Cytoskeleton

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  Subject Areas on Research

  • A Unified Model for Treadmilling and Nucleation of Single-Stranded FtsZ Protofilaments. 
  • A contractile actomyosin network linked to adherens junctions by Canoe/afadin helps drive convergent extension. 
  • A gene duplication of a septin reveals a developmentally regulated filament length control mechanism. 
  • A model for slow axonal transport and its application to neurofilamentous neuropathies. 
  • A rapid fluorescence assay for FtsZ assembly indicates cooperative assembly with a dimer nucleus. 
  • A structural comparison of tryptic fragments of three types of intermediate filaments. 
  • A two-tiered mechanism by which Cdc42 controls the localization and activation of an Arp2/3-activating motor complex in yeast. 
  • AJAP1 is dysregulated at an early stage of gliomagenesis and suppresses invasion through cytoskeleton reorganization. 
  • Abl kinases regulate actin comet tail elongation via an N-WASP-dependent pathway. 
  • Abl tyrosine kinases modulate cadherin-dependent adhesion upstream and downstream of Rho family GTPases. 
  • Absolute Arrangement of Subunits in Cytoskeletal Septin Filaments in Cells Measured by Fluorescence Microscopy. 
  • Abundant expression of ponsin, a focal adhesion protein, in lens and downregulation of its expression by impaired cytoskeletal signaling. 
  • Actin cytoskeletal disruption following cryopreservation alters the biodistribution of human mesenchymal stromal cells in vivo. 
  • Actin cytoskeletal network in aging and cancer. 
  • Actin dynamics: the arp2/3 complex branches out. 
  • Actin regulation and surface catalysis. 
  • Actin-dependent myoid elongation in teleost rod inner/outer segments occurs in the absence of net actin polymerization. 
  • Action potential-coupled Rho GTPase signaling drives presynaptic plasticity. 
  • Active cellular materials. 
  • Adducin in erythrocyte precursor cells of rats and humans: expression and compartmentalization. 
  • Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons. 
  • Adducin: Ca++-dependent association with sites of cell-cell contact. 
  • Adducin: structure, function and regulation. 
  • Alpha-2 adrenergic receptors stimulate actin organization in developing fetal rat cardiac myocytes. 
  • Alpha-adducin dissociates from F-actin and spectrin during platelet activation. 
  • Altered mechanobiology of Schlemm's canal endothelial cells in glaucoma. 
  • An expanded view of inositol signaling. 
  • Analysis of the regulation of microtubule dynamics by interaction of RGSZ1 (RGS20) with the neuronal stathmin, SCG10. 
  • Anastral spindle assembly: a mathematical model. 
  • Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments. 
  • Antibody against T lymphoblastic leukemia-associated antigen (3-40) identifies vimentin and keratin intermediate filaments in normal cells. 
  • Antibody binding to a conformation-dependent epitope induces L-selectin association with the detergent-resistant cytoskeleton. 
  • Are cross-bridging structures involved in the bundle formation of intermediate filaments and the decrease in locomotion that accompany cell aging? 
  • Association of myosin light chain kinase with lymphocyte membrane-cytoskeleton complex. 
  • Atomic force and total internal reflection fluorescence microscopy for the study of force transmission in endothelial cells. 
  • BCL2 interaction with actin in vitro may inhibit cell motility by enhancing actin polymerization. 
  • Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK. 
  • Binding of deoxyribonuclease I to actin: a new way to visualize microfilament bundles in nonmuscle cells. 
  • Biomechanical effects of flow and coculture on human aortic and cord blood-derived endothelial cells. 
  • BtubA-BtubB heterodimer is an essential intermediate in protofilament assembly. 
  • CDK5 regulates cell adhesion and migration in corneal epithelial cells. 
  • Calcium signals and calpain-dependent necrosis are essential for release of coxsackievirus B from polarized intestinal epithelial cells. 
  • Calmodulin as a mediator of hormone action and cell regulation. 
  • Calmodulin in endocrine cells and its multiple roles in hormone action. 
  • Cdk5 mediates changes in morphology and promotes apoptosis of astrocytoma cells in response to heat shock. 
  • Cell biology. Caveolae--not just craters in the cellular landscape. 
  • Cellular cytoskeleton dynamics modulates non-viral gene delivery through RhoGTPases 
  • Cellular requirements for the small molecule forchlorfenuron to stabilize the septin cytoskeleton. 
  • Cellularization in Drosophila melanogaster is disrupted by the inhibition of rho activity and the activation of Cdc42 function. 
  • Changes in dendritic structure and function following hippocampal lesions: correlations with developmental events? 
  • Changes in microfilament organization and surface topogrophy upon transformation of chick embryo fibroblasts with Rous sarcoma virus. 
  • Characterization of cytoskeleton-enriched protein fraction of the trabecular meshwork and ciliary muscle cells. 
  • Characterization of lens fiber cell triton insoluble fraction reveals ERM (ezrin, radixin, moesin) proteins as major cytoskeletal-associated proteins. 
  • Chemotactic peptide receptor-cytoskeletal interactions and functional correlations in differentiated HL-60 cells and human polymorphonuclear leukocytes. 
  • Clusterin promotes the aggregation and adhesion of renal porcine epithelial cells. 
  • Co-operative activation of skeletal muscle thin filaments by rigor crossbridges. The effect of troponin C extraction. 
  • Comprehensive analysis of tissue preservation and recording quality from chronic multielectrode implants. 
  • Contractile proteins in Drosophila development. 
  • Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension. 
  • Coordinating cytoskeletal tracks to polarize cellular movements. 
  • Cucurbitacin I inhibits cell motility by indirectly interfering with actin dynamics. 
  • Curved FtsZ protofilaments generate bending forces on liposome membranes. 
  • Cyclic mechanical stress and trabecular meshwork cell contractility. 
  • Cytoskeletal actin gene families of Xenopus borealis and Xenopus laevis. 
  • Cytoskeletal dependence of adenosine triphosphate release by human trabecular meshwork cells. 
  • Cytoskeletal regulation of TRPC channels in the cardiorenal system. 
  • Cytoskeleton. Evolution in bacteria. 
  • Dephosphorylation of ezrin as an early event in renal microvillar breakdown and anoxic injury. 
  • Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI. 
  • Diastolic filling vortex forces and cardiac adaptations: probing the epigenetic nexus. 
  • Differential Roles of Phospholipase D Proteins in FcεRI-Mediated Signaling and Mast Cell Function. 
  • Differential actions of PAR2 and PAR1 in stimulating human endothelial cell exocytosis and permeability: the role of Rho-GTPases. 
  • Direct localization of monoclonal antibody-binding sites on Acanthamoeba myosin-II and inhibition of filament formation by antibodies that bind to specific sites on the myosin-II tail. 
  • Directionality and processivity of molecular motors. 
  • Divide, multitask, and conquer: Coordination in channel regulation. 
  • Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis. 
  • Drosophila RhoA regulates the cytoskeleton and cell-cell adhesion in the developing epidermis. 
  • Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT. 
  • Dynamics of neutrophil membrane compliance and microstructure probed with a micropipet-based piconewton force transducer. 
  • Dysregulation of the Synaptic Cytoskeleton in the PFC Drives Neural Circuit Pathology, Leading to Social Dysfunction. 
  • Effect of cytoskeletal geometry on intracellular diffusion. 
  • Effect of vanadate on intracellular distribution and function of 10-nm filaments. 
  • Effects of colchicine and cytochalasin B on vasopressin- and cyclic adenosine monophosphate-induced changes in toad urinary bladder. 
  • Effects of novel ethacrynic acid derivatives on human trabecular meshwork cell shape, actin cytoskeletal organization, and transcellular fluid flow. 
  • Effects of pentoxifylline administration on blood viscosity and leukocyte cytoskeletal function in patients with intermittent claudication. 
  • Effects of taxol and Colcemid on myofibrillogenesis. 
  • Effects of the src gene product on microfilament and microtubule organization in avian and mammalian cells infected with the same temperature-sensitive mutant of Rous sarcoma virus. 
  • Efficient transdifferentiation of human dermal fibroblasts into skeletal muscle. 
  • Elasticity of 3D networks with rigid filaments and compliant crosslinks. 
  • Electrical stimulation directly induces pre-angiogenic responses in vascular endothelial cells by signaling through VEGF receptors. 
  • Electron microscopy of thin filaments decorated with a Ca2+-regulated myosin. 
  • Evidence for the role of cell stiffness in modulation of volume-regulated anion channels. 
  • Evolution of the cytoskeleton. 
  • Expanded polyglutamine stretches form an 'aggresome'. 
  • Expanding the role of NHERF, a PDZ-domain containing protein adapter, to growth regulation. 
  • F-actin aggregates in transformed cells. 
  • Fibronectin and glial fibrillary acidic protein expression in normal human brain and anaplastic human gliomas. 
  • Fluorescence staining of the actin cytoskeleton in living cells with 7-nitrobenz-2-oxa-1,3-diazole-phallacidin. 
  • Fluorescence studies on modes of cytochalasin B and phallotoxin action on cytoplasmic streaming in Chara. 
  • Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse. 
  • Fragility and mechanosensing in a thermalized cytoskeleton model with forced protein unfolding. 
  • FtsZ Constriction Force - Curved Protofilaments Bending Membranes. 
  • FtsZ in bacterial cytokinesis: cytoskeleton and force generator all in one. 
  • Function of cytoplasmic fibers in syncytia. 
  • Functions of cytoplasmic fibers in intracellular movements in BHK-21 cells. 
  • Functions of the myosin ATP and actin binding sites are required for C. elegans thick filament assembly. 
  • Fungal morphogenesis. 
  • Genetic interactions among regulators of septin organization. 
  • Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). 
  • Glypican-4 regulated actin cytoskeletal reorganization in glucocorticoid treated trabecular meshwork cells and involvement of Wnt/PCP signaling. 
  • Grab your partner with both hands: cytoskeletal remodeling by Arp2/3 signaling. 
  • Growth factor induced activation of Rho and Rac GTPases and actin cytoskeletal reorganization in human lens epithelial cells. 
  • Guides to the final frontier of the cytoskeleton: septins in filamentous fungi. 
  • Help for the miffed heart. 
  • How the cytoskeleton helps build the embryonic body plan: models of morphogenesis from Drosophila. 
  • How vinculin regulates force transmission. 
  • Human myelomeningocele risk and ultra-rare deleterious variants in genes associated with cilium, WNT-signaling, ECM, cytoskeleton and cell migration. 
  • Identification of glial filament protein and vimentin in the same intermediate filament system in human glioma cells. 
  • Impaired cytoskeletal organization and membrane integrity in lens fibers of a Rho GTPase functional knockout transgenic mouse. 
  • In vitro modeling of nonhypoxic cold ischemia-reperfusion simulating lung transplantation. 
  • In vitro reconstitution of septin assemblies on supported lipid bilayers. 
  • In vivo dynamics of clathrin and its adaptor-dependent recruitment to the actin-based endocytic machinery in yeast. 
  • In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation. 
  • In vivo staining of cytoskeletal actin by autointernalization of nontoxic concentrations of nitrobenzoxadiazole-phallacidin. 
  • Increased calmodulin affects cell morphology and mRNA levels of cytoskeletal protein genes. 
  • Increased organization of cytoskeleton accompanying the aging of human fibroblasts in vitro. 
  • Induction of spine growth and synapse formation by regulation of the spine actin cytoskeleton. 
  • Influence of actin cytoskeletal integrity on matrix metalloproteinase-2 activation in cultured human trabecular meshwork cells. 
  • Influence of cytoskeletal assembly on phosphatidylcholine synthesis in intact phagocytic cells. 
  • Interactions between dystrophin and the sarcolemma membrane. 
  • Interferon effects on microfilament organization, cellular fibronectin distribution, and cell motility in human fibroblasts. 
  • Interferon increases the abundance of submembranous microfilaments in HeLa-S3 cells in suspension culture. 
  • Interferon suppresses pinocytosis but stimulates phagocytosis in mouse peritoneal macrophages: related changes in cytoskeletal organization. 
  • Interplay between septin organization, cell cycle and cell shape in yeast. 
  • Interplay of septin amphipathic helices in sensing membrane-curvature and filament bundling. 
  • Involvement of dynamin-2 in formation of discoid vesicles in urinary bladder umbrella cells. 
  • Involvement of gamma and beta actin isoforms in mouse neuroblastoma differentiation. 
  • Involvement of microtubules and 10-nm filaments in the movement and positioning of nuclei in syncytia. 
  • Localization and structure of the ankyrin-binding site on beta2-spectrin. 
  • Lovastatin-induced cytoskeletal reorganization in lens epithelial cells: role of Rho GTPases. 
  • Maximal polar growth potential depends on the polarisome component AgSpa2 in the filamentous fungus Ashbya gossypii. 
  • Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells. 
  • Mechanosensitive channels in striated muscle and the cardiovascular system: not quite a stretch anymore. 
  • Messenger ribonucleoprotein complexes containing human ELAV proteins: interactions with cytoskeleton and translational apparatus. 
  • Micron-scale plasma membrane curvature is recognized by the septin cytoskeleton. 
  • Modulation of microfilament protein composition by transfected cytoskeletal actin genes. 
  • Molecular and cellular mechanisms of leukocyte chemotaxis. 
  • Monoclonal antibodies to epitopes on different regions of the 200 000 dalton neurofilament protein. Probes for the geometry of the filament. 
  • Multifunctional Abl kinases in health and disease. 
  • Myosin heavy-chain mutations that disrupt Caenorhabditis elegans thick filament assembly. 
  • Myristoylation of calcineurin B is not required for function or interaction with immunophilin-immunosuppressant complexes in the yeast Saccharomyces cerevisiae. 
  • NADPH oxidase 4: walking the walk with Poldip2. 
  • NHERF: targeting and trafficking membrane proteins. 
  • Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton. 
  • New ethacrynic acid derivatives as potent cytoskeletal modulators in trabecular meshwork cells. 
  • Nonequilibrium mechanics of active cytoskeletal networks. 
  • Nonmuscle myosin II generates forces that transmit tension and drive contraction in multiple tissues during dorsal closure. 
  • Noradrenaline-functionalized hyperbranched fluoropolymer-poly(ethylene glycol) cross-linked networks as dual-mode, anti-biofouling coatings. 
  • Novel critical role of Toll-like receptor 4 in lung ischemia-reperfusion injury and edema. 
  • Novel molecular insights into RhoA GTPase-induced resistance to aqueous humor outflow through the trabecular meshwork. 
  • PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice. 
  • Palmitate-mediated disruption of the endoplasmic reticulum decreases intracellular vesicle motility. 
  • Patterns of interdisk connections within the lamellar domains of retinal rod outer segment disks: observations relevant to the axial propagation of incisures. 
  • Phenotypes of trypsin- and collagenase-prepared bovine corneal endothelial cells in the presence of a selective Rho kinase inhibitor, Y-27632. 
  • Phorbol myristate acetate stimulates microtubule and 10-nm filament extension and lysosome redistribution in mouse macrophages. 
  • Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion. 
  • Phosphoproteomic analysis of human mesenchymal stromal cells during osteogenic differentiation. 
  • Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility. 
  • Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be 'preferentially' transported to the cSMAC. 
  • Physiological implications of the presence, distribution, and regulation of calmodulin in eukaryotic cells. 
  • Piezo1 channels mediate trabecular meshwork mechanotransduction and promote aqueous fluid outflow. 
  • Polar axis fixation in Fucus zygotes: components of the cytoskeleton and extracellular matrix. 
  • Polarized Fluorescence Microscopy to Study Cytoskeleton Assembly and Organization in Live Cells. 
  • Polyvinyl Pyrrolidone: A Novel Cryoprotectant in Islet Cell Cryopreservation. 
  • Principles that govern competition or co-existence in Rho-GTPase driven polarization. 
  • Probe Sensitivity to Cortical versus Intracellular Cytoskeletal Network Stiffness. 
  • Protein kinase C beta II specifically binds to and is activated by F-actin. 
  • Protein kinase C phosphorylates a recently identified membrane skeleton-associated calmodulin-binding protein in human erythrocytes. 
  • Proteomic analysis of desmosomes reveals novel components required for epidermal integrity. 
  • Proteomic identification of the cerebral cavernous malformation signaling complex. 
  • Quantifying cellular traction forces in three dimensions. 
  • Quantitative switch in integrin expression accompanies differentiation of F9 cells treated with retinoic acid. 
  • Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival. 
  • Rapid deformation of "passive" polymorphonuclear leukocytes: the effects of pentoxifylline. 
  • Rapid local compression in active gels is caused by nonlinear network response. 
  • Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions. 
  • Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein. 
  • Regulation of CTP Synthase Filament Formation During DNA Endoreplication in Drosophila. 
  • Regulation of macrophage motility by Irgm1. 
  • Regulation of microfilaments and microtubules by calcium and cyclic AMP. 
  • Regulation of the cytoskeleton by Ca2+-calmodulin and cAMP. 
  • Regulation of the postsynaptic cytoskeleton: roles in development, plasticity, and disorders. 
  • Regulation of the testis sertoli cell by follicle stimulating hormone. 
  • Relationship between movement and aggregation of centrioles in syncytia and formation of microtubule bundles. 
  • Retinoic acid-induced gene-1 (RIG-I) associates with the actin cytoskeleton via caspase activation and recruitment domain-dependent interactions. 
  • Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells. 
  • RhoA regulates initiation of invagination, but not convergent extension, during sea urchin gastrulation. 
  • RhoB-dependent modulation of postendocytic traffic in polarized Madin-Darby canine kidney cells. 
  • Role for the Abi/wave protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling. 
  • Role of Inn1 and its interactions with Hof1 and Cyk3 in promoting cleavage furrow and septum formation in S. cerevisiae. 
  • Role of autophosphorylation in regulating calmodulin-dependent protein kinases. 
  • Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration. 
  • Role of platelet activating factor in the intestinal epithelial secretory and Chinese hamster ovary cell cytoskeletal responses to cholera toxin. 
  • Role of the ABL tyrosine kinases in the epithelial-mesenchymal transition and the metastatic cascade. 
  • Roles for Ndel1 in keratin organization and desmosome function. 
  • Saccharomyces cerevisiae Bzz1p is implicated with type I myosins in actin patch polarization and is able to recruit actin-polymerizing machinery in vitro. 
  • Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton. 
  • Scaffold-mediated symmetry breaking by Cdc42p. 
  • Scd5p and clathrin function are important for cortical actin organization, endocytosis, and localization of sla2p in yeast. 
  • Self-Organized Nuclear Positioning Synchronizes the Cell Cycle in Drosophila Embryos. 
  • Septin complexes assemble during a kinetic window of opportunity. 
  • Septin filaments exhibit a dynamic, paired organization that is conserved from yeast to mammals. 
  • Septin ring assembly involves cycles of GTP loading and hydrolysis by Cdc42p. 
  • Septins may form a ubiquitous family of cytoskeletal filaments. 
  • Shortening of the calycal process actin cytoskeleton is correlated with myoid elongation in teleost rods. 
  • Simulated actin reorganization mediated by motor proteins. 
  • Site-specific glycosylation regulates the form and function of the intermediate filament cytoskeleton. 
  • Specification to biomineralization: following a single cell type as it constructs a skeleton. 
  • Spectral domain phase microscopy for local measurements of cytoskeletal rheology in single cells. 
  • Spectrin-based membrane skeleton: a multipotential adaptor between plasma membrane and cytoplasm. 
  • Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension. 
  • Stimulus-specific effects of pentoxifylline on neutrophil CR3 expression, degranulation, and superoxide production. 
  • Stress fibers in endothelial cells overlying atherosclerotic lesions in rabbit aorta. 
  • Structural characteristics of the desmin protofilament. 
  • Structure, chromosome location, and expression of the human gamma-actin gene: differential evolution, location, and expression of the cytoskeletal beta- and gamma-actin genes. 
  • Suprastructures and dynamic properties of Mycobacterium tuberculosis FtsZ. 
  • Synaptic vesicle biogenesis, docking, and fusion: a molecular description. 
  • Synergistic effect of shear stress and streptavidin-biotin on the expression of endothelial vasodilator and cytoskeleton genes. 
  • T cell homeostasis requires G protein-coupled receptor-mediated access to trophic signals that promote growth and inhibit chemotaxis. 
  • Targeting protein phosphatase 1 (PP1) to the actin cytoskeleton: the neurabin I/PP1 complex regulates cell morphology. 
  • Tau is essential to beta -amyloid-induced neurotoxicity. 
  • Terry Lechler: the cytoskeleton is skin deep. Interview by Nicole LeBrasseur. 
  • The Abl family kinases: mechanisms of regulation and signaling. 
  • The Arabidopsis thaliana chloroplast division protein FtsZ1 counterbalances FtsZ2 filament stability in vitro. 
  • The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory. 
  • The Chloroplast Tubulin Homologs FtsZA and FtsZB from the Red Alga Galdieria sulphuraria Co-assemble into Dynamic Filaments. 
  • The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction. 
  • The HDAC complex and cytoskeleton. 
  • The KASH domain protein MSP-300 plays an essential role in nuclear anchoring during Drosophila oogenesis. 
  • The Pseudomonas syringae Type III Effector HopG1 Induces Actin Remodeling to Promote Symptom Development and Susceptibility during Infection. 
  • The amphiphysin-like protein 1 (ALP1) interacts functionally with the cABL tyrosine kinase and may play a role in cytoskeletal regulation. 
  • The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis. 
  • The discovery of the prokaryotic cytoskeleton: 25th anniversary. 
  • The energetics of rapid cellular mechanotransduction. 
  • The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly. 
  • The microtubule-associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation. 
  • The molecular basis for membrane - cytoskeleton association in human erythrocytes. 
  • The physiological role of cardiac cytoskeleton and its alterations in heart failure. 
  • The role of protein kinase C in modulation of aqueous humor outflow facility. 
  • The role of the cytoskeleton in aging. 
  • The role of the lens actin cytoskeleton in fiber cell elongation and differentiation. 
  • The spectrin-based membrane skeleton: extensions of the current paradigm. 
  • The state of the septin cytoskeleton from assembly to function. 
  • The type III TGF-beta receptor regulates epithelial and cancer cell migration through beta-arrestin2-mediated activation of Cdc42. 
  • The type III TGFbeta receptor regulates directional migration: new tricks for an old dog. 
  • Therapeutic targets in focal and segmental glomerulosclerosis. 
  • Three-dimensional membrane crystals in amphibian cone outer segments: 2. Crystal type associated with the saddle point regions of cone disks. 
  • Thrombospondin-1 mediates Rho-kinase inhibitor-induced increase in outflow-facility. 
  • Towards a Dynamic Understanding of Cadherin-Based Mechanobiology. 
  • Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming. 
  • Transfer of the Septin Ring to Cytokinetic Remnants in ER Stress Directs Age-Sensitive Cell-Cycle Re-entry. 
  • Triggering a cell shape change by exploiting preexisting actomyosin contractions. 
  • Tubulin and calmodulin. Effects of microtubule and microfilament inhibitors on localization in the mitotic apparatus. 
  • Type I and type II keratins have evolved from lower eukaryotes to form the epidermal intermediate filaments in mammalian skin. 
  • Tyrosine phosphorylation of the beta3 cytoplasmic domain mediates integrin-cytoskeletal interactions. 
  • Ubiquitination and filamentous structure of cytidine triphosphate synthase. 
  • Ultrastructural analysis of the human lens fiber cell remodeling zone and the initiation of cellular compaction. 
  • Unified biophysical mechanism for cell-shape oscillations and cell ingression. 
  • Unphosphorylated gelsolin is localized in regions of cell-substratum contact or attachment in Rous sarcoma virus-transformed rat cells. 
  • Variant R94C in TNNT2-Encoded Troponin T Predisposes to Pediatric Restrictive Cardiomyopathy and Sudden Death Through Impaired Thin Filament Relaxation Resulting in Myocardial Diastolic Dysfunction. 
  • Vascular morphogenesis: tales of two syndromes. 
  • Visualization of a 21-nm axial periodicity in shadowed keratin filaments and neurofilaments. 
  • Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors. 
  • ZipA and FtsA* stabilize FtsZ-GDP miniring structures. 
  • beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. 
  • beta-Catenin protects the epidermis from mechanical stresses. 
  • c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Hoffman, Brenton D., James L. and Elizabeth M. Vincent Associate Professor of Biomedical Engineering, Biomedical Engineering
  • Lechler, Terry H., Professor in Dermatology, Cell Biology
  • Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology
  • Taylor, Gregory Alan, Professor in Medicine, Integrative Immunobiology