Complement Activation
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Subject Areas on Research
- A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation.
- Acute vascular rejection and accommodation: divergent outcomes of the humoral response to organ transplantation.
- Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad vector-triggered immune responses in vitro and in vivo.
- Aging and stress-induced changes in complement activation and neutrophil mobilization.
- An auto-anti-M causing hemolysis in vitro.
- Anaphylactic and anaphylactoid reactions. A review.
- Antibody-dependent enhancement of SIV infection: further characterization and cross reactivity between macaque and sooty mangabey isolates.
- Antibody-dependent enhancement of human immunodeficiency virus type 1 infection.
- Behçet's disease patients present high levels of deglycosylated anti-lipoteichoic acid IgG and high IL-8 production after lipoteichoic acid stimulation.
- Beyond Viral Neutralization.
- C1-esterase inhibitor and a novel peptide inhibitor improve contractile function in reperfused skeletal muscle.
- CD19 can regulate B lymphocyte signal transduction independent of complement activation.
- Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD.
- Clinical relevance and IgG subclass determination of non-HLA antibodies identified using endothelial cell precursors isolated from donor blood.
- Complement activation and cardiac surgery: a novel target for improving outcomes.
- Complement activation contributes to perioperative neurocognitive disorders in mice.
- Complement factor H variant increases the risk of age-related macular degeneration.
- Complement mediates binding and procoagulant effects of ultralarge HIT immune complexes.
- Complement system in lung transplantation.
- Complement-Mediated Regulation of Apolipoprotein E in Cultured Human RPE Cells.
- Complement-activating donor-specific anti-HLA antibodies and solid organ transplant survival: A systematic review and meta-analysis.
- Complement-induced vesiculation and exposure of membrane prothrombinase sites in platelets of paroxysmal nocturnal hemoglobinuria.
- Complement-mediated release of fibroblast growth factor 2 from human RPE cells.
- Complement-targeting therapeutics for ischemia-reperfusion injury in transplantation and the potential for ex vivo delivery.
- Component deficiencies. 5. The fifth component.
- Diagnosis and treatment of anaphylactic/anaphylactoid reactions.
- Direct tandem mass spectrometry reveals limitations in protein profiling experiments for plasma biomarker discovery.
- Dual islet transplantation modeling of the instant blood-mediated inflammatory reaction.
- Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular Degeneration.
- Effect of pexelizumab in coronary artery bypass graft surgery with extended aortic cross-clamp time.
- Effects of chronic mild stress on serum complement activity, saccharin preference, and corticosterone levels in Flinders lines of rats.
- Enhanced CDC of B cell chronic lymphocytic leukemia cells mediated by rituximab combined with a novel anti-complement factor H antibody.
- Epidemiology, pathophysiology and clinical presentation of gram-negative sepsis.
- Generation of a fibroblast chemotactic factor in serum by activation of complement.
- Genetic therapies for xenotransplantation.
- Glycosyl phosphatidylinositol-linked blood group antigens and paroxysmal nocturnal hemoglobinuria.
- Human complement factor H Y402H polymorphism causes an age-related macular degeneration phenotype and lipoprotein dysregulation in mice.
- IgG and complement-mediated tissue damage in the absence of C2: evidence of a functionally active C2-bypass pathway in a guinea pig model.
- Inhaled asbestos activates a complement-dependent chemoattractant for macrophages.
- Innate networking: Thrombotic microangiopathy, the activation of coagulation and complement in the sensitized kidney transplant recipient.
- Intramolecular immunological signal hypothesis revived--structural background of signalling revealed by using Congo Red as a specific tool.
- Leishmania species: mechanisms of complement activation by five strains of promastigotes.
- Lymphocyte phenotypes in wild-caught rats suggest potential mechanisms underlying increased immune sensitivity in post-industrial environments.
- Microparticles as autoantigens: making immune complexes big.
- Minimal role for the alternative pathway in complement activation by HIT immune complexes.
- Multiple hyperacute rejections in the absence of detectable complement activation in a patient with endothelial cell reactive antibody.
- Neuroinflammation after surgery: from mechanisms to therapeutic targets.
- Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency.
- Next-generation computational genetic analysis: multiple complement alleles control survival after Candida albicans infection.
- Novel Immunoassay for Complement Activation by PF4/Heparin Complexes.
- Novel adenovirus vectors 'capsid-displaying' a human complement inhibitor.
- Potentially functional genetic variants in the complement-related immunity gene-set are associated with non-small cell lung cancer survival.
- Regulation of humoral immune responses by CD21/CD35.
- Role of complement activation in obliterative bronchiolitis post-lung transplantation.
- Role of complement and Fc receptors in the pathogenesis of HIV-1 infection.
- Studies of complement-activating antibodies in the SIV/macaque model of acute primary infection and vaccine protection.
- Swine lungs expressing human complement-regulatory proteins are protected against acute pulmonary dysfunction in a human plasma perfusion model.
- Systemic Complement Activation in Donation After Brain Death Versus Donation After Circulatory Death Organ Donors.
- Targeting the Leukemia Antigen PR1 with Immunotherapy for the Treatment of Multiple Myeloma.
- The Host Response to Viral Infections Reveals Common and Virus-Specific Signatures in the Peripheral Blood.
- The endometria of women with endometriosis exhibit dysfunctional expression of complement regulatory proteins during the mid secretory phase.
- The genome of the sea urchin Stongylocentrotus purpuratus
- The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3.
- The immune consequences of trauma.
- The inflammatory response to cardiopulmonary bypass.
- The pathogenesis of dermatitis herpetiformis.
- The role of human CD46 in early xenoislet engraftment in a dual transplant model.
- The third component of complement: covalent attachment of a radioactive sugar to the labile binding site of C3 via the alternative pathway.
- V1V2-specific complement activating serum IgG as a correlate of reduced HIV-1 infection risk in RV144.
- Venous gas emboli and complement activation after deep repetitive air diving.
- Whole Recombinant Saccharomyces cerevisiae Yeast Expressing Ras Mutations as Treatment for Patients With Solid Tumors Bearing Ras Mutations: Results From a Phase 1 Trial.
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Keywords of People
- Ali, Hakim Azfar, Associate Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine
- Kelsoe, Garnett H., James B. Duke Distinguished Professor of Immunology, Immunology
- Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology