Cytomegalovirus

• 

  Subject Areas on Research

  • A Brief Prenatal Intervention of Behavioral Change to Reduce the Risk of Maternal Cytomegalovirus: A Randomized Controlled Trial. 
  • A phase I trial of hyperthermia-induced interleukin-12 gene therapy in spontaneously arising feline soft tissue sarcomas. 
  • A promising cancer vaccine. 
  • A proteomic approach for unraveling the oncogenic H-Ras protein networks in NIH/3T3 mouse embryonic fibroblast cells. 
  • A randomized, placebo-controlled trial of the safety and efficacy of oral ganciclovir for prophylaxis of cytomegalovirus disease in HIV-infected individuals. Terry Beirn Community Programs for Clinical Research on AIDS. 
  • A single, improbable B cell receptor mutation confers potent neutralization against cytomegalovirus. 
  • A single-center experience with ganciclovir-resistant cytomegalovirus in lung transplant recipients: treatment and outcome. 
  • Absence of cytomegalovirus-resistance mutations after valganciclovir prophylaxis, in a prospective multicenter study of solid-organ transplant recipients. 
  • Active cytomegalovirus particles in the eyes of an AIDS patient being treated with 9-[2-hydroxy-1-(hydroxymethyl) ethoxymethyl] guanine (Ganciclovir). 
  • Acute murine cytomegalovirus disrupts established transplantation tolerance and causes recipient allo-sensitization. 
  • Adenovirus-mediated transfer of the muscle glycogen phosphorylase gene into hepatocytes confers altered regulation of glycogen metabolism. 
  • Age matters: older age as a risk factor for CMV reactivation in the CMV serostatus-positive kidney transplant recipient. 
  • Age-related patterns of cytomegalovirus antibodies accompanying Epstein-Barr virus co-infection. 
  • Aging and reactivation of latent murine cytomegalovirus. 
  • Amniocentesis to diagnose congenital cytomegalovirus infection following maternal primary infection. 
  • Antigen-specific T-lymphocyte function after cord blood transplantation. 
  • Association of Postnatal Cytomegalovirus Infection With Head Growth-Reply. 
  • Breast Milk and Saliva Lactoferrin Levels and Postnatal Cytomegalovirus Infection. 
  • Breast Milk and Saliva for Postnatal Cyto†megalovirus Screening among Very Low Birth Weight Infants. 
  • Bridging the translation gap in cytomegalovirus therapeutics through ex vivo lung perfusion: Opportunities and challenges. 
  • CMV Primes Functional Alternative Signaling in Adaptive Δg NK Cells but Is Subverted by Lentivirus Infection in Rhesus Macaques. 
  • CMV reactivation drives posttransplant T-cell reconstitution and results in defects in the underlying TCRβ repertoire. 
  • Can viruses help us to understand and classify the MHC class I molecules at the maternal-fetal interface? 
  • Cell-mediated cytotoxicity of murine cytomegalovirus-infected target cells allows for release of residual infectious virus. 
  • Characterization of Plasma Immunoglobulin G Responses in Elite Neutralizers of Human Cytomegalovirus. 
  • Choice of Study Populations for Vaccines. 
  • Clinical factors associated with cytomegalovirus shedding among seropositive pregnant women. 
  • Clinical outcomes in cytomegalovirus-positive Posner-Schlossman syndrome patients treated with topical ganciclovir therapy. 
  • Clinical utility of cytomegalovirus viral load testing for predicting CMV disease in D+/R- solid organ transplant recipients. 
  • Comparison of cytomegalovirus polymerase chain reaction and serology for screening umbilical cord blood components. 
  • Comparison of the Digene Hybrid Capture System Cytomegalovirus (CMV) DNA (version 2.0), Roche CMV UL54 analyte-specific reagent, and QIAGEN RealArt CMV LightCycler PCR reagent tests using AcroMetrix OptiQuant CMV DNA quantification panels and specimens from allogeneic-stem-cell transplant recipients. 
  • Comparisons of CD8+ T cells specific for human immunodeficiency virus, hepatitis C virus, and cytomegalovirus reveal differences in frequency, immunodominance, phenotype, and interleukin-2 responsiveness. 
  • Congenital Human Cytomegalovirus Infection Is Associated With Decreased Transplacental IgG Transfer Efficiency Due to Maternal Hypergammaglobulinemia. 
  • Correlation between interferon- gamma secretion and cytotoxicity, in virus-specific memory T cells. 
  • Cytomegalovirus (CMV) shedding is highly correlated with markers of immunosuppression in CMV-seropositive women. 
  • Cytomegalovirus Immunoglobulin G (IgG) Titer and Coronary Artery Disease in People With Human Immunodeficiency Virus (HIV). 
  • Cytomegalovirus Infection Management in Multivisceral and Intestinal Transplant: A Dual Institution Study. 
  • Cytomegalovirus Screening in Pregnancy: A Cost-Effectiveness and Threshold Analysis. 
  • Cytomegalovirus Therapy: Role of Letermovir in Prophylaxis and Treatment in Transplant Recipients. 
  • Cytomegalovirus as an immunomodulator across the lifespan. 
  • Cytomegalovirus in Allogeneic Hematopoietic Transplantation: Impact on Costs and Clinical Outcomes Using a Preemptive Strategy. 
  • Cytomegalovirus infection in the normal host. 
  • Cytomegalovirus infection increases the risk for inflammatory bowel disease. 
  • Cytomegalovirus keratitis after penetrating keratoplasty. 
  • Cytomegalovirus pericarditis: a case series and review of the literature. 
  • Cytomegalovirus prevention in thoracic organ transplantation: A single-center evaluation of letermovir prophylaxis. 
  • Cytomegalovirus retinitis and immunodeficiency in homosexual males. 
  • Cytomegalovirus retinitis associated with Hodgkin's disease. 
  • Cytomegalovirus retinitis. 
  • Cytomegalovirus retinitis: a manifestation of the acquired immune deficiency syndrome (AIDS). 
  • Delay of CMV infection in high-risk CMV mismatch lung transplant recipients due to prophylaxis with oral ganciclovir. 
  • Delayed vs initial cytomegalovirus prophylaxis after kidney transplantation. 
  • Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma. 
  • Detailed analysis of cytomegalovirus (CMV)-specific T cells expanded for adoptive immunotherapy of CMV infection following allogeneic stem cell transplantation for malignant disease. 
  • Detection and Prevention of Perinatal Infection: Cytomegalovirus and Zika Virus. 
  • Detection of mouse cytomegalovirus nucleic acid in latently infected mice by in vitro enzymatic amplification. 
  • Detection of murine cytomegalovirus immediate early 1 transcripts in the spleens of latently infected mice. 
  • Determinants of the source of cytomegalovirus in murine renal allograft recipients. 
  • Development and preclinical evaluation of an alphavirus replicon particle vaccine for cytomegalovirus. 
  • Diagnosis of human congenital cytomegalovirus infection by amplification of viral DNA from dried blood spots on perinatal cards. 
  • Differential CMV-specific CD8+ effector T cell responses in the lung allograft predominate over the blood during human primary infection. 
  • Down-regulation of MHC class I antigen presentation by HCMV; lessons for tumor immunology. 
  • Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. 
  • Early KLRG1+ but Not CD57+CD8+ T Cells in Primary Cytomegalovirus Infection Predict Effector Function and Viral Control. 
  • Early versus delayed initiation of cytomegalovirus prophylaxis after liver transplant. 
  • Effect of cyclical intermittent hypoxia on Ad5CMVCre induced solitary lung cancer progression and spontaneous metastases in the KrasG12D+; p53fl/fl; myristolated p110fl/fl ROSA-gfp mouse. 
  • Engineered zinc finger-activating vascular endothelial growth factor transcription factor plasmid DNA induces therapeutic angiogenesis in rabbits with hindlimb ischemia. 
  • Enhancement of electric field-mediated gene delivery through pretreatment of tumors with a hyperosmotic mannitol solution. 
  • Enumerating antigen-specific T-cell responses in peripheral blood: a comparison of peptide MHC Tetramer, ELISpot, and intracellular cytokine analysis. 
  • Epstein-Barr virus and Guillain-Barrè syndrome. 
  • Evaluation of HLA polymorphisms in relation to schizophrenia risk and infectious exposure. 
  • Functional Characteristics and Phenotypic Plasticity of CD57+PD1- CD4 T Cells and Their Relationship with Transplant Immunosuppression. 
  • Fusion of the termini of the murine cytomegalovirus genome after infection. 
  • Geographic Disparities in Cytomegalovirus Infection During Pregnancy. 
  • Granulomatous hepatitis associated with acute cytomegalovirus infection. 
  • HCMV glycoprotein B subunit vaccine efficacy mediated by nonneutralizing antibody effector functions. 
  • HLA-G and HLA-C at the feto-maternal interface: lessons learned from pathogenic viruses. 
  • High throughput functional analysis of HIV-1 env genes without cloning. 
  • High-quality CMV-specific CD4+ memory is enriched in the lung allograft and is associated with mucosal viral control. 
  • Highlights from the clinical trials in organ transplantation (CTOT)-20 and CTOT-22 Consortium studies in lung transplant. 
  • Human Cytomegalovirus Glycoprotein B Nucleoside-Modified mRNA Vaccine Elicits Antibody Responses with Greater Durability and Breadth than MF59-Adjuvanted gB Protein Immunization. 
  • Human cytomegalovirus US2 endoplasmic reticulum-lumenal domain dictates association with major histocompatibility complex class I in a locus-specific manner. 
  • Humoral Immune Correlates for Prevention of Postnatal Cytomegalovirus Acquisition. 
  • Hyperimmune Globulin for Congenital Cytomegalovirus Infection. Reply. 
  • IL-12-Dependent Cytomegalovirus-Specific CD4+ T Cell Proliferation, T-bet Induction, and Effector Multifunction during Primary Infection Are Key Determinants for Early Immune Control. 
  • Identification of focal viral infections by confocal microscopy for subsequent ultrastructural analysis. 
  • Immune function, cortisol, and cognitive decline & dementia in an aging latino population. 
  • Immune interactions at the maternal-fetal interface: a focus on antigen presentation. 
  • Impact of cryopreservation on tetramer, cytokine flow cytometry, and ELISPOT. 
  • Impaired Cytomegalovirus Immunity in Idiopathic Pulmonary Fibrosis Lung Transplant Recipients with Short Telomeres. 
  • In vitro priming and expansion of cytomegalovirus-specific Th1 and Tc1 T cells from naive cord blood lymphocytes. 
  • Infection of T but not B lymphocytes by cytomegalovirus in lymph node. An immunophenotypic study. 
  • Infections after kidney transplantation. Does age matter? 
  • Infections after upper extremity allotransplantation: a worldwide population cohort study, 1998-2017. 
  • Inflammasome expression and cytomegalovirus viremia in critically ill patients with sepsis. 
  • Inflammatory bowel disease following solid organ transplantation. 
  • Interactions of 1263W94 with other antiviral agents in inhibition of human cytomegalovirus replication. 
  • Intravenous immune globulin prophylaxis in recipients of a marrow transplant. 
  • Is cytomegalovirus a therapeutic target in glioblastoma? 
  • Is prevention the best treatment? CMV after lung transplantation. 
  • Kaposi's sarcoma in homosexual men-a report of eight cases. 
  • Late gene expression-deficient cytomegalovirus vectors elicit conventional T cells that do not protect against SIV. 
  • Light-inducible gene regulation with engineered zinc finger proteins. 
  • Long-term Outcomes after Postnatal Cytomegalovirus Infection in Low Birthweight Preterm Infants: A Systematic Review. 
  • Long-term efficacy and safety of 12 months of valganciclovir prophylaxis compared with 3 months after lung transplantation: a single-center, long-term follow-up analysis from a randomized, controlled cytomegalovirus prevention trial. 
  • Loss to follow up of failed hearing screen and missed opportunities to detect congenital cytomegalovirus are better identified with the implementation of a new electronic health record system protocol. 
  • Macrophage colony-stimulating factor can modulate immune responses and attract dendritic cells in vivo. 
  • Maribavir for Refractory Cytomegalovirus Infections With or Without Resistance Post-Transplant: Results From a Phase 3 Randomized Clinical Trial. 
  • Marrow transplantation for severe aplastic anemia. Long-term outcome in fifty "untransfused" patients. 
  • Maternal Fc-mediated non-neutralizing antibody responses correlate with protection against congenital human cytomegalovirus infection. 
  • Mice immunosuppressed by murine retrovirus infection (MAIDS) are susceptible to cytomegalovirus retinitis. 
  • Microbial Vertical Transmission during Human Pregnancy. 
  • Molecular cloning and restriction endonuclease mapping of the murine cytomegalovirus genome (Smith Strain). 
  • Murine cytomegalovirus dissemination but not reactivation in donor-positive/recipient-negative allogeneic kidney transplantation can be effectively prevented by transplant immune tolerance. 
  • Murine cytomegalovirus gene amplification and culture after submaxillary salivary gland biopsy. 
  • Murine cytomegalovirus infection: hematological, morphological, and functional study of lymphoid cells. 
  • Nonhuman primate models of intrauterine cytomegalovirus infection. 
  • Novel integrase-defective lentiviral episomal vectors for gene transfer. 
  • Nuclear factor-kappaB mediates Kupffer cell apoptosis through transcriptional activation of Fas/FasL. 
  • Once, Twice, Three Times a Finding: Reproducibility of Dendritic Cell Vaccine Trials Targeting Cytomegalovirus in Glioblastoma. 
  • Optimizing gene transfer to conventional outflow cells in living mouse eyes. 
  • Overexpression of pre-pro-cholecystokinin stimulates beta-cell proliferation in mouse and human islets with retention of islet function. 
  • Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP. 
  • Persistent infection with neurotropic herpes viruses and cognitive impairment. 
  • Pharmacodynamics of oral ganciclovir and valganciclovir in solid organ transplant recipients. 
  • Phenotypic and functional characterization of cytotoxic T lymphocytes by flow cytometry. 
  • Plasmablast Response to Primary Rhesus Cytomegalovirus (CMV) Infection in a Monkey Model of Congenital CMV Transmission. 
  • Polyfunctional T-Cell Signatures to Predict Protection from Cytomegalovirus after Lung Transplantation. 
  • Polyfunctional cytomegalovirus-specific immunity in lung transplant recipients receiving valganciclovir prophylaxis. 
  • Postnatal Cytomegalovirus Infection and the Risk for Bronchopulmonary Dysplasia. 
  • Postnatally acquired CMV meningitis diagnosed via BioFire FilmArray: A case report. 
  • Pre-existing immunity to cytomegalovirus in macaques influences human CMV vaccine responses in preclinical models. 
  • Precision and linearity targets for validation of an IFNgamma ELISPOT, cytokine flow cytometry, and tetramer assay using CMV peptides. 
  • Preemptive ganciclovir administration based solely on asymptomatic pulmonary cytomegalovirus infection in allogeneic bone marrow transplant recipients: long-term follow-up. 
  • Prenatal Treatment of Congenital Cytomegalovirus With Valganciclovir: A Case Report. 
  • Primary cytomegalovirus phosphoprotein 65-specific CD8+ T-cell responses and T-bet levels predict immune control during early chronic infection in lung transplant recipients. 
  • Pulmonary Embolism in a Young Immunocompetent Adult Infected with Cytomegalovirus. Are Novel Oral Anticoagulants an Efficient Alternative? 
  • Randomized, placebo-controlled, double-blind study of a cytomegalovirus-specific monoclonal antibody (MSL-109) for prevention of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation. 
  • Reactivation of latent murine cytomegalovirus from kidney. 
  • Real-world effectiveness of preemptive therapy (PET) for cytomegalovirus (CMV) disease prevention in CMV high-risk donor seropositive/recipient seronegative (D+R-) liver transplant recipients (LTxR). 
  • Recognition and killing of autologous, primary glioblastoma tumor cells by human cytomegalovirus pp65-specific cytotoxic T cells. 
  • Reduced DNA repair capacity in lung cancer patients. 
  • Relationship Among Viremia/Viral Infection, Alloimmunity, and Nutritional Parameters in the First Year After Pediatric Kidney Transplantation. 
  • Replication of the murine cytomegalovirus genome: structure and role of the termini in the generation and cleavage of concatenates. 
  • Reply to Frange and Leruez-Ville, "Caution Is Required before Recommending Wide Use of Letermovir as Salvage Therapy for Cytomegalovirus Diseases". 
  • Retinitis in euthymic mice following inoculation of murine cytomegalovirus (MCMV) via the supraciliary route. 
  • Reversing adipocyte differentiation: implications for treatment of obesity. 
  • RhCMV serostatus and vaccine adjuvant impact immunogenicity of RhCMV/SIV vaccines. 
  • Role of MCP-1 and IL-8 in viral anterior uveitis, and contractility and fibrogenic activity of trabecular meshwork cells. 
  • Sensitive detection of human cytomegalovirus in tumors and peripheral blood of patients diagnosed with glioblastoma. 
  • Specificity and effector functions of non-neutralizing gB-specific monoclonal antibodies isolated from healthy individuals with human cytomegalovirus infection. 
  • Studies of viral antibody responses among Amish families. 
  • Subordinate Effect of -21M HLA-B Dimorphism on NK Cell Repertoire Diversity and Function in HIV-1 Infected Individuals of African Origin. 
  • Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infection. 
  • Survey on Transfusion-Transmitted Cytomegalovirus and Cytomegalovirus Disease Mitigation. 
  • Systemic correction of the muscle disorder glycogen storage disease type II after hepatic targeting of a modified adenovirus vector encoding human acid-alpha-glucosidase. 
  • T-bet:Eomes balance, effector function, and proliferation of cytomegalovirus-specific CD8+ T cells during primary infection differentiates the capacity for durable immune control. 
  • The Knife's Edge of Tolerance: Inducing Stable Multilineage Mixed Chimerism but With a Significant Risk of CMV Reactivation and Disease in Rhesus Macaques. 
  • The Role of Congenital Cytomegalovirus Infection in Adverse Birth Outcomes: A Review of the Potential Mechanisms. 
  • The Roles of Host and Viral Antibody Fc Receptors in Herpes Simplex Virus (HSV) and Human Cytomegalovirus (HCMV) Infections and Immunity. 
  • The allo- and viral-specific immunosuppressive effect of belatacept, but not tacrolimus, attenuates with progressive T cell maturation. 
  • The association of prior cytomegalovirus infection with neovascular age-related macular degeneration. 
  • The promoter of human T-cell leukemia virus type-I is repressed by the immediate-early gene region of human cytomegalovirus in primary blood lymphocytes. 
  • The repression of hormone-activated PEPCK gene expression by glucose is insulin-independent but requires glucose metabolism. 
  • The source of murine cytomegalovirus in mice receiving kidney allografts. 
  • Topical ganciclovir treatment in patients with cytomegalovirus endotheliitis receiving penetrating keratoplasty. 
  • Tracking KLRC2 (NKG2C)+ memory-like NK cells in SIV+ and rhCMV+ rhesus macaques. 
  • Transcription in mouse embryo cells permissively infected by murine cytomegalovirus. 
  • Transcription inhibits the replication of autonomously replicating plasmids in human cells. 
  • Transmission of latent cytomegalovirus in a murine kidney tissue transplantation model. 
  • Trophoblast class I major histocompatibility complex (MHC) products are resistant to rapid degradation imposed by the human cytomegalovirus (HCMV) gene products US2 and US11. 
  • Undernutrition and Hypoleptinemia Modulate Alloimmunity and CMV-specific Viral Immunity in Transplantation. 
  • Use of Letermovir as Salvage Therapy for Drug-Resistant Cytomegalovirus Retinitis. 
  • Viral infection-homograft interactions in a murine model. 
• 

  Keywords of People

  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • O'Connor, Christopher Michael, Adjunct Professor in the Department of Medicine, Medicine, Clinical Pharmacology