Cytochrome P-450 Enzyme System

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  Subject Areas on Research

  • A gain-of-function polymorphism controlling complex traits and fitness in nature. 
  • A gel-free MS-based quantitative proteomic approach accurately measures cytochrome P450 protein concentrations in human liver microsomes. 
  • A new path to auxin. 
  • A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism. 
  • Acetaminophen toxicity in cultured trout liver cells. I. Morphological alterations and effects on cytochrome P450 1A1. 
  • Acetaminophen toxicity in cultured trout liver cells. II. Maintenance of cytochrome P450 1A1. 
  • Alteration of the alkaloid profile in genetically modified tobacco reveals a role of methylenetetrahydrofolate reductase in nicotine N-demethylation. 
  • Altered carbohydrate, lipid, and xenobiotic metabolism by liver from rats flown on Cosmos 1887. 
  • Aminoanthracene is a mechanism-based inactivator of CYP1A in channel catfish hepatic tissue. 
  • Assessment of cytochrome P450 3A4 activity during the menstrual cycle using alfentanil as a noninvasive probe. 
  • Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye. 
  • Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer's disease. 
  • Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses. 
  • Biochemical and histochemical properties of hepatic tumors of rainbow trout, Oncorhynchus mykiss. 
  • Biotransformation of HBCD in biological systems can confound temporal-trend studies. 
  • Biotransformation of sevoflurane. 
  • CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells. 
  • CYP3A4/5 and pharmacogenetics in patients with sarcoma - Authors' reply. 
  • Caenorhabditis elegans generates biologically relevant levels of genotoxic metabolites from aflatoxin B1 but not benzo[a]pyrene in vivo 
  • Carcinogen induced unscheduled DNA synthesis in mouse hepatocytes. 
  • Catalytic role of cytochrome P4503A4 in multiple pathways of alfentanil metabolism. 
  • Characterization of a cDNA for the unexpressed form of cytochrome P-450g from the (-g) rat and differentiation of its mRNA from that of the (+g) phenotype using specific oligoprobes. 
  • Characterization of deltamethrin metabolism by rat plasma and liver microsomes. 
  • Characterization of the effects of tebufelone on hepatic cytochromes P450 in the beagle dog. 
  • Chloroperoxidase-catalyzed halogenation of antipyrine, a drug substrate of liver microsomal cytochrome P-450. 
  • Clinical application of cardiovascular pharmacogenetics. 
  • Clinical enflurane metabolism by cytochrome P450 2E1. 
  • Clinical sevoflurane metabolism and disposition. II. The role of cytochrome P450 2E1 in fluoride and hexafluoroisopropanol formation. 
  • Cloning genes that encode drug-metabolizing enzymes: developmental pharmacology and teratology. 
  • Cloning genes that encode inducible forms of P-450. 
  • Coal fly ash induces hepatic and pulmonary cytochrome P-450 and sigma-aminolevulinic acid synthetase in rats. 
  • Comparative in vitro and in vivo benzo[a]pyrene-DNA adduct formation and its relationship to CYP1A activity in two species of ictalurid catfish. 
  • Complex drug interactions of HIV protease inhibitors 2: in vivo induction and in vitro to in vivo correlation of induction of cytochrome P450 1A2, 2B6, and 2C9 by ritonavir or nelfinavir. 
  • Constitutive activation of NOTCH1 signaling in Sertoli cells causes gonocyte exit from quiescence. 
  • Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation. 
  • Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance. 
  • Contribution of itraconazole metabolites to inhibition of CYP3A4 in vivo. 
  • Cytochrome P-450- and glutathione-associated enzyme activities in freshly isolated enriched lung cell fractions from beta-naphthoflavone-treated male F344 rats. 
  • Cytochrome P1-450 structural gene in mouse, rat, and rabbit: differences in DNA methylation and developmental expression of mRNA. 
  • Cytochrome P450IA1 induction and localization in endothelium of vertebrate (teleost) heart. 
  • Cytochrome P450IIIA activity and cytokine-mediated synthesis of nitric oxide. 
  • Cytokine-mediated production of nitric oxide in isolated rat hepatocytes is dependent on cytochrome P-450III activity. 
  • Designing safer chemicals: predicting the rates of metabolism of halogenated alkanes. 
  • Determinants of the over-anticoagulation response during warfarin initiation therapy in Asian patients based on population pharmacokinetic-pharmacodynamic analyses. 
  • Developmental pharmacogenomics. 
  • Dietary influences on the hepatic mixed-function oxidase system in the rat after portacaval anastomosis. 
  • Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor. 
  • Does race modify the association between CYP1B1 Val432Leu polymorphism and breast cancer risk? A critical appraisal of a recent meta-analysis. 
  • Dynamic paradigms for human mortality and aging. 
  • Effect of age and gender on the activity of human hepatic CYP3A. 
  • Effect of intratracheal administration of DDT and endosulfan on cytochrome P-450 and glutathione-s-transferase in lung and liver of rats. 
  • Effect of rifampicin on S-ketamine and S-norketamine plasma concentrations in healthy volunteers after intravenous S-ketamine administration. 
  • Effect of simulated hypoxia (7620 m, 6 h) on hepatic microsomal drug metabolising enzymes activity in rats given ethanol and vitamin A. 
  • Effect of vitamin A on hepatic microsomal drug metabolising enzymes activity in rats exposed to acute hypoxia. 
  • Effects of 2,4-dichlorophenoxyacetic acid and picloram on biotransformation, peroxisomal and serum enzyme activities in channel catfish (Ictalurus punctatus). 
  • Effects of carbon tetrachloride on adrenocortical structure and function in guinea pigs. 
  • Effects of dietary N-(4-hydroxyphenyl)retinamide on N-nitrosomethylbenzylamine metabolism and esophageal tumorigenesis in the Fischer 344 rat. 
  • Effects of flavonoids on cytochrome P450-dependent acetaminophen metabolism in rats and human liver microsomes. 
  • Effects of herbal products and their constituents on human cytochrome P450(2E1) activity. 
  • Effects of inhibition and induction of cytochrome P-450 isozymes on hyperoxic lung injury in rats. 
  • Effects of tobacco smoking and nicotine on cancer treatment. 
  • Elucidation of the functions of genes central to diterpene metabolism in tobacco trichomes using posttranscriptional gene silencing. 
  • Enantiomeric metabolic interactions and stereoselective human methadone metabolism. 
  • Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway. 
  • Ethanol interferes with regeneration-associated changes in biotransforming enzymes: a potential mechanism underlying ethanol's carcinogenicity? 
  • Evaluation of first-pass cytochrome P4503A (CYP3A) and P-glycoprotein activities using alfentanil and fexofenadine in combination. 
  • Evaluation of the pharmacokinetic drug interaction potential of tivantinib (ARQ 197) using cocktail probes in patients with advanced solid tumours. 
  • Expression and subcellular distribution of mouse cytochrome P1-450 mRNA as determined by molecular hybridization with cloned P1-450 DNA. 
  • Expression of cyp26b1 during zebrafish early development. 
  • Feedback mechanisms regulate retinoic acid production and degradation in the zebrafish embryo. 
  • Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: implications for interindividual variability in disposition, efficacy, and drug interactions. 
  • Fibronectin-mediated hepatocyte shape change reprograms cytochrome P450 2C11 gene expression via an integrin-signaled induction of ribonuclease activity. 
  • Fine scale spatial investigation of multiple insecticide resistance and underlying target-site and metabolic mechanisms in Anopheles gambiae in central Côte d'Ivoire. 
  • Formation of azole-resistant Candida albicans by mutation of sterol 14-demethylase P450. 
  • Genetic polymorphisms in CYP17, CYP3A4, CYP19A1, SRD5A2, IGF-1, and IGFBP-3 and prostate cancer risk in African-American men: the Flint Men's Health Study. 
  • Genetic polymorphisms of metabolic enzymes and the pharmacokinetics of indapamide in Taiwanese subjects. 
  • Genotyping: one piece of the puzzle to personalize antiplatelet therapy. 
  • Hepatic cellular distribution of cytochrome P-450 IA1 in rainbow trout (Oncorhynchus mykiss): an immunohisto- and cytochemical study. 
  • Hepatic cytochrome P-4503A (CYP3A) activity in the elderly. 
  • Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol. 
  • Heterogeneity of toxicant response: sources of human variability. 
  • High vascular pressure-induced lung injury requires P450 epoxygenase-dependent activation of TRPV4. 
  • Hormonal regulation of male-specific rat hepatic cytochrome P-450g (P-450IIC13) by androgens and the pituitary. 
  • Human alfentanil metabolism by cytochrome P450 3A3/4. An explanation for the interindividual variability in alfentanil clearance? 
  • Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine. 
  • Human halothane metabolism, lipid peroxidation, and cytochromes P(450)2A6 and P(450)3A4. 
  • Human halothane reduction in vitro by cytochrome P450 2A6 and 3A4: identification of low and high KM isoforms. 
  • Human kidney methoxyflurane and sevoflurane metabolism. Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity. 
  • Human liver microsomal enflurane defluorination catalyzed by cytochrome P-450 2E1. 
  • Human reductive halothane metabolism in vitro is catalyzed by cytochrome P450 2A6 and 3A4. 
  • Identification and characterization of a cDNA encoding cytochrome P450 3A from the fresh water teleost medaka (Oryzias latipes). 
  • Identification and characterization of cDNA clones specific for cholesterol side-chain cleavage cytochrome P-450. 
  • Identification and quantification of a messenger ribonucleic acid induced by polynuclear aromatic hydrocarbons--using a cloned human cytochrome P-450 gene. 
  • Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane. 
  • Identification of late larval stage developmental checkpoints in Caenorhabditis elegans regulated by insulin/IGF and steroid hormone signaling pathways. 
  • Identification of the enzyme responsible for oxidative halothane metabolism: implications for prevention of halothane hepatitis. 
  • Identification, characterization, and ontogeny of a second cytochrome P450 3A gene from the fresh water teleost medaka (Oryzias latipes). 
  • In vitro hepatic metabolism explains higher clearance of voriconazole in children versus adults: role of CYP2C19 and flavin-containing monooxygenase 3. 
  • In vitro metabolism of cyclosporine A by human kidney CYP3A5. 
  • In vivo modulation of 17 beta-estradiol-induced vitellogenin synthesis and estrogen receptor in rainbow trout (Oncorhynchus mykiss) liver cells by beta-naphthoflavone. 
  • In-vivo phenotyping for CYP3A by a single-point determination of midazolam plasma concentration. 
  • Inactivation of metabolic enzymes by photo-treatment with zinc meta N-methylpyridylporphyrin. 
  • Increased blood pressure in mice lacking cytochrome P450 2J5. 
  • Increasing uptake and bioactivation with development positively modulate diazinon toxicity in early life stage medaka (Oryzias latipes). 
  • Induction of cytochrome P(1)450 RNA and benzo[a]pyrene metabolism in primary human hepatocyte cultures with benzanthracene. 
  • Induction of cytochrome P-450 and phosphatidylcholine synthesis by endosulfan in liver of rats: effect of quality of dietary proteins. 
  • Induction of cytochrome P-450 isozymes by hexachlorobenzene in rats and aromatic hydrocarbon (Ah)-responsive mice. 
  • Induction of hepatic drug metabolizing enzymes by coal fly ash in rats. 
  • Induction of pulmonary and hepatic cytochrome P-450 species by coal fly ash inhalation in rats. 
  • Induction of pulmonary drug metabolizing enzymes by coal fly ash in rats. 
  • Induction of rat cytochrome P-450 3 and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl. 
  • Induction of specific cytochrome P-450 isozymes by methylenedioxyphenyl compounds and antagonism by 3-methylcholanthrene. 
  • Influence of CYP3A5 genotype on the pharmacokinetics and pharmacodynamics of the cytochrome P4503A probes alfentanil and midazolam. 
  • Inhibition of coal fly ash polycyclic aromatic hydrocarbons and metals induced mixed-function oxidase activity in rat lung and liver by vitamin A and citrate. 
  • Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus). 
  • Instability of the Human Cytochrome P450 Reductase A287P Variant Is the Major Contributor to Its Antley-Bixler Syndrome-like Phenotype. 
  • Inter-individual differences in baseline coagulation activities and their implications for international normalized ratio control during warfarin initiation therapy. 
  • Interaction of endosulfan and dietary vitamin A on rat hepatic drug metabolising enzymes. 
  • Interaction of ethanol, cholesterol and vitamin A on phospholipid methylation in hepatic microsomes of rats. 
  • Interaction of the regulatory domains of the murine Cyp1a1 gene with two DNA-binding proteins in addition to the Ah receptor and the Ah receptor nuclear translocator (ARNT). 
  • Intraindividual variability in male hepatic CYP3A4 activity assessed by alfentanil and midazolam clearance. 
  • Intravillous eicosanoid compartmentalization and regulation of placental blood flow. 
  • Investigating the contribution of CYP2J2 to ritonavir metabolism in vitro and in vivo. 
  • Involvement of radical species in the oxidation of aminopyrine and 4-aminoantipyrine by cumene hydroperoxide in rat liver microsomes. 
  • Is genetic testing for cytochrome P450 polymorphisms ready for implementation? 
  • Isolation and characterization of the CYP71D16 trichome-specific promoter from Nicotiana tabacum L. 
  • Knockdown of AHR1A but not AHR1B exacerbates PAH and PCB-126 toxicity in zebrafish (Danio rerio) embryos. 
  • Lack of single-dose disulfiram effects on cytochrome P-450 2C9, 2C19, 2D6, and 3A4 activities: evidence for specificity toward P-450 2E1. 
  • Liver genomic responses to ciguatoxin: evidence for activation of phase I and phase II detoxification pathways following an acute hypothermic response in mice. 
  • Menstrual cycle variability in midazolam pharmacokinetics. 
  • Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants. 
  • Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by human CYP1B1 genetic variants. 
  • Metabolism of dapsone to its hydroxylamine by CYP2E1 in vitro and in vivo. 
  • Metabolism of levo-alpha-Acetylmethadol (LAAM) by human liver cytochrome P450: involvement of CYP3A4 characterized by atypical kinetics with two binding sites. 
  • Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation. 
  • Methadone pharmacogenetics in vitro and in vivo: Metabolism by CYP2B6 polymorphic variants and genetic variability in paediatric disposition. 
  • Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation. 
  • Microarray gene expression profiling during the segmentation phase of zebrafish development. 
  • Mitochondria as a target of organophosphate and carbamate pesticides: Revisiting common mechanisms of action with new approach methodologies. 
  • Molecular approaches to identify novel targets for future development of antifungal agents. 
  • Neuronal regulation of the spatial patterning of neurogenesis. 
  • New approach to the activation of anti-cancer pro-drugs by metalloporphyrin-based cytochrome P450 mimics in all-aqueous biologically relevant system. 
  • Nitric oxide and acetaminophen-mediated oxidative injury: modulation of interleukin-1-induced nitric oxide synthesis in cultured rat hepatocytes. 
  • Nitrofurantoin-stimulated superoxide production by channel catfish (Ictalurus punctatus) hepatic microsomal and soluble fractions. 
  • Novel DNA sequence variations of cytochrome P450 genes in the Han Chinese population. 
  • On the occurrence of cytochrome P-450 and aryl hydrocarbon hydroxylase activity in rat brain. 
  • Ontogeny of hepatic and plasma metabolism of deltamethrin in vitro: role in age-dependent acute neurotoxicity. 
  • Opposite effects of lead on chemical carcinogenesis in kidney and liver of rats. 
  • Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents. 
  • Oxidant, mixed-function oxidase and peroxisomal responses in channel catfish exposed to a bleached kraft mill effluent. 
  • P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity. 
  • Pharmacodynamic and pharmacokinetic study of chronic low-dose metronomic cyclophosphamide therapy in mice. 
  • Pharmacogenetic determinants of human liver microsomal alfentanil metabolism and the role of cytochrome P450 3A5. 
  • Pharmacogenetics of nevirapine-associated hepatotoxicity: an Adult AIDS Clinical Trials Group collaboration. 
  • Platensimycin and platencin congeners from Streptomyces platensis. 
  • Polymorphisms in genes encoding drug metabolizing enzymes and their influence on the outcome of children with neuroblastoma. 
  • Predictability and irreversibility of genetic changes associated with flower color evolution in Penstemon barbatus. 
  • Progesterone Metabolites Produced by Cytochrome P450 3A Modulate Uterine Contractility in a Murine Model. 
  • Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling. 
  • Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. 
  • Reaction phenotyping of vinblastine metabolism in dogs. 
  • Recent developments in clopidogrel pharmacology and their relation to clinical outcomes. 
  • Regulation of rat hepatic cytochrome P450IIE1 in primary monolayer hepatocyte culture. 
  • Relationship between adipose stromal-vascular cells and adipocytes in human adipose tissue. 
  • Retinoic acid regulates sex-specific timing of meiotic initiation in mice. 
  • Retinoid regulation of the zebrafish cyp26a1 promoter. 
  • Review of evidence for genetic testing for CYP450 polymorphisms in management of patients with nonpsychotic depression with selective serotonin reuptake inhibitors. 
  • Simultaneous measurement of in vivo P-glycoprotein and cytochrome P450 3A activities. 
  • Single-dose disulfiram does not inhibit CYP2A6 activity. 
  • Single-dose disulfiram inhibition of chlorzoxazone metabolism: a clinical probe for P450 2E1. 
  • Single-dose methoxsalen effects on human cytochrome P-450 2A6 activity. 
  • Spectrum and subcellular determinants of fluorinated anesthetic-mediated proximal tubular injury. 
  • Splenda alters gut microflora and increases intestinal p-glycoprotein and cytochrome p-450 in male rats. 
  • Stereochemical aspects of itraconazole metabolism in vitro and in vivo. 
  • Stereoselective Bupropion Hydroxylation by Cytochrome P450 CYP2B6 and Cytochrome P450 Oxidoreductase Genetic Variants. 
  • Stereoselective Ketamine Metabolism by Genetic Variants of Cytochrome P450 CYP2B6 and Cytochrome P450 Oxidoreductase. 
  • Stereoselective metabolism of enflurane by human liver cytochrome P450 2E1. 
  • Structure-activity relationships of chlorinated benzenes as inducers of hepatic cytochrome P-450 isozymes in the rat. 
  • Studies on the cellular toxicity of polychlorinated biphenyls (PCBs). I. Effect of PCBs on microsomal enzymes and on synthesis and turnover of microsomal and cytoplasmic lipids of rat liver- a morphological and biochemical study. 
  • Sulfoxidation of cysteine and mercapturic acid conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A). 
  • Suppression of a P450 hydroxylase gene in plant trichome glands enhances natural-product-based aphid resistance. 
  • Suppression of male-specific cytochrome P450 2c and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl in rat liver is not causally related to changes in serum testosterone. 
  • Suppression of the constitutive, male-specific rat hepatic cytochrome P-450 2c and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl and 3-methylcholanthrene. 
  • Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain. 
  • Temperature-sensitive mRNA degradation is an early event in hepatocyte de-differentiation. 
  • Testing for cytochrome P450 polymorphisms in adults with non-psychotic depression treated with selective serotonin reuptake inhibitors (SSRIs). 
  • The Aryl Hydrocarbon Receptor: A Mediator and Potential Therapeutic Target for Ocular and Non-Ocular Neurodegenerative Diseases. 
  • The Pharmacogenomic Association of Fcγ Receptors and Cytochrome P450 Enzymes With Response to Rituximab or Cyclophosphamide Treatment in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. 
  • The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation. 
  • The genetic basis of a flower-color polymorphism in the common 
  • The human constitutive androstane receptor promotes the differentiation and maturation of hepatic-like cells. 
  • The role of cytochrome P450 3A4 in alfentanil clearance. Implications for interindividual variability in disposition and perioperative drug interactions. 
  • Three polymorphisms in cytochrome P450 1B1 (CYP1B1) gene and breast cancer risk: a meta-analysis. 
  • Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3. 
  • Transfection of a human cytochrome P-450 gene into the human lymphoblastoid cell line, AHH-1, and use of the recombinant cell line in gene mutation assays. 
  • Triphenyl phosphate-induced developmental toxicity in zebrafish: potential role of the retinoic acid receptor. 
  • Variability in St. John's wort formulations is an important consideration. 
  • Zebrafish cardiotoxicity: the effects of CYP1A inhibition and AHR2 knockdown following exposure to weak aryl hydrocarbon receptor agonists. 
  • delta-Aminolevulinic acid synthetase and heme oxygenase activity in lung and liver of rats given DDT and endosulfan intratracheally. 
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  Keywords of People

  • Mitchell-Olds, Thomas, Newman Ivey White Distinguished Professor of Biology, Biology