Creatine

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  Subject Areas on Research

  • 1,25-Dihydroxycholecalciferol deficiency: the probable cause of hypocalcemia and metabolic bone disease in pseudohypoparathyroidism. 
  • 1H MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS. 
  • A fully automated method for tissue segmentation and CSF-correction of proton MRSI metabolites corroborates abnormal hippocampal NAA in schizophrenia. 
  • A magnetic resonance spectroscopic imaging study of adult nonhuman primates exposed to early-life stressors. 
  • A novel, efficient, randomized selection trial comparing combinations of drug therapy for ALS. 
  • A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease. 
  • A repeat proton magnetic resonance spectroscopy study in social phobia. 
  • AMPK and substrate availability regulate creatine transport in cultured cardiomyocytes. 
  • An increase in the myocardial PCr/ATP ratio in GLUT4 null mice. 
  • Antitumor activity of creatine analogs produced by alterations in pancreatic hormones and glucose metabolism. 
  • Assessment of early response to tumor-treating fields in newly diagnosed glioblastoma using physiologic and metabolic MRI: initial experience. 
  • Association Between Muscle Mass Determined by D3 -Creatine Dilution and Incident Fractures in a Prospective Cohort Study of Older Men. 
  • Association of change in muscle mass assessed by D3 -creatine dilution with changes in grip strength and walking speed. 
  • Association of metabolic syndrome and change in Unified Parkinson's Disease Rating Scale scores. 
  • Association of muscle mass measured by D3-Creatine (D3Cr), sarcopenic obesity, and insulin-glucose homeostasis in postmenopausal women. 
  • Automated spectral analysis II: application of wavelet shrinkage for characterization of non-parameterized signals. 
  • Automated spectral analysis III: application to in vivo proton MR spectroscopy and spectroscopic imaging. 
  • Biochemical abnormalities of the medial temporal lobe and medial prefrontal cortex in late-life depression. 
  • Brain metabolite profiles of T1-hypointense lesions in relapsing-remitting multiple sclerosis. 
  • Brief report: biochemical correlates of clinical impairment in high functioning autism and Asperger's disorder. 
  • Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis. 
  • Creatine and creatinine metabolism. 
  • Creatine and cyclocreatine attenuate MPTP neurotoxicity. 
  • Creatine and phosphocreatine analogs: anticancer activity and enzymatic analysis. 
  • Creatine for amyotrophic lateral sclerosis/motor neuron disease. 
  • Creatine for amyotrophic lateral sclerosis/motor neuron disease. 
  • Creatine monohydrate in ALS: effects on strength, fatigue, respiratory status and ALSFRS. 
  • Creatine supplementation reduces doxorubicin-induced cardiomyocellular injury. 
  • Cyclocreatine inhibits stimulated motility in tumor cells possessing creatine kinase. 
  • D3-creatine dilution for the noninvasive measurement of skeletal muscle mass in premature infants. 
  • Dependence of residual dipolar couplings on foot angle in (1)H MR spectra from skeletal muscle. 
  • Design innovations and baseline findings in a long-term Parkinson's trial: the National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson's Disease Long-Term Study-1. 
  • Dietary Intake, D3Cr Muscle Mass, and Appendicular Lean Mass in a Cohort of Older Men. 
  • Direct effects of CO on cerebral energy metabolism in bloodless rats. 
  • Distinct patterns of fat metabolism in skeletal muscle of normal-weight, overweight, and obese humans. 
  • Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a randomized clinical trial. 
  • Effects of Alzheimer disease on fronto-parietal brain N-acetyl aspartate and myo-inositol using magnetic resonance spectroscopic imaging. 
  • Effects of age, medication, and illness duration on the N-acetyl aspartate signal of the anterior cingulate region in schizophrenia. 
  • Effects of creatine and cyclocreatine supplementation on kainate induced injury in pre-pubescent rats. 
  • Effects of davunetide on N-acetylaspartate and choline in dorsolateral prefrontal cortex in patients with schizophrenia. 
  • Effects of therapy on the 1H NMR spectrum of a human glioma line. 
  • Elevation of guanidinoacetate in newborn dried blood spots and impact of early treatment in GAMT deficiency. 
  • Focal and lateralized subcortical abnormalities in unipolar major depressive disorder: an automated multivoxel proton magnetic resonance spectroscopy study. 
  • Global brain metabolic quantification with whole-head proton MRS at 3 T. 
  • Gray and white matter brain chemistry in young children with autism. 
  • How well does urinary lyso-Gb3 function as a biomarker in Fabry disease? 
  • Human brain-structure resolved T(2) relaxation times of proton metabolites at 3 Tesla. 
  • Hypoxia decreases creatine uptake in cardiomyocytes, while creatine supplementation enhances HIF activation. 
  • Increases in cortical glutamate concentrations in transgenic amyotrophic lateral sclerosis mice are attenuated by creatine supplementation. 
  • Laboratory diagnosis of creatine deficiency syndromes: a technical standard and guideline of the American College of Medical Genetics and Genomics. 
  • Left ventricular assist device effects on metabolic substrates in the failing heart. 
  • Lower concentration of hippocampal N-acetylaspartate in familial bipolar I disorder. 
  • Magnetic resonance spectroscopy as an early indicator of response to anti-angiogenic therapy in patients with recurrent glioblastoma: RTOG 0625/ACRIN 6677. 
  • Magnetic resonance spectroscopy in social phobia: preliminary findings. 
  • Metabolic brain mapping in Alzheimer's disease using proton magnetic resonance spectroscopy. 
  • Multisection proton MR spectroscopy for mesial temporal lobe epilepsy. 
  • Muscle Mass Assessed by the D3-Creatine Dilution Method and Incident Self-reported Disability and Mortality in a Prospective Observational Study of Community-Dwelling Older Men. 
  • Neuroprotective effects of creatine administration against NMDA and malonate toxicity. 
  • Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease. 
  • Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis. 
  • Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease. 
  • Observation of coupled 1H metabolite resonances at long TE. 
  • Performance-enhancing sports supplements: role in critical care. 
  • Person Ability Scores as an Alternative to Norm-Referenced Scores as Outcome Measures in Studies of Neurodevelopmental Disorders. 
  • Predictors of preterm birth in patients with mild systemic lupus erythematosus. 
  • Proton magnetic resonance spectroscopic imaging in childhood ataxia with diffuse central nervous system hypomyelination. 
  • Proton magnetic resonance spectroscopy and gadolinium-DTPA perfusion imaging of asymptomatic MRI white matter lesions. 
  • Proton spectroscopy of human brain: effects of age and sex. 
  • Quantification of creatine and guanidinoacetate using GC-MS and LC-MS/MS for the detection of cerebral creatine deficiency syndromes. 
  • Quantifying global-brain metabolite level changes with whole-head proton MR spectroscopy at 3T. 
  • Quantitation of proton NMR spectra of the human brain using tissue water as an internal concentration reference. 
  • Quantitative proton MR spectroscopic imaging of the human brain. 
  • Quantitative proton spectroscopy and histology of a canine brain tumor model. 
  • Regional brain chemical alterations in young children with autism spectrum disorder. 
  • Regional metabolite T2 in the healthy rhesus macaque brain at 7T. 
  • Relationship between fat-to-fat-free mass ratio and decrements in leg strength after downhill running. 
  • Reproducibility of 3D proton spectroscopy in the human brain. 
  • Results from a human renal allograft tolerance trial evaluating T-cell depletion with alemtuzumab combined with deoxyspergualin. 
  • Short TE in vivo (1)H MR spectroscopic imaging at 1.5 T: acquisition and automated spectral analysis. 
  • Short echo time multislice proton magnetic resonance spectroscopic imaging in human brain: metabolite distributions and reliability. 
  • Skeletal muscle mass can be estimated by creatine (methyl-d3) dilution and is correlated with fat-free mass in active young males. 
  • Sports and energy drink consumption are linked to health-risk behaviours among young adults. 
  • Strong Relation Between Muscle Mass Determined by D3-creatine Dilution, Physical Performance, and Incidence of Falls and Mobility Limitations in a Prospective Cohort of Older Men. 
  • The Importance of Muscle Versus Fat Mass in Sarcopenic Obesity: A Re-evaluation Using D3-Creatine Muscle Mass Versus DXA Lean Mass Measurements. 
  • Thromboxane receptor signalling in renal ischemia reperfusion injury. 
  • Time-restricted feeding mitigates obesity through adipocyte thermogenesis. 
  • Total body skeletal muscle mass: estimation by creatine (methyl-d3) dilution in humans. 
  • Total-body creatine pool size and skeletal muscle mass determination by creatine-(methyl-D3) dilution in rats. 
  • Treatment outcome of creatine transporter deficiency: international retrospective cohort study. 
  • Treatment outcome of twenty-two patients with guanidinoacetate methyltransferase deficiency: An international retrospective cohort study. 
  • Walking Speed and Muscle Mass Estimated by the D₃ -Creatine Dilution Method Are Important Components of Sarcopenia Associated With Incident Mobility Disability in Older Men: A Classification and Regression Tree Analysis. 
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  Keywords of People

  • Charles, Hal Cecil, Adjunct Associate Professor in the Department of Radiology, Radiology