Creatine Kinase

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  Subject Areas on Research

  • "Mirror-lake" serial relationship of electrocardiographic and biochemical indices for the detection of reperfusion and the prediction of salvage in patients with acute myocardial infarction. 
  • 2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Adult Dermatomyositis and Polymyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative. 
  • 2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Juvenile Dermatomyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative. 
  • A comparison of cardiac troponin T and creatine kinase-MB for patient evaluation after cardiac surgery. 
  • A non-invasive method to produce pressure ulcers of varying severity in a spinal cord-injured rat model. 
  • A randomized double-blinded multicenter comparison of remifentanil versus fentanyl when combined with isoflurane/propofol for early extubation in coronary artery bypass graft surgery. 
  • A randomized trial of the effects of early cardiac serum marker availability on reperfusion therapy in patients with acute myocardial infarction: the serial markers, acute myocardial infarction and rapid treatment trial (SMARTT). 
  • A randomized, placebo-controlled trial of early eptifibatide for non-ST-segment elevation acute coronary syndromes. 
  • A sensitivity analysis of enzymatic estimation of infarct size. 
  • Abnormal cardiac enzyme responses after strenuous exercise: alternative diagnostic aids. 
  • Aborted myocardial infarction in patients with ST-segment elevation: insights from the Assessment of the Safety and Efficacy of a New Thrombolytic Regimen-3 Trial Electrocardiographic Substudy. 
  • Accuracy of total serum enzymes and myocardial specific isoenzymes--a comparative study. 
  • Acute phase response in exercise. III. Neutrophil and IL-1 beta accumulation in skeletal muscle. 
  • Acute phase response in exercise: interaction of age and vitamin E on neutrophils and muscle enzyme release. 
  • Adenosine A3 receptor stimulation attenuates postischemic dysfunction through KATP channels 
  • Aging and stress-induced changes in complement activation and neutrophil mobilization. 
  • Analysis of muscle creatine kinase regulatory elements in recombinant adenoviral vectors. 
  • Antiproliferative effects of cyclocreatine on human prostatic carcinoma cells. 
  • Assessment of coronary reperfusion after thrombolysis with a model combining myoglobin, creatine kinase-MB, and clinical variables 
  • Association between admission white blood cell count and one-year mortality in patients with acute coronary syndromes. 
  • Association between minor elevations of creatine kinase-MB level and mortality in patients with acute coronary syndromes without ST-segment elevation 
  • Association of noninvasive markers of coronary artery reperfusion to assess microvascular obstruction in patients with acute myocardial infarction treated with primary angioplasty. 
  • Asymptomatic McArdle's disease associated with hyper-creatine kinase-emia and absence of myophosphorylase. 
  • Bedside multimarker testing for risk stratification in chest pain units: The chest pain evaluation by creatine kinase-MB, myoglobin, and troponin I (CHECKMATE) study. 
  • Biochemical markers in suspected acute myocardial infarction: the need for early assessment. 
  • Biochemical markers of early reperfusion. 
  • Biomarker evidence of myocardial cell injury is associated with mortality in acute respiratory distress syndrome. 
  • Branched-chain amino acid supplementation and indicators of muscle damage after endurance exercise. 
  • Cardiac markers following cardiac surgery and percutaneous coronary intervention. 
  • Cardiac markers in the assessment of acute coronary syndromes. 
  • Cardiac markers: point of care testing. 
  • Cardiac troponin T and I, echocardiographic [correction of electrocardiographic] wall motion analyses, and ejection fractions in athletes participating in the Hawaii Ironman Triathlon. 
  • Cardiac troponin T elevation after coronary artery bypass grafting is associated with increased one-year mortality. 
  • Cardiac troponin T levels for risk stratification in acute myocardial ischemia. GUSTO IIA Investigators. 
  • Cardiac troponins in acute coronary syndromes. 
  • Cardiospecific creatine kinase after strenuous exercise in female athletes. 
  • Carrier detection in Duchenne muscular dystrophy. 
  • Case report: successful treatment of acute exertional paraspinal compartment syndrome with hyperbaric oxygen therapy. 
  • Changing the diagnosis of acute myocardial infarction: implications for practice and clinical investigations. 
  • Characteristics and consequences of myocardial infarction after percutaneous coronary intervention: insights from the Coronary Angioplasty Versus Excisional Atherectomy Trial (CAVEAT). 
  • Characteristics of creatine kinase-MB and MB isoforms in serum after reperfusion in acute myocardial infarction. 
  • Characterization of myocardial infarction as an end point in two large trials of acute coronary syndromes. 
  • Chorea-acanthocytosis: a report of three new families and implications for genetic counselling. 
  • Clinical and genetic investigation in autosomal dominant limb-girdle muscular dystrophy. 
  • Clinical outcomes after detection of elevated cardiac enzymes in patients undergoing percutaneous intervention. IMPACT-II Investigators. Integrilin (eptifibatide) to Minimize Platelet Aggregation and Coronary Thrombosis-II. 
  • Clinical, electrocardiographic, and biochemical data for immediate risk stratification in acute coronary syndromes. 
  • Collaborative interactions between MEF-2 and Sp1 in muscle-specific gene regulation. 
  • Combination of Goldman risk and initial cardiac troponin I for emergency department chest pain patient risk stratification. 
  • Combined isoenzyme analysis in the diagnosis of myocardial injury: application of electrophoretic methods for the detection and quantitation of the creatine phosphokinase MB isoenzyme. 
  • Combining necrosis and platelet markers for perfecting myocardial infarction rule out: how close are we? 
  • Comparison of cardiac marker concentrations in healthy blood donors and hospital patients without acute coronary syndrome. 
  • Comparison of cardiac troponin T versus creatine kinase-MB for risk stratification in a chest pain evaluation unit. 
  • Comparison of troponin T and creatine Kinase-MB fraction in evaluating cardiac patients postoperatively. 
  • Concerning the mechanism of pexelizumab's benefit in acute myocardial infarction. 
  • Consensus or Controversy?: Evolution of Criteria for Myocardial Infarction After Percutaneous Coronary Intervention. 
  • Correction of glycogen storage disease type II by an adeno-associated virus vector containing a muscle-specific promoter. 
  • Creatine and phosphocreatine analogs: anticancer activity and enzymatic analysis. 
  • Creatine kinase MM and MB isoforms in patients receiving thrombolytic therapy and acute angiography. TAMI Study Group. 
  • Creatine kinase brain isoenzyme: relationship of cerebrospinal fluid concentration to the neurologic condition of newborns and cellular localization in the human brain. 
  • Creatine kinase levels during preseason camp in National Collegiate Athletic Association Division I football athletes. 
  • Creatine kinase-MB elevation after percutaneous coronary intervention predicts adverse outcomes in patients with acute coronary syndromes. 
  • Cultivation in rotating bioreactors promotes maintenance of cardiac myocyte electrophysiology and molecular properties. 
  • Cyclocreatine (1-carboxymethyl-2-iminoimidazolidine) inhibits growth of a broad spectrum of cancer cells derived from solid tumors. 
  • Cyclocreatine inhibits stimulated motility in tumor cells possessing creatine kinase. 
  • Depletion of energy reserve via the creatine kinase reaction during the evolution of heart failure in cardiomyopathic hamsters. 
  • Determination of the falloff constant (k(f)) from modeling biochemical marker release: a new variable for discriminating therapies. 
  • Diagnosis, incidence, and clinical significance of early postoperative ischemia after transmyocardial laser revascularization. 
  • Diagnostic and prognostic significance of minimally elevated creatine kinase-MB in suspected acute myocardial infarction. 
  • Diagnostic problem in acute myocardial infarction: CK-MB in the absence of abnormally elevated total creatine kinase levels. 
  • Does chronic Chlamydia pneumoniae infection increase the risk of myocardial injury? Insights from patients with non-ST-elevation acute coronary syndromes. 
  • E1A-mediated inhibition of myogenesis correlates with a direct physical interaction of E1A12S and basic helix-loop-helix proteins. 
  • Early detection of acute myocardial infarction: additional diagnostic information from serum concentrations of myoglobin in patients without ST elevation. 
  • Effect of abciximab on angiographic complications during percutaneous coronary stenting in the Evaluation of Platelet IIb/IIIa Inhibition in Stenting Trial (EPISTENT). 
  • Effect of eptifibatide on angiographic complications during percutaneous coronary intervention in the IMPACT--(Integrilin to Minimize Platelet Aggregation and Coronary Thrombosis) II Trial. 
  • Effect of glycoprotein IIb/IIIa receptor inhibition on angiographic complications during percutaneous coronary intervention in the ESPRIT trial. 
  • Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis. 
  • Effect of pexelizumab, an anti-C5 complement antibody, as adjunctive therapy to fibrinolysis in acute myocardial infarction: the COMPlement inhibition in myocardial infarction treated with thromboLYtics (COMPLY) trial. 
  • Effect of supersaturated oxygen delivery on infarct size after percutaneous coronary intervention in acute myocardial infarction. 
  • Effects of Proprotein Convertase Subtilisin/Kexin Type 9 Antibodies in Adults With Hypercholesterolemia: A Systematic Review and Meta-analysis. 
  • Effects of sustained ventricular fibrillation on nonhypertrophied heart. 
  • Effects of tirofiban plus heparin versus heparin alone on troponin I levels in patients with acute coronary syndromes. 
  • Efficacy and Tolerability of Evolocumab vs Ezetimibe in Patients With Muscle-Related Statin Intolerance: The GAUSS-3 Randomized Clinical Trial. 
  • Efficacy of recombinant human manganese superoxide dismutase compared to allopurinol in protection of ischemic skeletal muscle against "no-reflow". 
  • Electroconvulsive therapy does not change serum CK, LD, or LD isoenzymes. 
  • Elevated creatine kinase-MB with normal creatine kinase predicts worse outcomes in patients with acute coronary syndromes: results from 4 large clinical trials. 
  • Elevated skeletal muscle creatine kinase MB isoenzyme levels in marathon runners. 
  • Enhanced protein breakdown after eccentric exercise in young and older men. 
  • Enzyme elevation in patients with juvenile dermatomyositis and steroid myopathy. 
  • Epsilon aminocaproic acid therapy of hereditary angioneurotic edema. A double-blind study. 
  • Evasion of immune responses to introduced human acid alpha-glucosidase by liver-restricted expression in glycogen storage disease type II. 
  • Feasibility and applicability of paramedic-based prehospital fibrinolysis in a large North American center. 
  • Feasibility of endovascular cooling as an adjunct to primary percutaneous coronary intervention (results of the LOWTEMP pilot study). 
  • Final conclusions and recommendations of the National Lipid Association Statin Safety Assessment Task Force. 
  • Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6. 
  • Functional heterogeneity of mammalian TATA-box sequences revealed by interaction with a cell-specific enhancer. 
  • Genome-wide association study of perioperative myocardial infarction after coronary artery bypass surgery. 
  • Hfe deficiency increases susceptibility to cardiotoxicity and exacerbates changes in iron metabolism induced by doxorubicin. 
  • Impact of baseline platelet count in patients undergoing primary percutaneous coronary intervention in acute myocardial infarction (from the CADILLAC trial). 
  • Improved adenoviral vectors for gene therapy of Duchenne muscular dystrophy. 
  • Increased brain-type creatine phosphokinase in marathon runners. 
  • Induction of a cellular enzyme for energy metabolism by transforming domains of adenovirus E1a. 
  • Ischemia-modified albumin improves the usefulness of standard cardiac biomarkers for the diagnosis of myocardial ischemia in the emergency department setting. 
  • Isolation of a functional human gene for brain creatine kinase. 
  • LDH isoenzymes and myocardial infarction in patients undergoing coronary bypass surgery: an excellent correlation. 
  • Lactate dehydrogenase isoenzyme in detecting carriers of Duchenne muscular dystrophy. 
  • Late appearance of skin rash and abnormal serum enzymes in Rocky Mountain spotted fever. A case report. 
  • Lesion-directed administration of alteplase with intracoronary heparin in patients with unstable angina and coronary thrombus undergoing angioplasty. 
  • Limb preservation with isolated limb infusion for locally advanced nonmelanoma cutaneous and soft-tissue malignant neoplasms. 
  • Long-term monitoring of patients with infantile-onset Pompe disease on enzyme replacement therapy using a urinary glucose tetrasaccharide biomarker. 
  • Lovastatin increases exercise-induced skeletal muscle injury. 
  • Markers of cardiac ischemia, injury, and inflammation. 
  • Mathematical modifications fail to improve CPK estimates of extent of infarct. 
  • Metabolic changes following eccentric exercise in trained and untrained men. 
  • Minimal myocardial damage during coronary intervention is associated with impaired outcome. 
  • Minor myocardial damage and prognosis: are spontaneous and percutaneous coronary intervention-related events different? 
  • Multiple-analyte fluoroimmunoassay using an integrated optical waveguide sensor. 
  • Myocardial salvage after reperfusion. Observations from analysis of serial electrocardiographic and biochemical indices. 
  • Myonecrosis after revascularization procedures. 
  • Myopathy in human immunodeficiency virus-infected children receiving long-term zidovudine therapy. 
  • Noninvasive detection of reperfusion after thrombolysis based on serum creatine kinase MB changes and clinical variables. TAMI 7 Study Group. Thrombolysis and Angioplasty in Myocardial Infarction. 
  • Normal serum activities of some diagnostic enzymes in dromedary camel in Sudan. 
  • On the specificity of creatine kinase. New glycocyamines and glycocyamine analogs related to creatine. 
  • Optimal duration of eptifibatide infusion in percutaneous coronary intervention (an ESPRIT substudy). 
  • Pedigree testing in Duchenne muscular dystrophy. 
  • Periprocedural cardiac marker elevation after percutaneous coronary artery revascularization. Importance and implications. 
  • Persistence of MB isoenzyme of creatine phosphokinase in the serum after minor iatrogenic cardiac trauma. Absence of postmortem evidence of myocardial infarction. 
  • Pexelizumab, an anti-C5 complement antibody, as adjunctive therapy to primary percutaneous coronary intervention in acute myocardial infarction: the COMplement inhibition in Myocardial infarction treated with Angioplasty (COMMA) trial. 
  • Pharmacologically dosed oral glutamine reduces myocardial injury in patients undergoing cardiac surgery: a randomized pilot feasibility trial. 
  • Physiological mechanisms contributing to increased interleukin-1 secretion. 
  • Plasma creatine kinase activity and exercise-induced muscle damage in older men. 
  • Positive predictive value of a point-of-care testing strategy on first-draw specimens for the emergency department-based detection of acute coronary syndromes. 
  • Predictive factors of regional toxicity and serum creatine phosphokinase levels after isolated limb infusion for melanoma: a multi-institutional analysis. 
  • Presymptomatic and prenatal diagnosis in myotonic dystrophy by genetic linkage studies. 
  • Prognosis in cardiogenic shock after acute myocardial infarction in the interventional era. 
  • Prognostic implications of creatine kinase elevation after primary percutaneous coronary intervention for acute myocardial infarction. 
  • Prognostic importance of new small Q waves following non-ST-elevation acute coronary syndromes. 
  • Prognostic significance of elevated troponin I after percutaneous coronary intervention. 
  • Prognostic significance of isolated sinus tachycardia during first three days of acute myocardial infarction. 
  • Prognostic usefulness of white blood cell count and temperature in acute myocardial infarction (from the CARDINAL Trial). 
  • Prognostic value of clinical markers of reperfusion in patients with acute myocardial infarction treated by thrombolytic therapy. 
  • Prognostic value of isolated troponin elevation across the spectrum of chest pain syndromes. 
  • Prognostic value of the admission electrocardiogram in acute coronary syndromes. 
  • Prolonged total circulatory support using direct mechanical ventricular actuation. 
  • Prospective analysis of possible myocardial damage or hemolysis occurring as a result of prolonged autoperfusion angioplasty in humans. 
  • Q: elevated serum creatine kinase (does/does not) equal myocardial infarction? 
  • Quantification of infarct size by 201Tl single-photon emission computed tomography during acute myocardial infarction in humans. Comparison with enzymatic estimates. 
  • Quantification of myocardial infarction: template model for serial creatine kinase analysis. 
  • Quantitative influence of serum creatine kinase isoenzyme MB estimated infarct size and other prognostic variables on one year mortality after acute myocardial infarction. 
  • Ratio of ST-segment and myoglobin slopes to estimate myocardial salvage during thrombolytic therapy for acute myocardial infarction. 
  • Reactivation of ischemic events in acute coronary syndromes: results from GUSTO-IIb. Gobal Use of Strategies To Open occluded arteries in acute coronary syndromes. 
  • Recognition of postoperative acute myocardial infarction. Application of isoenzyme techniques. 
  • Reevaluation of myoglobin for acute chest pain evaluation: would false-positive results on "first-draw" specimens lead to increased hospital admissions? 
  • Relation between leucocyte count, myonecrosis, myocardial perfusion, and outcomes following primary angioplasty. 
  • Relation of creatine kinase isoenzyme MB to postoperative electrocardiographic diagnosis in patients undergoing coronary-artery bypass surgery. 
  • Relation of temporal creatine kinase-MB release and outcome after thrombolytic therapy for acute myocardial infarction. TAMI Study Group. 
  • Relationship between fat-to-fat-free mass ratio and decrements in leg strength after downhill running. 
  • Relationship of creatine kinase-myocardial band release to Thrombolysis in Myocardial Infarction perfusion grade after intracoronary stent placement: an ESPRIT substudy. 
  • Relative increase in creatine kinase MB isoenzyme during reperfusion after myocardial infarction is method dependent. 
  • Relaxation spectra of adenosine triphosphate-creatine phosphotransferase. 
  • Release of arachidonate from membrane phospholipids in cultured neonatal rat myocardial cells during adenosine triphosphate depletion. Correlation with the progression of cell injury. 
  • Reproducibility of chronic infarct size measurement by contrast-enhanced magnetic resonance imaging. 
  • Risk stratification in acute coronary syndromes: the need for continued vigilance in "low-risk" patients. 
  • Sarcoplasmic reticulum Ca-release channel and ATP-synthesis activities are early myocardial markers of heart failure produced by rapid ventricular pacing in dogs. 
  • Screening for Duchenne muscular dystrophy. 
  • Serum enzyme alterations in hypothyroidism before and after treatment. 
  • Serum myoglobin for the early non-invasive detection of coronary reperfusion in patients with acute myocardial infarction. 
  • Serum release of the creatine kinase tissue-specific isoforms MM3 and MB2 is simultaneous during myocardial reperfusion. 
  • Simvastatin reduces vasospasm after aneurysmal subarachnoid hemorrhage: results of a pilot randomized clinical trial. 
  • Simvastatin treatment duration and cognitive preservation in experimental subarachnoid hemorrhage. 
  • Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization. 
  • Skeletal muscle injury and repair in marathon runners after competition. 
  • Spectrum of ischemic heart disease and the role of biochemical markers. 
  • Stimulation of slow skeletal muscle fiber gene expression by calcineurin in vivo. 
  • Sustained suppression of ischemic complications of coronary intervention by platelet GP IIb/IIIa blockade with abciximab: one-year outcome in the EPILOG trial. Evaluation in PTCA to Improve Long-term Outcome with abciximab GP IIb/IIIa blockade. 
  • Temporal creatine kinase curves in acute myocardial infarction. Implications of a good empiric fit with the log-normal function. 
  • Temporal spectrum of ischemic complications with percutaneous coronary intervention: the ESPRIT experience. 
  • The SLCO1B1*5 genetic variant is associated with statin-induced side effects. 
  • The clinical and electrodiagnostic characteristics of Pompe disease with post-enzyme replacement therapy findings. 
  • The diagnosis of acute myocardial infarction. 
  • The emerging role of myoglobin for risk stratification. 
  • The importance of identification of the myocardial-specific isoenzyme of creatine phosphokinase (MB form) in the diagnosis of acute myocardial infarction. 
  • The prognostic value of creatine kinase elevations extends across the whole spectrum of acute coronary syndromes. 
  • The relationship between enzymatic and histologic estimates of the extent of myocardial infarction in conscious dogs with permanent coronary occlusion. 
  • The relationship between periprocedural myocardial infarction and subsequent target vessel revascularization following percutaneous coronary revascularization: insights from the EPIC trial. Evaluation of IIb/IIIa platelet receptor antagonist 7E3 in Preventing Ischemic Complications. 
  • The role of allopurinol and deferoxamine in preventing pressure ulcers in pigs. 
  • The safety of induced ventricular fibrillation during cardiopulmonary bypass in nonhypertrophied hearts. 
  • The significance of elevated troponin T in patients with nondialysis-dependent renal insufficiency: a validation with coronary angiography. 
  • The spectrum of unstable angina: prognostic role of serum creatine kinase determination. 
  • Thresholds for the electrocardiographic change range of biochemical markers of acute myocardial infarction (GUSTO-IIa data). 
  • Tissue engineering of functional cardiac muscle: molecular, structural, and electrophysiological studies. 
  • Troponin and other cardiac markers: role in management of acute coronary syndromes. 
  • Usefulness of combining necrosis and platelet markers in triaging patients presenting with chest pain to the emergency department. 
  • Very early diagnosis and risk stratification of patients admitted with suspected acute myocardial infarction by the combined evaluation of a single serum value of cardiac troponin-T, myoglobin, and creatine kinase MB(mass) 
  • Visualisation of presence, location, and transmural extent of healed Q-wave and non-Q-wave myocardial infarction. 
  • Visualization of discrete microinfarction after percutaneous coronary intervention associated with mild creatine kinase-MB elevation. 
  • Vitamin E, vitamin C, and exercise. 
  • [Electrocardiography and serum CK-MB determination in myocardial infarction and reperfusion in patients treated with intravenous streptokinase or placebo] 
  • [Serum creatine kinase isoenzyme MB and myoglobin in patients with acute myocardial infarction and coronary reperfusion]. 
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  Keywords of People

  • Alexander, John Hunter Peel, Professor of Medicine, Medicine, Cardiology
  • Laskowitz, Daniel Todd, Professor of Neurology, Duke Innovation & Entrepreneurship