Corpus Striatum

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  Subject Areas on Research

  • "Speed" warps time: methamphetamine's interactive roles in drug abuse, habit formation, and the biological clocks of circadian and interval timing. 
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced astrogliosis does not require activation of ornithine decarboxylase. 
  • 6-Hydroxydopamine injections into the nigrostriatal pathway attenuate striatal malonate and 3-nitropropionic acid lesions. 
  • A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons. 
  • A simple, inexpensive method of monitoring brain temperature in conscious rodents. 
  • A thalamocorticostriatal dopamine network for psychostimulant-enhanced human cognitive flexibility. 
  • A unique role for striatal serotonergic systems in the withdrawal from adolescent nicotine administration. 
  • Administration of nicotine to adolescent rats evokes regionally selective upregulation of CNS alpha 7 nicotinic acetylcholine receptors. 
  • Adult age differences in frontostriatal representation of prediction error but not reward outcome. 
  • Affinity chromatography of the D1 dopamine receptor from rat corpus striatum. 
  • Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism. 
  • Altered striatal activation predicting real-world positive affect in adolescent major depressive disorder. 
  • Altered striatal functional connectivity in subjects with an at-risk mental state for psychosis. 
  • An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. 
  • Anticipation of monetary gain but not loss in healthy older adults. 
  • Augmented methamphetamine-induced overflow of striatal dopamine 1 day after GDNF administration. 
  • Autoreceptor presynaptic control of dopamine release from striatum is lost at early stages of manganese poisoning. 
  • Basal ganglia morphometry and repetitive behavior in young children with autism spectrum disorder. 
  • Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice. 
  • Biochemical and behavioral evaluation of pergolide as a dopamine agonist in the rat brain. 
  • Blockade of NMDA receptors in the dorsomedial striatum prevents action-outcome learning in instrumental conditioning. 
  • Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors. 
  • CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease. 
  • Catecholamine synthesis is mediated by tyrosinase in the absence of tyrosine hydroxylase. 
  • Cerebral blood flow and brain oxygenation in rats breathing oxygen under pressure. 
  • Chlorpromazine methiodide-induced barrel rotation: an antimuscarinic effect. 
  • Chlorpyrifos oxon binds directly to muscarinic receptors and inhibits cAMP accumulation in rat striatum. 
  • Cholinergic synaptic signaling mechanisms underlying behavioral teratogenicity: effects of nicotine, chlorpyrifos, and heroin converge on protein kinase C translocation in the intermedial part of the hyperstriatum ventrale and on imprinting behavior in an avian model. 
  • Chronic cocaine administration increases CNS tyrosine hydroxylase enzyme activity and mRNA levels and tryptophan hydroxylase enzyme activity levels. 
  • Chronic levodopa or pergolide administration induces down-regulation of dopamine receptors in denervated striatum. 
  • Chronic sulpiride increased 3H-spiperone binding and calmodulin dependent phosphorylation in rat striatum. 
  • Circuit-selective striatal synaptic dysfunction in the Sapap3 knockout mouse model of obsessive-compulsive disorder. 
  • Clorgyline and deprenyl attenuate striatal malonate and 3-nitropropionic acid lesions. 
  • Clozapine-, but not haloperidol-, induced increases in deltaFosB-like immunoreactivity are completely blocked in the striatum of mice lacking D3 dopamine receptors. 
  • Colchicine administered into the area of the nucleus basalis decreases cortical nicotinic cholinergic receptors labelled by [3H]-acetylcholine. 
  • Comparative antidopaminergic properties of thioridazine, mesoridazine and sulforidazine on the corpus striatum. 
  • Comparative dopamine-cholinergic mechanisms in the olfactory tubercle and the striatum: effects of metoclopramide. 
  • Comparison of interval timing behaviour in mice following dorsal or ventral hippocampal lesions with mice having δ-opioid receptor gene deletion. 
  • Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia. 
  • Contributions of the hippocampus to feedback learning. 
  • Convergent transcriptional specializations in the brains of humans and song-learning birds. 
  • Correlation between behavior and extracellular dopamine levels in rat striatum: comparison of microdialysis and fast-scan cyclic voltammetry. 
  • Cortico-striatal representation of time in animals and humans. 
  • D1 dopamine receptor binding and mRNA levels are not altered after neonatal 6-hydroxydopamine treatment: evidence against dopamine-mediated induction of D1 dopamine receptors during postnatal development. 
  • Deconstructing behavioral neuropharmacology with cellular specificity. 
  • Decreased spontaneous motor activity parallels reserpine-induced supersensitivity of catecholamine-responsive rat cerebral cortex adenylate cyclase. 
  • Deficits in development of central cholinergic pathways caused by fetal nicotine exposure: differential effects on choline acetyltransferase activity and [3H]hemicholinium-3 binding. 
  • Delayed oculogyric crises associated with striatocapsular infarction. 
  • Diazepam, given postischemia, protects selectively vulnerable neurons in the rat hippocampus and striatum. 
  • Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents. 
  • Differential corticostriatal plasticity during fast and slow motor skill learning in mice. 
  • Differential expression of two isoforms of the neurokinin-1 (substance P) receptor in vivo. 
  • Differential regulation of the dopamine D1, D2 and D3 receptor gene expression and changes in the phenotype of the striatal neurons in mice lacking the dopamine transporter. 
  • Differential response of ventral midbrain and striatal progenitor cells to lesions of the nigrostriatal dopaminergic projection. 
  • Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum. 
  • Dissecting the brain's internal clock: how frontal-striatal circuitry keeps time and shifts attention. 
  • Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties. 
  • Does dopamine contribute to striatal damage caused by impaired mitochondrial function? 
  • Dopamine autoreceptor regulation of release and uptake in mouse brain slices in the absence of D(3) receptors. 
  • Dopamine release and uptake are greater in female than male rat striatum as measured by fast cyclic voltammetry. 
  • Dopamine transporter is required for in vivo MPTP neurotoxicity: evidence from mice lacking the transporter. 
  • Dopamine-sensitive adenylate cyclase: antagonism by impiramine and its analogues. 
  • Dopamine: Context and counterfactuals. 
  • Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons. 
  • Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice. 
  • Drd1a-tdTomato BAC transgenic mice for simultaneous visualization of medium spiny neurons in the direct and indirect pathways of the basal ganglia. 
  • Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill. 
  • Dysnomia, ataxia, choreoathetosis, sensory impairment, and gait imbalance after lentiform nucleus stroke. 
  • Effect of photoperiod reversal on twenty-four hour patterns for dopamine levels in the corpus striatum and upper and lower brainstem of the rat. 
  • Effect of tolcapone, a catechol-O-methyltransferase inhibitor, on striatal dopaminergic transmission during blockade of dopamine uptake. 
  • Effects of NMDA receptor antagonists and body temperature in the gerbil carotid occlusion model of transient forebrain ischemia. 
  • Effects of a psychostimulant drug sydnocarb on rat brain dopaminergic transmission in vivo. 
  • Effects of classical and atypical antipsychotic drugs on isolation-induced aggression in male mice. 
  • Effects of intrastriatal infusion of D2 and D3 dopamine receptor preferring antagonists on dopamine release in rat dorsal striatum (in vivo microdialysis study). 
  • Effects of prenatal cocaine exposure on haloperidol-induced increases in prolactin release and dopamine turnover in weanling, periadolescent, and adult offspring. 
  • Effects of sub-chronic in vivo chlorpyrifos exposure on muscarinic receptors and adenylate cyclase of rat striatum. 
  • Elucidation of G-protein and β-arrestin functional selectivity at the dopamine D2 receptor. 
  • Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice. 
  • Estimation of the interstitial free concentration of the putative dopamine D3 receptor selective agonist 7-OH-DPAT in the dorsal striatum of freely moving rats. 
  • Ethanol reverses the direction of long-term synaptic plasticity in the dorsomedial striatum. 
  • Experimental dystonia induced by quaternary-chlorpromazine. 
  • Fetal nicotine exposure alters ontogeny of M1-receptors and their link to G-proteins. 
  • Focal not widespread grafts induce novel dyskinetic behavior in parkinsonian rats. 
  • Frontal cortex lesions eliminate the clock speed effect of dopaminergic drugs on interval timing. 
  • Frontal-striatal circuitry activated by human peak-interval timing in the supra-seconds range. 
  • Frontostriatal white matter integrity mediates adult age differences in probabilistic reward learning. 
  • Functional hyperdopaminergia in dopamine transporter knock-out mice. 
  • Functional magnetic resonance imaging guided transcranial magnetic stimulation in obsessive-compulsive disorder. 
  • Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase. 
  • Functional significance of striatal responses during episodic decisions: recovery or goal attainment? 
  • Genetic deletion of A2A adenosine receptors in the striatum selectively impairs habit formation. 
  • Hippocampal and striatal gray matter volume are associated with a smoking cessation treatment outcome: results of an exploratory voxel-based morphometric analysis. 
  • Human neural stem cell transplants improve motor function in a rat model of Huntington's disease. 
  • Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits. 
  • Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice. 
  • Hyperbaric oxygen reduces cerebral blood flow by inactivating nitric oxide. 
  • IKKβ and mutant huntingtin interactions regulate the expression of IL-34: implications for microglial-mediated neurodegeneration in HD. 
  • Identification of the D2-dopamine receptor binding subunit in several mammalian tissues and species by photoaffinity labeling. 
  • Identification of the binding subunit of the D1-dopamine receptor by photoaffinity crosslinking. 
  • Imaging frontostriatal function in ultra-high-risk, early, and chronic schizophrenia during executive processing. 
  • Impact of adolescent nicotine exposure on adenylyl cyclase-mediated cell signaling: enzyme induction, neurotransmitter-specific effects, regional selectivities, and the role of withdrawal. 
  • Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner. 
  • Implanted reuptake-deficient or wild-type dopaminergic neurons improve ON L-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease. 
  • In vivo evidence for preferential role of dopamine D3 receptor in the presynaptic regulation of dopamine release but not synthesis. 
  • In vivo regulation of [3H]acetylcholine recognition sites in brain by nicotinic cholinergic drugs. 
  • Inactivation of dorsolateral striatum enhances sensitivity to changes in the action-outcome contingency in instrumental conditioning. 
  • Increased MPTP neurotoxicity in vesicular monoamine transporter 2 heterozygote knockout mice. 
  • Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice. 
  • Increased methamphetamine neurotoxicity in heterozygous vesicular monoamine transporter 2 knock-out mice. 
  • Individual differences in striatum activity to food commercials predict weight gain in adolescents. 
  • Induction of the protective antioxidant response element pathway by 6-hydroxydopamine in vivo and in vitro. 
  • Influence of lesion size and location on amphetamine-facilitated recovery of beam-walking in rats. 
  • Insulin-like growth factor-1 is a radial cell-associated neurotrophin that promotes neuronal recruitment from the adult songbird edpendyma/subependyma. 
  • Interactive roles of the cerebellum and striatum in sub-second and supra-second timing: Support for an initiation, continuation, adjustment, and termination (ICAT) model of temporal processing. 
  • Interval timing and the encoding of signal duration by ensembles of cortical and striatal neurons. 
  • Ketamine "unlocks" the reduced clock-speed effects of cocaine following extended training: evidence for dopamine--glutamate interactions in timing and time perception. 
  • Ketamine potentiates oxidative stress and influences behavior and inflammation in response to lipolysaccharide (LPS) exposure in early life. 
  • Lesioning of the striatum reverses motor asymmetry in the 6-hydroxydopamine rodent model of parkinsonism. 
  • Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain. 
  • Loss of response to levodopa in Parkinson's disease and co-occurrence with dementia: role of D3 and not D2 receptors. 
  • MR imaging of microcirculation in rat brain: correlation with carbon dioxide-induced changes in blood flow. 
  • Maturation of coordinated immediate early gene expression by cocaine during adolescence. 
  • MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants. 
  • MeCP2 phosphorylation limits psychostimulant-induced behavioral and neuronal plasticity. 
  • Medical treatment of Parkinson disease. 
  • Memory Meets Control in Hippocampal and Striatal Binding of Stimuli, Responses, and Attentional Control States. 
  • Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase. 
  • Molecular cloning and expression of the gene for a human D1 dopamine receptor. 
  • N6-phenyladenosines: pronounced effect of phenyl substituents on affinity for A2 adenosine receptors. 
  • Nasal toxicity of manganese sulfate and manganese phosphate in young male rats following subchronic (13-week) inhalation exposure. 
  • Neuroanatomical localization of an internal clock: a functional link between mesolimbic, nigrostriatal, and mesocortical dopaminergic systems. 
  • Neuroprotective effects of creatine administration against NMDA and malonate toxicity. 
  • Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease. 
  • Neurotensin interacts with dopaminergic neurons in rat brain. 
  • New Concepts in Dopamine D2 Receptor Biased Signaling and Implications for Schizophrenia Therapy. 
  • Nonintralaminar thalamostriatal projections in the gray squirrel (Sciurus carolinensis) and tree shrew (Tupaia glis). 
  • Not "just" a coincidence: frontal-striatal interactions in working memory and interval timing. 
  • Of mice, birds, and men: the mouse ultrasonic song system has some features similar to humans and song-learning birds. 
  • Ontogeny of the striatal neurons expressing the D1 dopamine receptor in humans. 
  • Opposite function of dopamine D1 and N-methyl-D-aspartate receptors in striatal cannabinoid-mediated signaling. 
  • Orientation selectivity and the arrangement of horizontal connections in tree shrew striate cortex. 
  • Paradoxical striatal cellular signaling responses to psychostimulants in hyperactive mice. 
  • Parallel contributions of distinct human memory systems during probabilistic learning. 
  • Pathway-Specific Striatal Substrates for Habitual Behavior. 
  • Photoaffinity labeling of the D2-dopamine receptor using a novel high affinity radioiodinated probe. 
  • Physiological organization of layer 4 in macaque striate cortex. 
  • Pramipexole vs levodopa as initial treatment for Parkinson disease: A randomized controlled trial. Parkinson Study Group. 
  • Prenatal availability of choline alters the development of acetylcholinesterase in the rat hippocampus. 
  • Prenatal stress elicits regionally selective changes in basal FGF-2 gene expression in adulthood and alters the adult response to acute or chronic stress. 
  • Presynaptic dopaminergic function is largely unaltered in mesolimbic and mesostriatal terminals of adult rats that were prenatally exposed to cocaine. 
  • Presynaptic inhibition of dopamine synthesis in rat striatum: effects of chronic dopamine depletion and receptor blockade. 
  • Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction. 
  • Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo. 
  • Rat brain synaptic vesicles: uptake specificities of [3H]norepinephrine and [3H]serotonin in preparations from whole brain and brain regions. 
  • Recovery of presynaptic dopaminergic functioning in rats treated with neurotoxic doses of methamphetamine. 
  • Reduced D2-mediated signaling activity and trans-synaptic upregulation of D1 and D2 dopamine receptors in mice overexpressing the dopamine transporter. 
  • Reduced dopamine receptors and transporters but not synthesis capacity in normal aging adults: a meta-analysis. 
  • Region-specific impairments in striatal synaptic transmission and impaired instrumental learning in a mouse model of Angelman syndrome. 
  • Regionally selective effects of NMDA receptor antagonists against ischemic brain damage in the gerbil. 
  • Regulatory T cells attenuate Th17 cell-mediated nigrostriatal dopaminergic neurodegeneration in a model of Parkinson's disease. 
  • Release of corticotropin-releasing factor from rat brain regions in vitro. 
  • Remoxipride and raclopride differ from metoclopramide by their effects on striatal dopamine release and biosynthesis in rats. 
  • Reserpine-induced up-regulation of dopamine D2 receptors in the rat striatum is enhanced by denervation but not by chronic receptor blockade. 
  • Restorative effects of GDNF on striatal dopamine release in rats treated with neurotoxic doses of methamphetamine. 
  • Reward-related learning via multiple memory systems. 
  • Role of dopamine transporter in methamphetamine-induced neurotoxicity: evidence from mice lacking the transporter. 
  • Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. 
  • Sapap3 deletion anomalously activates short-term endocannabinoid-mediated synaptic plasticity. 
  • Serotonin depletion exacerbates changes in striatal gene expression following quinolinic acid injection. 
  • Sex differences in neurochemical effects of dopaminergic drugs in rat striatum. 
  • Simultaneous monitoring of dopamine, its metabolites and trans-isomer of atypical neuroleptic drug carbidine concentrations in striatal dialysates of conscious rats. 
  • Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective. 
  • Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. 
  • Stereoisomers of the atypical neuroleptic carbidine modulate striatal dopamine release in awake rats. 
  • Striatal abnormalities and spontaneous dyskinesias in non-clinical psychosis. 
  • Striatal firing rate reflects head movement velocity. 
  • Subunit composition and pharmacology of two classes of striatal presynaptic nicotinic acetylcholine receptors mediating dopamine release in mice. 
  • Survival of grafted fetal neural cells in kainic acid lesioned CA3 region of adult hippocampus depends upon cell specificity. 
  • Sustained elevation of extracellular dopamine causes motor dysfunction and selective degeneration of striatal GABAergic neurons. 
  • Synaptic plasticity in drug reward circuitry. 
  • Synaptic relationship between substance P and the substance P receptor: light and electron microscopic characterization of the mismatch between neuropeptides and their receptors. 
  • The action of hydrogen peroxide on paired pulse and long-term potentiation in the hippocampus. 
  • The dopamine metabolite 3-methoxytyramine is a neuromodulator. 
  • The effects of chronic bromocriptine treatment on behaviour and dopamine receptor binding in the rat striatum. 
  • The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. 
  • The involvement of the dopaminergic midbrain and cortico-striatal-thalamic circuits in the integration of reward prospect and attentional task demands. 
  • The role of the dorsomedial striatum in instrumental conditioning. 
  • The sensorimotor striatum is necessary for serial order learning. 
  • The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin. 
  • The use of locomotor activity as a behavioral screen for neuronal damage following transient forebrain ischemia in gerbils. 
  • The vascular depression subtype: evidence of internal validity. 
  • Tryptophan hydroxylase-2 controls brain serotonin synthesis. 
  • Unity and diversity of tonic and phasic executive control components in episodic and working memory. 
  • Ventral striatum reactivity to reward and recent life stress interact to predict positive affect. 
  • Wernicke's encephalopathy: an experimental study in the rhesus monkey. 
  • Withdrawal from continuous or intermittent cocaine administration: changes in D2 receptor function. 
  • [3H]dihydroergocryptine binding in rat brain. 
  • [A comparative study of the neurochemical profiles of carbidine stereoisomers]. 
  • [Different effects of typical and atypical neuroleptics on K+-stimulated dopamine release from isolated rat striatum]. 
  • [Dopamine autoreceptors subtype D3 predominantly regulate the liberation of dopamine in rat brain basal ganglia]. 
  • [Effect of aspartic acid derivatives, N-acetyl-aspartate and its phosphonic analog PIR-87-6-0, on dopamine release from the rat striatum during perfusion in vitro]. 
  • [Effect of subchronic administration of tolcapone on release of striatum dopamine and its metabolites induced by L-DOPA and carbidopa]. 
  • [Microdialysis study of tolcapone effect during blockage of neuronal dopamine reuptake caused by GBR-12909]. 
  • [Pharmacological modulation of dopaminergic transmission in the rat striatum in vivo]. 
  • [Regulation of liberation and metabolism of dopamine in the dorsal striatum of free-living rats: the role of D2- and D3-dopamine autoreceptors]. 
  • [Selective analyzers of dopamine D2 receptors modulate serotonin metabolism in the striatum and nucleus accumbens of the rat brain during blockade of dopaminergic impulse flow]. 
  • [Study by the intracerebral microdialysis method of the effects of atypical neuroleptics and anxiolytics on striatal release and metabolism of dopamine in awake rats]. 
  • [Substances that increase the extracellular level of dopamine in the striatum prevent development of haloperidol catalepsy in rats]. 
  • [The effect of a low dose of piracetam on the activity of the dopaminergic system in the rat striatum]. 
  • [The effect of bromantane, a new immunostimulant with psychostimulating action, on release and metabolism of dopamine in the dorsal striatum of freely moving rats: a microdialysis study]. 
  • [The effect of the dopamine neuronal reuptake inhibitor GBR 12909 on the dopaminergic neurotransmission parameters in the rat striatum in vivo]. 
  • [The sodium oxybutyrate and nooglutil correction of dopamine release in the striatum of prenatally alcoholized rat pups]. 
  • fMRI of alterations in reward selection, anticipation, and feedback in major depressive disorder. 
  • α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration. 
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  Keywords of People

  • Cabeza, Roberto, Professor of Psychology and Neuroscience, Duke Science & Society
  • Calakos, Nicole, Professor in Neurology, Duke Science & Society
  • Nicolelis, Miguel Angelo L., Duke School of Medicine Professor in Neuroscience, Biomedical Engineering
  • Schwartz-Bloom, Rochelle D., Professor in Pharmacology & Cancer Biology, Duke Science & Society