Complement C9
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Subject Areas on Research
- Formation of complement membrane attack complex in mammalian cerebral cortex evokes seizures and neurodegeneration.
- Mechanism of action of blocking immunoglobulin G for Neisseria gonorrhoeae.
- Mechanism of bacterial resistance to complement-mediated killing: inserted C5b-9 correlates with killing for Escherichia coli O111B4 varying in O-antigen capsule and O-polysaccharide coverage of lipid A core oligosaccharide.
- Membrane attack complex of complement in rheumatoid synovial tissue demonstrated by immunofluorescent microscopy.
- Monoclonal antibodies directed against gonococcal protein I vary in bactericidal activity.
- Multimeric C9 within C5b-9 is required for inner membrane damage to Escherichia coli J5 during complement killing.
- Multimeric complement component C9 is necessary for killing of Escherichia coli J5 by terminal attack complex C5b-9.
- Quantitation of activation of the human terminal complement pathway by ELISA.
- Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration.
- Studies of the mechanism of bacterial resistance to complement-mediated killing. V. IgG and F(ab')2 mediate killing of E. coli 0111B4 by the alternative complement pathway without increasing C5b-9 deposition.
- Studies on the mechanism of bacterial resistance to complement-mediated killing. I. Terminal complement components are deposited and released from Salmonella minnesota S218 without causing bacterial death.
- Studies on the mechanism of bacterial resistance to complement-mediated killing. II. C8 and C9 release C5b67 from the surface of Salmonella minnesota S218 because the terminal complex does not insert into the bacterial outer membrane.
- Studies on the mechanism of bacterial resistance to complement-mediated killing. III. C5b-9 deposits stably on rough and type 7 S. pneumoniae without causing bacterial killing.
- Studies on the mechanism of bacterial resistance to complement-mediated killing. IV. C5b-9 forms high molecular weight complexes with bacterial outer membrane constituents on serum-resistant but not on serum-sensitive Neisseria gonorrhoeae.
- Terminal complement complexes (SC5b-9) in cerebrospinal fluid in autoimmune nervous system diseases.
- The utility of C4d, C9, and troponin T immunohistochemistry in acute myocardial infarction.