Cycloheximide

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  Subject Areas on Research

  • 3H-uridine incorporation as a T lymphocyte indicator in the rat. 
  • A STE12 homolog is required for mating but dispensable for filamentation in candida lusitaniae. 
  • A critical role of eEF-2K in mediating autophagy in response to multiple cellular stresses. 
  • A kinetic study of embryonic cell adhesion. 
  • A requirement for trypsin-sensitive cell-surface components for cell-cell interactions of embryonic neural retina cells. 
  • A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation. 
  • Activation of the heat shock transcription factor by hypoxia in mammalian cells. 
  • Alpha interferon and gamma interferon stimulate transcription of a single gene through different signal transduction pathways. 
  • Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells. 
  • Angiotensin II induces c-fos expression in smooth muscle via transcriptional control. 
  • Apoptosis rate can be accelerated or decelerated by overexpression or reduction of the level of elongation factor-1 alpha. 
  • Beta adrenergic stimulation of protein carboxymethylation and amylase secretion in rat parotid gland. 
  • Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells. 
  • CYLD deubiquitinates RIP1 in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis. 
  • Ca(2+)-independent arachidonic acid release by vascular endothelium requires protein synthesis de novo. 
  • Cell cycle-dependent expression of thyroid hormone receptor-beta is a mechanism for variable hormone sensitivity. 
  • Characterization of equine herpesvirus type 1 immediate early proteins. 
  • Characterization of human chemotactic lymphokine production induced by mitogens and mixed leukocyte reactions using a new microassay. 
  • Chemistry and biology of copper-chelatin. 
  • Chemoattractant-induced activation of c-fos gene expression in human monocytes. 
  • Chemotactic factor and P15E-related chemotaxis inhibitor in human melanoma cell lines with different macrophage content and tumorigenicity in nude mice. 
  • Commitment to cell death is signaled by the appearance of a terminin protein of 30 kDa. 
  • Control of phenylalanine hydroxylase synthesis in tissue culture by serum and insulin. 
  • Copper-induced synthesis of copper-chelatin in rat liver. 
  • Cycloheximide-resistant temperature-sensitive lethal mutations of Saccharomyces cerevisiae. 
  • Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand. 
  • Decreased protein synthesis of transforming lymphocytes from aged humans: relationship to impaired mitogenesis with age. 
  • Decrements in auditory responses to a repeated conspecific song are long-lasting and require two periods of protein synthesis in the songbird forebrain. 
  • Delineation of the signaling pathways involved in glucocorticoid-induced and spontaneous apoptosis of rat thymocytes. 
  • Direct allelic variation scanning of the yeast genome. 
  • Effect of growth conditions on the activity of ornithine decarboxylase in cultured hepatoma cells. I. Effect of amino acid supply. 
  • Effect of growth conditions on the ornithine decarboxylase activity of rat hepatoma cells. 
  • Evidence for depression of nuclear protein synthesis and concomitant stimulation of nuclear RNA synthesis during early estrogen action. 
  • Expression of interleukin-1 alpha, interleukin-1 beta, and an interleukin-1 receptor antagonist in human retinal pigment epithelial cells. 
  • Expression, distribution, and biochemistry of human CD39. Role in activation-associated homotypic adhesion of lymphocytes. 
  • Faithful expression of GFP from the PLCbeta2 promoter in a functional class of taste receptor cells. 
  • Fibrillar systems in cell motility. 
  • Glucagon-induced desensitization of adenylyl cyclase in primary cultures of chick hepatocytes. Evidence for multiple pathways. 
  • Heat shock protein 90 suppresses tumor necrosis factor alpha induced apoptosis by preventing the cleavage of Bid in NIH3T3 fibroblasts. 
  • Homoserine toxicity in Saccharomyces cerevisiae and Candida albicans homoserine kinase (thr1Delta) mutants. 
  • Human leukemia antigens: partial isolation and characterization. 
  • Hyaluronan fragments activate an NF-kappa B/I-kappa B alpha autoregulatory loop in murine macrophages. 
  • Hyaluronan fragments synergize with interferon-gamma to induce the C-X-C chemokines mig and interferon-inducible protein-10 in mouse macrophages. 
  • Identification of a novel GTPase, the inducibly expressed GTPase, that accumulates in response to interferon gamma. 
  • In vitro stimulation of alkaline phosphatase activity in immature embryonic chick pelvic cartilage by adenosine 3'5'-monophosphate. 
  • Induction of human tenascin (neuronectin) by growth factors and cytokines: cell type-specific signals and signalling pathways. 
  • Inhibition of protein synthesis also inhibits synthesis of lipid-linked oligosaccharides. 
  • Inhibitory effects of vesicular stomatitis virus on cellular and influenza viral RNA metabolism and protein synthesis. 
  • Interactions of alpha- and gamma-interferon in the transcriptional regulation of the gene encoding a guanylate-binding protein. 
  • Involvement of microtubules and 10-nm filaments in the movement and positioning of nuclei in syncytia. 
  • Isolation and regulation of the protein kinase inhibitor and the calcium-dependent cyclic nucleotide phosphodiesterase regulator in the Sertoli cell-enriched testis. 
  • Isolation of polyribosomes and characteristics of an amino acid-incorporation system from the liver of a primate (Papio papio). 
  • Ligand binding to the LFA-3 cell adhesion molecule induces IL-1 production by human thymic epithelial cells. 
  • Ligation of the alpha 2-macroglobulin signaling receptor on macrophages induces synthesis of platelet activating factor. 
  • Ligation of the alpha2M* signaling receptor regulates synthesis of cytosolic phospholipase A2. 
  • Mitochondrial Genome Variation Affects Multiple Respiration and Nonrespiration Phenotypes in Saccharomyces cerevisiae. 
  • Molecular basis of the biological function of molybdenum. Effect of tungsten on xanthine oxidase and sulfite oxidase in the rat. 
  • Molecular mechanisms of pathogenesis. 
  • Monocyte chemotactic peptide receptor. Functional characteristics and ligand-induced regulation. 
  • Noradrenaline treatment of rats stimulates H2O2 generation in liver mitochondria. 
  • Oxidative stress-induced expression and modulation of Phosphatase of Regenerating Liver-1 (PRL-1) in mammalian retina. 
  • Participation of p53 protein in the cellular response to DNA damage. 
  • Progesterone stimulates mitochondrial activity with subsequent inhibition of apoptosis in MCF-10A benign breast epithelial cells. 
  • Protein bisoynthesis in the testis. IV. Isolation and properties of polyribosomes. 
  • Protein synthesis inhibition blocks maintenance but not induction of epileptogenesis in hippocampal slice. 
  • Protein synthesis-dependent potentiation by thyroxine of antiviral activity of interferon-gamma. 
  • Rapid degradation of puromycyl peptides in hepatoma cells and reticulocytes. 
  • Recovery of porcine aortic endothelial cell prostaglandin synthesis following inhibition by sublethal concentrations of hydrogen peroxide. 
  • Regulation of Sertoli cell differentiation by the testicular paracrine factor PModS: potential role of immediate-early genes. 
  • Regulation of adenylate cyclase coupled beta-adrenergic receptors by beta-adrenergic catecholamines. 
  • Regulation of apoptosis in S49 cells. 
  • Regulation of brain ornithine decarboxylase activity in the neonatal rat. 
  • Regulation of cell division and of tyrosinase in B16 melanoma cells by imidazole: a possible role for the concept of metabolite gene regulation in mammalian cells. 
  • Regulation of cytokine production in the human thymus: epidermal growth factor and transforming growth factor alpha regulate mRNA levels of interleukin 1 alpha (IL-1 alpha), IL-1 beta, and IL-6 in human thymic epithelial cells at a post-transcriptional level. 
  • Regulation of intracellular pH mediates Bax activation in HeLa cells treated with staurosporine or tumor necrosis factor-alpha. 
  • Regulation of rat heart ornithine decarboxylase: change in affinity for ornithine evoked by neuronal, hormonal, and ontogenetic stimuli. 
  • Role of platelet-activating factor in Chinese hamster ovary cell responses to cholera toxin. 
  • Stability of nuclear triiodothyronine binding sites. 
  • Stimulation of brain hexokinase gene expression by recombinant brain insulin-like growth factor in C6 glial cells. 
  • Stimulation of cystine uptake by nitric oxide: regulation of endothelial cell glutathione levels. 
  • Studies on cellular autophagocytosis. The relationship of autophagocytosis to protein synthesis and to energy metabolism in rat liver and flounder kidney tubules in vitro. 
  • Synergistic effects of oPL and insulin on glycogen metabolism in fetal rat hepatocytes. 
  • Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3. 
  • T cell CD7 mRNA expression is regulated by both transcriptional and post-transcriptional mechanisms. 
  • TNFalpha and IL-4 regulation of hyaluronan binding to monocyte CD44 involves posttranslational modification of CD44. 
  • Temperature-sensitive mRNA degradation is an early event in hepatocyte de-differentiation. 
  • The L84F polymorphic variant of human O6-methylguanine-DNA methyltransferase alters stability in U87MG glioma cells but not temozolomide sensitivity. 
  • The TOR signaling cascade regulates gene expression in response to nutrients. 
  • The constitutive secretory pathway is a major route for islet amyloid polypeptide secretion in neonatal but not adult rat islet cells. 
  • The extracellular release of HMGB1 during apoptotic cell death. 
  • The protein synthetic surge in response to mitogen triggers high glycolytic enzyme levels in human lymphocytes and occurs prior to DNA synthesis. 
  • The role of protein synthesis in striatal long-term depression. 
  • Tissue-specific expression and regulation of the alternatively-spliced forms of lysyl hydroxylase 2 (LH2) in human kidney cells and skin fibroblasts. 
  • Transcript length heterogeneity at the small heat shock protein genes of Drosophila. 
  • Transcription in mouse embryo cells permissively infected by murine cytomegalovirus. 
  • Transcriptional down-regulation of tumor necrosis factor-alpha gene expression by a synthetic peptide homologous to retroviral envelope protein. 
  • Upregulation of AKT1 protein expression in forskolin-stimulated macrophage: evidence from ChIP analysis that CREB binds to and activates the AKT1 promoter. 
  • he effect of inhibitors of protein synthesis on the level of ribosomal subunits in ascites cells. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor of Cell Biology, Cell Biology