Complement C8
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Subject Areas on Research
- Formation of complement membrane attack complex in mammalian cerebral cortex evokes seizures and neurodegeneration.
- Genetic modifiers of the severity of sickle cell anemia identified through a genome-wide association study.
- High-dose intravenous immunoglobulin modifies complement-mediated in vivo clearance.
- Inherited deficiency of C8 in a patient with recurrent meningococcal infections: further evidence for a dysfunctional C8 molecule and nonlinkage to the HLA system.
- Neisseria meningitidis and Neisseria gonorrhoeae bacteremia associated with C6, C7, or C8 deficiency.
- Prevalence of congenital or acquired complement deficiency in patients with sporadic meningococcal disease.
- Regulation of complement activity by immunoglobulin. I. Effect of immunoglobulin isotype on C4 uptake on antibody-sensitized sheep erythrocytes and solid phase immune complexes.
- Selective blockade of membrane attack complex formation during simulated extracorporeal circulation inhibits platelet but not leukocyte activation.
- Studies on the mechanism of bacterial resistance to complement-mediated killing. II. C8 and C9 release C5b67 from the surface of Salmonella minnesota S218 because the terminal complex does not insert into the bacterial outer membrane.
- Terminal complement components play a role in the expression of C5a.
- Underlying complement deficiency in patients with disseminated gonococcal infection.