Dactinomycin
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Subject Areas on Research
- A multi-institutional experience of isolated limb infusion: defining response and toxicity in the US.
- Alternating weekly chemotherapy with etoposide-methotrexate-dactinomycin/cyclophosphamide-vincristine for high-risk gestational trophoblastic disease.
- Are different methotrexate regimens as first line therapy for low risk gestational trophoblastic neoplasia more cost effective than the dactinomycin regimen used in GOG 0174?
- Burden of disease predicts response to isolated limb infusion with melphalan and actinomycin D in melanoma.
- Chemistry and biology of copper-chelatin.
- Chemoattractant-induced activation of c-fos gene expression in human monocytes.
- Childhood rhabdomyosarcoma. Analysis of coordinated therapy and results.
- Control of phenylalanine hydroxylase synthesis in tissue culture by serum and insulin
- Copper-induced synthesis of copper-chelatin in rat liver.
- Decrements in auditory responses to a repeated conspecific song are long-lasting and require two periods of protein synthesis in the songbird forebrain.
- Diagnosis and management of Wilms' tumor.
- Effect of actinomycin D on serum betalipoproteins of partially hepatectomized dogs. I. Proteins, lipids, triglycerides and cholesterol.
- Effect of actinomycin D on serum betalipoproteins of partially hepatectomized dogs. II - Phospholipids.
- Effect of actinomycin D on serum betalipoproteins of partially hepatectomized dogs. III - Fatty acid distribution.
- Effect of growth conditions on the activity of ornithine decarboxylase in cultured hepatoma cells. II. Effect of serum and insulin.
- Effect of growth conditions on the ornithine decarboxylase activity of rat hepatoma cells.
- Evidence for depression of nuclear protein synthesis and concomitant stimulation of nuclear RNA synthesis during early estrogen action.
- Expression, distribution, and biochemistry of human CD39. Role in activation-associated homotypic adhesion of lymphocytes.
- Follicle stimulating hormone regulation of protein kinase activity and protein synthesis in testis.
- High dose chemotherapy with autologous peripheral blood progenitor cell transplantation in an anephric child with multiply recurrent Wilms tumor.
- High-risk gestational trophoblastic neoplasia with brain metastases: individualized multidisciplinary therapy in the management of four patients.
- Human leukemia antigens: partial isolation and characterization.
- Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage.
- Hyperthermia: an overview of current progress and problems.
- Immunosuppressant target protein FKBP12 is required for P-glycoprotein function in yeast.
- Induction of cyclooxygenase-2 synthesis by ligation of the macrophage alpha(2)-macroglobulin signalling receptor.
- Induction of cytochrome P-450 and phosphatidylcholine synthesis by endosulfan in liver of rats: effect of quality of dietary proteins.
- Induction of human tenascin (neuronectin) by growth factors and cytokines: cell type-specific signals and signalling pathways.
- Inhibitory effects of vesicular stomatitis virus on cellular and influenza viral RNA metabolism and protein synthesis.
- Inhibitory proteins in the Newcastle disease virus-induced suppression of cell protein synthesis.
- Isolated Limb Infusion as a Limb Salvage Strategy for Locally Advanced Extremity Sarcoma.
- Isolated limb infusion for in-transit malignant melanoma of the extremity: a well-tolerated but less effective alternative to hyperthermic isolated limb perfusion.
- Ligand binding to the LFA-3 cell adhesion molecule induces IL-1 production by human thymic epithelial cells.
- Ligation of the alpha2M* signaling receptor regulates synthesis of cytosolic phospholipase A2.
- Limb preservation with isolated limb infusion for locally advanced nonmelanoma cutaneous and soft-tissue malignant neoplasms.
- Measurement of the DNA synthetic capacity of activated lymphocytes: nucleotide triphosphate incorporation by permeabilized cells.
- Mechanism of estrogen action: early transcriptional and translational events.
- Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes.
- Modulation of Hoogsteen dynamics on DNA recognition.
- Molecular mechanism of fibronectin gene activation by cyclic stretch in vascular smooth muscle cells.
- Next-generation sequencing of apoptotic DNA breakpoints reveals association with actively transcribed genes and gene translocations.
- Participation of p53 protein in the cellular response to DNA damage.
- Patterns of recurrence following complete response to regional chemotherapy for in-transit melanoma
- Phase II study demonstrating failure of both a five-drug continuous-therapy regimen and a two-drug pulse-therapy regimen in the treatment of metastatic neuroblastoma: Southwest Oncology Group Study 822.
- Phase III trial of weekly methotrexate or pulsed dactinomycin for low-risk gestational trophoblastic neoplasia: a gynecologic oncology group study.
- Protein biosynthesis in the testis. V. Concerning the mechanism of stimulation by follicle-stimulating hormone.
- RNA-binding protein FXR2 regulates adult hippocampal neurogenesis by reducing Noggin expression.
- Recombinant human tumor necrosis factor alone and with chemotherapeutic agents. Effect on nude mouse-supported human bladder cancer heterografts.
- Regulation of brain ornithine decarboxylase activity in the neonatal rat.
- Regulation of cell division and of tyrosinase in B16 melanoma cells by imidazole: a possible role for the concept of metabolite gene regulation in mammalian cells.
- Regulation of cytokine production in the human thymus: epidermal growth factor and transforming growth factor alpha regulate mRNA levels of interleukin 1 alpha (IL-1 alpha), IL-1 beta, and IL-6 in human thymic epithelial cells at a post-transcriptional level.
- Regulation of tumor necrosis factor cytotoxicity by calcineurin.
- Relation between Irofulven (MGI-114) systemic exposure and tumor response in human solid tumor xenografts.
- Rhabdomyosarcoma in adult prostate.
- Ribosomal subunits of Landschütz ascites cells during changes in polysome distribution.
- Role of platelet-activating factor in Chinese hamster ovary cell responses to cholera toxin.
- Schedule-dependent enhanced lethality with combined administration of actinomycin D and tumor necrosis factor in mice.
- Stability of nuclear triiodothyronine binding sites.
- Stimulation of synthesis of ribonucleic acid in sub-apical sections of Avena coleoptile by indolyl-3-acetic acid.
- Studies on cellular autophagocytosis. The relationship of autophagocytosis to protein synthesis and to energy metabolism in rat liver and flounder kidney tubules in vitro.
- Synthesis of (3H)DNA complementary to ovalbumin messenger RNA: evidence for limited copies of the ovalbumin gene in chick oviduct.
- Synthesis of very low density lipoproteins in the cockerel. Effects of estrogen.
- Upregulation of AKT1 protein expression in forskolin-stimulated macrophage: evidence from ChIP analysis that CREB binds to and activates the AKT1 promoter.
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Keywords of People
- Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
- Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering
- Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Immunology