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Subject Areas on Research
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A chimeric kinesin-1 head/kinesin-5 tail motor switches between diffusive and processive motility.
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A compliant biological vascular prosthesis.
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A hybrid polymer gel with controlled rates of cross-link rupture and self-repair.
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A laminin and nerve growth factor-laden three-dimensional scaffold for enhanced neurite extension.
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A novel intracellular protein delivery platform based on single-protein nanocapsules.
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A photopolymerized sealant for corneal lacerations.
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A preliminary study of the fixation mechanism of collagen reaction with a polyepoxy fixative.
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A structural basis for a phosphoramide mustard-induced DNA interstrand cross-link at 5'-d(GAC).
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Activity-dependent expression of RNA binding protein HuD and its association with mRNAs in neurons.
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Allelic exclusion of the TCR alpha-chain is an active process requiring TCR-mediated signaling and c-Cbl.
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Allosteric transition intermediates modelled by crosslinked haemoglobins.
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Altered posttranslational modifications of collagen in keloid.
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An assessment of the effects of shell cross-linked nanoparticle size, core composition, and surface PEGylation on in vivo biodistribution.
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Avidin-biotin interactions at vesicle surfaces: adsorption and binding, cross-bridge formation, and lateral interactions.
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B Lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse.
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BiPS, a photocleavable, isotopically coded, fluorescent cross-linker for structural proteomics.
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Binding of placental lactogen and growth hormone to fetal sheep fibroblasts.
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Biochemical identity and characterization of the mouse interleukin-2 receptor beta and gamma c subunits.
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Both heptad repeats of human respiratory syncytial virus fusion protein are potent inhibitors of viral fusion.
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Branhamella catarrhalis activates human B lymphocytes following interactions with surface IgD and class I major histocompatibility complex antigens.
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Camptothecin analogues with enhanced antitumor activity at acidic pH.
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Characterization of DNA lesions induced by CaCrO4 in synchronous and asynchronous cultured mammalian cells.
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Characterization of cDNAs encoding the polypyrimidine tract-binding protein.
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Chemical and structural modifications of alpha 2-macroglobulin: effects on receptor binding and endocytosis studied in an in vivo model.
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Chemical structure of carbamoylating groups and their relationship to bone marrow toxicity and antiglioma activity of bifunctionally alkylating and carbamoylating nitrosoureas.
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Chondrocytic differentiation of human adipose-derived adult stem cells in elastin-like polypeptide.
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Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor.
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Chromium(VI) treatment of normal human lung cells results in guanine-specific DNA polymerase arrest, DNA-DNA cross-links and S-phase blockade of cell cycle.
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Collision-induced dissociative chemical cross-linking reagents and methodology: Applications to protein structural characterization using tandem mass spectrometry analysis.
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Comparison of covalently and physically cross-linked polyethylene glycol-based hydrogels for the prevention of postoperative adhesions in a rat model.
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Consequences of chemical modifications on the free radical reactions of human hemoglobin.
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Controlled release of simvastatin from in situ forming hydrogel triggers bone formation in MC3T3-E1 cells.
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Controlling the kinetics of thiol-maleimide Michael-type addition gelation kinetics for the generation of homogenous poly(ethylene glycol) hydrogels.
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Corneal crosslinking: Current protocols and clinical approach.
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Correlation of enzymatic activities and aggregation state in chicken liver fatty acid synthase.
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Correlation of total and interstrand DNA adducts in tumor and kidney with antitumor efficacies and differential nephrotoxicities of cis-ammine/cyclohexylamine-dichloroplatinum(II) and cisplatin.
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Covalent binding of inhaled formaldehyde to DNA in the respiratory tract of rhesus monkeys: pharmacokinetics, rat-to-monkey interspecies scaling, and extrapolation to man.
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Cross-linking and disulfide bond formation of introduced cysteine residues suggest a modified model for the tertiary structure of URF13 in the pore-forming oligomers.
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Cross-linking of the cms-T maize mitochondrial pore-forming protein URF13 by N,N'-dicyclohexylcarbodiimide and its effect on URF13 sensitivity to fungal toxins.
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Crosslinked hyaluronic acid hydrogels: a strategy to functionalize and pattern.
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Crosslinking of apolipoprotein E by products of lipid peroxidation.
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DNA interstrand crosslinking and strand break repair in human glioma cell lines of varying [1,3-bis(2-chloroethyl)-1-nitrosourea] resistance.
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DNA polymerase arrest by adducted trivalent chromium.
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DNA-protein cross-links induced by nickel compounds in intact cultured mammalian cells.
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Design, expression, and immunogenicity of a soluble HIV trimeric envelope fragment adopting a prefusion gp41 configuration.
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Desmoplakin I and desmoplakin II. Purification and characterization.
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Development of bioactive photocrosslinkable fibrous hydrogels.
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Differential solubilization of placental lactogen (PL)- and growth hormone-binding sites: further evidence for a unique PL receptor in fetal and maternal liver.
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Direct liquid chromatography determination of the reactive imine SJG-136 (NSC 694501).
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Directed intermixing in multicomponent self-assembling biomaterials.
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Early metabolite levels predict long-term matrix accumulation for chondrocytes in elastin-like polypeptide biopolymer scaffolds.
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Effect of IGFBP-3 on IGF- and IGF-analogue-induced insulin-like growth factor-I receptor (IGFIR) signalling.
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Effects of a synthetic allosteric modifier of hemoglobin oxygen affinity on outcome from global cerebral ischemia in the rat.
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Effects of diethyldithiocarbamate and nine other nucleophiles on the intersubunit protein cross-linking and inactivation of purified human alpha 2-macroglobulin by cis-diamminedichloroplatinum(II).
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Effects of glutathione on chromium-induced DNA crosslinking and DNA polymerase arrest.
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Elastin-like polypeptides: biomedical applications of tunable biopolymers.
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Elicitation of neutralizing antibodies directed against CD4-induced epitope(s) using a CD4 mimetic cross-linked to a HIV-1 envelope glycoprotein.
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Endoscopic injection of glutaraldehyde cross-linked collagen for the treatment of intrinsic sphincter deficiency in women.
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Engineering oxidative stability in human hemoglobin based on the Hb providence (βK82D) mutation and genetic cross-linking.
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Ethylenecarbodiimide-fixed donor splenocyte infusions differentially target direct and indirect pathways of allorecognition for induction of transplant tolerance.
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Evidence that Gsta4 modifies susceptibility to skin tumor development in mice and humans.
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Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents.
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FMRP targets distinct mRNA sequence elements to regulate protein expression.
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Fanconi anemia complementation group A cells are hypersensitive to chromium(VI)-induced toxicity.
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Fluorescence changes on contractile activation in TnC(DANZ) labeled skinned rabbit psoas fibers.
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Formation and repair of 1,3-bis-(2-chloroethyl)-1-nitrosourea and cisplatin induced total genomic DNA interstrand crosslinks in human glioma cells.
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Free pentosidine and neopterin as markers of progression rate in diabetic nephropathy. Collaborative Study Group.
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Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif.
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Gene expression analysis of messenger RNP complexes.
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Genipin-crosslinked cartilage-derived matrix as a scaffold for human adipose-derived stem cell chondrogenesis.
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Hemoglobin-based oxygen carriers (HBOCs): structural alterations that affect free radical generation.
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Hepatitis delta virus ribozymes fold to generate a solvent-inaccessible core with essential nucleotides near the cleavage site phosphate.
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Heterogeneous basis of the type VIB form of Ehlers-Danlos syndrome (EDS VIB) that is unrelated to decreased collagen lysyl hydroxylation.
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High-frequency stress relaxation in semiflexible polymer solutions and networks.
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Human inter-α-inhibitor is a substrate for factor XIIIa and tissue transglutaminase.
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Identification of novel quaternary domain interactions in the Hsp90 chaperone, GRP94.
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Identification of the binding subunit of the D1-dopamine receptor by photoaffinity crosslinking.
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Immune focusing and enhanced neutralization induced by HIV-1 gp140 chemical cross-linking.
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Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene.
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Importance of the tmRNA system for cell survival when transcription is blocked by DNA-protein cross-links.
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Inactivation Kinetics and Mechanical Gating of Piezo1 Ion Channels Depend on Subdomains within the Cap.
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Independent analysis of bait region cleavage dependent and thiolester bond cleavage dependent conformational changes by cross-linking of alpha 2-macroglobulin with cis-dichlorodiammineplatinum(II) and dithiobis(succinimidyl propionate).
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Inter-α-inhibitor impairs TSG-6-induced hyaluronan cross-linking.
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Interaction of FANCD2 and NBS1 in the DNA damage response.
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Interlaboratory validation of a new assay for DNA-protein crosslinks.
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Intersubunit cross-linking by cis-dichlorodiammineplatinum(II) stabilizes an alpha 2-macroglobulin "nascent" state: evidence that thiol ester bond cleavage correlates with receptor recognition site exposure.
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Investigating the relationship between surface chemistry and endothelial cell growth: partial least-squares regression of the static secondary ion mass spectra of oxygen-containing plasma-deposited films.
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Kinetic study of collagen fixation with polyepoxy fixatives.
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Long-term toughness of photopolymerizable (meth)acrylate networks in aqueous environments.
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Mechanism of hypochlorite-mediated inactivation of proteinase inhibition by alpha 2-macroglobulin.
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Mechanism of the anti-tumour effect of biochemotherapy in melanoma: preliminary results.
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Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners.
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Microporous annealed particle hydrogel stiffness, void space size, and adhesion properties impact cell proliferation, cell spreading, and gene transfer.
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Mimosine, a novel inhibitor of DNA replication, binds to a 50 kDa protein in Chinese hamster cells.
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Mismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinks.
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Modification of the pharmacokinetics of high-dose cyclophosphamide and cisplatin by antiemetics.
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Murine polypyrimidine tract binding protein. Purification, cloning, and mapping of the RNA binding domain.
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Mutations near amino end of alpha1(I) collagen cause combined osteogenesis imperfecta/Ehlers-Danlos syndrome by interference with N-propeptide processing.
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N,N'-dicyclohexylcarbodiimide cross-linking suggests a central core of helices II in oligomers of URF13, the pore-forming T-toxin receptor of cms-T maize mitochondria.
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NMR-derived solution conformations of a hybrid synthetic peptide containing multiple epitopes of envelope protein gp120 from the RF strain of human immunodeficiency virus.
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Nitric oxide binding to human ferrihemoglobins cross-linked between either alpha or beta subunits.
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Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditions.
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Nucleo-cytoplasmic interactions that control nuclear envelope breakdown and entry into mitosis in the sea urchin zygote.
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Optimization of photocrosslinkable resin components and 3D printing process parameters.
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Outer membrane protein I of Pseudomonas aeruginosa is a target of cationic antimicrobial peptide/protein.
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Overexpression of lysyl oxidase to increase matrix crosslinking and improve tissue strength in dermal wound healing.
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Pathogenesis of NOD diabetes is initiated by reactivity to the insulin B chain 9-23 epitope and involves functional epitope spreading.
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Peptide array X-linking (PAX): a new peptide-protein identification approach.
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Photo cross-linkable Biodendrimers as ophthalmic adhesives for central lacerations and penetrating keratoplasties.
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Photo-activated psoralen binds the ErbB2 catalytic kinase domain, blocking ErbB2 signaling and triggering tumor cell apoptosis.
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Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be 'preferentially' transported to the cSMAC.
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Photoreceptor phosphodiesterase: interaction of inhibitory gamma subunit and cyclic GMP with specific binding sites on catalytic subunits.
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Platelet-derived growth factor receptors form a high affinity state in membrane preparations. Kinetics and affinity cross-linking studies.
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Prenylated peptides in identification of specific binding proteins.
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Prospective randomized trial of standard versus highly crosslinked tibial polyethylene in primary posterior-stabilized total knee arthroplasty: clinical and radiological follow-up at 2 to 11 years.
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Protein polymer hydrogels by in situ, rapid and reversible self-gelation.
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Proteome-Wide Structural Biology: An Emerging Field for the Structural Analysis of Proteins on the Proteomic Scale.
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Purification and properties of a multifunctional calcium/calmodulin-dependent protein kinase from rat pancreas.
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Purification of a distinct placental lactogen receptor, a new member of the growth hormone/prolactin receptor family.
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Pyrrole oxidation and protein cross-linking as necessary steps in the development of gamma-diketone neuropathy.
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Quantitative assessment of fibrinogen cross-linking by epsilon aminocaproic acid in patients with end-stage liver disease.
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Quenching of DNA cross-link precursors of chloroethylnitrosoureas and attenuation of DNA interstrand cross-linking by glutathione.
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Rapid cross-linking of elastin-like polypeptides with (hydroxymethyl)phosphines in aqueous solution.
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Rapid self-healing hydrogels.
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Regulation of leukocyte migration by activation of the leukocyte adhesion molecule-1 (LAM-1) selectin.
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Repair analysis of 4-hydroperoxycyclophosphamide-induced DNA interstrand crosslinking in the c-myc gene in 4-hydroperoxycyclophosphamide-sensitive and -resistant medulloblastoma cell lines.
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Repair of mitomycin C cross-linked DNA in mammalian cells measured by a host cell reactivation assay.
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Reshaping procedures for the surgical management of corneal ectasia.
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Resorbable, amino acid-based poly(ester urea)s crosslinked with osteogenic growth peptide with enhanced mechanical properties and bioactivity.
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Reversible cross-linking combined with immunoprecipitation to study RNA-protein interactions in vivo.
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Rotation of nucleotide sites is not required for the enzymatic activity of chloroplast coupling factor 1.
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S1-nuclease enhancement of the ethidium bromide binding assay of drug-induced DNA interstrand crosslinking in human brain tumor cells.
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SP75 is encoded by the DP87 gene and belongs to a family of modular Dictyostelium discoideum outer layer spore coat proteins.
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Sequences within a small yeast RNA required for inhibition of internal initiation of translation: interaction with La and other cellular proteins influences its inhibitory activity.
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Small-molecule dynamics and mechanisms underlying the macroscopic mechanical properties of coordinatively cross-linked polymer networks.
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Specificity of alpha 2-macroglobulin covalent cross-linking for the active domain of proteinases.
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Stabilization of HIV-1 envelope in the CD4-bound conformation through specific cross-linking of a CD4 mimetic.
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Stage- and ribosome-specific alterations in nascent chain-Sec61p interactions accompany translocation across the ER membrane.
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Stimulation and inhibition of 1,3-bis(2-chloroethyl)-1-nitrosourea-induced strand breaks and interstrand cross-linking in Col E1 plasmid deoxyribonucleic acid by polyamines and inorganic cations.
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Strong means slow: dynamic contributions to the bulk mechanical properties of supramolecular networks.
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Structural and Biochemical Characterization of the Francisella tularensis Pathogenicity Regulator, Macrophage Locus Protein A (MglA).
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Structural and Functional Analyses Reveal Insights into the Molecular Properties of the Escherichia coli Z Ring Stabilizing Protein, ZapC.
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Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins.
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Structure and function of the UvrB protein.
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Structure of the Z Ring-associated Protein, ZapD, Bound to the C-terminal Domain of the Tubulin-like Protein, FtsZ, Suggests Mechanism of Z Ring Stabilization through FtsZ Cross-linking.
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Studies of the molecular pathogenesis of hexane neuropathy. II. Evidence that pyrrole derivatization of lysyl residues leads to protein crosslinking.
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Studies on the preparation of chitosan microcarriers cross-linked by oxidized lactose and culture of primary hepatocytes.
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Swelling and mechanical behaviors of chemically cross-linked hydrogels of elastin-like polypeptides.
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Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition.
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Synthesis, characterization, and cyclic stress-influenced degradation of a poly(ethylene glycol)-based poly(beta-amino ester).
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Tandem mass spectrometry acquisition approaches to enhance identification of protein-protein interactions using low-energy collision-induced dissociative chemical crosslinking reagents.
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The MotA transcriptional activator of bacteriophage T4 binds to its specific DNA site as a monomer.
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The beta-adrenergic receptor: rapid purification and covalent labeling by photoaffinity crosslinking.
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The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks.
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The chemokines IL-8, monocyte chemoattractant protein-1, and I-309 are monomers at physiologically relevant concentrations.
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The cyanide-resistant alternative oxidases from the fungi Pichia stipitis and Neurospora crassa are monomeric and lack regulatory features of the plant enzyme.
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The effects of crosslinking of scaffolds engineered from cartilage ECM on the chondrogenic differentiation of MSCs.
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The spreading, migration and proliferation of mouse mesenchymal stem cells cultured inside hyaluronic acid hydrogels.
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The tor pathway regulates gene expression by linking nutrient sensing to histone acetylation.
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The type III transforming growth factor-beta receptor negatively regulates nuclear factor kappa B signaling through its interaction with beta-arrestin2.
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Time and distance dependence of reversible polymer bridging followed by single-molecule force spectroscopy.
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Tissue-specific expression and regulation of the alternatively-spliced forms of lysyl hydroxylase 2 (LH2) in human kidney cells and skin fibroblasts.
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Truncated forms of the insulin-like growth factor II (IGF-II)/mannose 6-phosphate receptor encompassing the IGF-II binding site: characterization of a point mutation that abolishes IGF-II binding.
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Two forms of mitochondrial DNA ligase III are produced in Xenopus laevis oocytes.
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TβRIII independently binds type I and type II TGF-β receptors to inhibit TGF-β signaling.
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URF13, a maize mitochondrial pore-forming protein, is oligomeric and has a mixed orientation in Escherichia coli plasma membranes.
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Utilizing cell-matrix interactions to modulate gene transfer to stem cells inside hyaluronic acid hydrogels.
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Vasoactive intestinal peptide (VIP) inhibits the proliferation of bone marrow progenitors through the VPAC1 receptor.
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Visualization of purified fibronectin-transglutaminase complexes.
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beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation.
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Keywords of People
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Bennett, Vann,
George Barth Geller Distinguished Professor of Molecular Biology,
Duke Cancer Institute
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Erickson, Harold Paul,
James B. Duke Distinguished Professor of Cell Biology,
Cell Biology
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Freemark, Michael Scott,
Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine,
Pediatrics, Endocrinology