Crystallins
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Subject Areas on Research
- A non-lens member of the beta gamma-crystallin superfamily in a vertebrate, the amphibian Cynops.
- Alpha-crystallin, a molecular chaperone, forms a stable complex with carbonic anhydrase upon heat denaturation.
- Assignment of human gamma crystallin multigene family to chromosome 2.
- Assignment of the zeta-crystallin gene (CRYZ) to human chromosome 1p22-p31 and identification of restriction fragment length polymorphisms.
- Betaine-homocysteine methyltransferase is a developmentally regulated enzyme crystallin in rhesus monkey lens.
- Carbonyl-metabolizing enzymes and their relatives recruited as structural proteins in the eye lens.
- Chaperone-like activity of alpha-crystallin. The effect of NADPH on its interaction with zeta-crystallin.
- Colloid osmotic pressure of steer alpha- and beta-crystallins: possible functional roles for lens crystallin distribution and structural diversity.
- Colloid osmotic pressure of steer crystallins: implications for the origin of the refractive index gradient and transparency of the lens.
- Comparative analysis of the zeta-crystallin/quinone reductase gene in guinea pig and mouse.
- Coordinated activation of corneal wound response genes in vivo as observed by in situ hybridization.
- Developmental analysis of ocular morphogenesis in alpha A-crystallin/diphtheria toxin transgenic mice undergoing ablation of the lens.
- Electron tomography of fiber cell cytoplasm and dense cores of multilamellar bodies from human age-related nuclear cataracts.
- Embryology and morphology of microphthalmia in transgenic mice expressing a gamma F-crystallin/diphtheria toxin A hybrid gene.
- Enzyme/crystallins and extremely high pyridine nucleotide levels in the eye lens.
- Evidence for independent recruitment of zeta-crystallin/quinone reductase (CRYZ) as a crystallin in camelids and hystricomorph rodents.
- Evidence that alpha-crystallin prevents non-specific protein aggregation in the intact eye lens.
- Evolution of graded refractive index in squid lenses.
- Extremely high levels of NADPH in guinea pig lens: correlation with zeta-crystallin concentration.
- Genetic ablation in transgenic mice with an attenuated diphtheria toxin A gene.
- Guinea pig and bovine zeta-crystallins have distinct functional characteristics highlighting replacements in otherwise similar structures.
- Identification and characterization of the enzymatic activity of zeta-crystallin from guinea pig lens. A novel NADPH:quinone oxidoreductase.
- Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA.
- Inhibition of Rho-kinase induces alphaB-crystallin expression in lens epithelial cells.
- Meta-analysis of genome-wide association studies in multiethnic Asians identifies two loci for age-related nuclear cataract.
- Molecular cloning and sequencing of zeta-crystallin/quinone reductase cDNA from human liver.
- Mutant zeta-crystallin from guinea-pig hereditary cataracts has altered structural and enzymatic properties.
- Obstruction of aqueous outflow by lens particles and by heavy-molecular-weight soluble lens proteins.
- Organization of the human zeta-crystallin/quinone reductase gene (CRYZ).
- Proteomic analysis of regenerated rabbit lenses reveal crystallin expression characteristic of adult rabbits.
- Purification and characterization of zeta-crystallin/quinone reductase from guinea pig liver.
- Regulation and localization of HSP70 and HSP25 in the kidney of rats undergoing long-term administration of angiotensin II.
- Spectral studies on normal and cataractous intact human lenses.
- The transcripts of zeta-crystallin, a lens protein related to the alcohol dehydrogenase family, are altered in a guinea-pig hereditary cataract.
- The tyrosine corner: a feature of most Greek key beta-barrel proteins.
- Transcriptional regulation of crystallin, redox, and apoptotic genes by C-Phycocyanin in the selenite-induced cataractogenic rat model.
- Transient regulation of c-fos, alpha B-crystallin, and hsp70 in muscle during recovery from contractile activity.
- Tryptophan excited states and cataracts in the human lens.
- Ultrastructural analysis of the human lens fiber cell remodeling zone and the initiation of cellular compaction.
- Zeta-crystallin from guinea pig lens is capable of functioning catalytically as an oxidoreductase.
- Zeta-crystallin versus other members of the alcohol dehydrogenase super-family. Variability as a functional characteristic.
- Zeta-crystallin: a lens-specific promoter and the gene recruitment of an enzyme as a crystallin.
- alpha-Crystallin chaperone activity is reduced by calpain II in vitro and in selenite cataract.
- alpha-Crystallin localizes to the leading edges of migrating lens epithelial cells.
- zeta-Crystallin is a major protein in the lens of Camelus dromedarius.