarthropathy: report of a case and literature review. 
  • Correlation of endoscopic optical coherence tomography with histology in the lower-GI tract. 
  • Cystometric properties of ileum and right colon after bladder augmentation, substitution or replacement. 
  • Daily intake of high dietary fiber slows accelerated colonic transit induced by restrain stress in rats. 
  • Deficiency of activation-induced cytidine deaminase in a murine model of ulcerative colitis. 
  • Detection of colonic polyps in a phantom model: implications for virtual colonoscopy data acquisition. 
  • Determining the Optimal Quantitative Threshold for Preoperative Albumin Level Before Elective Colorectal Surgery. 
  • Development and Preliminary Evaluation of a Murine Model of Chronic Radiation-Induced Proctitis. 
  • Diagnosis and surgical treatment of colonic endometriosis. 
  • Dietary Salt Exacerbates Experimental Colitis. 
  • Differential expression of substance P receptors in patients with Crohn's disease and ulcerative colitis. 
  • Differential production of high molecular weight sulfated glycoproteins in normal colonic mucosa, primary colon carcinoma, and metastases. 
  • Disease Monitoring Using Post-induction Circulating Tumor DNA Analysis Following First-Line Therapy in Patients with Metastatic Colorectal Cancer. 
  • Distinct Kinase-Independent Role of RIPK3 in CD11c+ Mononuclear Phagocytes in Cytokine-Induced Tissue Repair. 
  • Duke procedure for super obesity: preliminary report with 3.5-year follow-up. 
  • Editorial: older patients are significantly more likely to have colon ischaemia-associated conditions that are chronic and complex. 
  • Effect of adenoviral-mediated transfer of transforming growth factor-beta1 on colonic anastomotic healing. 
  • Effect of removal of pancreaticobiliary secretions on adaptation to short bowel in orally nourished rats. 
  • Electroacupuncture at ST-36 accelerates colonic motility and transit in freely moving conscious rats. 
  • Elevation of topoisomerase I messenger RNA, protein, and catalytic activity in human tumors: demonstration of tumor-type specificity and implications for cancer chemotherapy. 
  • Epigenetic Heterogeneity in Human Colorectal Tumors Reveals Preferential Conservation And Evidence of Immune Surveillance. 
  • Erythromycin lacks colon prokinetic effect in children with functional gastrointestinal disorders: a retrospective study. 
  • Evaluation of malnutrition via modified GLIM criteria for in patients undergoing emergent gastrointestinal surgery. 
  • Evaluation of peritoneal fluid following intestinal resection and anastomosis in horses. 
  • Expert Commentary on Anastomotic Leak After Colonic Resection. 
  • Extrinsic surgical denervation ameliorates TNBS-induced colitis in rats. 
  • FOXO3 growth inhibition of colonic cells is dependent on intraepithelial lipid droplet density. 
  • Factors influencing postoperative adverse events after Hartmann's reversal. 
  • Fasting prevents experimental murine colitis produced by dextran sulfate sodium and decreases interleukin-1 beta and insulin-like growth factor I messenger ribonucleic acid. 
  • Free of speckle ultrasound images of small tissue structures. 
  • Gastrointestinal pathology in patients with common variable immunodeficiency and X-linked agammaglobulinemia. 
  • Gastrointestinal stromal tumors (GISTs) arising in uncommon locations: clinicopathologic features and risk assessment of esophageal, colonic, and appendiceal GISTs. 
  • Gender differences in human immunodeficiency virus type 1-specific CD8 responses in the reproductive tract and colon following nasal peptide priming and modified vaccinia virus Ankara boosting. 
  • Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis. 
  • Genomic dissection of conserved transcriptional regulation in intestinal epithelial cells. 
  • Genomic instability and endoreduplication triggered by RAD17 deletion. 
  • Getting to a Man's Heart through His Colon. 
  • Glucagon like peptide-1 accelerates colonic transit via central CRF and peripheral vagal pathways in conscious rats. 
  • Glutamine therapy improves outcome of in vitro and in vivo experimental colitis models. 
  • Gross intestinal morphometry and allometry in ruminants. 
  • High-fat diet induced leptin and Wnt expression: RNA-sequencing and pathway analysis of mouse colonic tissue and tumors. 
  • High-fat diet-induced colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide. 
  • High-resolution cross-sectional imaging of the gastrointestinal tract using optical coherence tomography: preliminary results. 
  • Hirschsprung's disease in an infant with colonic atresia and normal fixation of the distal colon. 
  • Histamine stimulates calcium-mediated protein phosphorylation in a colonic epithelial cell line. 
  • Human colonic biota studied by ribosomal DNA sequence analysis. 
  • Human colonic sulfomucin identified by a specific monoclonal antibody. 
  • Identification of pathologic features associated with "ulcerative colitis-like" Crohn's disease. 
  • Image of the month. Syphilitic proctitis. 
  • Immunohistochemical analysis of statin in colorectal adenocarcinoma, polyps, and normal mucosa. 
  • In response. 
  • Increased prevalence of eosinophilic gastrointestinal disorders in pediatric PTEN hamartoma tumor syndromes. 
  • Increased substance P receptor expression by blood vessels and lymphoid aggregates in Clostridium difficile-induced pseudomembranous colitis. 
  • Inflammatory pseudotumour of the colon. 
  • Infliximab Reduces Endoscopic, but Not Clinical, Recurrence of Crohn's Disease After Ileocolonic Resection. 
  • Ingestion of unusual foreign bodies and malrotation: a "perfect storm". 
  • Inhibition of the vanilloid receptor subtype-1 attenuates TNBS-colitis. 
  • Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis. 
  • Intracorporeal ileocolic anastomosis: a review. 
  • Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium. 
  • Ischemic colitis: a clinical review. 
  • Kock versus right colon continent urinary diversion: comparison of outcome and reoperation rate. 
  • Lactobacillus rhamnosus GG treatment improves intestinal permeability and modulates inflammatory response and homeostasis of spleen and colon in experimental model of Pseudomonas aeruginosa pneumonia. 
  • Localization of specific binding sites for atrial natriuretic factor in peripheral tissues of the guinea pig, rat, and human. 
  • Location of the transverse colon in relationship to the umbilicus: implications for laparoscopic techniques. 
  • Loss of Forkhead Box O3 Facilitates Inflammatory Colon Cancer: Transcriptome Profiling of the Immune Landscape and Novel Targets. 
  • Loss of KAI1 expression in the progression of colorectal cancer. 
  • Loss of aryl hydrocarbon receptor potentiates FoxM1 signaling to enhance self-renewal of colonic stem and progenitor cells. 
  • Luminally released serotonin stimulates colonic motility and accelerates colonic transit in rats. 
  • Management of penetrating intraperitoneal colon injuries: A meta-analysis and practice management guideline from the Eastern Association for the Surgery of Trauma. 
  • Manifestations of Crohn's disease. 
  • Marine ω-3 Polyunsaturated Fatty Acid and Fish Intake after Colon Cancer Diagnosis and Survival: CALGB 89803 (Alliance). 
  • Mesenchymal stem cells support growth and organization of host-liver colorectal-tumor organoids and possibly resistance to chemotherapy. 
  • Metabolic liver disease - what's in a name? 
  • Metabolism of 1,2-dimethylhydrazine by cultured human colon. 
  • Metabolism of aflatoxin B1, benzo[a]pyrene, and 1,2-dimethylhydrazine by cultured rat and human colon. 
  • Metastatic potential of colon carcinoma. Expression of ABO/Lewis-related antigens. 
  • Mice lacking the dopamine transporter display altered regulation of distal colonic motility. 
  • Minimally invasive colopexy for pediatric Chilaiditi syndrome. 
  • Molecular characterization of mucosal adherent bacteria and associations with colorectal adenomas. 
  • Mucosal vaccine efficacy against intrarectal SHIV is independent of anti-Env antibody response. 
  • Multifocal anaplastic astrocytoma in a patient with hereditary colorectal cancer, transcobalamin II deficiency, agenesis of the corpus callosum, mental retardation, and inherited PMS2 mutation. 
  • Multiple congenital septal atresias of the intestine: histomorphologic and pathogenetic implications. 
  • NFIL3-deficient mice develop microbiota-dependent, IL-12/23-driven spontaneous colitis. 
  • Nano-architectural alterations in mucus layer fecal colonocytes in field carcinogenesis: potential for screening. 
  • Neo-angiogenesis and the premalignant micro-circulatory augmentation of early colon carcinogenesis. 
  • Neuroanatomical mapping of hypothalamic regions mediating verapamil hyper- and hypothermia in the cat. 
  • Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells. 
  • Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses. 
  • Outcomes of primary repair and primary anastomosis in war-related colon injuries. 
  • Patterns of gene expression in different histotypes of epithelial ovarian cancer correlate with those in normal fallopian tube, endometrium, and colon. 
  • Pediatric patients with eosinophilic esophagitis: an 8-year follow-up. 
  • Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. 
  • Peripheral plasma corticotropin-releasing factor concentration does not correlate with augmented colonic motility in response to restraint stress in rats. 
  • Peripherally administered CRF stimulates colonic motility via central CRF receptors and vagal pathways in conscious rats. 
  • Perspective volume rendering of CT and MR images: applications for endoscopic imaging. 
  • Phylogenetic placement of community members of human colonic biota. 
  • Piezo2 mediates visceral mechanosensation: A new therapeutic target for gut pain? 
  • Piroxicam treatment of IL-10-deficient mice enhances colonic epithelial apoptosis and mucosal exposure to intestinal bacteria. 
  • Pituitary adenylate cyclase-activating polypeptide stimulates secretion in T84 cells. 
  • Population dynamics of ingested Clostridium difficile in the gastrointestinal tract of the Syrian hamster. 
  • Pouchogram Prior to Ileostomy Reversal after Ileal Pouch-Anal Anastomosis in Pediatric Patients: Is it Useful in the Setting of Routine EUA? 
  • Preneoplastic lesions induced by myc and src oncogenes in a heterotopic rat colon. 
  • Probiotic administration reduces mortality and improves intestinal epithelial homeostasis in experimental sepsis. 
  • Proliferative activity at colonic anastomoses as determined by statin. A nonproliferation-specific nuclear protein. 
  • Proliferative activity of colonic mucosa at different distances from primary adenocarcinoma as determined by the presence of statin: a nonproliferation-specific nuclear protein. 
  • Prospective comparison of patient experience with colon imaging tests. 
  • Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome. 
  • Quantitative laser scanning confocal autofluorescence microscopy of normal, premalignant, and malignant colonic tissues. 
  • Receptors for sensory neuropeptides in human inflammatory diseases: implications for the effector role of sensory neurons. 
  • Repair of CFTR mRNA by spliceosome-mediated RNA trans-splicing. 
  • Restraint stress stimulates colonic motility via central corticotropin-releasing factor and peripheral 5-HT3 receptors in conscious rats. 
  • Retinoic acid-induced gene-1 (RIG-I) associates with the actin cytoskeleton via caspase activation and recruitment domain-dependent interactions. 
  • Routine contrast imaging of low pelvic anastomosis prior to closure of defunctioning ileostomy: is it necessary? 
  • SSRI Augmentation by 5-Hydroxytryptophan Slow Release: Mouse Pharmacodynamic Proof of Concept. 
  • Selective antimicrobial modulation of human microbial flora. 
  • Selective role for TRPV4 ion channels in visceral sensory pathways. 
  • Short duration exercise increases breath hydrogen excretion after lactulose ingestion: description of a new phenomenon. 
  • Short-chain fatty acids stimulate colonic transit via intraluminal 5-HT release in rats. 
  • Smad3 has a critical role in TGF-beta-mediated growth inhibition and apoptosis in colonic epithelial cells. 
  • Soluble factor in normal tissues that stimulates high-molecular-weight sialoglycoprotein production by human colon carcinoma cells. 
  • Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types. 
  • Sonography of benign cystic teratoma of the ovary: pitfalls in diagnosis. 
  • Spatial organization of bacterial flora in normal and inflamed intestine: a fluorescence in situ hybridization study in mice. 
  • Split tolerance permits safe Ad5-GUCY2C-PADRE vaccine-induced T-cell responses in colon cancer patients. 
  • Spontaneous bacterial cell lysis and biofilm formation in the colon of the Cape Dune mole-rat and the laboratory rabbit. 
  • Status of colon cancer vaccines. [An interview with Michael Morse by H&O]. 
  • Stimulation of secretion by the T84 colonic epithelial cell line with dietary flavonols. 
  • Surgical autonomic denervation results in altered colonic motility: an explanation for low anterior resection syndrome? 
  • Surgical experience of colon resection in the extreme elderly. 
  • Surgical treatment of interstitial cystitis. Indications, techniques, and results. 
  • Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation. 
  • Template for reporting results of biomarker testing of specimens from patients with carcinoma of the colon and rectum. 
  • Th17 Immunity in the Colon Is Controlled by Two Novel Subsets of Colon-Specific Mononuclear Phagocytes. 
  • The Authors Reply. 
  • The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy. 
  • The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. 
  • The anatomical distribution of colorectal polyps at colonoscopy. 
  • The apolipoprotein E-mimetic peptide COG112 inhibits NF-kappaB signaling, proinflammatory cytokine expression, and disease activity in murine models of colitis. 
  • The apolipoprotein E-mimetic peptide COG112 inhibits the inflammatory response to Citrobacter rodentium in colonic epithelial cells by preventing NF-kappaB activation. 
  • The colorectal microRNAome. 
  • The differential expression of statin in the nuclei of human colonic crypts adjacent to a cancer: an immunohistochemical study. 
  • The effect of epidural clonidine on perioperative cytokine response, postoperative pain, and bowel function in patients undergoing colorectal surgery. 
  • The management of chronic interstitial cystitis by substitution cystoplasty. 
  • The microecology of Clostridium difficile. 
  • The paracrine hormone for the GUCY2C tumor suppressor, guanylin, is universally lost in colorectal cancer. 
  • The side of the primary tumor affects overall survival in colon adenocarcinoma: an analysis of the national cancer database. 
  • The significantly reduced number of interstitial cells of Cajal in chagasic megacolon (CM) patients might contribute to the pathophysiology of CM. 
  • Transcriptional and proteomic insights into the host response in fatal COVID-19 cases. 
  • Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission. 
  • Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia. 
  • Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms. 
  • Updates in colorectal cancer screening in inflammatory bowel disease. 
  • Use of vascularized posterior rectus sheath allograft in pediatric multivisceral transplantation--report of two cases. 
  • Vanilloid receptor-1 containing primary sensory neurones mediate dextran sulphate sodium induced colitis in rats. 
  • Variable Pringle Maneuvers and Effect on Intestinal Epithelium in Rats. A Pilot Experimental Study in Rats. 
  • Variable levels of normal RNA in different fetal organs carrying a cystic fibrosis transmembrane conductance regulator splicing mutation. 
  • Vasoactive intestinal peptide stimulates protein phosphorylation in a colonic epithelial cell line. 
  • ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal-Anal Task Forces whitepaper. 
  • miR-34a is a microRNA safeguard for Citrobacter-induced inflammatory colon oncogenesis. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Buckley, Rebecca Hatcher, James Buren Sidbury Distinguished Professor Emeritus of Pediatrics, in the School of Medicine, Pediatrics, Allergy and Immunology