Cytidine Deaminase

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  Subject Areas on Research

  • A germ-line deletion of APOBEC3B does not contribute to subtype-specific childhood acute lymphoblastic leukemia etiology. 
  • A novel role for activation-induced cytidine deaminase: central B-cell tolerance. 
  • AID expression during B-cell development: searching for answers. 
  • Activation-induced cytidine deaminase expression and activity in the absence of germinal centers: insights into hyper-IgM syndrome. 
  • Activation-induced cytidine deaminase mediates central tolerance in B cells. 
  • An initial genetic analysis of gemcitabine-induced high-grade neutropenia in pancreatic cancer patients in CALGB 80303 (Alliance). 
  • Analysis of APOBEC-induced mutations in yeast strains with low levels of replicative DNA polymerases. 
  • Analysis of somatic hypermutation in X-linked hyper-IgM syndrome shows specific deficiencies in mutational targeting. 
  • BCR and Endosomal TLR Signals Synergize to Increase AID Expression and Establish Central B Cell Tolerance. 
  • Curiouser and curiouser: the role(s) of AID expression in self-tolerance. 
  • Deficiency of activation-induced cytidine deaminase in a murine model of ulcerative colitis. 
  • Disproportionate relationship between APOBEC-1 expression and apolipoprotein B mRNA editing activity. 
  • Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development. 
  • Further investigation of simian immunodeficiency virus Vif function in human cells. 
  • Guanine repeat-containing sequences confer transcription-dependent instability in an orientation-specific manner in yeast. 
  • HIV evolution in early infection: selection pressures, patterns of insertion and deletion, and the impact of APOBEC. 
  • Identification of the yeast cytidine deaminase CDD1 as an orphan C-->U RNA editase. 
  • Methotrexate and cytarabine inhibit progression of human lymphoma in NOD/SCID mice carrying a mutant dihydrofolate reductase and cytidine deaminase fusion gene. 
  • Mutations in activation-induced cytidine deaminase in patients with hyper IgM syndrome. 
  • Pancreatic cancer: translating lessons from mouse models. 
  • Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein. 
  • SETD2 Haploinsufficiency Enhances Germinal Center-Associated AICDA Somatic Hypermutation to Drive B-cell Lymphomagenesis. 
  • T-independent activation-induced cytidine deaminase expression, class-switch recombination, and antibody production by immature/transitional 1 B cells. 
  • The First B-Cell Tolerance Checkpoint in Mice and Humans: Control by AID. 
  • The role of innate APOBEC3G and adaptive AID immune responses in HLA-HIV/SIV immunized SHIV infected macaques. 
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  Keywords of People

  • Ferrari, Guido, Professor in Surgery, Molecular Genetics and Microbiology
  • Kelsoe, Garnett H., James B. Duke Distinguished Professor of Immunology, Integrative Immunobiology