Concanavalin A

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  Subject Areas on Research

  • A comparison of the fine saccharide-binding specificity of Dioclea grandiflora lectin and concanavalin A. 
  • Ablation of c-FLIP in hepatocytes enhances death-receptor mediated apoptosis and toxic liver injury in vivo. 
  • Activated T lymphocytes regulate hyaluronan binding to monocyte CD44 via production of IL-2 and IFN-gamma. 
  • Activation of human B lymphocytes. III. Concanavalin A-induced generation of suppressor cells of the plaque-forming cell response of normal human B lymphocytes. 
  • Activation of human B lymphocytes. V. Kinetics and mechanisms of suppression of plaque-forming cell responses by concanavalin A-generated suppressor cells. 
  • Activation of human B lymphocytes. VI. Immunoregulation of antibody production by mitogen-induced and naturally occurring cells in normal individuals. 
  • Activation of human B lymphocytes. X. Heterogeneity of concanavalin A-generated suppressor cells of the pokeweed mitogen-induced plaque-forming cell response of human peripheral blood lymphocytes. 
  • Adolescent nicotine: deficits in immune function. 
  • Age-related studies of SIg, Leu-4 and concanavalin A receptor densities and capping in human lymphocytes. 
  • An endogenous source of the superoxide anion in the central nervous system. 
  • Anti-epidermal-cell-surface pemphigus antibody detaches viable epidermal cells from culture plates by activation of proteinase. 
  • Association of cytokine polymorphic inheritance and in vitro cytokine production in anti-CD3/CD28-stimulated peripheral blood lymphocytes. 
  • Association of myosin light chain kinase with lymphocyte membrane-cytoskeleton complex. 
  • Beta-adrenergic receptor sequestration. A potential mechanism of receptor resensitization. 
  • CD7 and CD28 are required for murine CD4+CD25+ regulatory T cell homeostasis and prevention of thyroiditis. 
  • Calorimetric analysis of the binding of lectins with overlapping carbohydrate-binding ligand specificities. 
  • Characterization of human chemotactic lymphokine production induced by mitogens and mixed leukocyte reactions using a new microassay. 
  • Cloning of murine splenic T lymphocytes and natural killer (NK) cells on filter paper discs: detection of a novel NK/T phenotype. 
  • Comparative rates of desensitization of beta-adrenergic receptors by the beta-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase. 
  • Comparison of thymocyte development and cytokine production in CD7-deficient, CD28-deficient and CD7/CD28 double-deficient mice. 
  • Con A-induced suppressor cell function depends on the activation of the CD4+CD45RA inducer T cell subpopulation. 
  • Crystallization of succinylated concanavalin A bound to a synthetic bivalent ligand and preliminary structural analysis. 
  • Effects of CKS-17, a synthetic retroviral envelope peptide, on cell-mediated immunity in vivo: immunosuppression, immunogenicity, and relation to immunosuppressive tumor products. 
  • Effects of cytokines on porcine granulosa cell steroidogenesis in vitro. 
  • Energetics of lectin-carbohydrate binding. A microcalorimetric investigation of concanavalin A-oligomannoside complexation. 
  • Flow cytometric analysis of cell surface carbohydrates in metastatic human breast cancer. 
  • General immunocompetence of rats bearing avian sarcoma virus-induced intracranial tumors. 
  • Immunologic consequences of acute ethanol ingestion in rats. 
  • Immunologic studies on T and B lymphocytes in chimpanzees: effects of thymectomy and irradiation. 
  • Immunoregulatory aberrations in systemic lupus erythematosus. 
  • In vitro inhibition of murine IFN gamma production by phosphorothioate deoxyguanosine oligomers. 
  • Intercellular recognition: quantitation of initial binding events. 
  • L-selectin and intercellular adhesion molecule-1 regulate the development of Concanavalin A-induced liver injury. 
  • Lack of generation of killer cells in the mixed lymphocyte reaction between mitogen-stimulated and unstimulated autologous lymphocytes. 
  • Lectin staining of cultured CNS microglia. 
  • Lymphocytic leukemia in children: prognostic significance of clinical and laboratory findings at time of diagnosis. 
  • Mechanisms of corticosteroid action on lymphocyte subpopulations. IV. Effects of in vitro hydrocortisone on naturally occuring and mitogen-induced suppressor cells in man. 
  • Mechanisms of corticosteroid action on lymphocyte subpopulations. V. Effects of in vivo hydrocortisone on the circulatory kinetics and function of naturally occuring and mitogen-induced suppressor cells in man. 
  • Melatonin enhancement of splenocyte proliferation is attenuated by luzindole, a melatonin receptor antagonist. 
  • Modulation of in vitro autologous melanoma-specific cytotoxic T-cell responses by phorbol dibutyrate and ionomycin. 
  • Modulation of lymphocyte functions by group A streptococcal membrane. 
  • Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors. 
  • Neonatal chlorpyrifos administration elicits deficits in immune function in adulthood: a neural effect? 
  • Phenytoin hypersensitivity. 
  • Preneoplastic and neoplastic lesions of rat hereditary renal cell tumors express markers of proximal and distal nephron. 
  • Reactivity of avian RNA tumor viruses with lectins. 
  • Regulation of insulin receptors in frog erythrocytes by insulin and concanavalin A. Evidence for discrete classes of insulin binding sites. 
  • Requirement for metalloendoprotease in exocytosis: evidence in mast cells and adrenal chromaffin cells. 
  • Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells. 
  • Separation of two thyrotropin binding components from porcine thyroid tissue by affinity chromatography: characterization of high and low affinity sites. 
  • Solid-phase synthesis for the identification of high-affinity bivalent lectin ligands. 
  • Specificity of C-glycoside complexation by mannose/glucose specific lectins. 
  • Stimulation of mitogen-activated protein kinase by G protein-coupled alpha(2)-adrenergic receptors does not require agonist-elicited endocytosis. 
  • T cell traffic and the inflammatory response in experimental autoimmune uveoretinitis. 
  • The role of the L3T4 molecule in mitogen and antigen-activated signal transduction. 
  • Topoisomerase II levels during granulocytic maturation in vitro and in vivo. 
  • Use of a human plaque-forming cell assay to study peripheral blood bursa-equivalent cell activation and excessive suppressor cell activity in humoral immunodeficiency. 
  • Variation in DNA and RNA synthetic responses during activation of lymphocytes from inbred strains of mice. 
  • Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. 
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  Keywords of People

  • Cianciolo, George James, Associate Professor Emeritus of Pathology, Pathology