Cytosol

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  Subject Areas on Research

  • (3H)norepinephrine binding: unrelated to catechol-O-methyl transferase. 
  • 5-Lipoxygenase products modulate the activity of the 85-kDa phospholipase A2 in human neutrophils. 
  • A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol. 
  • A beta-lactam inhibitor of cytosolic phospholipase A2 which acts in a competitive, reversible manner at the lipid/water interface. 
  • A mathematical model for persistent post-CSD vasoconstriction. 
  • A mathematical model of glutathione metabolism. 
  • A mathematical model quantifying GnRH-induced LH secretion from gonadotropes. 
  • A method to measure myocardial calcium handling in adult Drosophila. 
  • A novel chloride channel in Vicia faba guard cell vacuoles activated by the serine/threonine kinase, CDPK. 
  • A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex. 
  • A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion. 
  • A quantitative study of the intracellular fate of pH-responsive doxorubicin-polypeptide nanoparticles. 
  • A role for GAPDH in apoptosis and neurodegeneration. 
  • A simulation environment for directional sensing as a phase separation process. 
  • ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase. 
  • Abscisic acid activation of plasma membrane Ca(2+) channels in guard cells requires cytosolic NAD(P)H and is differentially disrupted upstream and downstream of reactive oxygen species production in abi1-1 and abi2-1 protein phosphatase 2C mutants. 
  • Activation of protein kinase C by oleic acid. Determination and analysis of inhibition by detergent micelles and physiologic membranes: requirement for free oleate. 
  • Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. 
  • Adrenergic desensitization in left ventricle from streptozotocin diabetic swine. 
  • Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration. 
  • Aluminum is a weak agonist for the calcium-sensing receptor. 
  • Aluminum-induced DNA synthesis in osteoblasts: mediation by a G-protein coupled cation sensing mechanism. 
  • Alveolar type II cell responses to chronic inhalation of chrysotile asbestos in rats. 
  • Analysis of calcium homeostasis in activated human polymorphonuclear leukocytes. Evidence for two distinct mechanisms for lowering cytosolic calcium. 
  • Analysis of mRNA partitioning between the cytosol and endoplasmic reticulum compartments of mammalian cells. 
  • Analyzing mRNA localization to the endoplasmic reticulum via cell fractionation. 
  • Association between cytosolic expression of BRCA1 and metastatic risk in breast cancer. 
  • Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein. 
  • Autophagy May Allow a Cell to Forbear Pyroptosis When Confronted With Cytosol-Invasive Bacteria. 
  • Bcr-Abl-mediated protection from apoptosis downstream of mitochondrial cytochrome c release. 
  • Beta-adrenergic receptor kinase-2 and beta-arrestin-2 as mediators of odorant-induced desensitization. 
  • Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors. 
  • Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. 
  • Bi-allelic KARS1 pathogenic variants affecting functions of cytosolic and mitochondrial isoforms are associated with a progressive and multisystem disease. 
  • Biochemical and toxicopathic biomarkers assessed in smallmouth bass recovered from a polychlorinated biphenyl-contaminated river. 
  • Both stimulatory and inhibitory GDP/GTP exchange proteins, smg GDS and rho GDI, are active on multiple small GTP-binding proteins. 
  • Brevetoxin-6 (PbTx-6), a nonaromatic marine neurotoxin, is a ligand of the aryl hydrocarbon receptor. 
  • CDK5 regulates cell adhesion and migration in corneal epithelial cells. 
  • Ca(2+)/calmodulin regulates Kvβ1.1-mediated inactivation of voltage-gated K(+) channels. 
  • Calcium influx stimulates a second pathway for sustained diacylglycerol production in leukocytes activated by chemoattractants. 
  • Calpain mediates ischemic injury of the liver through modulation of apoptosis and necrosis. 
  • Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium. 
  • Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway. 
  • Cardiopulmonary bypass decreases G protein-coupled receptor kinase activity and expression in human peripheral blood mononuclear cells. 
  • Caspase-11 protects against bacteria that escape the vacuole. 
  • Cdc37/Hsp90 protein-mediated regulation of IRE1α protein activity in endoplasmic reticulum stress response and insulin synthesis in INS-1 cells. 
  • Characterization and distribution of protein kinase C isoforms in human skin fibroblasts. 
  • Characterization of additional components of the environmental pH-sensing complex in the pathogenic fungus Cryptococcus neoformans. 
  • Characterization of androgen receptor in Sertoli cell-enriched testis. 
  • Chemical Modulation of Endocytic Sorting Augments Adeno-associated Viral Transduction. 
  • Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases. 
  • Comparative metabolism and excretion of benzo(a)pyrene in 2 species of ictalurid catfish. 
  • Comparison of alkylacylglycerol vs. diacylglycerol as activators of mitogen-activated protein kinase and cytosolic phospholipase A2 in human neutrophil priming. 
  • Concerning the hormonal regulation of androgen binding protein in rat testis. 
  • Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses. 
  • Control of cholecystokinin receptor dephosphorylation in pancreatic acinar cells. 
  • Coxiella burnetii effector proteins that localize to the parasitophorous vacuole membrane promote intracellular replication. 
  • Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2. 
  • Cyclosporin A inhibits chromium(VI)-induced apoptosis and mitochondrial cytochrome c release and restores clonogenic survival in CHO cells. 
  • Cytochemistry of sex steroid receptors: a critique. 
  • Cytoplasmic sharing through apical membrane remodeling. 
  • Cytosolic TMEM88 promotes invasion and metastasis in lung cancer cells by binding DVLS. 
  • Cytosolic accumulation of small nucleolar RNAs (snoRNAs) is dynamically regulated by NADPH oxidase. 
  • Cytosolic delivery of macromolecules 4. Head group-dependent membrane permeabilization by pH-sensitive detergents. 
  • Cytosolic delivery of macromolecules. 3. Synthesis and characterization of acid-sensitive bis-detergents. 
  • Cytosolic delivery of macromolecules. II. Mechanistic studies with pH-sensitive morpholine lipids. 
  • Cytosolic delivery of macromolecules: I. Synthesis and characterization of pH-sensitive acyloxyalkylimidazoles. 
  • Cytosolic phospholipase A(2) activity associated with nuclei is not inhibited by arachidonyl trifluoromethyl ketone in macrophages stimulated with receptor-recognized forms of alpha(2)-macroglobulin. 
  • Cytosolic phospholipase A2 alpha-deficient mice are resistant to experimental autoimmune encephalomyelitis. 
  • DT diaphorase [NAD(P)H: (quinone acceptor) oxidoreductase] facilitates redox cycling of menadione in channel catfish (Ictalurus punctatus) cytosol. 
  • DYT-TOR1A subcellular proteomics reveals selective vulnerability of the nuclear proteome to cell stress. 
  • De novo translation initiation on membrane-bound ribosomes as a mechanism for localization of cytosolic protein mRNAs to the endoplasmic reticulum. 
  • Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility. 
  • Detection of cytosolic bacteria by inflammatory caspases. 
  • Development and cardiac contractility: cardiac troponin T isoforms and cytosolic calcium in rabbit. 
  • Diazepam promotes ATP recovery and prevents cytochrome c release in hippocampal slices after in vitro ischemia. 
  • Dicoumarol-sensitive NADPH: phenanthrenequinone oxidoreductase in channel catfish (Ictalurus punctatus). 
  • Difference between mitochondrial RNase P and nuclear RNase P. 
  • Differential activation of human neutrophil cytosolic phospholipase A2 and secretory phospholipase A2 during priming by 1,2-diacyl- and 1-O-alkyl-2-acylglycerols. 
  • Differential localization and potency of manganese porphyrin superoxide dismutase-mimicking compounds in Saccharomyces cerevisiae. 
  • Differential stimulation of the respiratory burst and lysosomal enzyme secretion in human polymorphonuclear leukocytes by synthetic diacylglycerols. 
  • Dipeptidyl peptidase IV (DPP IV/CD26) is a cell-surface plasminogen receptor. 
  • Discovery of a novel Toxoplasma gondii conoid-associated protein important for parasite resistance to reactive nitrogen intermediates. 
  • Divergent regulation of protein synthesis in the cytosol and endoplasmic reticulum compartments of mammalian cells. 
  • Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. 
  • E1-like activating enzyme Atg7 is preferentially sequestered into p62 aggregates via its interaction with LC3-I. 
  • Effect of p38 MAP kinases on contractility and ischemic injury in intact heart. 
  • Effects of buthionine sulfoximine and diethyl maleate on glutathione turnover in the channel catfish. 
  • Effects of hypoxia and toxicant exposure on adenylate energy charge and cytosolic ADP concentrations in abalone. 
  • Enhanced sensitivity to cytochrome c-induced apoptosis mediated by PHAPI in breast cancer cells. 
  • Extracellular trafficking of myocilin in human trabecular meshwork cells. 
  • FSH-induction of androgen binding protein in testes of Sertoli cell-only rats. 
  • Fibrillar systems in cell motility. 
  • Flavonoids. 8. Synthesis and antifertility and estrogen receptor binding activities of coumarins and delta3-isoflavenes. 
  • Follicle-stimulating hormone, the Sertoli cell, and spermatogenesis. 
  • Functions of cytochrome c in regulation of electron transfer and protein folding. 
  • Genome-wide analysis of genomic alterations induced by oxidative DNA damage in yeast. 
  • Glucose 6-phosphate produced by glucokinase, but not hexokinase I, promotes the activation of hepatic glycogen synthase. 
  • Glutamate mobilizes [Zn2+] through Ca2+ -dependent reactive oxygen species accumulation. 
  • Glutathione S-conjugation of the sevoflurane degradation product, fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human liver, kidney, and blood in vitro. 
  • Gonadotropin releasing hormone stimulates calmodulin redistribution in rat pituitary. 
  • Hel-N1/Hel-N2 proteins are bound to poly(A)+ mRNA in granular RNP structures and are implicated in neuronal differentiation. 
  • Heterogeneous translational landscape of the endoplasmic reticulum revealed by ribosome proximity labeling and transcriptome analysis. 
  • High lipophilicity of meta Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase mimics compensates for their lower antioxidant potency and makes them as effective as ortho analogues in protecting superoxide dismutase-deficient Escherichia coli. 
  • Human IRGM induces autophagy to eliminate intracellular mycobacteria. 
  • Hydroxyl radical production in the brain after CO hypoxia in rats. 
  • Hypophosphorylation of the architectural chromatin protein DEK in death-receptor-induced apoptosis revealed by the isotope coded protein label proteomic platform. 
  • IDH3α regulates one-carbon metabolism in glioblastoma. 
  • Identification of high-affinity calmodulin-binding proteins in rat liver. 
  • Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1. 
  • Immune-related intestinal chloride secretion. II. Effect of adenosine on T84 cell line. 
  • Immunocytochemical analysis of estrogen receptors as a predictor of prognosis in breast cancer patients: comparison with quantitative biochemical methods. 
  • In silico experimentation with a model of hepatic mitochondrial folate metabolism. 
  • Increase in liver protein phosphatase-1 in spontaneously diabetic Chinese hamsters. 
  • Induction of hepatic drug metabolizing enzymes by coal fly ash in rats. 
  • Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins. 
  • Inhibition of Human Adenovirus Replication by the Importin α/β1 Nuclear Import Inhibitor Ivermectin. 
  • Inhibition of calcium-independent phospholipase A2 suppresses proliferation and tumorigenicity of ovarian carcinoma cells. 
  • Inhibition of mTOR attenuates store-operated Ca2+ entry in cells from endarterectomized tissues of patients with chronic thromboembolic pulmonary hypertension. 
  • Kinetics of iron release from ferric binding protein (FbpA): mechanistic implications in bacterial periplasm-to-cytosol Fe3+ transport. 
  • Kinetics of protein farnesyltransferase: sigmoidal vs hyperbolic behavior as a function of assay conditions. 
  • L-Met Activates Arabidopsis GLR Ca²⁺ Channels Upstream of ROS Production and Regulates Stomatal Movement. 
  • Ligation of the alpha 2-macroglobulin signalling receptor on macrophages induces protein phosphorylation and an increase in cytosolic pH. 
  • MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis. 
  • Mastoparan, a wasp venom peptide, identifies two discrete mechanisms for elevating cytosolic calcium and inositol trisphosphates in human polymorphonuclear leukocytes. 
  • Mature macrophage cell lines exhibit variable responses to LPS. 
  • Mechanisms of nonimmunological histamine and tryptase release from human cutaneous mast cells. 
  • Menstrual cycle-dependent variations of breast cyst fluid proteins and sex steroid receptors in the normal human breast. 
  • Metabolic capacity regulates iron homeostasis in endothelial cells. 
  • Mg2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channels. 
  • Microsomal and cytosolic epoxide hydrolase and glutathione S-transferase activities in the gill, liver, and kidney of the rainbow trout, Salmo gairdneri. Baseline levels and optimization of assay conditions. 
  • Mitochondrial adaptations to obesity-related oxidant stress. 
  • Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues. 
  • Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice. 
  • Molecular mechanisms of exocytosis: the adrenal chromaffin cell as a model system. 
  • Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection. 
  • Multiple calcium-mediated effector mechanisms regulate chloride secretory responses in T84-cells. 
  • Multiple roles of calcium in anoxic-induced injury in renal proximal tubules. 
  • Myelin basic protein phosphatase activity in rat brain. 
  • Myosin from human erythrocytes. 
  • NADPH oxidase AtrbohD and AtrbohF genes function in ROS-dependent ABA signaling in Arabidopsis. 
  • NPR1 modulates cross-talk between salicylate- and jasmonate-dependent defense pathways through a novel function in the cytosol. 
  • Naegleria fowleri amoebae express a membrane-associated calcium-independent phospholipase A(2). 
  • Negative control of diacylglycerol kinase ζ-mediated inhibition of T cell receptor signaling by nuclear sequestration in mice. 
  • Neurobehavioral teratogenicity of perfluorinated alkyls in an avian model. 
  • Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium. 
  • Nicotine therapy in adulthood reverses the synaptic and behavioral deficits elicited by prenatal exposure to phenobarbital. 
  • Osmotic stress alters circadian cytosolic Ca²⁺ oscillations and OSCA1 is required in circadian gated stress adaptation. 
  • Outer membrane protein I of Pseudomonas aeruginosa is a target of cationic antimicrobial peptide/protein. 
  • Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family. 
  • Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production. 
  • Phenylalanine-stimulated secretion of cholecystokinin is calcium dependent. 
  • Phorbol myristate acetate mediates redistribution of protein kinase C in human neutrophils: potential role in the activation of the respiratory burst enzyme. 
  • Phosphatidic acid modulates Cl- secretion in T84 cells: varying effects depending on mode of stimulation. 
  • Phosphatidylcholine transfer protein promotes apolipoprotein A-I-mediated lipid efflux in Chinese hamster ovary cells. 
  • Phosphoregulation provides specificity to biomolecular condensates in the cell cycle and cell polarity. 
  • Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10). 
  • PolyQ-dependent RNA-protein assemblies control symmetry breaking. 
  • Polymorphisms of cytosolic serine hydroxymethyltransferase and risk of lung cancer: a case-control analysis. 
  • Primary role for endoplasmic reticulum-bound ribosomes in cellular translation identified by ribosome profiling. 
  • Protect this house: cytosolic sensing of viruses. 
  • Protein kinase A, cytosolic calcium, and phosphate uptake in human proximal renal cells. 
  • Pseudomonas aeruginosa activates caspase 1 through Ipaf. 
  • Purification and properties of a multifunctional calcium/calmodulin-dependent protein kinase from rat pancreas. 
  • Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane. 
  • RINT-1 interacts with MSP58 within nucleoli and plays a role in ribosomal gene transcription. 
  • Receptor class desensitization of leukocyte chemoattractant receptors. 
  • Receptor interconversion model of hormone action. 2. Requirement of both kinase and phosphatase activities for conferring estrogen binding activity to the estrogen receptor. 
  • Recruitment of endoplasmic reticulum-targeted and cytosolic mRNAs into membrane-associated stress granules. 
  • Regulating the regulator: NF-kappaB signaling in heart. 
  • Regulation of cholecystokinin secretion by ATP-sensitive potassium channels. 
  • Regulation of cytosolic phospholipase A2 activity in macrophages stimulated with receptor-recognized forms of alpha 2-macroglobulin: role in mitogenesis and cell proliferation. 
  • Regulation of the dynamics of hsp90 action on the glucocorticoid receptor by acetylation/deacetylation of the chaperone. 
  • Regulation of the ribosome-membrane junction at early stages of presecretory protein translocation in the mammalian endoplasmic reticulum. 
  • Regulation of thromboxane receptor (TP) phosphorylation by protein phosphatase 1 (PP1) and PP2A. 
  • Relationship between NaCl- and H2O2-induced cytosolic Ca2+ increases in response to stress in Arabidopsis. 
  • Release of nonmuscle myosin II from the cytosolic domain of tumor necrosis factor receptor 2 is required for target gene expression. 
  • RhoB-dependent modulation of postendocytic traffic in polarized Madin-Darby canine kidney cells. 
  • Ribosome exchange revisited: a mechanism for translation-coupled ribosome detachment from the ER membrane. 
  • Robustness of MetaNet graph models: predicting control of urea production in humans. 
  • Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB. 
  • Septin assemblies form by diffusion-driven annealing on membranes. 
  • Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets. 
  • Single-cell quantification and dose-response of cytosolic siRNA delivery. 
  • Somatostatin induces translocation of the beta-adrenergic receptor kinase and desensitizes somatostatin receptors in S49 lymphoma cells. 
  • Spatial heterogeneity of the cytosol revealed by machine learning-based 3D particle tracking. 
  • Specific blockers of myoblast fusion inhibit a soluble and not the membrane-associated metalloendoprotease in myoblasts. 
  • Specific nuclear binding of adenosine 3',5'-monophosphate-binding protein complex with subsequent poly(A) RNA synthesis in embryonic chick cartilage. 
  • Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. 
  • Steroids induce hypothalamic progestin receptors and facilitate female sexual behavior in neonatal rats. 
  • Structural analyses of Ca²⁺/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation. 
  • Synthetic peptide corresponding to a conserved domain of the retroviral protein p15E blocks IL-1-mediated signal transduction. 
  • Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins. 
  • Thapsigargin demonstrates calcium-dependent regulation of phosphate uptake in HeLa cells. 
  • The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress. 
  • The hepatitis delta virus large antigen is farnesylated both in vitro and in animal cells. 
  • The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors. 
  • The influence of the synergistic anion on iron chelation by ferric binding protein, a bacterial transferrin. 
  • The interface between membrane-spanning and cytosolic domains in Ca²+-dependent K+ channels is involved in β subunit modulation of gating. 
  • The mitochondrial 2-oxoglutarate carrier is part of a metabolic pathway that mediates glucose- and glutamine-stimulated insulin secretion. 
  • The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion. 
  • The unfolded protein response triggers selective mRNA release from the endoplasmic reticulum. 
  • Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe. 
  • Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes. 
  • Ubiquitylation of the transducin betagamma subunit complex. Regulation by phosducin. 
  • Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases. 
  • Visualizing cytoplasmic ATP in C. elegans larvae using PercevalHR. 
  • XIAP regulates cytosol-specific innate immunity to Listeria infection. 
  • alpha(1)-adrenergic receptors mediate LH-releasing hormone secretion through phospholipases C and A(2) in immortalized hypothalamic neurons. 
  • beta-Arrestin mediates beta1-adrenergic receptor-epidermal growth factor receptor interaction and downstream signaling. 
  • beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation. 
  • mRNA translation is compartmentalized to the endoplasmic reticulum following physiological inhibition of cap-dependent translation. 
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  Keywords of People

  • Schwartz-Bloom, Rochelle D., Professor Emeritus of Pharmacology & Cancer Biology, Duke Science & Society
  • Taylor, Gregory Alan, Professor in Medicine, Integrative Immunobiology