Cytomegalovirus Infections

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  Subject Areas on Research

  • A Brief Prenatal Intervention of Behavioral Change to Reduce the Risk of Maternal Cytomegalovirus: A Randomized Controlled Trial. 
  • A prospective randomized trial comparing sequential ganciclovir-high dose acyclovir to high dose acyclovir for prevention of cytomegalovirus disease in adult liver transplant recipients. 
  • A randomized, placebo-controlled trial of the safety and efficacy of oral ganciclovir for prophylaxis of cytomegalovirus disease in HIV-infected individuals. Terry Beirn Community Programs for Clinical Research on AIDS. 
  • A retrospective analysis of the long-term effect of splenectomy on late infections, graft-versus-host disease, relapse, and survival after allogeneic marrow transplantation for chronic myelogenous leukemia. 
  • A single-center experience with ganciclovir-resistant cytomegalovirus in lung transplant recipients: treatment and outcome. 
  • Absence of cytomegalovirus-resistance mutations after valganciclovir prophylaxis, in a prospective multicenter study of solid-organ transplant recipients. 
  • Acquired cytomegalovirus retinitis. Four new cases and a review of the literature with implications for management. 
  • Active cytomegalovirus particles in the eyes of an AIDS patient being treated with 9-[2-hydroxy-1-(hydroxymethyl) ethoxymethyl] guanine (Ganciclovir). 
  • Acute hemolysis in a patient with cytomegalovirus pneumonitis treated with intravenous immunoglobulin (IVIG). 
  • Acyclovir in human immunodeficiency virus patients. 
  • Advancing Our Understanding of Protective Maternal Immunity as a Guide for Development of Vaccines To Reduce Congenital Cytomegalovirus Infections. 
  • Age matters: older age as a risk factor for CMV reactivation in the CMV serostatus-positive kidney transplant recipient. 
  • Aging and reactivation of latent murine cytomegalovirus. 
  • Alemtuzumab induction and triple maintenance immunotherapy in kidney transplantation from donors after cardiac death. 
  • Animal Models of Congenital Cytomegalovirus Transmission: Implications for Vaccine Development. 
  • Antibody prevalence to torch agents in pregnant women and relative risk of congenital infections in Italy (Liguria). 
  • Antigen-specific T-lymphocyte function after cord blood transplantation. 
  • Association of Adverse Hearing, Growth, and Discharge Age Outcomes With Postnatal Cytomegalovirus Infection in Infants With Very Low Birth Weight. 
  • Association of Postnatal Cytomegalovirus Infection With Head Growth-Reply. 
  • CMV reactivation drives posttransplant T-cell reconstitution and results in defects in the underlying TCRβ repertoire. 
  • Choice of Study Populations for Vaccines. 
  • Clinical and virological monitoring of human cytomegalovirus infection in 294 heart transplant recipients. 
  • Clinical utility of cytomegalovirus viral load testing for predicting CMV disease in D+/R- solid organ transplant recipients. 
  • Coats' disease in a renal transplant recipient. 
  • Combined short- and long-term therapy for the treatment of cytomegalovirus retinitis using ganciclovir (BW B759U). 
  • Comparison of Minnesota antilymphoblast globulin and Upjohn antithymocyte globulin for induction immunosuppression of human renal allografts. 
  • Comparison of cytomegalovirus polymerase chain reaction and serology for screening umbilical cord blood components. 
  • Comparison of the Digene Hybrid Capture System Cytomegalovirus (CMV) DNA (version 2.0), Roche CMV UL54 analyte-specific reagent, and QIAGEN RealArt CMV LightCycler PCR reagent tests using AcroMetrix OptiQuant CMV DNA quantification panels and specimens from allogeneic-stem-cell transplant recipients. 
  • Comparisons of CD8+ T cells specific for human immunodeficiency virus, hepatitis C virus, and cytomegalovirus reveal differences in frequency, immunodominance, phenotype, and interleukin-2 responsiveness. 
  • Cystic disease of liver and kidney with portal hypertension. A cause of sudden unexpected hematemesis. 
  • Cytomegaloviral infection presenting as a solitary pulmonary nodule. 
  • Cytomegalovirus (CMV) shedding is highly correlated with markers of immunosuppression in CMV-seropositive women. 
  • Cytomegalovirus PP65 antigenemia monitoring as a guide for preemptive therapy: a cost effective strategy for prevention of cytomegalovirus disease in adult liver transplant recipients. 
  • Cytomegalovirus Screening in Pregnancy: A Cost-Effectiveness and Threshold Analysis. 
  • Cytomegalovirus encephalomyelitis: MR imaging findings documenting response to ganciclovir therapy. 
  • Cytomegalovirus infection after intestinal transplantation in children. 
  • Cytomegalovirus infection and chronic hemodialysis. 
  • Cytomegalovirus infection following liver transplantation: review of the literature. 
  • Cytomegalovirus infection in the normal host. 
  • Cytomegalovirus infection increases the risk for inflammatory bowel disease. 
  • Cytomegalovirus infection presenting as bronchial polyps in lung transplant recipients. 
  • Cytomegalovirus infection. 
  • Cytomegalovirus keratitis after penetrating keratoplasty. 
  • Cytomegalovirus pericarditis: a case series and review of the literature. 
  • Cytomegalovirus pneumonia in transplant patients: CT findings. 
  • Cytomegalovirus pneumonia. 
  • Cytomegalovirus pneumonitis is a risk for bronchiolitis obliterans syndrome in lung transplantation. 
  • Cytomegalovirus retinitis and immunodeficiency in homosexual males. 
  • Cytomegalovirus retinitis. 
  • Cytomegalovirus retinitis: a manifestation of the acquired immune deficiency syndrome (AIDS). 
  • Cytomegalovirus sialadenitis in patients with the acquired immunodeficiency syndrome: a potential diagnostic pitfall with fine-needle aspiration cytology. 
  • Delay of CMV infection in high-risk CMV mismatch lung transplant recipients due to prophylaxis with oral ganciclovir. 
  • Detailed analysis of cytomegalovirus (CMV)-specific T cells expanded for adoptive immunotherapy of CMV infection following allogeneic stem cell transplantation for malignant disease. 
  • Detection and Prevention of Perinatal Infection: Cytomegalovirus and Zika Virus. 
  • Detection of mouse cytomegalovirus nucleic acid in latently infected mice by in vitro enzymatic amplification. 
  • Determinants of the source of cytomegalovirus in murine renal allograft recipients. 
  • Development and preclinical evaluation of an alphavirus replicon particle vaccine for cytomegalovirus. 
  • Diagnosis and antenatal management of congenital cytomegalovirus infection. 
  • Diagnosis of human congenital cytomegalovirus infection by amplification of viral DNA from dried blood spots on perinatal cards. 
  • Diagnostic yield of bronchoscopies after isolated lung transplantation. 
  • Differential CMV-specific CD8+ effector T cell responses in the lung allograft predominate over the blood during human primary infection. 
  • Donor immune reconstitution after liver-small bowel transplantation for multiple intestinal atresia with immunodeficiency. 
  • Early KLRG1+ but Not CD57+CD8+ T Cells in Primary Cytomegalovirus Infection Predict Effector Function and Viral Control. 
  • Early and late interstitial pneumonia following human bone marrow transplantation. 
  • Economic evaluation of everolimus vs. azathioprine at one year after de novo heart transplantation. 
  • Effects of murine cytomegalovirus infection on the immune response to a tumor allograft. 
  • Efficacy and safety of valganciclovir vs. oral ganciclovir for prevention of cytomegalovirus disease in solid organ transplant recipients. 
  • Enumerating antigen-specific T-cell responses in peripheral blood: a comparison of peptide MHC Tetramer, ELISpot, and intracellular cytokine analysis. 
  • Evaluation of HLA polymorphisms in relation to schizophrenia risk and infectious exposure. 
  • Evaluation of clinical outcomes of prophylactic versus preemptive cytomegalovirus strategy in liver transplant recipients. 
  • Exfoliative cytopathologic studies in organ transplantation. I. The cytologic diagnosis of cytomegalic inclusion disease in the urine of renal allograft recipients. 
  • Extended valganciclovir prophylaxis to prevent cytomegalovirus after lung transplantation: a randomized, controlled trial. 
  • Factors associated with recurrent cytomegalovirus disease after small bowel transplantation. 
  • Fatal cytomegalovirus bronchiolitis in a patient with Nezelof's syndrome. 
  • Fetal Ventriculomegaly. 
  • Five hundred intestinal and multivisceral transplantations at a single center: major advances with new challenges. 
  • Fludarabine followed by alemtuzumab consolidation for previously untreated chronic lymphocytic leukemia: final report of Cancer and Leukemia Group B study 19901. 
  • Foscarnet-Ganciclovir Cytomegalovirus Retinitis Trial: 5. Clinical features of cytomegalovirus retinitis at diagnosis. Studies of ocular complications of AIDS Research Group in collaboration with the AIDS Clinical Trials Group. 
  • Foundation for the Accreditation of Hematopoietic Cell Therapy (FAHCT) response to FDA (Docket no. 97N-0068). FAHCT Board of Directors. 
  • Fractionated total body irradiation and high-dose etoposide as a preparatory regimen for bone marrow transplantation for 99 patients with acute leukemia in first complete remission. 
  • Fusion of the termini of the murine cytomegalovirus genome after infection. 
  • Ganciclovir/acyclovir prophylaxis reduces the incidence of cytomegalovirus infections in pancreas transplant recipients. 
  • Gastric graft-versus-host disease: a blinded histologic study. 
  • Geographic Disparities in Cytomegalovirus Infection During Pregnancy. 
  • HCMV glycoprotein B subunit vaccine efficacy mediated by nonneutralizing antibody effector functions. 
  • Haploidentical Bone Marrow Transplantation with Post-Transplant Cyclophosphamide for Children and Adolescents with Fanconi Anemia. 
  • High-dose immunosuppressive therapy and autologous peripheral blood stem cell transplantation for severe multiple sclerosis. 
  • High-quality CMV-specific CD4+ memory is enriched in the lung allograft and is associated with mucosal viral control. 
  • Human Cytomegalovirus Glycoprotein B Nucleoside-Modified mRNA Vaccine Elicits Antibody Responses with Greater Durability and Breadth than MF59-Adjuvanted gB Protein Immunization. 
  • Human immunodeficiency virus-1 disease progression in hemophiliacs. 
  • Humoral Immune Correlates for Prevention of Postnatal Cytomegalovirus Acquisition. 
  • IL-12-Dependent Cytomegalovirus-Specific CD4+ T Cell Proliferation, T-bet Induction, and Effector Multifunction during Primary Infection Are Key Determinants for Early Immune Control. 
  • Identification of focal viral infections by confocal microscopy for subsequent ultrastructural analysis. 
  • Identification of viral infection by confocal microscopy. 
  • Immune Correlates of Protection Against Human Cytomegalovirus Acquisition, Replication, and Disease. 
  • Immunoglobulin therapy in bone marrow transplantation. 
  • Immunomodulatory and antimicrobial efficacy of intravenous immunoglobulin in bone marrow transplantation. 
  • Impact of cryopreservation on tetramer, cytokine flow cytometry, and ELISPOT. 
  • Impaired Cytomegalovirus Immunity in Idiopathic Pulmonary Fibrosis Lung Transplant Recipients with Short Telomeres. 
  • In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia. 
  • Incidence and risk factors associated with the development of cytomegalovirus disease after intestinal transplantation. 
  • Incidence of cytomegalovirus disease in renal transplantation without antilymphocyte induction: is prophylaxis necessary? 
  • Infection of T but not B lymphocytes by cytomegalovirus in lymph node. An immunophenotypic study. 
  • Infection prophylaxis in pancreas transplant recipients. 
  • Infections after kidney transplantation. Does age matter? 
  • Infections after upper extremity allotransplantation: a worldwide population cohort study, 1998-2017. 
  • Infections in patients with cystic fibrosis following lung transplantation. 
  • Inflammasome expression and cytomegalovirus viremia in critically ill patients with sepsis. 
  • Inflammatory bowel disease after liver transplantation: risk factors for recurrence and de novo disease. 
  • Intrahost cytomegalovirus population genetics following antibody pretreatment in a monkey model of congenital transmission. 
  • Intranuclear inclusion bodies. 
  • Intravenous immune globulin prophylaxis in recipients of a marrow transplant. 
  • Intravitreal foscarnet for cytomegalovirus retinitis in a patient with acquired immunodeficiency syndrome. 
  • Is prevention the best treatment? CMV after lung transplantation. 
  • Kidney and pancreas transplantation at Wake Forest University Baptist Medical Center. 
  • Long-term efficacy and safety of 12 months of valganciclovir prophylaxis compared with 3 months after lung transplantation: a single-center, long-term follow-up analysis from a randomized, controlled cytomegalovirus prevention trial. 
  • Maribavir prophylaxis for prevention of cytomegalovirus infection in allogeneic stem cell transplant recipients: a multicenter, randomized, double-blind, placebo-controlled, dose-ranging study. 
  • Marrow transplantation for severe aplastic anemia. Long-term outcome in fifty "untransfused" patients. 
  • Maternal Antibody Responses and Nonprimary Congenital Cytomegalovirus Infection of HIV-1-Exposed Infants. 
  • Maternal CD4+ T cells protect against severe congenital cytomegalovirus disease in a novel nonhuman primate model of placental cytomegalovirus transmission. 
  • Maternal cytomegalovirus-specific immune responses and symptomatic postnatal cytomegalovirus transmission in very low-birth-weight preterm infants. 
  • Maternal immune correlates of protection against placental transmission of cytomegalovirus. 
  • Microbial Vertical Transmission during Human Pregnancy. 
  • Murine cytomegalovirus gene amplification and culture after submaxillary salivary gland biopsy. 
  • Murine cytomegalovirus infection: hematological, morphological, and functional study of lymphoid cells. 
  • Natural history of postnatal rhesus cytomegalovirus shedding by dams and acquisition by infant rhesus monkeys. 
  • Neighborhood Disadvantage is Associated with High Cytomegalovirus Seroprevalence in Pregnancy. 
  • Nonhuman primate models of intrauterine cytomegalovirus infection. 
  • Nonurban male homosexuals: epidemiologic, immunologic and virologic characteristics. 
  • OKT3 vs ALG induction therapy in combined pancreas-kidney transplantation. 
  • Ocular effects in acquired immune deficiency syndrome. 
  • Opportunistic infections and Kaposi's sarcoma in homosexual men. 
  • Opportunistic intraocular infections in AIDS. 
  • Pediatric kidney transplantation at the University of Pittsburgh. 
  • Penile erosions associated with foscarnet therapy in a child. 
  • Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells. 
  • Perinatal cytomegalovirus and varicella zoster virus infections: epidemiology, prevention, and treatment. 
  • Persistent infection with neurotropic herpes viruses and cognitive impairment. 
  • Pharmacodynamics of oral ganciclovir and valganciclovir in solid organ transplant recipients. 
  • Pharmacokinetic profile of ganciclovir after its oral administration and from its prodrug, valganciclovir, in solid organ transplant recipients. 
  • Pharmacokinetics of low and maintenance dose valganciclovir in kidney transplant recipients. 
  • Phase 2 Study of Anti-Human Cytomegalovirus Monoclonal Antibodies for Prophylaxis in Hematopoietic Cell Transplantation. 
  • Phosphonylmethoxyalkyl purine and pyrimidine derivatives for treatment of opportunistic cytomegalovirus and herpes simplex virus infections in murine AIDS. 
  • Photopheresis for the prevention of rejection in cardiac transplantation. Photopheresis Transplantation Study Group. 
  • Plasmablast Response to Primary Rhesus Cytomegalovirus (CMV) Infection in a Monkey Model of Congenital CMV Transmission. 
  • Polyfunctional T-Cell Signatures to Predict Protection from Cytomegalovirus after Lung Transplantation. 
  • Polyfunctional cytomegalovirus-specific immunity in lung transplant recipients receiving valganciclovir prophylaxis. 
  • Porcine cytomegalovirus infection is associated with early rejection of kidney grafts in a pig to baboon xenotransplantation model. 
  • Post-mortem incidental finding of cytomegalovirus oophoritis after an allogeneic stem cell transplant. 
  • Postnatal Cytomegalovirus Infection and the Risk for Bronchopulmonary Dysplasia. 
  • Postnatal cytomegalovirus exposure in infants of antiretroviral-treated and untreated HIV-infected mothers. 
  • Posttransplant B, non-A non-B, and cytomegalovirus hepatitis increase the risk of developing chronic rejection after liver transplantation. 
  • Posttransplant infection in enteric versus bladder-drained simultaneous pancreas-kidney transplant recipients. 
  • Preemptive ganciclovir administration based solely on asymptomatic pulmonary cytomegalovirus infection in allogeneic bone marrow transplant recipients: long-term follow-up. 
  • Prevalence survey of cytomegalovirus infection in children in Chengdu. 
  • Prevalence, pathophysiology, and treatment of rhegmatogenous retinal detachment in treated cytomegalovirus retinitis. 
  • Preventing postnatal cytomegalovirus infection in the preterm infant: should it be done, can it be done, and at what cost? 
  • Primary cytomegalovirus phosphoprotein 65-specific CD8+ T-cell responses and T-bet levels predict immune control during early chronic infection in lung transplant recipients. 
  • Progress toward Development of a Vaccine against Congenital Cytomegalovirus Infection. 
  • Prophylactic use of human leukocyte interferon after allogeneic marrow transplantation. 
  • Prophylaxis of cytomegalovirus disease in allogeneic bone marrow transplantation. 
  • Pulmonary Embolism in a Young Immunocompetent Adult Infected with Cytomegalovirus. Are Novel Oral Anticoagulants an Efficient Alternative? 
  • Pulmonary cytology of the acquired immune deficiency syndrome: an analysis of 36 cases. 
  • Rabbit antithymocyte globulin decreases acute rejection after lung transplantation: results of a randomized, prospective study. 
  • Randomized, placebo-controlled, double-blind study of a cytomegalovirus-specific monoclonal antibody (MSL-109) for prevention of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation. 
  • Reactivation of latent murine cytomegalovirus from kidney. 
  • Recombinant leukocyte A interferon for the treatment of serious viral infections after marrow transplant: a phase I study. 
  • Reduction in transplant-related complications in patients given intravenous immuno globulin after allogeneic marrow transplantation. 
  • Relationship Among Viremia/Viral Infection, Alloimmunity, and Nutritional Parameters in the First Year After Pediatric Kidney Transplantation. 
  • Renal transplantation in children. 
  • Reply to Gantt et al., "Higher Expectations for a Vaccine To Prevent Congenital Cytomegalovirus Infection". 
  • Results of life-supporting galactosyltransferase knockout kidneys in cynomolgus monkeys using two different sources of galactosyltransferase knockout Swine. 
  • Retinal manifestations of the acquired immune deficiency syndrome (AIDS): cytomegalovirus, candida albicans, cryptococcus, toxoplasmosis and Pneumocystis carinii. 
  • Retinitis in euthymic mice following inoculation of murine cytomegalovirus (MCMV) via the supraciliary route. 
  • Rhesus monkeys for a nonhuman primate model of cytomegalovirus infections. 
  • Risk factors for cytomegalovirus viremia and disease developing after prophylaxis in high-risk solid-organ transplant recipients. 
  • Screening indices for cytomegalovirus retinitis in patients with human immunodeficiency virus. 
  • Sensitive detection of human cytomegalovirus in tumors and peripheral blood of patients diagnosed with glioblastoma. 
  • Sequential measurement of peripheral blood allogeneic microchimerism levels and association with pulmonary function. 
  • Single-center analysis of infectious complications in older adults during the first year after kidney transplantation. 
  • Specificity and effector functions of non-neutralizing gB-specific monoclonal antibodies isolated from healthy individuals with human cytomegalovirus infection. 
  • Standardization of cytokine flow cytometry assays. 
  • Subordinate Effect of -21M HLA-B Dimorphism on NK Cell Repertoire Diversity and Function in HIV-1 Infected Individuals of African Origin. 
  • Successful immune reconstitution in severe combined immunodeficiency despite Epstein-Barr virus and cytomegalovirus infections. 
  • Survey on Transfusion-Transmitted Cytomegalovirus and Cytomegalovirus Disease Mitigation. 
  • Symptomatic Postnatal Cytomegalovirus Testing among Very Low-Birth-Weight Infants: Indications and Outcomes. 
  • Systemic antiviral drugs used in ophthalmology. 
  • T cell depletion increases susceptibility to murine cytomegalovirus retinitis. 
  • T-bet:Eomes balance, effector function, and proliferation of cytomegalovirus-specific CD8+ T cells during primary infection differentiates the capacity for durable immune control. 
  • Tacrolimus with mycophenolate mofetil (MMF) or sirolimus vs. cyclosporine with MMF in cardiac transplant patients: 1-year report. 
  • The Knife's Edge of Tolerance: Inducing Stable Multilineage Mixed Chimerism but With a Significant Risk of CMV Reactivation and Disease in Rhesus Macaques. 
  • The March towards a Vaccine for Congenital CMV: Rationale and Models. 
  • The Role of Congenital Cytomegalovirus Infection in Adverse Birth Outcomes: A Review of the Potential Mechanisms. 
  • The Roles of Host and Viral Antibody Fc Receptors in Herpes Simplex Virus (HSV) and Human Cytomegalovirus (HCMV) Infections and Immunity. 
  • The acquired immunodeficiency syndrome in intravenous drug abusers and patients with a sexual risk: clinical and postmortem comparisons. 
  • The age-related increase in low-grade systemic inflammation (Inflammaging) is not driven by cytomegalovirus infection. 
  • The allo- and viral-specific immunosuppressive effect of belatacept, but not tacrolimus, attenuates with progressive T cell maturation. 
  • The association of prior cytomegalovirus infection with neovascular age-related macular degeneration. 
  • The effect of prophylactic intravenous immune globulin on the incidence of septicemia in marrow transplant recipients. 
  • The expression level of C19MC miRNAs in early pregnancy and in response to viral infection. 
  • The impact of blood transfusion on the occurrence of pneumonitis in primary cytomegalovirus infection after liver transplantation. 
  • The impact of hypoalbuminemia in kidney-pancreas transplant recipients. 
  • The pathophysiology and treatment of graft-versus-host disease. 
  • The retinal lesions of the acquired immune deficiency syndrome. 
  • The source of murine cytomegalovirus in mice receiving kidney allografts. 
  • Tracking KLRC2 (NKG2C)+ memory-like NK cells in SIV+ and rhCMV+ rhesus macaques. 
  • Transcriptional Profiling of CD8+ CMV-Specific T Cell Functional Subsets Obtained Using a Modified Method for Isolating High-Quality RNA From Fixed and Permeabilized Cells. 
  • Transmission of latent cytomegalovirus in a murine kidney tissue transplantation model. 
  • Two rare forms of renal allograft glomerulopathy during cytomegalovirus infection and treatment. 
  • Use of intravenous immunoglobulin in human disease: a review of evidence by members of the Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology. 
  • Viral infection-homograft interactions in a murine model. 
  • Viral infections in the acquired immunodeficiency syndrome. 
  • [Organ transplantation infection and its prevention and treatment]. 
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  Keywords of People

  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Murdoch, David Martin, Associate Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine
  • O'Connor, Christopher Michael, Richard Sean Stack, M.D. Distinguished Professor, Medicine, Clinical Pharmacology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, in the School of Medicine, Immunology