Cyclization

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  Subject Areas on Research

  • A convenient synthesis of cis and trans 4-tert-butoxycarbonyl-substituted cyclohexylglycine. 
  • A new strategy toward indole alkaloids involving an intramolecular cycloaddition/rearrangement cascade. 
  • A robust platform for the synthesis of new tetracycline antibiotics. 
  • An efficient synthesis of fluorinated azaheterocycles by aminocyclization of alkenes. 
  • Application of ruthenium-induced macrocyclization for the construction of macrocyclic depsipeptides. 
  • Bicyclo[3.2.0]heptane mechanophores for the non-scissile and photochemically reversible generation of reactive bis-enones. 
  • Close the ring to break the cycle: tandem quinolone-alkyne-cyclisation gives access to tricyclic pyrrolo[1,2-a]quinolin-5-ones with potent anti-protozoal activity. 
  • Cyclization/hydrosilylation of functionalized 1,6-diynes catalyzed by cationic platinum complexes containing bidentate nitrogen ligands. 
  • Dichloroketene-induced cyclizations of vinyl sulfilimines: application of the method in the synthesis of (+/-)-desoxyeseroline. 
  • Enantioselective cyclization/hydrosilylation of 1,6-enynes catalyzed by a cationic rhodium bis(phosphine) complex. 
  • Enantioselective synthesis of cyclic enol ethers and all-carbon quaternary stereogenic centers through catalytic asymmetric ring-closing metathesis. 
  • Gold(I)-catalyzed enantioselective intramolecular dehydrative amination of allylic alcohols with carbamates. 
  • Gold(I)-catalyzed intramolecular amination of allylic alcohols with alkylamines. 
  • Gold(I)-catalyzed intramolecular dihydroamination of allenes with N,N'-disubstituted ureas to form bicyclic imidazolidin-2-ones. 
  • Mechanism of palladium-catalyzed diene cyclization/hydrosilylation: direct observation of intramolecular carbometalation. 
  • Metabolomics and mass isotopomer analysis as a strategy for pathway discovery: pyrrolyl and cyclopentenyl derivatives of the pro-drug of abuse, levulinate. 
  • Metal-catalyzed nitrogen-atom transfer methods for the oxidation of aliphatic C-H bonds. 
  • Model Studies To Access the [6,7,5,5]-Core of Ineleganolide Using Tandem Translactonization-Cope or Cyclopropanation-Cope Rearrangements as Key Steps. 
  • One-pot synthesis of 3-azido- and 3-aminopiperidines by intramolecular cyclization of unsaturated amines. 
  • Palladium-catalyzed asymmetric diene cyclization/hydrosilylation employing functionalized silanes and disiloxanes. 
  • Platinum-catalyzed intramolecular alkylation of indoles with unactivated olefins. 
  • Platinum-catalyzed intramolecular hydroalkoxylation of gamma- and delta-hydroxy olefins to form cyclic ethers. 
  • Post-assembly derivatization of electrospun nanofibers via strain-promoted azide alkyne cycloaddition. 
  • Recent developments in enantioselective gold(I) catalysis. 
  • Stereoselective synthesis of tetrahydrofuran lignans via BF(3) x OEt(2)-promoted reductive deoxygenation/epimerization of cyclic hemiketal: synthesis of (-)-odoratisol C, (-)-futokadsurin A, (-)-veraguensin, (+)-fragransin A(2), (+)-galbelgin, and (+)-talaumidin. 
  • Stress-responsive polymers containing cyclobutane core mechanophores: reactivity and mechanistic insights. 
  • Synthesis of the tetracyclic framework of the erythrina alkaloids using a [4 + 2]-cycloaddition/Rh(I)-catalyzed cascade of 2-imidofurans. 
  • Synthetic and mechanistic studies of the cycloisomerization and cyclization/hydrosilylation of functionalized dienes catalyzed by cationic palladium(II) complexes. 
  • Total synthesis and molecular target of largazole, a histone deacetylase inhibitor. 
  • Use of pentamethyldisiloxane in the palladium-catalyzed cyclization/hydrosilylation of functionalized dienes. 
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  Keywords of People

  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma