Complement System Proteins

• 

  Subject Areas on Research

  • A Therapeutic Antibody for Cancer, Derived from Single Human B Cells. 
  • A chemotactic factor for mononuclear leukocytes. 
  • A combined approach for purging multidrug-resistant leukemic cell lines in bone marrow using a monoclonal antibody and chemotherapy. 
  • A human CD46 transgenic pig model system for the study of discordant xenotransplantation. 
  • A human mononuclear leukocyte chemotactic factor: characterization, specificity and kinetics of production by homologous leukocytes. 
  • A neutrophil chemotatic factor derived from C'5 upon interaction of guinea pig serum with endotoxin. 
  • A role for immunogenic DNA in the pathogenesis of systemic lupus erythematosus. 
  • A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation. 
  • Abnormalities of chemotactic lymphokine synthesis and mononuclear leukocyte chemotaxis in Wiskott-Aldrich syndrome. 
  • Activation of complement by endotoxin. 
  • Activation of complement by endotoxin: a role for 2 globulin, C1, C4 and C2 in the consumption of terminal complement components by endotoxin-coated erythrocytes. 
  • Activation of human B lymphocytes. X. Heterogeneity of concanavalin A-generated suppressor cells of the pokeweed mitogen-induced plaque-forming cell response of human peripheral blood lymphocytes. 
  • Alpha 2-macroglobulin: a sensor for proteolysis. 
  • Alteration of human erythrocyte membrane properties by complement fixation. 
  • Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration. 
  • Antibody-dependent enhancement of SIV infection: further characterization and cross reactivity between macaque and sooty mangabey isolates. 
  • Antibody-independent, complement-mediated enhancement of HIV-1 infection by mannosidase I and II inhibitors. 
  • Antibody-induced proteinase activation: a proposed mechanism for pemphigus. 
  • Autocrine Complement Inhibits IL10-Dependent T-cell-Mediated Antitumor Immunity to Promote Tumor Progression. 
  • Biological activity of complement in vivo. Role of C5 in the accumulation of polymorphonuclear leukocytes in inflammatory exudates. 
  • Biologics in organ transplantation. 
  • Bone marrow-derived lymphoid cells (B cells): functional depletion with cobra factor and fresh serum. 
  • CD21/35 promotes protective immunity to Streptococcus pneumoniae through a complement-independent but CD19-dependent pathway that regulates PD-1 expression. 
  • CD4-independent binding of HIV-1 to the B lymphocyte receptor CR2 (CD21) in the presence of complement and antibody. 
  • Cellular serine proteinase induces chemotaxis by complement activation. 
  • Centronuclear myopathy: histochemistry and electron microscopy. Report of two cases. 
  • Chemotactic and anaphylatoxic fragment cleaved from the fifth component of guinea pig complement. 
  • Chemotaxis of mononuclear leukocytes. 
  • Circulating adhesion molecules and inflammatory mediators in demyelination: a review. 
  • Clusterin: an enigmatic protein recruited by diverse stimuli. 
  • Combined chemoseparation and immunoseparation of clonogenic T lymphoma cells from human bone marrow using 2'-deoxycoformycin, deoxyadenosine, 3A1 monoclonal antibody, and complement. 
  • Complement activation contributes to perioperative neurocognitive disorders in mice. 
  • Complement control proteins, CD46, CD55, and CD59, as common surface constituents of human and simian immunodeficiency viruses and possible targets for vaccine protection. 
  • Complement deficiency and sporadic meningococcal disease. 
  • Complement factor H in AMD: Bridging genetic associations and pathobiology. 
  • Complement levels in patients with bloodstream infection due to Staphylococcus aureus or Gram-negative bacteria. 
  • Complement sensitivity of paroxysmal nocturnal hemoglobinuria bone marrow cells. 
  • Complement system in lung transplantation. 
  • Complement-Dependent Synaptic Uptake and Cognitive Decline after Stroke and Reperfusion Therapy. 
  • Complement-activating antibodies in sera from infected individuals and vaccinated volunteers that target human immunodeficiency virus type 1 to complement receptor type 1 (CR1, CD35). 
  • Complement-mediated antibody-dependent enhancement of HIV-1 infection requires CD4 and complement receptors. 
  • Complement-mediated binding of naturally glycosylated and glycosylation-modified human immunodeficiency virus type 1 to human CR2 (CD21). 
  • Complement-mediated release of fibroblast growth factor 2 from human RPE cells. 
  • Complement-mediated vasoconstriction and graft rejection. 
  • Complement-mediated, infection-enhancing antibodies in plasma from vaccinated macaques before and after inoculation with live simian immunodeficiency virus. 
  • Complement-targeted therapies in kidney transplantation-insights from preclinical studies. 
  • Complement-targeting therapeutics for ischemia-reperfusion injury in transplantation and the potential for ex vivo delivery. 
  • Connecting genetic risk to disease end points through the human blood plasma proteome. 
  • Consumption of hamster complement by bacterial endotoxin. 
  • Cryoglobulinemia and glomerular rhomboid inclusions in a child with acute kidney injury. 
  • Cytogenetic engineering in vivo: restoration of biologic complement activity to C5-deficient mice by intravenous inoculation of hybrid cells. 
  • Decreased C'-1q protein concentration and agglutinating activity in agammaglobulinaemia syndromes: an inborn error reflected in the complement system. 
  • Decreased fibrinolytic activity in porcine-to-primate cardiac xenotransplantation. 
  • Decreased properdin activity in acute glomerulonephritis. 
  • Defective mononuclear leukocyte chemotaxis: a previously unrecognized immune dysfunction. Studies in a patient with chronic mucocutaneous candidiasis. 
  • Dermatitis herpetiformis: the skin and the gut. 
  • Detection and partial characterization of human thymus-leukemia antigens. 
  • Developmental immunology and the immunodeficiency diseases. 
  • Discordant complement systems as a factor in hyperacute xenograft rejection. 
  • Disorders of human leukocyte chemotaxis. 
  • Diverse humoral and cell-mediated effects of antisperm antibodies on reproduction. 
  • Early complement genes are associated with visual system degeneration in multiple sclerosis. 
  • Effect of C4 depletion on the utilization of the terminal components of guinea-pig complement by endotoxin. 
  • Effect of complement consumption by cobra venom factor on the course of primary infection with simian immunodeficiency virus in rhesus monkeys. 
  • Effects of chronic mild stress on serum complement activity, saccharin preference, and corticosterone levels in Flinders lines of rats. 
  • Elimination of clonogenic malignant human T cells using monoclonal antibodies in combination with 2'-deoxycoformycin. 
  • Expression of murine leukemia virus structural antigens on the surface of chemically induced murine sarcomas. 
  • Formation of complement membrane attack complex in mammalian cerebral cortex evokes seizures and neurodegeneration. 
  • Functional and molecular characterization of human monoclonal antibody reactive with the immunodominant region of HIV type 1 glycoprotein 41. 
  • Generation of chemotactic activity by immune complexes carrying clustered or nonclustered C42 sites. 
  • GluR3 autoantibodies destroy neural cells in a complement-dependent manner modulated by complement regulatory proteins. 
  • Glutamate receptor GluR3 antibodies and death of cortical cells. 
  • Hemolytic transfusion reactions caused by failure of commercial antiglobulin reagents to detect complement. 
  • High-frequency S-layer protein variation in Campylobacter fetus revealed by sapA mutagenesis. 
  • Human T-cell lymphotropic virus IIIB glycoprotein (gp120) bound to CD4 determinants on normal lymphocytes and expressed by infected cells serves as target for immune attack. 
  • Human acute leukemia cells with membrane-bound immunoglobulin. 
  • Human lymphocyte complement receptors. Quantitative requirements for C3 of normal and chronic lymphocyte leukemia lymphocytes. 
  • Human lymphocyte complement receptors. Stimulation of lymphocyte RNA synthesis by complement-coated human red cells. 
  • Human mononuclear leukocyte chemotaxis: a quantitative assay for humoral and cellular chemotactic factors. 
  • Humoral mediators of chemotaxis of mononuclear leukocytes. 
  • ICON: the early diagnosis of congenital immunodeficiencies. 
  • Identification and functional analysis of human natural anti-pig xenoantibodies. 
  • Identifying alemtuzumab as an anti-myeloid cell antiangiogenic therapy for the treatment of ovarian cancer. 
  • IgA-containing circulating immune complexes in patients with igA nephropathy. 
  • Immune fever in the rabbit: responses of the hematologic and complement systems. 
  • Immunogenicity and safety of the quadrivalent meningococcal ACWY-tetanus toxoid conjugate vaccine (MenACWY-TT) in splenectomized or hyposplenic children and adolescents: Results of a phase III, open, non-randomized study. 
  • Immunoglobulin G and complement immunoreactivity in the cerebral cortex of patients with Rasmussen's encephalitis. 
  • Immunological recovery in 48 patients following syngeneic marrow transplantation or hematological malignancy. 
  • Immunopathology of porcine livers perfused with blood of humans with fulminant hepatic failure. 
  • Impaired volume regulation is the mechanism of excitotoxic sensitization to complement. 
  • Improving Clinical Trials for Anticomplement Therapies in Complement-Mediated Glomerulopathies: Report of a Scientific Workshop Sponsored by the National Kidney Foundation. 
  • Inflammation and herpes simplex virus: release of a chemotaxis-generating factor from infected cells. 
  • Inflammation and viral infection: chemotactic activity resulting from the interaction of antiviral antibody and complement with cells infected with herpes simplex virus. 
  • Influence of functional deficiency of complement mannose-binding lectin on outcome of patients with acute ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. 
  • Inhaled asbestos activates a complement-dependent chemoattractant for macrophages. 
  • Instrinsic defect of the polymorphonuclear leucocyte resulting in impaired chemotaxis and phagocytosis. 
  • Interaction of complex polysaccharides with the complement system: effect of calcium depletion on terminal component consumption. 
  • Interactions of the complement system with endotoxic lipopolysaccharide. Generation of a factor chemotactic for polymorphonuclear leukocytes. 
  • Interactions of the complement system with endotoxic lipopolysaccharides in immunoglobulin-deficient sera. 
  • Isolation and characterization of C4-synthesizing cells from guinea-pig spleen. 
  • LOCALIZATION OF IMMUNOGLOBULINS IN CHRONIC THYROIDITIS. 
  • Lack of enhancing effect of human anti-human immunodeficiency virus type 1 (HIV-1) antibody on HIV-1 infection of human blood monocytes and peritoneal macrophages. 
  • Lipopolysaccharide Potentiates Insulin-Driven Hypoglycemic Shock. 
  • Macrophage proteinase and inflammation: the production of chemotactic activity from the fifth complement by macrophage proteinase. 
  • Measurement of the third component of complement bound to red blood cells in patients with the cold agglutinin syndrome. 
  • Mechanisms by which HIV envelope minimizes immunogenicity. 
  • Mechanisms of inflammation and leukocyte chemotaxis in the rheumatic diseases. 
  • Mediators of pulmonary injury induced by inhalation of bacterial endotoxin. 
  • Mediators of the chemotaxis of mononuclear leucocytes. 
  • Membranoproliferative glomerulonephritis. Progression from the pure form to the crescentic form with recurrence after transplantation. 
  • Meningococcemia and acquired complement deficiency. Association in patients with hepatic failure. 
  • Microarray analysis of murine retinal light damage reveals changes in iron regulatory, complement, and antioxidant genes in the neurosensory retina and isolated RPE. 
  • Microglial dopamine receptor elimination defines sex-specific nucleus accumbens development and social behavior in adolescent rats. 
  • Minimal role for the alternative pathway in complement activation by HIT immune complexes. 
  • Molecular barriers to xenotransplantation. 
  • Neuroinflammation after surgery: from mechanisms to therapeutic targets. 
  • Neuronal integrity and complement control synaptic material clearance by microglia after CNS injury. 
  • Neutralization of sensitized virus by purified components of complement. 
  • Neutralization of sensitized virus by the fourth component of complement. 
  • Neutrophil margination, sequestration, and emigration in the lungs of L-selectin-deficient mice. 
  • Optimization and qualification of an Fc Array assay for assessments of antibodies against HIV-1/SIV. 
  • Passively transferred antibodies directed against conserved regions of SIV envelope protect macaques from SIV infection. 
  • Pathogenesis of autoimmunity in pemphigus. 
  • Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge. 
  • Peripheral blood detection of systemic graft-specific xeno-antibodies following transplantation of human neural progenitor cells into the porcine spinal cord. 
  • Phenotypic characterization of human bone marrow granulocyte-macrophage forming progenitor cells. 
  • Phosphoethanolamine decoration of Neisseria gonorrhoeae lipid A plays a dual immunostimulatory and protective role during experimental genital tract infection. 
  • Polymorphonuclear leukocytes: possible mechanism of accumulation in psoriasis. 
  • Positively selected Leu-11a (CD16+) cells require the presence of accessory cells or factors for the lysis of herpes simplex virus-infected fibroblasts but not herpes simplex virus-infected Raji. 
  • Potentially functional genetic variants in the complement-related immunity gene-set are associated with non-small cell lung cancer survival. 
  • Practice parameters for the diagnosis and management of immunodeficiency. The Clinical and Laboratory Immunology Committee of the American Academy of Allergy, Asthma, and Immunology (CLIC-AAAAI). 
  • Preliminary criteria for global flares in childhood-onset systemic lupus erythematosus. 
  • Prevalence of congenital or acquired complement deficiency in patients with sporadic meningococcal disease. 
  • Production of chemotactic activity by guinea pig immunoglobulins following activation of the C3 complement shunt pathway. 
  • Pulmonary complications of primary immunodeficiencies. 
  • Purging multidrug resistant cells from bone marrow. 
  • Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis. 
  • Quantification of mouse macrophage chemotaxis in vitro: role of C5 for the production of chemotactic activity. 
  • RBC transfusions in paroxysmal nocturnal hemoglobinuria. 
  • Reaction of a cobra venom factor with guinea pig complement and generation of an activity chemotactic for polymorphonuclear leukocytes. 
  • Regulation of the B cell response to T-dependent antigens by classical pathway complement. 
  • Removal of fibroblasts from human epithelial cell cultures with use of a complement fixing monoclonal antibody reactive with human fibroblasts and monocytes/macrophages. 
  • Replication-attenuated Human Adenoviral Type 4 vectors elicit capsid dependent enhanced innate immune responses that are partially dependent upon interactions with the complement system. 
  • Retinal pigment epithelial cell death by the alternative complement cascade: role of membrane regulatory proteins, calcium, PKC, and oxidative stress. 
  • Role for endotoxin and complement in periodontal tissue destruction. 
  • Role of complement C9 and calcium in the generation of arachidonic acid and its metabolites from rat polymorphonuclear leukocytes. 
  • Role of complement and Fc receptors in the pathogenesis of HIV-1 infection. 
  • Role of complement receptors 1 and 2 (CD35 and CD21), C3, C4, and C5 in survival by mice of Staphylococcus aureus bacteremia. 
  • Role of the CD19 and CD21/35 receptor complex in innate immunity, host defense and autoimmunity. 
  • Separation of the acetylcholinesterase-deficient red cells in paroxysmal nocturnal hemoglobinuria. 
  • Significance of complement to the mechanism of action of endotoxin. 
  • Silencing porcine genes significantly reduces human-anti-pig cytotoxicity profiles: an alternative to direct complement regulation. 
  • Studies of the humoral immune response. 
  • Swine lungs expressing human complement-regulatory proteins are protected against acute pulmonary dysfunction in a human plasma perfusion model. 
  • Terminal complement blockade with pexelizumab during coronary artery bypass graft surgery requiring cardiopulmonary bypass: a randomized trial. 
  • The Inab phenotype: characterization of the membrane protein and complement regulatory defect. 
  • The acetylcholinesterase defect in paroxysmal nocturnal hemoglobinuria: evidence that the enzyme is absent from the cell membrane. 
  • The antigenic complex in HIT binds to B cells via complement and complement receptor 2 (CD21). 
  • The association between immunodeficiency and the development of autoimmune disease. 
  • The endometria of women with endometriosis exhibit dysfunctional expression of complement regulatory proteins during the mid secretory phase. 
  • The erythrocytes in paroxysmal nocturnal haemoglobinuria of intermediate sensitivity to complement lysis. 
  • The inflammatory response and resistance to endotoxin in mice. 
  • The nephritogenic immune response. 
  • The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited. 
  • The relationship of complement consumption to immune fever. 
  • The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants. 
  • The role of complement dysregulation in AMD mouse models. 
  • The role of microparticles in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus. 
  • The urinary proteome infers dysregulation of mitochondrial, lysosomal, and protein reabsorption processes in chronic kidney disease of unknown etiology (CKDu). 
  • Toll-like receptors, innate immunity and lung transplantation. 
  • Two biochemical markers in lymphocyte subpopulations. 
  • Underlying complement deficiency in patients with disseminated gonococcal infection. 
  • Vitamin A in liposomes. Inhibition of complement binding and alteration of membrane structure. 
  • alpha 2-Macroglobulin, complement, and biologic defense: antigens, growth factors, microbial proteases, and receptor ligation. 
• 

  Keywords of People

  • Bowes Rickman, Catherine, George and Geneva Boguslavsky Distinguished Professor of Eye Research, Cell Biology
  • Farsiu, Sina, Professor in the Department of Biomedical Engineering, Electrical and Computer Engineering
  • Schanberg, Laura Eve, Professor of Pediatrics, Pediatrics, Rheumatology