Cytoskeletal Proteins

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  Subject Areas on Research

  • A Unified Model for Treadmilling and Nucleation of Single-Stranded FtsZ Protofilaments. 
  • A conserved family of enzymes that phosphorylate inositol hexakisphosphate. 
  • A germline mutation at the extreme 3' end of the APC gene results in a severe desmoid phenotype and is associated with overexpression of beta-catenin in the desmoid tumor. 
  • A micromere induction signal is activated by beta-catenin and acts through notch to initiate specification of secondary mesenchyme cells in the sea urchin embryo. 
  • A model for slow axonal transport and its application to neurofilamentous neuropathies. 
  • A new function for adducin. Calcium/calmodulin-regulated capping of the barbed ends of actin filaments. 
  • A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif. 
  • A physical interaction network of dengue virus and human proteins. 
  • A rapid fluorescence assay for FtsZ assembly indicates cooperative assembly with a dimer nucleus. 
  • A role for myocilin in receptor-mediated endocytosis. 
  • A splice-site mutation in a retina-specific exon of BBS8 causes nonsyndromic retinitis pigmentosa. 
  • A tissue-engineered human trabecular meshwork hydrogel for advanced glaucoma disease modeling. 
  • A two-tiered mechanism by which Cdc42 controls the localization and activation of an Arp2/3-activating motor complex in yeast. 
  • Abi-1 forms an epidermal growth factor-inducible complex with Cbl: role in receptor endocytosis. 
  • Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling. 
  • Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels. 
  • Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin. 
  • Actin dynamics: the arp2/3 complex branches out. 
  • Activated armadillo/beta-catenin does not play a general role in cell migration and process extension in Drosophila. 
  • Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility. 
  • Activation of pmar1 controls specification of micromeres in the sea urchin embryo. 
  • Activation of the yeast Arp2/3 complex by Bee1p, a WASP-family protein. 
  • Activity-regulated cytoskeleton-associated protein Arc/Arg3.1 binds to spectrin and associates with nuclear promyelocytic leukemia (PML) bodies. 
  • Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C. 
  • Adducin: Ca++-dependent association with sites of cell-cell contact. 
  • Adenomatous polyposis coli gene mutation alters proliferation through its beta-catenin-regulatory function in aggressive fibromatosis (desmoid tumor). 
  • Alterations in gene expression induced by cyclic mechanical stress in trabecular meshwork cells. 
  • An integrative approach identified genes associated with drug response in gastric cancer. 
  • Analogs of tetrahydroisoquinoline natural products that inhibit cell migration and target galectin-3 outside of its carbohydrate-binding site. 
  • Analysis of the role of membrane polarity in polycystic kidney disease of transgenic SBM mice. 
  • Apparent cooperative assembly of the bacterial cell division protein FtsZ demonstrated by isothermal titration calorimetry. 
  • Arc/Arg3.1 translation is controlled by convergent N-methyl-D-aspartate and Gs-coupled receptor signaling pathways. 
  • Assembly dynamics of FtsZ rings in Bacillus subtilis and Escherichia coli and effects of FtsZ-regulating proteins. 
  • Assembly dynamics of Mycobacterium tuberculosis FtsZ. 
  • Assembly of the dystrophin-associated protein complex does not require the dystrophin COOH-terminal domain. 
  • Asymmetric cell divisions promote stratification and differentiation of mammalian skin. 
  • Asynchronous nuclear division cycles in multinucleated cells. 
  • Atomic structures of tubulin and FtsZ. 
  • Axin2 regulates chondrocyte maturation and axial skeletal development. 
  • BMPs induce dermal markers and ectopic feather tracts. 
  • Bacterial Nucleoid Occlusion: Multiple Mechanisms for Preventing Chromosome Bisection During Cell Division. 
  • Bacterial cell division protein FtsZ assembles into protofilament sheets and minirings, structural homologs of tubulin polymers. 
  • Beta-catenin expression in Dupuytren's disease: potential role for cell-matrix interactions in modulating beta-catenin levels in vivo and in vitro. 
  • Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin. 
  • Bi-modal regulation of a formin by srGAP2. 
  • Borg proteins control septin organization and are negatively regulated by Cdc42. 
  • CC2D2A is mutated in Joubert syndrome and interacts with the ciliopathy-associated basal body protein CEP290. 
  • CCP1 promotes mitochondrial fusion and motility to prevent Purkinje cell neuron loss in pcd mice. 
  • CD44--a molecule involved in leukocyte adherence and T-cell activation. 
  • CYP1B1, MYOC, and LTBP2 mutations in primary congenital glaucoma patients in the United States. 
  • Ca++-switch induction of RPE differentiation. 
  • Calbindin D28K interacts with Ran-binding protein M: identification of interacting domains by NMR spectroscopy. 
  • Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex. 
  • Cell division without FtsZ--a variety of redundant mechanisms. 
  • Changes in the pattern of adherens junction-associated beta-catenin accompany morphogenesis in the sea urchin embryo. 
  • Chapter 1 - Tubular liposomes with variable permeability for reconstitution of FtsZ rings. 
  • Characterization of a gene trap insertion into a novel gene, cordon-bleu, expressed in axial structures of the gastrulating mouse embryo. 
  • Characterization of autoantibodies in pemphigus using antigen-specific enzyme-linked immunosorbent assays with baculovirus-expressed recombinant desmogleins. 
  • Characterization of cytoskeleton-enriched protein fraction of the trabecular meshwork and ciliary muscle cells. 
  • Characterization of lens fiber cell triton insoluble fraction reveals ERM (ezrin, radixin, moesin) proteins as major cytoskeletal-associated proteins. 
  • Characterization of the role of cadherin in regulating cell adhesion during sea urchin development. 
  • Characterizing differences between MSCs and TM cells: Toward autologous stem cell therapies for the glaucomatous trabecular meshwork. 
  • Clathrin is important for normal actin dynamics and progression of Sla2p-containing patches during endocytosis in yeast. 
  • Coiled-coil targeting of myocilin to intracellular membranes. 
  • Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. 
  • Comparative epitope mapping of sera from United States (US) and Japanese patients with bullous pemphigoid (BP) to fusion proteins encoded by BPAG1. 
  • Conformational changes of FtsZ reported by tryptophan mutants. 
  • Control of septin filament flexibility and bundling by subunit composition and nucleotide interactions. 
  • Cordon-bleu is a conserved gene involved in neural tube formation. 
  • Cordon-bleu is an actin nucleation factor and controls neuronal morphology. 
  • Curved FtsZ protofilaments generate bending forces on liposome membranes. 
  • Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor). 
  • Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma. 
  • De novo mutations in NALCN cause a syndrome characterized by congenital contractures of the limbs and face, hypotonia, and developmental delay. 
  • Dephosphorylation of ezrin as an early event in renal microvillar breakdown and anoxic injury. 
  • Desmoplakin I and desmoplakin II. Purification and characterization. 
  • Desmoplakin: an unexpected regulator of microtubule organization in the epidermis. 
  • Differential binding of apolipoprotein E isoforms to tau and other cytoskeletal proteins. 
  • Differential extraction and enrichment of human sperm surface proteins in a proteome: identification of immunocontraceptive candidates. 
  • Differential renal distribution of NHERF isoforms and their colocalization with NHE3, ezrin, and ROMK. 
  • Differential response and withdrawal profile of glucocorticoid-treated human trabecular meshwork cells. 
  • Direct interaction of Gas11 with microtubules: implications for the dynein regulatory complex. 
  • Direct involvement of yeast type I myosins in Cdc42-dependent actin polymerization. 
  • Dissection of epistasis in oligogenic Bardet-Biedl syndrome. 
  • Dissociable effects of advanced age on prefrontal cortical and medial temporal lobe ensemble activity. 
  • Distinct regions of the cadherin cytoplasmic domain are essential for functional interaction with Galpha 12 and beta-catenin. 
  • Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin 
  • Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis. 
  • Dynamics of PTH-induced disassembly of Npt2a/NHERF-1 complexes in living OK cells. 
  • Dynamin and FtsZ. Missing links in mitochondrial and bacterial division. 
  • E-4-hydroxy-2-nonenal is cytotoxic and cross-links cytoskeletal proteins in P19 neuroglial cultures. 
  • ESR1/SYNE1 polymorphism and invasive epithelial ovarian cancer risk: an Ovarian Cancer Association Consortium study. 
  • Effects of elevated intraocular pressure on outflow facility and TIGR/MYOC expression in perfused human anterior segments. 
  • Elevated levels of beta-catenin and fibronectin in three-dimensional collagen cultures of Dupuytren's disease cells are regulated by tension in vitro. 
  • Evidence for RPGRIP1 gene as risk factor for primary open angle glaucoma. 
  • Evolution of the cytoskeleton. 
  • Exploring the mechanism of Physcomitrella patens desiccation tolerance through a proteomic strategy. 
  • Expression of RNAs for calmodulin, actins, and tubulins in rat testis cells. 
  • Expression of ezrin correlates with malignant phenotype of lung cancer, and in vitro knockdown of ezrin reverses the aggressive biological behavior of lung cancer cells. 
  • Expression of utrophin A mRNA correlates with the oxidative capacity of skeletal muscle fiber types and is regulated by calcineurin/NFAT signaling. 
  • Extracellular trafficking of myocilin in human trabecular meshwork cells. 
  • Ezrin Orchestrates Signal Transduction in Airway Cells. 
  • Ezrin binding domain-deficient NHERF attenuates cAMP-mediated inhibition of Na(+)/H(+) exchange in OK cells. 
  • Fetal antisense oligonucleotide therapy for congenital deafness and vestibular dysfunction. 
  • Force generation by kinesin and myosin cytoskeletal motor proteins. 
  • Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse. 
  • Fragility and mechanosensing in a thermalized cytoskeleton model with forced protein unfolding. 
  • FtsZ Constriction Force - Curved Protofilaments Bending Membranes. 
  • FtsZ Protofilament Curvature Is the Opposite of Tubulin Rings. 
  • FtsZ at mid-cell is essential in Escherichia coli until the late stage of constriction. 
  • FtsZ condensates: an in vitro electron microscopy study. 
  • FtsZ filament capping by MciZ, a developmental regulator of bacterial division. 
  • FtsZ filament dynamics at steady state: subunit exchange with and without nucleotide hydrolysis. 
  • FtsZ from Escherichia coli, Azotobacter vinelandii, and Thermotoga maritima--quantitation, GTP hydrolysis, and assembly. 
  • FtsZ from divergent foreign bacteria can function for cell division in Escherichia coli. 
  • FtsZ in bacterial cytokinesis: cytoskeleton and force generator all in one. 
  • FtsZ, a prokaryotic homolog of tubulin? 
  • G protein-coupled receptor kinase 2 activates radixin, regulating membrane protrusion and motility in epithelial cells. 
  • Gene expression in the rectus abdominus muscle of patients with and without pelvic organ prolapse. 
  • Gene expression profile in human trabecular meshwork from patients with primary open-angle glaucoma. 
  • Gene product 0.4 increases bacteriophage T7 competitiveness by inhibiting host cell division. 
  • Genetic Influences on Plasma Homocysteine Levels in African Americans and Yoruba Nigerians. 
  • Genetic interactions among regulators of septin organization. 
  • Genetic investigation of fibromuscular dysplasia identifies risk loci and shared genetics with common cardiovascular diseases. 
  • Genetics of adult glaucoma. 
  • Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians. 
  • Genomic abnormalities of the murine model of Fabry disease after disease-related perturbation, a systems biology approach. 
  • Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors. 
  • Gigaxonin glycosylation regulates intermediate filament turnover and may impact giant axonal neuropathy etiology or treatment. 
  • Glaucoma genetics. 
  • Glaucoma in Ghana, West Africa: clinical features and the role of mutations in Myocilin. 
  • Gln368STOP myocilin mutation in families with late-onset primary open-angle glaucoma. 
  • Glypican-4 regulated actin cytoskeletal reorganization in glucocorticoid treated trabecular meshwork cells and involvement of Wnt/PCP signaling. 
  • Growth factors regulate beta-catenin-mediated TCF-dependent transcriptional activation in fibroblasts during the proliferative phase of wound healing. 
  • HPV status-independent association of alcohol and tobacco exposure or prior radiation therapy with promoter methylation of FUSSEL18, EBF3, IRX1, and SEPT9, but not SLC5A8, in head and neck squamous cell carcinomas. 
  • Hic-5 Regulates Actin Cytoskeletal Reorganization and Expression of Fibrogenic Markers and Myocilin in Trabecular Meshwork Cells. 
  • High-resolution crystal structures of Escherichia coli FtsZ bound to GDP and GTP. 
  • Hypomorphic mutations in syndromic encephalocele genes are associated with Bardet-Biedl syndrome. 
  • ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation. 
  • Identification of Drosophila cytoskeletal proteins by induction of abnormal cell shape in fission yeast. 
  • Identification of IGFBP-6 as a significantly downregulated gene by beta-catenin in desmoid tumors. 
  • Identification of a role for beta-catenin in the establishment of a bipolar mitotic spindle. 
  • Identification of novel murine- and human-specific RPGRIP1 splice variants with distinct expression profiles and subcellular localization. 
  • Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1. 
  • IgG antibodies from patients with bullous pemphigoid bind to localized epitopes on synthetic peptides encoded by bullous pemphigoid antigen cDNA. 
  • Impaired cytoskeletal organization and membrane integrity in lens fibers of a Rho GTPase functional knockout transgenic mouse. 
  • In vitro assembly studies of FtsZ/tubulin-like proteins (TubZ) from Bacillus plasmids: evidence for a capping mechanism. 
  • In vitro reconstitution of cortical actin assembly sites in budding yeast. 
  • In vivo characterization of Escherichia coli ftsZ mutants: effects on Z-ring structure and function. 
  • In vivo dynamics of clathrin and its adaptor-dependent recruitment to the actin-based endocytic machinery in yeast. 
  • In vivo electroporation and non-protein based screening assays to identify antibodies against native protein conformations. 
  • In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation. 
  • Increased beta-catenin protein and somatic APC mutations in sporadic aggressive fibromatoses (desmoid tumors). 
  • Increased calmodulin affects cell morphology and mRNA levels of cytoskeletal protein genes. 
  • Increased expression of utrophin in a slow vs. a fast muscle involves posttranscriptional events. 
  • Inside-out Z rings--constriction with and without GTP hydrolysis. 
  • Insights into X-linked retinitis pigmentosa type 3, allied diseases and underlying pathomechanisms. 
  • Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release. 
  • Interaction of nephrocystin-4 and RPGRIP1 is disrupted by nephronophthisis or Leber congenital amaurosis-associated mutations. 
  • Interactions between dystrophin and the sarcolemma membrane. 
  • Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome. 
  • Interplay between septin organization, cell cycle and cell shape in yeast. 
  • Interplay of septin amphipathic helices in sensing membrane-curvature and filament bundling. 
  • Isolation, culture, and characterization of endothelial cells from Schlemm's canal. 
  • KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development. 
  • Lack of evidence for an association between alpha-adducin and blood pressure regulation in Asian populations. 
  • Limited proteolysis differentially modulates the stability and subcellular localization of domains of RPGRIP1 that are distinctly affected by mutations in Leber's congenital amaurosis. 
  • Liposome division by a simple bacterial division machinery. 
  • Localization and interaction of NHERF isoforms in the renal proximal tubule of the mouse. 
  • Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system. 
  • Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport. 
  • Loss of the cytoskeletal protein Pdlim7 predisposes mice to heart defects and hemostatic dysfunction. 
  • Lovastatin-induced cytoskeletal reorganization in lens epithelial cells: role of Rho GTPases. 
  • Low prevalence of myocilin mutations in an African American population with primary open-angle glaucoma. 
  • LvGroucho and nuclear beta-catenin functionally compete for Tcf binding to influence activation of the endomesoderm gene regulatory network in the sea urchin embryo. 
  • LvNotch signaling plays a dual role in regulating the position of the ectoderm-endoderm boundary in the sea urchin embryo. 
  • LvTbx2/3, a T-box Family Transcription Factor Involved in Formation of the Oral/Aboral Axis of the Sea Urchin Embryo 
  • MOP2 (SLA2) affects the abundance of the plasma membrane H(+)-ATPase of Saccharomyces cerevisiae. 
  • Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4. 
  • Maximal polar growth potential depends on the polarisome component AgSpa2 in the filamentous fungus Ashbya gossypii. 
  • Modeling the physics of FtsZ assembly and force generation. 
  • Modulation of myocilin/TIGR expression in human trabecular meshwork. 
  • Modulation of smooth muscle contractility by CHASM, a novel member of the smoothelin family of proteins. 
  • Molecular mechanism by which the nucleoid occlusion factor, SlmA, keeps cytokinesis in check. 
  • Molecular mechanisms of exocytosis: the adrenal chromaffin cell as a model system. 
  • Moving into the cell: single-molecule studies of molecular motors in complex environments. 
  • Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection. 
  • Multiple regulatory events controlling the expression and localization of utrophin in skeletal muscle fibers: insights into a therapeutic strategy for Duchenne muscular dystrophy. 
  • Multiplex detection of disease biomarkers using SERS molecular sentinel-on-chip. 
  • Mutants of FtsZ targeting the protofilament interface: effects on cell division and GTPase activity. 
  • Mutation in the mismatch repair gene Msh6 causes cancer susceptibility. 
  • Mutation of MeCP2 alters transcriptional regulation of select immediate-early genes. 
  • Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. 
  • Mutations in NCAPG2 Cause a Severe Neurodevelopmental Syndrome that Expands the Phenotypic Spectrum of Condensinopathies. 
  • Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS. 
  • Myocilin Mutations in Patients With Normal-Tension Glaucoma. 
  • Myocilin and optineurin coding variants in Hispanics of Mexican descent with POAG. 
  • Myocilin levels in primary open-angle glaucoma and pseudoexfoliation glaucoma human aqueous humor. 
  • Myocilin mutations in black South Africans with POAG. 
  • Myocilin polymorphisms and high myopia in subjects of European origin. 
  • Myocilin, a component of a membrane-associated protein complex driven by a homologous Q-SNARE domain. 
  • Myocilin-associated exosomes in human ocular samples. 
  • Myotilin is mutated in limb girdle muscular dystrophy 1A. 
  • Myotilin is not the causative gene for vocal cord and pharyngeal weakness with distal myopathy (VCPDM). 
  • NHERF and regulation of the renal sodium-hydrogen exchanger NHE3. 
  • NHERF associations with sodium-hydrogen exchanger isoform 3 (NHE3) and ezrin are essential for cAMP-mediated phosphorylation and inhibition of NHE3. 
  • NHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in mouse renal apical membranes. 
  • NHERF: targeting and trafficking membrane proteins. 
  • NMDA-glutamate receptors regulate phosphorylation of dendritic cytoskeletal proteins in the hippocampus. 
  • Negative-stain electron microscopy of inside-out FtsZ rings reconstituted on artificial membrane tubules show ribbons of protofilaments. 
  • Neonatal Escherichia coli infection alters glial, cytokine, and neuronal gene expression in response to acute amphetamine in adolescent rats. 
  • Neonatal infection modulates behavioral flexibility and hippocampal activation on a Morris Water Maze task. 
  • Non-muscle myosins control radial glial basal endfeet to mediate interneuron organization. 
  • Novel function of clathrin light chain in promoting endocytic vesicle formation. 
  • NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions. 
  • Nuclear beta-catenin is required to specify vegetal cell fates in the sea urchin embryo. 
  • Nuclear beta-catenin-dependent Wnt8 signaling in vegetal cells of the early sea urchin embryo regulates gastrulation and differentiation of endoderm and mesodermal cell lineages. 
  • Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis. 
  • Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway. 
  • Osteogenesis imperfecta and primary open angle glaucoma: genotypic analysis of a new phenotypic association. 
  • Palladin is an actin cross-linking protein that uses immunoglobulin-like domains to bind filamentous actin. 
  • Pcp1p, an Spc110p-related calmodulin target at the centrosome of the fission yeast Schizosaccharomyces pombe. 
  • Pentablock copolymer dexamethasone nanoformulations elevate MYOC: in vitro liberation, activity and safety in human trabecular meshwork cells. 
  • Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling. 
  • Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility. 
  • Phylogeny of Wolbachia pipientis based on gltA, groEL and ftsZ gene sequences: clustering of arthropod and nematode symbionts in the F supergroup, and evidence for further diversity in the Wolbachia tree. 
  • Physiological genomics of human arteries: quantitative relationship between gene expression and arterial stiffness. 
  • Planar cell polarity acts through septins to control collective cell movement and ciliogenesis. 
  • Polymerization of Ftsz, a bacterial homolog of tubulin. is assembly cooperative? 
  • Polyspecific reactivity of a murine monoclonal antibody that binds to nuclear matrix-associated, chromatin-bound autoantigens. 
  • Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction. 
  • Predominance of beta-catenin mutations and beta-catenin dysregulation in sporadic aggressive fibromatosis (desmoid tumor). 
  • Prevalence of mutations in TIGR/Myocilin in patients with adult and juvenile primary open-angle glaucoma. 
  • Prevalence of myocilin mutations in adults with primary open-angle glaucoma in Ghana, West Africa. 
  • Probing for Binding Regions of the FtsZ Protein Surface through Site-Directed Insertions: Discovery of Fully Functional FtsZ-Fluorescent Proteins. 
  • Probing the domain structure of FtsZ by random truncation and insertion of GFP. 
  • Prolonged beta-catenin stabilization and tcf-dependent transcriptional activation in hyperplastic cutaneous wounds. 
  • Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus. 
  • Protein phosphatase 2A: a panoply of enzymes. 
  • Protein profile of exosomes from trabecular meshwork cells. 
  • Protofilaments and rings, two conformations of the tubulin family conserved from bacterial FtsZ to alpha/beta and gamma tubulin. 
  • Purification and assembly of FtsZ. 
  • Purification of brain analogs of red blood cell membrane skeletal proteins: ankyrin, protein 4.1 (synapsin), spectrin, and spectrin subunits. 
  • Quinocarmycin analog DX-52-1 inhibits cell migration and targets radixin, disrupting interactions of radixin with actin and CD44. 
  • RPGRIP1 is essential for normal rod photoreceptor outer segment elaboration and morphogenesis. 
  • RPGRIP1s with distinct neuronal localization and biochemical properties associate selectively with RanBP2 in amacrine neurons. 
  • Rabbits immunized with a peptide encoded for by the 230-kD bullous pemphigoid antigen cDNA develop an enhanced inflammatory response to UVB irradiation: a potential animal model for bullous pemphigoid. 
  • Randomized, Double-Blind, Placebo-Controlled Trial of the Effect of Vitamin D3 on the Interferon Signature in Patients With Systemic Lupus Erythematosus. 
  • Rapid assembly dynamics of the Escherichia coli FtsZ-ring demonstrated by fluorescence recovery after photobleaching. 
  • Rapid de-localization of actin leading edge components with BDM treatment. 
  • Rapid in vitro assembly of Caulobacter crescentus FtsZ protein at pH 6.5 and 7.2. 
  • Reconstitution of contractile FtsZ rings in liposomes. 
  • Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A. 
  • Regulation of cell-cell adhesion by Abi/Diaphanous complexes. 
  • Regulation of endothelial cell adherens junctions by a Ras-dependent signal transduction pathway. 
  • Regulation of myocilin-associated exosome release from human trabecular meshwork cells. 
  • Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins. 
  • Regulation of spine structural plasticity by Arc/Arg3.1. 
  • Restriction of hepatic competence by Fgf signaling. 
  • Rho GDP dissociation inhibitor-mediated disruption of Rho GTPase activity impairs lens fiber cell migration, elongation and survival. 
  • Role for the Abi/wave protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling. 
  • Role of Scd5, a protein phosphatase-1 targeting protein, in phosphoregulation of Sla1 during endocytosis. 
  • Rvs161p and sphingolipids are required for actin repolarization following salt stress. 
  • SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice. 
  • SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. 
  • Saccharomyces cerevisiae Bzz1p is implicated with type I myosins in actin patch polarization and is able to recruit actin-polymerizing machinery in vitro. 
  • Sample preparation of the human TRPA1 ion channel for cryo-EM studies. 
  • Scd5p and clathrin function are important for cortical actin organization, endocytosis, and localization of sla2p in yeast. 
  • Seeking truth on Monte Verita. Workshop on the molecular biology and biochemistry of septins and septin function. 
  • Selective loss of RPGRIP1-dependent ciliary targeting of NPHP4, RPGR and SDCCAG8 underlies the degeneration of photoreceptor neurons. 
  • Sensing heart stress. 
  • Septin ring size scaling and dynamics require the coiled-coil region of Shs1p. 
  • Septins enforce morphogenetic events during sexual reproduction and contribute to virulence of Cryptococcus neoformans. 
  • Septins may form a ubiquitous family of cytoskeletal filaments. 
  • Sequential roles of Hedgehog and Wnt signaling in osteoblast development. 
  • Serial analysis of gene expression (SAGE) in normal human trabecular meshwork. 
  • Signaling by wingless in Drosophila. 
  • Skeletal muscle heavy-chain polypeptide 3 and myosin binding protein H in the pubococcygeus muscle in patients with and without pelvic organ prolapse. 
  • SlmA forms a higher-order structure on DNA that inhibits cytokinetic Z-ring formation over the nucleoid. 
  • Species-specific subcellular localization of RPGR and RPGRIP isoforms: implications for the phenotypic variability of congenital retinopathies among species. 
  • Specification of endoderm and mesoderm in the sea urchin. 
  • Straight and curved conformations of FtsZ are regulated by GTP hydrolysis. 
  • Structural and Functional Analyses Reveal Insights into the Molecular Properties of the Escherichia coli Z Ring Stabilizing Protein, ZapC. 
  • Structural evidence that the P/Q domain of ZipA is an unstructured, flexible tether between the membrane and the C-terminal FtsZ-binding domain. 
  • Structure of the Z Ring-associated Protein, ZapD, Bound to the C-terminal Domain of the Tubulin-like Protein, FtsZ, Suggests Mechanism of Z Ring Stabilization through FtsZ Cross-linking. 
  • Structures of the nucleoid occlusion protein SlmA bound to DNA and the C-terminal domain of the cytoskeletal protein FtsZ. 
  • SulA inhibits assembly of FtsZ by a simple sequestration mechanism. 
  • Suppressor of fused negatively regulates beta-catenin signaling. 
  • Suprastructures and dynamic properties of Mycobacterium tuberculosis FtsZ. 
  • Synapsin I is a spectrin-binding protein immunologically related to erythrocyte protein 4.1. 
  • Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation. 
  • Synergistic effect of shear stress and streptavidin-biotin on the expression of endothelial vasodilator and cytoskeleton genes. 
  • TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone. 
  • Tau deficiency leads to the upregulation of BAF-57, a protein involved in neuron-specific gene repression. 
  • Tcf-3 expression and beta-catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour). 
  • Tension-sensitive actin assembly supports contractility at the epithelial zonula adherens. 
  • Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila. 
  • The 120-kDa soluble ectodomain of type XVII collagen is recognized by autoantibodies in patients with pemphigoid and linear IgA dermatosis. 
  • The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia. 
  • The C-terminal linker of Escherichia coli FtsZ functions as an intrinsically disordered peptide. 
  • The Chloroplast Tubulin Homologs FtsZA and FtsZB from the Red Alga Galdieria sulphuraria Co-assemble into Dynamic Filaments. 
  • The FtsZ protofilament and attachment of ZipA--structural constraints on the FtsZ power stroke. 
  • The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. 
  • The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. 
  • The NMDA receptor subunit GluN3A regulates synaptic activity-induced and myocyte enhancer factor 2C (MEF2C)-dependent transcription. 
  • The Role of Brachyruy (T) During Gastrulations Movement in the Sea Urchin, Lytechinus variegatus 
  • The cell division protein MinD from Pseudomonas aeruginosa dominates the assembly of the MinC-MinD copolymers. 
  • The discovery of the prokaryotic cytoskeleton: 25th anniversary. 
  • The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators. 
  • The genetics of primary open-angle glaucoma: a review. 
  • The membrane skeleton of human erythrocytes and its implications for more complex cells. 
  • The retinitis pigmentosa GTPase regulator (RPGR) interacts with novel transport-like proteins in the outer segments of rod photoreceptors. 
  • The rho-guanine nucleotide exchange factor domain of obscurin regulates assembly of titin at the Z-disk through interactions with Ran binding protein 9. 
  • The role of Alzheimer's disease-related presenilin 1 in intercellular adhesion. 
  • The spectrin-based membrane skeleton and micron-scale organization of the plasma membrane. 
  • The straight and curved conformation of FtsZ protofilaments-evidence for rapid exchange of GTP into the curved protofilament. 
  • Transgenic mice expressing the myotilin T57I mutation unite the pathology associated with LGMD1A and MFM. 
  • Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice. 
  • Ultrastructural localization of erythrocyte cytoskeletal and integral membrane proteins in Plasmodium falciparum-infected erythrocytes. 
  • Under lock and key: spatiotemporal regulation of WASP family proteins coordinates separate dynamic cellular processes. 
  • Unique response profile of trabecular meshwork cells to the novel selective glucocorticoid receptor agonist, GW870086X. 
  • Whole genome re-sequencing to identify suppressor mutations of mutant and foreign Escherichia coli FtsZ. 
  • Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates. 
  • ZipA and FtsA* stabilize FtsZ-GDP miniring structures. 
  • [A study of E-cadherin and beta-catenin expression and their correlation with prognosis of nonsmall cell lung carcinoma]. 
  • alpha-Crystallin localizes to the leading edges of migrating lens epithelial cells. 
  • beta-Catenin is a Nek2 substrate involved in centrosome separation. 
  • beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds. 
  • myotilin Mutation found in second pedigree with LGMD1A. 
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  Keywords of People

  • Bejsovec, Amy, Associate Professor of Biology, Biology
  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Ginsburg, Geoffrey Steven, Adjunct Professor in the Department of Medicine, School of Nursing
  • Hoffman, Brenton D., James L. and Elizabeth M. Vincent Associate Professor of Biomedical Engineering, Biomedical Engineering
  • Lee, Walter T, Professor of Head and Neck Surgery & Communication Sciences, Radiation Oncology
  • Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology
  • Sparks, Matthew A., Associate Professor of Medicine, Medicine, Nephrology