Crosses, Genetic

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  Subject Areas on Research

  • 3D phenotyping and quantitative trait locus mapping identify core regions of the rice genome controlling root architecture. 
  • A biometrical genome search in rats reveals the multigenic basis of blood pressure variation. 
  • A broad competence to respond to SHORT ROOT revealed by tissue-specific ectopic expression. 
  • A cytonuclear incompatibility causes anther sterility in Mimulus hybrids. 
  • A decrease in the dose of the lgl tumor suppressor increases life span of Drosophila in stress and is related to the maternal effect. 
  • A genetic linkage map of the laboratory rat, Rattus norvegicus. 
  • A genetic map in the Mimulus guttatus species complex reveals transmission ratio distortion due to heterospecific interactions 
  • A high-density integrated genetic linkage and radiation hybrid map of the laboratory rat. 
  • A linkage map reveals a complex basis for segregation distortion in an interpopulation cross in the moss Ceratodon purpureus. 
  • A microsatellite linkage map of Drosophila mojavensis. 
  • A novel meiotic drive locus almost completely distorts segregation in mimulus (monkeyflower) hybrids. 
  • A novel modifier gene for plasma von Willebrand factor level maps to distal mouse chromosome 11. 
  • A simple genetic incompatibility causes hybrid male sterility in mimulus. 
  • A test of the chromosomal rearrangement model of speciation in Drosophila pseudoobscura. 
  • AT2 receptor and vascular smooth muscle cell differentiation in vascular development. 
  • Age-related changes in cardiac structure and function in Fischer 344 x Brown Norway hybrid rats. 
  • Airway smooth muscle relaxation is impaired in mice lacking the p47phox subunit of NAD(P)H oxidase. 
  • Allele-specific assay reveals functional variation in the chalcone synthase promoter of Arabidopsis thaliana that is compatible with neutral evolution. 
  • Allelic Imbalance Is a Prevalent and Tissue-Specific Feature of the Mouse Transcriptome. 
  • Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice. 
  • An MYH9 human disease model in flies: site-directed mutagenesis of the Drosophila non-muscle myosin II results in hypomorphic alleles with dominant character. 
  • An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion. 
  • Apolipoprotein E isoform mediated regulation of nitric oxide release. 
  • BAX-mediated cell death affects early germ cell loss and incidence of testicular teratomas in Dnd1(Ter/Ter) mice. 
  • Bayesian models for multivariate current status data with informative censoring. 
  • Bcl-2 accelerates multistep prostate carcinogenesis in vivo. 
  • Blood pressure of chickens selected for leanness or obesity. 
  • Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. 
  • C-myc-induced apoptosis in polycystic kidney disease is Bcl-2 and p53 independent. 
  • CD19 maps to a region of conservation between human chromosome 16 and mouse chromosome 7. 
  • CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes. 
  • Calcium- and calcineurin-independent roles for calmodulin in Cryptococcus neoformans morphogenesis and high-temperature growth. 
  • Canine model and genomic structural organization of glycogen storage disease type Ia (GSD Ia). 
  • Cardiac myocyte p38α kinase regulates angiogenesis via myocyte-endothelial cell cross-talk during stress-induced remodeling in the heart. 
  • Catecholamine synthesis is mediated by tyrosinase in the absence of tyrosine hydroxylase. 
  • Cell binding specificity of mouse R-cadherin and chromosomal mapping of the gene. 
  • Cellular interactions implicated in the mechanism of photoreceptor degeneration in transgenic mice expressing a mutant rhodopsin gene. 
  • Characterization and expression of the complementary DNA encoding rat histidine decarboxylase. 
  • Characterization of a male-predominant antisense transcript underexpressed in hybrids of Drosophila pseudoobscura and D. persimilis. 
  • Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci. 
  • Chromosomal localization of the ankyrinG gene (ANK3/Ank3) to human 10q21 and mouse 10. 
  • Chromosomal organization of rRNA operons in Bacillus subtilis. 
  • Chromosome breakage in Drosophila melanogaster induced by a monofunctional alkylating agent (EMS). 
  • Cis-regulatory evolution of chalcone-synthase expression in the genus Arabidopsis. 
  • Cloned mice have an obese phenotype not transmitted to their offspring. 
  • Close genetic and physical linkage between the murine haemopoietic growth factor genes GM-CSF and Multi-CSF (IL3). 
  • Comparing the linkage maps of the close relatives Arabidopsis lyrata and A. thaliana. 
  • Comparison of dose-response relationships for ethyl methanesulfonate and 1-ethyl-1-nitrosourea in Drosophila melanogaster spermatozoa. 
  • Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis. 
  • Contribution of horizontal gene transfer to the evolution of Saccharomyces cerevisiae. 
  • Contribution of various carbon sources toward isoprene biosynthesis in poplar leaves mediated by altered atmospheric CO2 concentrations. 
  • Control of expression of insulin resistance and hyperglycemia by different genetic factors in diabetic C57BL/6J mice. 
  • Control of meiotic recombination and gene expression in yeast by a simple repetitive DNA sequence that excludes nucleosomes. 
  • Coupled mutagenesis screens and genetic mapping in zebrafish. 
  • Cross-species amplification, non-invasive genotyping, and non-Mendelian inheritance of human STRPs in Savannah baboons. 
  • Cryptococcus neoformans Mating and Genetic Crosses. 
  • Cytoplasmic sharing through apical membrane remodeling. 
  • Data and animal management software for large-scale phenotype screening. 
  • Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice. 
  • Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors. 
  • Deficiency of 5-lipoxygenase accelerates renal allograft rejection in mice. 
  • Detection and localization of a single binary trait locus in experimental populations. 
  • Differences in (G+C) content between species: a commentary on Forsdyke's "chromosomal viewpoint" of speciation. 
  • Differential phosphorylation of functional tyrosines in CD19 modulates B-lymphocyte activation. 
  • Diploid strains of the pathogenic basidiomycete Cryptococcus neoformans are thermally dimorphic. 
  • Disruption of endosperm development is a major cause of hybrid seed inviability between Mimulus guttatus and Mimulus nudatus. 
  • Disruption of lysosome function promotes tumor growth and metastasis in Drosophila. 
  • Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. 
  • Down-regulation of the orphan nuclear receptor ROR gamma t is essential for T lymphocyte maturation. 
  • Drosophila as a model for the identification of genes causing adult human heart disease. 
  • Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function. 
  • Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. 
  • Effects of inversions on within- and between-species recombination and divergence. 
  • Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. 
  • Enhanced central response to dehydration in mice lacking angiotensin AT(1a) receptors. 
  • Epistasis and balanced polymorphism influencing complex trait variation. 
  • Expression of human complement factor H prevents age-related macular degeneration-like retina damage and kidney abnormalities in aged Cfh knockout mice. 
  • Factors enforcing the species boundary between the human pathogens Cryptococcus neoformans and Cryptococcus deneoformans. 
  • Failure to replicate two mate preference QTLs across multiple strains of Drosophila pseudoobscura. 
  • Fine mapping of a putative rd cDNA and its co-segregation with rd expression. 
  • Fine mapping of the Pc locus of Sorghum bicolor, a gene controlling the reaction to a fungal pathogen and its host-selective toxin. 
  • Fine-scale mapping of recombination rate in Drosophila refines its correlation to diversity and divergence. 
  • Further evidence that transposition of Tn5 in Escherichia coli is strongly enhanced by constitutively activated RecA proteins. 
  • Further selection of rat lines differing in 5-HT-1A receptor sensitivity: behavioral and functional correlates. 
  • GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination. 
  • Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system. 
  • Gene A of X174. 1. Isolation and identification of its products. 
  • Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. 
  • Gene expression divergence and the origin of hybrid dysfunctions. 
  • Genes for the neuronal immunoglobulin domain cell adhesion molecules neurofascin and Nr-CAM map to mouse chromosomes 1 and 12 and homologous human chromosomes. 
  • Genetic Dissection of Heritable Traits in Yeast Using Bulk Segregant Analysis. 
  • Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci. 
  • Genetic analysis of a morphological shape difference in the male genitalia of Drosophila simulans and D. mauritiana. 
  • Genetic animal models of depression and ethanol preference provide support for cholinergic and serotonergic involvement in depression and alcoholism. 
  • Genetic characterization of pathogenic Saccharomyces cerevisiae isolates. 
  • Genetic control of inflammatory arthritis and glomerulonephritis in congenic lpr mice and their F1 hybrids. 
  • Genetic control of peripheral leukocyte response to endotoxin in mice. 
  • Genetic control of the immune response to staphylococcal nuclease. IX. Recombination between genes determining BALB/c antinuclease idiotypes and the heavy chain allotype locus. 
  • Genetic divergence causes parallel evolution of flower color in Chilean Mimulus. 
  • Genetic factors determine the contribution of leukotrienes to acute inflammatory responses. 
  • Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. 
  • Genetic mapping of the beta-arrestin 1 and 2 genes on mouse chromosomes 7 and 11 respectively. 
  • Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling. 
  • Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice. 
  • Genetics and evolution: an iOS application to supplement introductory courses in transmission and evolutionary genetics. 
  • Genetics of a difference in cuticular hydrocarbons between Drosophila pseudoobscura and D. persimilis. 
  • Genetics of drought adaptation in Arabidopsis thaliana II. QTL analysis of a new mapping population, KAS-1 x TSU-1. 
  • Genetics of resistance to the rust fungus Coleosporium ipomoeae in three species of morning glory (Ipomoea). 
  • Genetics. Origin of species in overdrive. 
  • Genome-wide patterns of expression in Drosophila pure species and hybrid males. 
  • Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution. 
  • Geographical variation in postzygotic isolation and its genetic basis within and between two Mimulus species. 
  • Glutathione peroxidase-deficient smooth muscle cells cause paracrine activation of normal smooth muscle cells via cyclophilin A. 
  • Gnao1 (G alphaO protein) is a likely genetic contributor to variation in physical dependence on opioids in mice. 
  • Haploidy and androgenesis in Drosophila. 
  • Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4. 
  • Hepcidin, a candidate modifier of the hemochromatosis phenotype in mice. 
  • Heterothallic mating in Mucor irregularis and first isolate of the species outside of Asia. 
  • How hot are drosophila hotspots? examining recombination rate variation and associations with nucleotide diversity, divergence, and maternal age in Drosophila pseudoobscura. 
  • Hypertension and albuminuria in chronic kidney disease mapped to a mouse chromosome 11 locus. 
  • IL-4-STAT6 signal transduction-dependent induction of the clinical phase of Sjögren's syndrome-like disease of the nonobese diabetic mouse. 
  • Id3 and Id2 act as a dual safety mechanism in regulating the development and population size of innate-like γδ T cells. 
  • Identification of major quantitative trait loci underlying floral pollination syndrome divergence in Penstemon. 
  • Identification of quantitative trait loci and a candidate locus for freezing tolerance in controlled and outdoor environments in the overwintering crucifer Boechera stricta. 
  • Identifying Genetic Players in Cell Sheet Morphogenesis Using a Drosophila Deficiency Screen for Genes on Chromosome 2R Involved in Dorsal Closure. 
  • Incomplete Y chromosomes promote magnification in male and female Drosophila. 
  • Increased skin carcinogenesis in caspase-activated DNase knockout mice. 
  • Individual variation in inbreeding depression: the roles of inbreeding history and mutation. 
  • Induction of cross-reactive anti-dsDNA antibodies in preautoimmune NZB/NZW mice by immunization with bacterial DNA. 
  • Influence of genetic background on albuminuria and kidney injury in Ins2(+/C96Y) (Akita) mice. 
  • Influences of inbreeding and genetics on telomere length in mice. 
  • Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras. 
  • Integrated proteomic and transcriptomic profiling of mouse lung development and Nmyc target genes. 
  • Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity. 
  • Intrinsic and induced regulation of the age-associated onset of spontaneous experimental autoimmune encephalomyelitis. 
  • Involvement of multiple factors in the clonal deletion of self-reactive T cells. 
  • Iron in skin of mice with three etiologies of systemic iron overload. 
  • Iron increases expression of iron-export protein MTP1 in lung cells. 
  • L-selectin-deficient mice have impaired leukocyte recruitment into inflammatory sites. 
  • Leaf shape evolution has a similar genetic architecture in three edaphic specialists within the Mimulus guttatus species complex. 
  • Light controls growth and development via a conserved pathway in the fungal kingdom. 
  • Linkage mapping of the angiotensin AT2 receptor gene (Agtr2) to the mouse X chromosome. 
  • Little qualitative RNA misexpression in sterile male F1 hybrids of Drosophila pseudoobscura and D. persimilis. 
  • Localization of a retroviral element within the rd gene coding for the beta subunit of cGMP phosphodiesterase. 
  • Localization of three genes expressed in retina on mouse chromosome 11. 
  • Location of the gene involving the small eye mutation on mouse chromosome 2 suggests homology with human aniridia 2 (AN2). 
  • Loss of MST/Hippo Signaling in a Genetically Engineered Mouse Model of Fusion-Positive Rhabdomyosarcoma Accelerates Tumorigenesis. 
  • Loss of col8a1a function during zebrafish embryogenesis results in congenital vertebral malformations. 
  • Loss of the cytoskeletal protein Pdlim7 predisposes mice to heart defects and hemostatic dysfunction. 
  • Lymphocyte responses exacerbate angiotensin II-dependent hypertension. 
  • Magnification of the ribosomal genes in female Drosophila melanogaster. 
  • Mapping of sex determination loci on the white campion (Silene latifolia) Y chromosome using amplified fragment length polymorphism. 
  • Mapping of the mouse Rar loci encoding retinoic acid receptors RAR alpha, RAR beta and RAR gamma. 
  • Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors RXR alpha, RXR beta, and RXR gamma. 
  • Maximum-likelihood estimation of rates of recombination within mating-type regions. 
  • Mechanisms for dominance: Adh heterodimer formation in heterozygotes between ENU or X-ray induced null alleles and normal alleles in Drosophila melanogaster. 
  • Meiotic mutants that cause a polar decrease in recombination on the X chromosome in Caenorhabditis elegans. 
  • Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat. 
  • Microbial genetics: Love the one you're with. 
  • Modifier locus on mouse chromosome 3 for renal vascular pathology in AT1A receptor-deficiency. 
  • Molecular and genetic characterization of a radiation-induced structural rearrangement in mouse chromosome 2 causing mutations at the limb deformity and agouti loci. 
  • Molecular and phenotypic characterization of a new mouse insertional mutation that causes a defect in the distal vertebrae of the spine. 
  • Mouse small eye results from mutations in a paired-like homeobox-containing gene. 
  • Mu-opioid receptors selectively regulate basal inhibitory transmission in the central amygdala: lack of ethanol interactions. 
  • Multiple origins of hybrid strains of Cryptococcus neoformans with serotype AD. 
  • Multiple quantitative trait loci modify the heart failure phenotype in murine cardiomyopathy. 
  • Mutant mice and neuroscience: recommendations concerning genetic background. Banbury Conference on genetic background in mice. 
  • Mutants of the microtubule motor protein, nonclaret disjunctional, affect spindle structure and chromosome movement in meiosis and mitosis. 
  • Mutations produced by transmutation of phosphorus-32 to sulfur-32 within Drosophila DNA. 
  • Myocyte nuclear factor, a novel winged-helix transcription factor under both developmental and neural regulation in striated myocytes. 
  • Natural selection on a leaf-shape polymorphism in the ivyleaf morning glory (Ipomoea hederacea). 
  • Natural variation for a hybrid incompatibility between two species of Mimulus. 
  • Natural variation in CDC28 underlies morphological phenotypes in an environmental yeast isolate. 
  • Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease. 
  • Nonobese diabetic congenic strain analysis of autoimmune diabetes reveals genetic complexity of the Idd18 locus and identifies Vav3 as a candidate gene. 
  • Optimized regimen for expression of heat-inducible Cre in mice. 
  • Oxidative stress survival in a clinical Saccharomyces cerevisiae isolate is influenced by a major quantitative trait nucleotide. 
  • Patterns of evolution of genes disrupted in expression in Drosophila species hybrids. 
  • Pharmacologic disruption of TRPV1-expressing primary sensory neurons but not genetic deletion of TRPV1 protects mice against pancreatitis. 
  • Phenotypic plasticity and adaptive evolution contribute to advancing flowering phenology in response to climate change. 
  • Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung. 
  • Precise spatio-temporal regulation of the anthocyanin biosynthetic pathway leads to petal spot formation in Clarkia gracilis (Onagraceae). 
  • Properties of mouse leukemia viruses. XVII. Factors required for successful treatment of spontaneous AKR leukemia by antibodies against gp71. 
  • Protective and pathogenic roles for B cells during systemic autoimmunity in NZB/W F1 mice. 
  • Pseudohyphal growth of Cryptococcus neoformans is a reversible dimorphic transition in response to ammonium that requires Amt1 and Amt2 ammonium permeases. 
  • QTL mapping in a mouse model of cardiomyopathy reveals an ancestral modifier allele affecting heart function and survival. 
  • Rab11 helps maintain apical crumbs and adherens junctions in the Drosophila embryonic ectoderm. 
  • RacGap50C negatively regulates wingless pathway activity during Drosophila embryonic development. 
  • Ras1 controls pheromone expression and response during mating in Cryptococcus neoformans. 
  • Re-patterning of skeletal muscle energy metabolism by fat storage-inducing transmembrane protein 2. 
  • Recapitulation of the sexual cycle of the primary fungal pathogen Cryptococcus neoformans var. gattii: implications for an outbreak on Vancouver Island, Canada. 
  • Recombination, statistical power, and genetic studies of sexual isolation in Drosophila. 
  • Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II. 
  • Reduced levels of DNA polymerase delta induce chromosome fragile site instability in yeast. 
  • Reducing cerebral microvascular amyloid-beta protein deposition diminishes regional neuroinflammation in vasculotropic mutant amyloid precursor protein transgenic mice. 
  • Regulatory genes linked to the albino locus in the mouse confer competence for inducible expression on the structural gene encoding serine dehydratase. 
  • Renal growth and development in mice lacking AT1A receptors for angiotensin II. 
  • Renal tubular cell expression of MHC class II (I-Eb) is insufficient to initiate immune injury in a transgenic kidney transplant model. 
  • Requirement for Ca2+/calmodulin-dependent kinase type IV/Gr in setting the thymocyte selection threshold. 
  • Restoring striatal WAVE-1 improves maze exploration performance of GluN1 knockdown mice. 
  • Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis. 
  • Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. 
  • Role of 14-3-3-mediated p38 mitogen-activated protein kinase inhibition in cardiac myocyte survival. 
  • S-allele diversity in a natural population of Physalis crassifolia (Solanaceae) (ground cherry) assessed by RT-PCR. 
  • SXI1alpha controls uniparental mitochondrial inheritance in Cryptococcus neoformans. 
  • Small eyes (Sey): a homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse. 
  • Speciation genetics: evolving approaches. 
  • Structure of the human gene (COX6A2) for the heart/muscle isoform of cytochrome c oxidase subunit VIa and its chromosomal location in humans, mice, and cattle. 
  • Structure, function, and phylogeny of the mating locus in the Rhizopus oryzae complex. 
  • TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection. 
  • Targeted overexpression of phospholamban to mouse atrium depresses Ca2+ transport and contractility. 
  • The Sox10(Dom) mouse: modeling the genetic variation of Waardenburg-Shah (WS4) syndrome. 
  • The association of enhancement of renal allograft survival by donor-specific blood transfusion with host MHC-linked inhibition of IgG anti-donor class I alloantibody responses. 
  • The chromosomal mapping of four genes encoding winged helix proteins expressed early in mouse development. 
  • The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. 
  • The evolution of conspecific sperm precedence in Drosophila. 
  • The genetic basis of developmental abnormalities in interpopulation hybrids of the moss Ceratodon purpureus. 
  • The genetics of speciation by reinforcement. 
  • The mammalian twisted gastrulation gene functions in foregut and craniofacial development. 
  • The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine. 
  • The scale of population structure in Arabidopsis thaliana 
  • The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex. 
  • Tissue-specific expression of the human CD19 gene in transgenic mice inhibits antigen-independent B-lymphocyte development. 
  • Towards a genetic theory for the evolution of the sex ratio. III. Parental and sibling control of brood investment ratio under partial sib-mating. 
  • Transcription factors are required for the meiotic recombination hotspot at the HIS4 locus in Saccharomyces cerevisiae. 
  • Transitions in sexuality: recapitulation of an ancestral tri- and tetrapolar mating system in Cryptococcus neoformans. 
  • Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2). 
  • Uniparental mitochondrial transmission in sexual crosses in Cryptococcus neoformans. 
  • alpha AD alpha hybrids of Cryptococcus neoformans: evidence of same-sex mating in nature and hybrid fitness. 
  • dishevelled and armadillo act in the wingless signalling pathway in Drosophila. 
  • p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. 
  • zipper Nonmuscle myosin-II functions downstream of PS2 integrin in Drosophila myogenesis and is necessary for myofibril formation. 
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  Keywords of People

  • Bejsovec, Amy, Associate Professor of Biology, Biology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Noor, Mohamed A. F., Professor of Biology, Duke University