Cryptococcus neoformans

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  Subject Areas on Research

  • A MAP kinase cascade composed of cell type specific and non-specific elements controls mating and differentiation of the fungal pathogen Cryptococcus neoformans. 
  • A PCR-based strategy to generate integrative targeting alleles with large regions of homology. 
  • A Rac homolog functions downstream of Ras1 to control hyphal differentiation and high-temperature growth in the pathogenic fungus Cryptococcus neoformans. 
  • A Ras1-Cdc24 signal transduction pathway mediates thermotolerance in the fungal pathogen Cryptococcus neoformans. 
  • A Sch9 protein kinase homologue controlling virulence independently of the cAMP pathway in Cryptococcus neoformans. 
  • A flucytosine-responsive Mbp1/Swi4-like protein, Mbs1, plays pleiotropic roles in antifungal drug resistance, stress response, and virulence of Cryptococcus neoformans. 
  • A genetic linkage map of Cryptococcus neoformans variety neoformans serotype D (Filobasidiella neoformans). 
  • A glucan synthase FKS1 homolog in cryptococcus neoformans is single copy and encodes an essential function. 
  • A new dominant selectable marker for use in Cryptococcus neoformans. 
  • A unique chromosomal rearrangement in the Cryptococcus neoformans var. grubii type strain enhances key phenotypes associated with virulence. 
  • A unique fungal two-component system regulates stress responses, drug sensitivity, sexual development, and virulence of Cryptococcus neoformans. 
  • AIDS‐associated Cryptococcus neoformans and Penicillium marneffei coinfection: a therapeutic dilemma in resource‐limited settings. 
  • Adenylyl cyclase functions downstream of the Galpha protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans. 
  • Adenylyl cyclase-associated protein Aca1 regulates virulence and differentiation of Cryptococcus neoformans via the cyclic AMP-protein kinase A cascade. 
  • Allograft loss in renal transplant recipients with cryptococcus neoformans associated immune reconstitution syndrome. 
  • Amphotericin B lipid complex in the treatment of experimental cryptococcal meningitis and disseminated candidosis. 
  • Amt2 permease is required to induce ammonium-responsive invasive growth and mating in Cryptococcus neoformans. 
  • An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens. 
  • An auxotrophic pigmented Cryptococcus neoformans strain causing infection of the bone marrow. 
  • Analyses of pediatric isolates of Cryptococcus neoformans from South Africa. 
  • Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation. 
  • Antifungal management practices and evolution of infection in organ transplant recipients with cryptococcus neoformans infection. 
  • Antifungal susceptibilities of Cryptococcus neoformans. 
  • Antisense repression in Cryptococcus neoformans as a laboratory tool and potential antifungal strategy. 
  • Association of calcineurin with the COPI protein Sec28 and the COPII protein Sec13 revealed by quantitative proteomics. 
  • Binding of purified and radioiodinated capsular polysaccharides from Cryptococcus neoformans serotype A strains to capsule-free mutants. 
  • Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis. 
  • Brain inositol is a novel stimulator for promoting Cryptococcus penetration of the blood-brain barrier. 
  • C. elegans germline-deficient mutants respond to pathogen infection using shared and distinct mechanisms. 
  • C1q enhances the phagocytosis of Cryptococcus neoformans blastospores by human monocytes. 
  • Calcineurin Targets Involved in Stress Survival and Fungal Virulence. 
  • Calcineurin colocalizes with P-bodies and stress granules during thermal stress in Cryptococcus neoformans. 
  • Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with cryptococcosis. 
  • Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans. 
  • Calcineurin is required for virulence of Cryptococcus neoformans. 
  • Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans. 
  • Calcineurin, Mpk1 and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformans. 
  • Calcineurin-binding protein Cbp1 directs the specificity of calcineurin-dependent hyphal elongation during mating in Cryptococcus neoformans. 
  • Calcium- and calcineurin-independent roles for calmodulin in Cryptococcus neoformans morphogenesis and high-temperature growth. 
  • Carbonic anhydrase and CO2 sensing during Cryptococcus neoformans growth, differentiation, and virulence. 
  • Cch1 mediates calcium entry in Cryptococcus neoformans and is essential in low-calcium environments. 
  • Cell identity and sexual development in Cryptococcus neoformans are controlled by the mating-type-specific homeodomain protein Sxi1alpha. 
  • Central Role of the Trehalose Biosynthesis Pathway in the Pathogenesis of Human Fungal Infections: Opportunities and Challenges for Therapeutic Development. 
  • Challenge of Drosophila melanogaster with Cryptococcus neoformans and role of the innate immune response. 
  • Characterization and regulation of the trehalose synthesis pathway and its importance in the pathogenicity of Cryptococcus neoformans. 
  • Characterization of additional components of the environmental pH-sensing complex in the pathogenic fungus Cryptococcus neoformans. 
  • Characterization of the MFalpha pheromone of the human fungal pathogen cryptococcus neoformans. 
  • Characterization of the PMT gene family in Cryptococcus neoformans. 
  • Chemical and functional properties of metal chelators that mobilize copper to elicit fungal killing of Cryptococcus neoformans. 
  • Chlamydospore formation during hyphal growth in Cryptococcus neoformans. 
  • Chromosomal translocation and segmental duplication in Cryptococcus neoformans. 
  • Chronic cryptococcal meningitis: a new experimental model in rabbits. 
  • Clinical and environmental isolates of Cryptococcus gattii from Australia that retain sexual fecundity. 
  • Cloning the Cryptococcus neoformans TRP1 gene by complementation in Saccharomyces cerevisiae. 
  • Combination antifungals: an update. 
  • Combined activity of amphotericin B and 5-fluorocytosine against Cryptococcus neoformans in vitro and in vivo in mice. 
  • Comparative analyses of clinical and environmental populations of Cryptococcus neoformans in Botswana. 
  • Comparative analysis of environmental and clinical populations of Cryptococcus neoformans. 
  • Comparative gene genealogical analyses of strains of serotype AD identify recombination in populations of serotypes A and D in the human pathogenic yeast Cryptococcus neoformans. 
  • Comparative hybridization reveals extensive genome variation in the AIDS-associated pathogen Cryptococcus neoformans. 
  • Comparative transcriptome analysis reveals novel roles of the Ras and cyclic AMP signaling pathways in environmental stress response and antifungal drug sensitivity in Cryptococcus neoformans. 
  • Comparison of Isolator 1.5 and BACTEC NR660 aerobic 6A blood culture systems for detection of fungemia in children. 
  • Comparison of commercial kits for detection of cryptococcal antigen. 
  • Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells. 
  • Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans. 
  • Complement depletion in cryptococcal sepsis. 
  • Consensus multi-locus sequence typing scheme for Cryptococcus neoformans and Cryptococcus gattii. 
  • Conserved cAMP signaling cascades regulate fungal development and virulence. 
  • Conserved elements of the RAM signaling pathway establish cell polarity in the basidiomycete Cryptococcus neoformans in a divergent fashion from other fungi. 
  • Convergent evolution of chromosomal sex-determining regions in the animal and fungal kingdoms. 
  • Coping with stress: calmodulin and calcineurin in model and pathogenic fungi. 
  • Cryptococcal cell morphology affects host cell interactions and pathogenicity. 
  • Cryptococcal meningitis in patients with glioma: a report of two cases. 
  • Cryptococcal osteomyelitis in an adolescent survivor of T-cell acute lymphoblastic leukemia. 
  • Cryptococcal pathogenic mechanisms: a dangerous trip from the environment to the brain. 
  • Cryptococcal titan cell formation is regulated by G-protein signaling in response to multiple stimuli. 
  • Cryptococcal ventricular-peritoneal shunt infection: clinical and epidemiological evaluation of two closely associated cases. 
  • Cryptococcemia. 
  • Cryptococcosis Serotypes Impact Outcome and Provide Evidence of Cryptococcus neoformans Speciation. 
  • Cryptococcosis in human immunodeficiency virus-negative patients in the era of effective azole therapy. 
  • Cryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformans. 
  • Cryptococcosis. 
  • Cryptococcosis: a model for the understanding of infectious diseases. 
  • Cryptococcus neoformans Ilv2p confers resistance to sulfometuron methyl and is required for survival at 37 degrees C and in vivo. 
  • Cryptococcus neoformans Iron-Sulfur Protein Biogenesis Machinery Is a Novel Layer of Protection against Cu Stress. 
  • Cryptococcus neoformans Kin1 protein kinase homologue, identified through a Caenorhabditis elegans screen, promotes virulence in mammals. 
  • Cryptococcus neoformans Rim101 is associated with cell wall remodeling and evasion of the host immune responses. 
  • Cryptococcus neoformans copper detoxification machinery is critical for fungal virulence. 
  • Cryptococcus neoformans differential gene expression detected in vitro and in vivo with green fluorescent protein. 
  • Cryptococcus neoformans gene expression during experimental cryptococcal meningitis. 
  • Cryptococcus neoformans gene expression during murine macrophage infection. 
  • Cryptococcus neoformans gene involved in mammalian pathogenesis identified by a Caenorhabditis elegans progeny-based approach. 
  • Cryptococcus neoformans histone acetyltransferase Gcn5 regulates fungal adaptation to the host. 
  • Cryptococcus neoformans hyperfilamentous strain is hypervirulent in a murine model of cryptococcal meningoencephalitis. 
  • Cryptococcus neoformans in organ transplant recipients: impact of calcineurin-inhibitor agents on mortality. 
  • Cryptococcus neoformans is resistant to surfactant protein A mediated host defense mechanisms. 
  • Cryptococcus neoformans isolates from transplant recipients are not selected for resistance to calcineurin inhibitors by current immunosuppressive regimens. 
  • Cryptococcus neoformans mates on pigeon guano: implications for the realized ecological niche and globalization. 
  • Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP. 
  • Cryptococcus neoformans methionine synthase: expression analysis and requirement for virulence. 
  • Cryptococcus neoformans mitochondrial genomes from serotype A and D strains do not influence virulence. 
  • Cryptococcus neoformans mitochondrial superoxide dismutase: an essential link between antioxidant function and high-temperature growth. 
  • Cryptococcus neoformans requires a functional glycolytic pathway for disease but not persistence in the host. 
  • Cryptococcus neoformans shows a remarkable genotypic diversity in Brazil. 
  • Cryptococcus neoformans virulence gene discovery through insertional mutagenesis. 
  • Cryptococcus neoformans {alpha} strains preferentially disseminate to the central nervous system during coinfection. 
  • Cryptococcus neoformans-Cryptococcus gattii species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for amphotericin B and flucytosine. 
  • Cryptococcus neoformans: a sugar-coated killer with designer genes. 
  • Cryptococcus neoformans: the yeast that likes it hot. 
  • Cryptococcus neoformans: virulence and host defences. 
  • Cutaneous cryptococcosis in solid organ transplant recipients. 
  • Cyclic AMP signaling in Cryptococcus neoformans. 
  • Cyclic AMP-dependent protein kinase catalytic subunits have divergent roles in virulence factor production in two varieties of the fungal pathogen Cryptococcus neoformans. 
  • Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans. 
  • Cytochrome c peroxidase contributes to the antioxidant defense of Cryptococcus neoformans. 
  • DNA- and PCR-fingerprinting in fungi. 
  • Deciphering the model pathogenic fungus Cryptococcus neoformans. 
  • Defects in intracellular trafficking of fungal cell wall synthases lead to aberrant host immune recognition. 
  • Deletion of Cryptococcus neoformans AIF ortholog promotes chromosome aneuploidy and fluconazole-resistance in a metacaspase-independent manner. 
  • Development and characterization of a genetic linkage map of Cryptococcus neoformans var. neoformans using amplified fragment length polymorphisms and other markers. 
  • Development of an aerosol model of Cryptococcus reveals humidity as an important factor affecting the viability of Cryptococcus during aerosolization. 
  • Diploid strains of the pathogenic basidiomycete Cryptococcus neoformans are thermally dimorphic. 
  • Diploids in the Cryptococcus neoformans serotype A population homozygous for the alpha mating type originate via unisexual mating. 
  • Dismantling the Cryptococcus coat. 
  • Distinct and redundant roles of exonucleases in Cryptococcus neoformans: implications for virulence and mating. 
  • Divergence of protein kinase A catalytic subunits in Cryptococcus neoformans and Cryptococcus gattii illustrates evolutionary reconfiguration of a signaling cascade. 
  • Dominant selection system for use in Cryptococcus neoformans. 
  • Dynamic and heterogeneous mutations to fluconazole resistance in Cryptococcus neoformans. 
  • Eca1, a sarcoplasmic/endoplasmic reticulum Ca2+-ATPase, is involved in stress tolerance and virulence in Cryptococcus neoformans. 
  • Effect of the laccase gene CNLAC1, on virulence of Cryptococcus neoformans. 
  • Effects of cyclosporine in experimental cryptococcal meningitis. 
  • Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans. 
  • Environmental predictors and incubation period of AIDS-associated penicillium marneffei infection in Ho Chi Minh City, Vietnam. 
  • Enzymes that counteract nitrosative stress promote fungal virulence. 
  • Establishment and Use of Epidemiological Cutoff Values for Molds and Yeasts by Use of the Clinical and Laboratory Standards Institute M57 Standard. 
  • Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo. 
  • Evaluation of host immune responses to pulmonary cryptococcosis using a temperature-sensitive C. neoformans calcineurin A mutant strain. 
  • Evidence of mRNA-mediated intron loss in the human-pathogenic fungus Cryptococcus neoformans. 
  • Evidence of sexual recombination among Cryptococcus neoformans serotype A isolates in sub-Saharan Africa. 
  • Evidence that the human pathogenic fungus Cryptococcus neoformans var. grubii may have evolved in Africa. 
  • Experimental Models of Short Courses of Liposomal Amphotericin B for Induction Therapy for Cryptococcal Meningitis. 
  • Extracellular phospholipase activity is a virulence factor for Cryptococcus neoformans. 
  • Failure of ketoconazole in cryptococcal meningitis. 
  • Fatty acid synthesis is essential for survival of Cryptococcus neoformans and a potential fungicidal target. 
  • Fever and human immunodeficiency virus infection as sentinels for emerging mycobacterial and fungal bloodstream infections in hospitalized patients >/=15 years old, Bangkok. 
  • Full characterization of the Cu-, Zn-, and Cd-binding properties of CnMT1 and CnMT2, two metallothioneins of the pathogenic fungus Cryptococcus neoformans acting as virulence factors. 
  • Function of Cryptococcus neoformans KAR7 (SEC66) in karyogamy during unisexual and opposite-sex mating. 
  • Fungal genome and mating system transitions facilitated by chromosomal translocations involving intercentromeric recombination. 
  • Fungal meningitis. 
  • G protein signaling governing cell fate decisions involves opposing Galpha subunits in Cryptococcus neoformans. 
  • G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in Cryptococcus neoformans. 
  • Galleria mellonella as a model system to study Cryptococcus neoformans pathogenesis. 
  • Gene disruption by biolistic transformation in serotype D strains of Cryptococcus neoformans. 
  • Gene transfer in Cryptococcus neoformans by use of biolistic delivery of DNA. 
  • Genetics of Cryptococcus neoformans. 
  • Had1 Is Required for Cell Wall Integrity and Fungal Virulence in Cryptococcus neoformans. 
  • Human alveolar and peritoneal macrophages mediate fungistasis independently of L-arginine oxidation to nitrite or nitrate. 
  • Human immunodeficiency virus (HIV)-infected human blood monocytes and peritoneal macrophages have reduced anticryptococcal activity whereas HIV-infected alveolar macrophages retain normal activity. 
  • Human natural killer cells do not inhibit growth of Cryptococcus neoformans in the absence of antibody. 
  • Hybridization probes for conventional DNA fingerprinting used as single primers in the polymerase chain reaction to distinguish strains of Cryptococcus neoformans. 
  • Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans. 
  • Identification and characterization of an SKN7 homologue in Cryptococcus neoformans. 
  • Identification and characterization of the Cryptococcus neoformans phosphomannose isomerase-encoding gene, MAN1, and its impact on pathogenicity. 
  • Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans. 
  • Identification of Cryptococcus neoformans temperature-regulated genes with a genomic-DNA microarray. 
  • Identification of ENA1 as a virulence gene of the human pathogenic fungus Cryptococcus neoformans through signature-tagged insertional mutagenesis. 
  • Identification of a Cryptococcus neoformans gene that directs expression of the cryptic Saccharomyces cerevisiae mannitol dehydrogenase gene. 
  • Identification of cyclosporin C from Amphichorda felina using a Cryptococcus neoformans differential temperature sensitivity assay. 
  • Identification of genes from the fungal pathogen Cryptococcus neoformans related to transmigration into the central nervous system. 
  • Identification of the MATa mating-type locus of Cryptococcus neoformans reveals a serotype A MATa strain thought to have been extinct. 
  • Identifying a novel connection between the fungal plasma membrane and pH-sensing. 
  • Immunology of infection caused by Cryptococcus neoformans. 
  • Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin. 
  • Impact of Protein Palmitoylation on the Virulence Potential of Cryptococcus neoformans. 
  • Impact of mating type, serotype, and ploidy on the virulence of Cryptococcus neoformans. 
  • Impact of surfactant protein D, interleukin-5, and eosinophilia on Cryptococcosis. 
  • In vitro and in vivo efficacies of the azole SCH56592 against Cryptococcus neoformans. 
  • In vitro and in vivo efficacies of the new triazole albaconazole against Cryptococcus neoformans. 
  • In vitro and in vivo efficacy of the triazole TAK-187 against Cryptococcus neoformans. 
  • In vitro phagocytosis and intracellular fate of variously encapsulated strains of Cryptococcus neoformans. 
  • In-vitro activity of dicationic aromatic compounds and fluconazole against Cryptococcus neoformans and Candida spp. 
  • Induction of interleukin-6 mRNA in rat alveolar macrophages by in vitro exposure to both Cryptococcus neoformans and anti-C. neoformans antiserum. 
  • Influence of agglutinating antibody in experimental cryptococcal meningitis. 
  • Inhibition of Cryptococcus neoformans replication by nitrogen oxides supports the role of these molecules as effectors of macrophage-mediated cytostasis. 
  • Interaction between genetic background and the mating-type locus in Cryptococcus neoformans virulence potential. 
  • Interaction of Cryptococcus neoformans Rim101 and protein kinase A regulates capsule. 
  • Intracellular Action of a Secreted Peptide Required for Fungal Virulence. 
  • Investigating Conservation of the Cell-Cycle-Regulated Transcriptional Program in the Fungal Pathogen, Cryptococcus neoformans. 
  • Investigation of the basis of virulence in serotype A strains of Cryptococcus neoformans from apparently immunocompetent individuals. 
  • Isolates of Cryptococcus neoformans from infected animals reveal genetic exchange in unisexual, alpha mating type populations. 
  • Isolation of Cryptococcus gattii and Cryptococcus neoformans var. grubii from the flowers and bark of Eucalyptus trees in India. 
  • It infects me, it infects me not: phenotypic switching in the fungal pathogen Cryptococcus neoformans. 
  • Karyotyping of Cryptococcus neoformans as an epidemiological tool. 
  • Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis. 
  • Killing of Cryptococcus neoformans by rat alveolar macrophages. 
  • Killing of Cryptococcus neoformans strains by human neutrophils and monocytes. 
  • Life-threatening asymptomatic incidentaloma: a case report of idiopathic CD4 lymphocytopenia and opportunistic infections. 
  • Light controls growth and development via a conserved pathway in the fungal kingdom. 
  • Live Imaging of Host-Parasite Interactions in a Zebrafish Infection Model Reveals Cryptococcal Determinants of Virulence and Central Nervous System Invasion. 
  • Loss of allergen 1 confers a hypervirulent phenotype that resembles mucoid switch variants of Cryptococcus neoformans. 
  • Macrophage-mediated fungistasis in vitro: requirements for intracellular and extracellular cytotoxicity. 
  • Macrophage-mediated fungistasis: requirement for a macromolecular component in serum. 
  • Manifestations of pulmonary cryptococcosis in patients with acquired immunodeficiency syndrome. 
  • Many globally isolated AD hybrid strains of Cryptococcus neoformans originated in Africa. 
  • Mating-type locus of Cryptococcus neoformans: a step in the evolution of sex chromosomes. 
  • Mating-type-specific and nonspecific PAK kinases play shared and divergent roles in Cryptococcus neoformans. 
  • Mechanisms for copper acquisition, distribution and regulation. 
  • Metabolic adaptation in Cryptococcus neoformans during early murine pulmonary infection. 
  • Metabolic fate of L-arginine in relation to microbiostatic capability of murine macrophages. 
  • Method for the purification of Filobasidiella neoformans basidiospores by flow cytometry. 
  • Microevolution of Serial Clinical Isolates of Cryptococcus neoformans var. grubii and C. gattii. 
  • Molecular analysis of the Cryptococcus neoformans ADE2 gene, a selectable marker for transformation and gene disruption. 
  • Molecular and genetic analysis of the Cryptococcus neoformans MET3 gene and a met3 mutant. 
  • Morphogenesis of Cryptococcus neoformans. 
  • Most environmental isolates of Cryptococcus neoformans var. grubii (serotype A) are not lethal for mice. 
  • Multilocus sequence typing of serially collected isolates of Cryptococcus from HIV-infected patients in South Africa. 
  • Multilocus sequence typing reveals three genetic subpopulations of Cryptococcus neoformans var. grubii (serotype A), including a unique population in Botswana. 
  • Multiple gene genealogies reveal recent dispersion and hybridization in the human pathogenic fungus Cryptococcus neoformans. 
  • Multiple origins of hybrid strains of Cryptococcus neoformans with serotype AD. 
  • Network-assisted genetic dissection of pathogenicity and drug resistance in the opportunistic human pathogenic fungus Cryptococcus neoformans. 
  • Next generation multilocus sequence typing (NGMLST) and the analytical software program MLSTEZ enable efficient, cost-effective, high-throughput, multilocus sequencing typing. 
  • Novel chimeric spermidine synthase-saccharopine dehydrogenase gene (SPE3-LYS9) in the human pathogen Cryptococcus neoformans. 
  • Novel gene functions required for melanization of the human pathogen Cryptococcus neoformans. 
  • On the origins of congenic MATalpha and MATa strains of the pathogenic yeast Cryptococcus neoformans. 
  • Opsonic activity of cerebrospinal fluid in experimental cryptococcal meningitis. 
  • Ordered kinetochore assembly in the human-pathogenic basidiomycetous yeast Cryptococcus neoformans. 
  • PAK kinases Ste20 and Pak1 govern cell polarity at different stages of mating in Cryptococcus neoformans. 
  • PRM1 and KAR5 function in cell-cell fusion and karyogamy to drive distinct bisexual and unisexual cycles in the Cryptococcus pathogenic species complex. 
  • Pathogenesis of Cryptococcus neoformans is associated with quantitative differences in multiple virulence factors. 
  • Pde1 phosphodiesterase modulates cyclic AMP levels through a protein kinase A-mediated negative feedback loop in Cryptococcus neoformans. 
  • Peroxisome function regulates growth on glucose in the basidiomycete fungus Cryptococcus neoformans. 
  • Phagocytosis and killing of Cryptococcus neoformans by rat alveolar macrophages in the absence of serum. 
  • Phagocytosis of Cryptococcus neoformans by rat alveolar macrophages. 
  • Pharmacodynamics of liposomal amphotericin B and flucytosine for cryptococcal meningoencephalitis: safe and effective regimens for immunocompromised patients. 
  • Pharmacokinetics and pharmacodynamics of fluconazole for cryptococcal meningoencephalitis: implications for antifungal therapy and in vitro susceptibility breakpoints. 
  • Phenotypic Variability Correlates with Clinical Outcome in Cryptococcus Isolates Obtained from Botswanan HIV/AIDS Patients. 
  • Pheromones stimulate mating and differentiation via paracrine and autocrine signaling in Cryptococcus neoformans. 
  • Phospholipid-binding protein Cts1 controls septation and functions coordinately with calcineurin in Cryptococcus neoformans. 
  • Physical maps for genome analysis of serotype A and D strains of the fungal pathogen Cryptococcus neoformans. 
  • Pleiotropic effects of deubiquitinating enzyme Ubp5 on growth and pathogenesis of Cryptococcus neoformans. 
  • Pleiotropic roles of the Msi1-like protein Msl1 in Cryptococcus neoformans. 
  • Polymerase chain reaction fingerprinting in fungi using single primers specific to minisatellites and simple repetitive DNA sequences: strain variation in Cryptococcus neoformans. 
  • Population genetic analyses reveal the African origin and strain variation of Cryptococcus neoformans var. grubii. 
  • Population genomics and the evolution of virulence in the fungal pathogen Cryptococcus neoformans. 
  • Practice guidelines for the management of cryptococcal disease. Infectious Diseases Society of America. 
  • Production of the hexitol D-mannitol by Cryptococcus neoformans in vitro and in rabbits with experimental meningitis. 
  • Protection against cryptococcosis by using a murine gamma interferon-producing Cryptococcus neoformans strain. 
  • Pseudohyphal growth of Cryptococcus neoformans is a reversible dimorphic transition in response to ammonium that requires Amt1 and Amt2 ammonium permeases. 
  • Pulmonary cryptococcosis in patients without HIV infection: factors associated with disseminated disease. 
  • Pulmonary cryptococcosis in solid organ transplant recipients: clinical relevance of serum cryptococcal antigen. 
  • RAS1 regulates filamentation, mating and growth at high temperature of Cryptococcus neoformans. 
  • RNAi function, diversity, and loss in the fungal kingdom. 
  • Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR. 
  • Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans. 
  • Rapid mapping of insertional mutations to probe cell wall regulation in Cryptococcus neoformans. 
  • Ras1 acts through duplicated Cdc42 and Rac proteins to regulate morphogenesis and pathogenesis in the human fungal pathogen Cryptococcus neoformans. 
  • Ras1 and Ras2 contribute shared and unique roles in physiology and virulence of Cryptococcus neoformans. 
  • Ras1 controls pheromone expression and response during mating in Cryptococcus neoformans. 
  • Recapitulation of the sexual cycle of the primary fungal pathogen Cryptococcus neoformans var. gattii: implications for an outbreak on Vancouver Island, Canada. 
  • Recent evolution of the human pathogen Cryptococcus neoformans by intervarietal transfer of a 14-gene fragment. 
  • Reciprocal functions of Cryptococcus neoformans copper homeostasis machinery during pulmonary infection and meningoencephalitis. 
  • Recombination hotspots flank the Cryptococcus mating-type locus: implications for the evolution of a fungal sex chromosome. 
  • Regulation of cytochrome c oxidase subunit 1 (COX1) expression in Cryptococcus neoformans by temperature and host environment. 
  • Relationship of the glyoxylate pathway to the pathogenesis of Cryptococcus neoformans. 
  • Remodeling of global transcription patterns of Cryptococcus neoformans genes mediated by the stress-activated HOG signaling pathways. 
  • Repeated therapeutic lumbar punctures in cryptococcal meningitis - necessity and/or opportunity? 
  • Restricted substrate specificity for the geranylgeranyltransferase-I enzyme in Cryptococcus neoformans: implications for virulence. 
  • Rewiring of Signaling Networks Modulating Thermotolerance in the Human Pathogen Cryptococcus neoformans. 
  • Rim Pathway-Mediated Alterations in the Fungal Cell Wall Influence Immune Recognition and Inflammation. 
  • Role of PLB1 in pulmonary inflammation and cryptococcal eicosanoid production. 
  • Role of alternative oxidase gene in pathogenesis of Cryptococcus neoformans. 
  • Role of protein O-mannosyltransferase Pmt4 in the morphogenesis and virulence of Cryptococcus neoformans. 
  • Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans. 
  • Seasonal variation in the etiology of bloodstream infections in a febrile inpatient population in a developing country. 
  • Secretion of FK506/FK520 and rapamycin by Streptomyces inhibits the growth of competing Saccharomyces cerevisiae and Cryptococcus neoformans. 
  • Separation of chromosomes of Cryptococcus neoformans by pulsed field gel electrophoresis. 
  • Septins enforce morphogenetic events during sexual reproduction and contribute to virulence of Cryptococcus neoformans. 
  • Serotype AD strains of Cryptococcus neoformans are diploid or aneuploid and are heterozygous at the mating-type locus. 
  • Sex-induced silencing defends the genome of Cryptococcus neoformans via RNAi. 
  • Sex-induced silencing operates during opposite-sex and unisexual reproduction in Cryptococcus neoformans. 
  • Sex-specific homeodomain proteins Sxi1alpha and Sxi2a coordinately regulate sexual development in Cryptococcus neoformans. 
  • Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates. 
  • Sexual reproduction between partners of the same mating type in Cryptococcus neoformans. 
  • Signal transduction cascades regulating mating, filamentation, and virulence in Cryptococcus neoformans. 
  • Signal transduction pathways regulating differentiation and pathogenicity of Cryptococcus neoformans. 
  • Signalling pathways in the pathogenesis of Cryptococcus. 
  • Specialization of the HOG pathway and its impact on differentiation and virulence of Cryptococcus neoformans. 
  • Specific activities of dolastatin 10 and peptide derivatives against Cryptococcus neoformans. 
  • Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages. 
  • Spores as infectious propagules of Cryptococcus neoformans. 
  • Ssk2 mitogen-activated protein kinase kinase kinase governs divergent patterns of the stress-activated Hog1 signaling pathway in Cryptococcus neoformans. 
  • Strain variation in antiphagocytic activity of capsular polysaccharides from Cryptococcus neoformans serotype A. 
  • Strain variation in composition and molecular size of the capsular polysaccharide of Cryptococcus neoformans serotype A. 
  • Strain-dependent effects of environmental signals on the production of extracellular phospholipase by Cryptococcus neoformans. 
  • Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance. 
  • Structures of Cryptococcus neoformans protein farnesyltransferase reveal strategies for developing inhibitors that target fungal pathogens. 
  • Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis. 
  • Study of Cryptococcus neoformans actin gene regulation with a beta-galactosidase-actin fusion. 
  • Subcellular localization directs signaling specificity of the Cryptococcus neoformans Ras1 protein. 
  • Superoxide dismutase influences the virulence of Cryptococcus neoformans by affecting growth within macrophages. 
  • Surfactant protein D binding to Aspergillus fumigatus hyphae is calcineurin-sensitive. 
  • Surfactant protein D facilitates Cryptococcus neoformans infection. 
  • Surfactant protein D increases phagocytosis of hypocapsular Cryptococcus neoformans by murine macrophages and enhances fungal survival. 
  • Survival defects of Cryptococcus neoformans mutants exposed to human cerebrospinal fluid result in attenuated virulence in an experimental model of meningitis. 
  • Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans. 
  • Synthesis and antifungal activities of miltefosine analogs. 
  • Synthesis of polymerized melanin by Cryptococcus neoformans in infected rodents. 
  • Systematic functional profiling of transcription factor networks in Cryptococcus neoformans. 
  • Targeted gene replacement demonstrates that myristoyl-CoA: protein N-myristoyltransferase is essential for viability of Cryptococcus neoformans. 
  • Temperature affects the susceptibility of Cryptococcus neoformans biofilms to antifungal agents. 
  • The C2 domain protein Cts1 functions in the calcineurin signaling circuit during high-temperature stress responses in Cryptococcus neoformans. 
  • The Case for Adopting the "Species Complex" Nomenclature for the Etiologic Agents of Cryptococcosis 
  • The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function. 
  • The Cryptococcus neoformans Rho-GDP dissociation inhibitor mediates intracellular survival and virulence. 
  • The Cryptococcus neoformans Rim101 transcription factor directly regulates genes required for adaptation to the host. 
  • The Cryptococcus neoformans alkaline response pathway: identification of a novel rim pathway activator. 
  • The Cryptococcus neoformans capsule: a sword and a shield. 
  • The Cryptococcus neoformans catalase gene family and its role in antioxidant defense. 
  • The Cryptococcus neoformans genome sequencing project. 
  • The Cryptococcus neoformans transcriptome at the site of human meningitis. 
  • The G-protein beta subunit GPB1 is required for mating and haploid fruiting in Cryptococcus neoformans. 
  • The RAM1 gene encoding a protein-farnesyltransferase beta-subunit homologue is essential in Cryptococcus neoformans. 
  • The STE12alpha homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans. 
  • The actin gene from Cryptococcus neoformans: structure and phylogenetic analysis. 
  • The alpha-specific cell identity factor Sxi1alpha is not required for virulence of Cryptococcus neoformans. 
  • The biology of the Cryptococcus neoformans species complex. 
  • The copper regulon of the human fungal pathogen Cryptococcus neoformans H99. 
  • The gene encoding phosphoribosylaminoimidazole carboxylase (ADE2) is essential for growth of Cryptococcus neoformans in cerebrospinal fluid. 
  • The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans. 
  • The human fungal pathogen Cryptococcus can complete its sexual cycle during a pathogenic association with plants. 
  • The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein. 
  • The impact of the host on fungal infections. 
  • The pharmacokinetics of BAY R3783 and its efficacy in the treatment of experimental cryptococcal meningitis. 
  • The role of Aspartyl aminopeptidase (Ape4) in Cryptococcus neoformans virulence and authophagy. 
  • The role of the classical and alternate complement pathways in host defenses against Cryptococcus neoformans infection. 
  • The role of the de novo pyrimidine biosynthetic pathway in Cryptococcus neoformans high temperature growth and virulence. 
  • The triple threat of cryptococcosis: it's the body site, the strain, and/or the host. 
  • Threonine biosynthetic genes are essential in Cryptococcus neoformans. 
  • Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators. 
  • Tracing Genetic Exchange and Biogeography of Cryptococcus neoformans var. grubii at the Global Population Level. 
  • Transcription factor Nrg1 mediates capsule formation, stress response, and pathogenesis in Cryptococcus neoformans. 
  • Transcription factors Mat2 and Znf2 operate cellular circuits orchestrating opposite- and same-sex mating in Cryptococcus neoformans. 
  • Transcriptional network of multiple capsule and melanin genes governed by the Cryptococcus neoformans cyclic AMP cascade. 
  • Transgene induced co-suppression during vegetative growth in Cryptococcus neoformans. 
  • Transitions in sexuality: recapitulation of an ancestral tri- and tetrapolar mating system in Cryptococcus neoformans. 
  • Treatment of experimental cryptococcal meningitis and disseminated candidiasis with SCH39304. 
  • Treatment of experimental cryptococcal meningitis with amphotericin B, 5-fluorocytosine, and ketoconazole. 
  • Two CDC42 paralogues modulate Cryptococcus neoformans thermotolerance and morphogenesis under host physiological conditions. 
  • Two Rac paralogs regulate polarized growth in the human fungal pathogen Cryptococcus neoformans. 
  • Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans. 
  • Uniparental mitochondrial transmission in sexual crosses in Cryptococcus neoformans. 
  • Unique oligonucleotide primers in PCR for identification of Cryptococcus neoformans. 
  • Unisexual and heterosexual meiotic reproduction generate aneuploidy and phenotypic diversity de novo in the yeast Cryptococcus neoformans. 
  • Unisexual reproduction drives meiotic recombination and phenotypic and karyotypic plasticity in Cryptococcus neoformans. 
  • Unisexual reproduction enhances fungal competitiveness by promoting habitat exploration via hyphal growth and sporulation. 
  • Unisexual reproduction reverses Muller's ratchet. 
  • Unisexual reproduction. 
  • Unisexual versus bisexual mating in Cryptococcus neoformans: Consequences and biological impacts. 
  • Unveiling Protein Kinase A Targets in Cryptococcus neoformans Capsule Formation. 
  • Urease as a virulence factor in experimental cryptococcosis. 
  • Urease expression by Cryptococcus neoformans promotes microvascular sequestration, thereby enhancing central nervous system invasion. 
  • Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients. 
  • Very low levels of 25-hydroxyvitamin D are not associated with immunologic changes or clinical outcome in South African patients with HIV-associated cryptococcal meningitis. 
  • Virulence attributes and hyphal growth of C. neoformans are quantitative traits and the MATalpha allele enhances filamentation. 
  • Virulence factors identified by Cryptococcus neoformans mutant screen differentially modulate lung immune responses and brain dissemination. 
  • Virulence mechanisms and Cryptococcus neoformans pathogenesis. 
  • Virulence of Cryptococcus neoformans. Regulation of capsule synthesis by carbon dioxide. 
  • Wsp1 is downstream of Cin1 and regulates vesicle transport and actin cytoskeleton as an effector of Cdc42 and Rac1 in Cryptococcus neoformans. 
  • alpha AD alpha hybrids of Cryptococcus neoformans: evidence of same-sex mating in nature and hybrid fitness. 
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  Keywords of People

  • Aballay, Alejandro, Adjunct Professor in the Department of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology