Copper

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  Subject Areas on Research

  • 2-Azadienes as Reagents for Preparing Chiral Amines: Synthesis of 1,2-Amino Tertiary Alcohols by Cu-Catalyzed Enantioselective Reductive Couplings with Ketones. 
  • A Diastereodivergent and Enantioselective Approach to syn - and anti -Diamines: Development of 2-Azatrienes for Cu-Catalyzed Reductive Couplings with Imines That Furnish Allylic Amines. 
  • A Mets motif peptide found in copper transport proteins selectively binds Cu(I) with methionine-only coordination. 
  • A comparison of methionine, histidine and cysteine in copper(I)-binding peptides reveals differences relevant to copper uptake by organisms in diverse environments. 
  • A high-temperature superconducting Helmholtz probe for microscopy at 9.4 T. 
  • A hot spot for hydrogen peroxide-induced damage in the human hypoxia-inducible factor 1 binding site of the PGK 1 gene. 
  • A lytic polysaccharide monooxygenase-like protein functions in fungal copper import and meningitis. 
  • A novel cyanide ion sensing approach based on Raman scattering for the detection of environmental cyanides. 
  • A novel role for XIAP in copper homeostasis through regulation of MURR1. 
  • A photolabile ligand for light-activated release of caged copper. 
  • A probe for specimen magnetic resonance microscopy. 
  • A prochelator activated by beta-secretase inhibits Abeta aggregation and suppresses copper-induced reactive oxygen species formation. 
  • A prochelator activated by hydrogen peroxide prevents metal-induced amyloid Beta aggregation. 
  • A simple route towards CuO nanowires and nanorods. 
  • ALSUntangled 43: copper. 
  • Ab initio based calculations of electron-transfer rates in metalloproteins. 
  • Alkenylation of C(sp3 )-H Bonds by Zincation/Copper-Catalyzed Cross-Coupling with Iodonium Salts. 
  • Alpha-carbon coordinates for bovine Cu,Zn superoxide dismutase. 
  • Amyloid beta peptides do not form peptide-derived free radicals spontaneously, but can enhance metal-catalyzed oxidation of hydroxylamines to nitroxides. 
  • An assessment of the effects of shell cross-linked nanoparticle size, core composition, and surface PEGylation on in vivo biodistribution. 
  • An exposure indicator for digital radiography: AAPM Task Group 116 (executive summary). 
  • Analysis of copper-induced protein precipitation across the E. coli proteome. 
  • Assessment of metals in cosmetics commonly used in Saudi Arabia. 
  • Behavior of the copper band of cytochrome c oxidase in rat brain during FC-43-for-blood substitution. 
  • Blood levels of trace metals and amyotrophic lateral sclerosis. 
  • Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs. 
  • Chemical and functional properties of metal chelators that mobilize copper to elicit fungal killing of Cryptococcus neoformans. 
  • Chemical cross-linking studies of beef heart mitochondrial coupling factor 1. 
  • Chemistry and biology of copper-chelatin. 
  • Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in rats. 
  • Comparative toxicities of selected compounds to nauplii of Balanus amphitrite amphitrite Darwin and Artemia sp. 
  • Comparative transcriptome analysis of the CO2 sensing pathway via differential expression of carbonic anhydrase in Cryptococcus neoformans. 
  • Connecting copper and cancer: from transition metal signalling to metalloplasia. 
  • Construction of new ligand binding sites in proteins of known structure. I. Computer-aided modeling of sites with pre-defined geometry. 
  • Construction of new ligand binding sites in proteins of known structure. II. Grafting of a buried transition metal binding site into Escherichia coli thioredoxin. 
  • Converting a maltose receptor into a nascent binuclear copper oxygenase by computational design. 
  • Coordination chemistry of copper proteins: how nature handles a toxic cargo for essential function. 
  • Coordination environment for the type 3 copper center of tree laccase and CuB of cytochrome c oxidase as determined by electron nuclear double resonance. 
  • Copper Availability Influences the Transcriptomic Response of Candida albicans to Fluconazole Stress. 
  • Copper Chelation Inhibits BRAFV600E-Driven Melanomagenesis and Counters Resistance to BRAFV600E and MEK1/2 Inhibitors. 
  • Copper Chelation as Targeted Therapy in a Mouse Model of Oncogenic BRAF-Driven Papillary Thyroid Cancer. 
  • Copper Influences the Antibacterial Outcomes of a β-Lactamase-Activated Prochelator against Drug-Resistant Bacteria. 
  • Copper and Gold Nanoparticles Increase Nutrient Excretion Rates of Primary Consumers. 
  • Copper as a robust and transparent electrocatalyst for water oxidation. 
  • Copper complexes containing thiosemicarbazones derived from 6-nitropiperonal: Antimicrobial and biophysical properties. 
  • Copper exposure affects hemocyte apoptosis and Perkinsus marinus infection in eastern oysters Crassostrea virginica (Gmelin). 
  • Copper ion-mediated modification of bases in DNA in vitro by benzoyl peroxide. 
  • Copper is a potent inhibitor of both the canonical and non-canonical NFκB pathways. 
  • Copper is required for oncogenic BRAF signalling and tumorigenesis. 
  • Copper shares a piece of the pi. 
  • Copper signaling axis as a target for prostate cancer therapeutics. 
  • Copper-Catalyzed 1,2-Aminocyanation of Unactivated Alkenes via Cyano Migration. 
  • Copper-Catalyzed Alkene Aminoazidation as a Rapid Entry to 1,2-Diamines and Installation of an Azide Reporter onto Azahetereocycles. 
  • Copper-Catalyzed Modular Amino Oxygenation of Alkenes: Access to Diverse 1,2-Amino Oxygen-Containing Skeletons. 
  • Copper-Catalyzed Three-Component Aminofluorination of Alkenes and 1,3-Dienes: Direct Entry to Diverse β-Fluoroalkylamines. 
  • Copper-catalyzed cyclization of steroidal acylaminoacetylenes: syntheses of novel 11beta-aryl-17,17- spiro[(4'H,5'-methylene)oxazol]-substituted steroids. 
  • Copper-catalyzed electrophilic amination of heteroarenes and arenes by C-H zincation. 
  • Copper-catalyzed α-amination of phosphonates and phosphine oxides: a direct approach to α-amino phosphonic acids and derivatives. 
  • Copper-chelatin: isolation from various eucaryotic sources. 
  • Copper-chelatin: purification and properties of a copper-binding protein from rat liver. 
  • Copper-dependent site-specific mutagenesis by benzoyl peroxide in the supF gene of the mutation reporter plasmid pS189. 
  • Copper-induced synthesis of copper-chelatin in rat liver. 
  • Copper-mediated amidation of heterocyclic and aromatic C-H bonds. 
  • Corrosion behavior of Au and Ag modified Cu-Ni-Mn alloys. 
  • Covalent protein-oligonucleotide conjugates by copper-free click reaction. 
  • Crucial role of copper in detection of metal-coordinating odorants. 
  • Cryptococcus neoformans copper detoxification machinery is critical for fungal virulence. 
  • Crystal structure of bovine Cu,Zn superoxide dismutase at 3 A resolution: chain tracing and metal ligands. 
  • Crystal structure of deoxygenated Limulus polyphemus subunit II hemocyanin at 2.18 A resolution: clues for a mechanism for allosteric regulation. 
  • Crystallographic analysis of oxygenated and deoxygenated states of arthropod hemocyanin shows unusual differences. 
  • Cupric ion/ascorbate/hydrogen peroxide-induced DNA damage: DNA-bound copper ion primarily induces base modifications. 
  • Cupric-amyloid beta peptide complex stimulates oxidation of ascorbate and generation of hydroxyl radical. 
  • Current status of metals as therapeutic targets in Alzheimer's disease. 
  • Cytotoxicity of oxidized LDL to porcine aortic smooth muscle cells is associated with the oxysterols 7-ketocholesterol and 7-hydroxycholesterol. 
  • Deficiency of α-1-antitrypsin influences systemic iron homeostasis. 
  • Determination and analysis of the 2 A-structure of copper, zinc superoxide dismutase. 
  • Development of next-generation photolabile copper cages with improved copper binding properties. 
  • Differential Reactivity of Copper- and Gold-Based Nanomaterials Controls Their Seasonal Biogeochemical Cycling and Fate in a Freshwater Wetland Mesocosm. 
  • Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer. 
  • Dithiocarbamate prodrugs activated by prostate specific antigen to target prostate cancer. 
  • ELEMENTARY STEPS IN ENZYME REACTIONS (AS STUDIED BY RELAXATION SPECTROMETRY). 
  • Effects of Copper and Cross-Linking on the Extracellular Matrix of Tissue-Engineered Arteries. 
  • Effects of cadmium ingestion and food restriction on energy metabolism and tissue metal concentrations in mallard ducks (Anas platyrhynchos). 
  • Effects of copper and cross-linking on the extracellular matrix of tissue-engineered arteries. 
  • Electrostatic recognition between superoxide and copper, zinc superoxide dismutase. 
  • Enantioselective Synthesis of anti-1,2-Diamines by Cu-Catalyzed Reductive Couplings of Azadienes with Aldimines and Ketimines. 
  • Encapsulation and retention of chelated-copper inside hydrophobic nanoparticles: Liquid cored nanoparticles show better retention than a solid core formulation. 
  • Engineered nanoparticles interact with nutrients to intensify eutrophication in a wetland ecosystem experiment. 
  • Exploiting innate immune cell activation of a copper-dependent antimicrobial agent during infection. 
  • Exploration of the Potential Role for Aβ in Delivery of Extracellular Copper to Ctr1. 
  • Exploration of the Potential Role of Serum Albumin in the Delivery of Cu(I) to Ctr1. 
  • Expression of a copper-containing amine oxidase by human ciliary body. 
  • Fatty acid synthesis is essential for survival of Cryptococcus neoformans and a potential fungicidal target. 
  • Formation of DNA-protein cross-links in cultured mammalian cells upon treatment with iron ions. 
  • Four-decade responses of soil trace elements to an aggrading old-field forest: B, Mn, Zn, Cu, and Fe. 
  • Genome-wide analysis of the regulation of Cu metabolism in Cryptococcus neoformans. 
  • Heme-copper oxidases use tunneling pathways. 
  • Hemocyanin of the chambered nautilus: structure-function relationships. 
  • Hemoglobin conformation couples erythrocyte S-nitrosothiol content to O2 gradients. 
  • High-efficiency solar cell with Earth-abundant liquid-processed absorber. 
  • How Copper Nanowires Grow and How To Control Their Properties. 
  • Hypolipidemic activity of tetrakis-mu-(trimethylamine-boranecarboxylato)-bis(trimethylamin e- carboxyborane)-dicopper(II) in rodents and its effect on lipid metabolism. 
  • Immunoreactivity of apolipoprotein B-100 in oxidatively modified low density lipoprotein. 
  • In vivo and in vitro analyses of amygdalar function reveal a role for copper. 
  • In vivo magnetic resonance imaging of the blue crab, Callinectes sapidus: effect of cadmium accumulation in tissues on proton relaxation properties. 
  • Indium-free CIGS analogues: general discussion. 
  • Inflammatory breast cancer tumor emboli express high levels of anti-apoptotic proteins: use of a quantitative high content and high-throughput 3D IBC spheroid assay to identify targeting strategies. 
  • Interactions between copper homeostasis and the fungal cell wall affect copper stress resistance. 
  • Interactions of peptide amidation and copper: novel biomarkers and mechanisms of neural dysfunction. 
  • Interlaboratory validation of a new assay for DNA-protein crosslinks. 
  • Internal electron transfer between hemes and Cu(II) bound at cysteine beta93 promotes methemoglobin reduction by carbon monoxide. 
  • Internal triplication in the structure of human ceruloplasmin. 
  • Intestinal mucin is a chaperone of multivalent copper. 
  • Investigation of copper-manganese-nickel alloys for dental purposes. 
  • Iterative in situ click chemistry creates antibody-like protein-capture agents. 
  • Joint effects of dietary trace metals and DNA repair capacity in lung cancer risk. 
  • Kinetic mechanism of quinone oxidoreductase 2 and its inhibition by the antimalarial quinolines. 
  • Leveraging γ-Glutamyl Transferase To Direct Cytotoxicity of Copper Dithiocarbamates against Prostate Cancer Cells. 
  • Light uncages a copper complex to induce nonapoptotic cell death. 
  • Lipid hydroperoxy and hydroxy derivatives in copper-catalyzed oxidation of low density lipoprotein. 
  • Long-Term Effects of Copper Nanopesticides on Soil and Sediment Community Diversity in Two Outdoor Mesocosm Experiments. 
  • Mapping of copper/hydrogen peroxide-induced DNA damage at nucleotide resolution in human genomic DNA by ligation-mediated polymerase chain reaction. 
  • Mapping oxidative DNA damage at nucleotide level. 
  • Marginal zinc deficiency in older adults: responsiveness of zinc status indicators. 
  • Market basket survey for some heavy metals in Egyptian fruits and vegetables. 
  • Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight. 
  • Mechanism Dictates Mechanics: A Molecular Substituent Effect in the Macroscopic Fracture of a Covalent Polymer Network. 
  • Meditations on the ubiquity and mutability of nano-sized materials in the environment. 
  • Metal ion-dependent hydrogen peroxide-induced DNA damage is more sequence specific than metal specific. 
  • Metal sites of copper-zinc superoxide dismutase. 
  • Metal transporters and disease. 
  • Metal-induced formation of metallothionein in rat liver. 
  • Methionine motifs of copper transport proteins provide general and flexible thioether-only binding sites for Cu(I) and Ag(I). 
  • Micronutrient deficiencies in critically ill patients receiving continuous renal replacement therapy. 
  • Mimosine, a novel inhibitor of DNA replication, binds to a 50 kDa protein in Chinese hamster cells. 
  • Mining copper transport genes. 
  • Mitochondrial Genome Variation Affects Multiple Respiration and Nonrespiration Phenotypes in Saccharomyces cerevisiae. 
  • Model Peptide Studies Reveal a Mixed Histidine-Methionine Cu(I) Binding Site at the N-Terminus of Human Copper Transporter 1. 
  • Model peptides provide new insights into the role of histidine residues as potential ligands in human cellular copper acquisition via Ctr1. 
  • Model-based CT performance assessment and optimization for iodinated and noniodinated imaging tasks as a function of kVp and body size. 
  • Mutational analysis of ATP7B and genotype-phenotype correlation in Japanese with Wilson's disease. 
  • Mutations in SCO2 are associated with autosomal-dominant high-grade myopia. 
  • Near infrared spectroscopy: in situ studies of skeletal and cardiac muscle. 
  • Novel gene functions required for melanization of the human pathogen Cryptococcus neoformans. 
  • Ortho Isomeric Mn(III) N-Alkyl- and Alkoxyalkylpyridylporphyrins-Enhancers of Hyaluronan Degradation Induced by Ascorbate and Cupric Ions. 
  • Peptidylglycine α-amidating monooxygenase heterozygosity alters brain copper handling with region specificity. 
  • Persisting neurobehavioral effects of developmental copper exposure in wildtype and metallothionein 1 and 2 knockout mice. 
  • Pharmacological activity of metal binding agents that alter copper bioavailability. 
  • Plasma uptake of manganese as affected by oral loads of manganese, calcium, milk, phosphorus, copper, and zinc. 
  • Pollutant particles produce vasoconstriction and enhance MAPK signaling via angiotensin type I receptor. 
  • Positive Engagement with Pets Buffers the Impact of Intimate Partner Violence on Callous-Unemotional Traits in Children. 
  • Prochelators triggered by hydrogen peroxide provide hexadentate iron coordination to impede oxidative stress. 
  • Prospective clinical trial of disulfiram plus copper in men with metastatic castration-resistant prostate cancer. 
  • Protein Folding Stability Changes Across the Proteome Reveal Targets of Cu Toxicity in E. coli . 
  • Protein polymer hydrogels by in situ, rapid and reversible self-gelation. 
  • Purification and characterization of the Cu,Zn SOD from Escherichia coli. 
  • QM/MM model of the mouse olfactory receptor MOR244-3 validated by site-directed mutagenesis experiments. 
  • Quorum-sensing regulation of a copper toxicity system in Pseudomonas aeruginosa. 
  • Rapid (<3 min) microwave synthesis of block copolymer templated ordered mesoporous metal oxide and carbonate films using nitrate-citric acid systems. 
  • Real-time visualization of diffusion-controlled nanowire growth in solution. 
  • Regulation of the copper chaperone CCS by XIAP-mediated ubiquitination. 
  • Relative Contributions of Copper Oxide Nanoparticles and Dissolved Copper to Cu Uptake Kinetics of Gulf Killifish (Fundulus grandis) Embryos. 
  • S-nitrosoglutathione/glutathione disulphide/Cu2+-dependent stimulation of L-arginine transport in human platelets. 
  • S-nitrosylation in health and disease. 
  • Selective α-amination and α-acylation of esters and amides via dual reactivity of O-acylhydroxylamines toward zinc enolates. 
  • Sequence proximity between Cu(II) and Cu(I) binding sites of human copper transporter 1 model peptides defines reactivity with ascorbate and O2. 
  • Shape-Dependent Surface Reactivity and Antimicrobial Activity of Nano-Cupric Oxide. 
  • Similarity of three-dimensional structure between the immunoglobulin domain and the copper, zinc superoxide dismutase subunit. 
  • Siroheme and sirohydrochlorin. The basis for a new type of porphyrin-related prosthetic group common to both assimilatory and dissimilatory sulfite reductases. 
  • Site-Selective Copper-Catalyzed Amination and Azidation of Arenes and Heteroarenes via Deprotonative Zincation. 
  • Solubilization of a [3H]cimetidine binding site from rat brains. A clonidine-sensitive H-2 receptor subtype? 
  • Specific Histidine Residues Confer Histatin Peptides with Copper-Dependent Activity against Candida albicans 
  • Stability of Metal-Glutathione Complexes During Oxidation by Hydrogen Peroxide and Cu(II)-Catalysis 
  • Stoichiometric preference in copper-promoted oxidative DNA damage by ochratoxin A. 
  • Structural model of human ceruloplasmin based on internal triplication, hydrophilic/hydrophobic character, and secondary structure of domains. 
  • Structure and Affinity of Cu(I) Bound to Human Serum Albumin. 
  • Structure and mechanism of copper, zinc superoxide dismutase. 
  • Studies of the copper and heme cofactors of pseudomonad L-tryptophan-2,3-dioxygenase by electron paramagnetic resonance spectroscopy. 
  • Subacute combined degeneration due to copper deficiency. 
  • Superoxide dismutase from Streptococcus mutans. Isolation and characterization of two forms of the enzyme. 
  • Synthesis and characterization of copper(II) complexes of cysteinyldopa and benzothiazine model ligands related to pheomelanin. 
  • Synthesis of Modular Brush Polymer-Protein Hybrids Using Diazotransfer and Copper Click Chemistry. 
  • Synthesis of oxidation-resistant cupronickel nanowires for transparent conducting nanowire networks. 
  • Technical Note: On maximizing Cherenkov emissions from medical linear accelerators. 
  • The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(ii) from albumin. Implications for copper uptake by Ctr1. 
  • The association between serum copper and anaemia in the adult Second National Health and Nutrition Examination Survey (NHANES II) population. 
  • The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies. 
  • The crystal structure of bovine Cu2+,Zn2+ superoxide dismutase at 5.5-A resolution. 
  • The decomposition of thionitrites. 
  • The effect of zinc and other divalent cations on the structure and function of human alpha 2-macroglobulin. 
  • The growth mechanism of copper nanowires and their properties in flexible, transparent conducting films. 
  • The interaction of biological and noxious transition metals with the zinc probes FluoZin-3 and Newport Green. 
  • The role of soluble components in ambient fine particles-induced changes in human lungs and blood. 
  • The synthesis and coating of long, thin copper nanowires to make flexible, transparent conducting films on plastic substrates. 
  • Thermodynamics of metal ion binding. 1. Metal ion binding by wild-type carbonic anhydrase. 
  • Total reconstitution of copper-zinc superoxide dismutase. 
  • Total synthesis, assignment of the absolute stereochemistry, and structure-activity relationship studies of subglutinols A and B. 
  • Toward the detection of cellular copper(II) by a light-activated fluorescence increase. 
  • Toward the development of prochelators as fluorescent probes of copper-mediated oxidative stress. 
  • Toxicity of oxidized low density lipoproteins for vascular smooth muscle cells and partial protection by antioxidants. 
  • Transcription factor-driven alternative localization of Cryptococcus neoformans superoxide dismutase. 
  • Using N-Terminal Coordination of Cu(II) and Ni(II) to Isolate the Coordination Environment of Cu(I) and Cu(II) Bound to His13 and His14 in Amyloid-β(4-16). 
  • Utilizing in vivo nuclear magnetic resonance spectroscopy to study sublethal stress in aquatic organisms. 
  • Virulence attributes and hyphal growth of C. neoformans are quantitative traits and the MATalpha allele enhances filamentation. 
  • White monkey syndrome and presumptive copper deficiency in wild savannah baboons. 
  • XIAP Is a copper binding protein deregulated in Wilson's disease and other copper toxicosis disorders. 
  • XIAP: cell death regulation meets copper homeostasis. 
  • Zinc and immunocompetence in elderly people: effects of zinc supplementation for 3 months. 
  • Zinc, magnesium, copper, and protein concentrations in human saliva: age- and sex-related differences. 
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  Keywords of People

  • Blum, Volker, Associate Professor in the Department of Mechanical Engineering and Materials Science, Nicholas Institute-Energy Initiative
  • Hsu-Kim, Heileen, Professor in the Department of Civil and Environmental Engineering, Civil and Environmental Engineering