Hepatitis Delta Virus
-
Subject Areas on Research
- A circular trans-acting hepatitis delta virus ribozyme.
- A conserved bulged adenosine in a peripheral duplex of the antigenomic HDV self-cleaving RNA reduceskinetic trapping of inactive conformations.
- A nested double pseudoknot is required for self-cleavage activity of both the genomic and antigenomic hepatitis delta virus ribozymes.
- A pH-sensitive RNA tertiary interaction affects self-cleavage activity of the HDV ribozymes in the absence of added divalent metal ion.
- A pseudoknot-like structure required for efficient self-cleavage of hepatitis delta virus RNA.
- A single nucleotide linked to a switch in metal ion reactivity preference in the HDV ribozymes.
- A toggle duplex in hepatitis delta virus self-cleaving RNA that stabilizes an inactive and a salt-dependent pro-active ribozyme conformation.
- Assessment of disparate structural features in three models of the hepatitis delta virus ribozyme.
- Catalytic strategies of the hepatitis delta virus ribozymes.
- Chemical rescue, multiple ionizable groups, and general acid-base catalysis in the HDV genomic ribozyme.
- Circular ribozymes generated in Escherichia coli using group I self-splicing permuted intron-exon sequences.
- Cis- and trans-acting ribozymes from a human pathogen, hepatitis delta virus.
- Cleavage of oligoribonucleotides by a ribozyme derived from the hepatitis delta virus RNA sequence.
- Core sequences and a cleavage site wobble pair required for HDV antigenomic ribozyme self-cleavage.
- Core-associated non-duplex sequences distinguishing the genomic and antigenomic self-cleaving RNAs of hepatitis delta virus.
- Energetic contribution of non-essential 5' sequence to catalysis in a hepatitis delta virus ribozyme.
- Epidemiology of hepatitis B in eastern Kenya.
- Evidence that genomic and antigenomic RNA self-cleaving elements from hepatitis delta virus have similar secondary structures.
- Experimental evidence for the secondary structure of the hepatitis delta virus ribozyme.
- HDV ribozyme activity in monovalent cations.
- HDV ribozymes.
- Hepatitis delta virus ribozymes fold to generate a solvent-inaccessible core with essential nucleotides near the cleavage site phosphate.
- Imidazole rescue of a cytosine mutation in a self-cleaving ribozyme.
- Increasing utilization of human T-cell lymphotropic virus (+) donors in liver transplantation: is it safe?
- Involvement of a cytosine side chain in proton transfer in the rate-determining step of ribozyme self-cleavage.
- Kinetic scheme for intermolecular RNA cleavage by a ribozyme derived from hepatitis delta virus RNA.
- Molecular biology. Versatility of self-cleaving ribozymes.
- New tools provide a second look at HDV ribozyme structure, dynamics and cleavage.
- Optimal self-cleavage activity of the hepatitis delta virus RNA is dependent on a homopurine base pair in the ribozyme core.
- Reversible cross-linking combined with immunoprecipitation to study RNA-protein interactions in vivo.
- Ribozyme activity in the genomic and antigenomic RNA strands of hepatitis delta virus.
- Ribozyme cleavage of a 2,5-phosphodiester linkage: mechanism and a restricted divalent metal-ion requirement.
- Secondary structure of the self-cleaving RNA of hepatitis delta virus: applications to catalytic RNA design.
- Self-cleavage of hepatitis delta virus genomic strand RNA is enhanced under partially denaturing conditions.
- Self-cleaving ribozymes of hepatitis delta virus RNA.
- The hepatitis delta virus large antigen is farnesylated both in vitro and in animal cells.
- The poly(A) site sequence in HDV RNA alters both extent and rate of self-cleavage of the antigenomic ribozyme.
- The self-cleaving domain from the genomic RNA of hepatitis delta virus: sequence requirements and the effects of denaturant.
-
Keywords of People
- Been, Michael Douglas, Professor Emeritus of Biochemistry, Biochemistry
- Richardson, David C., Professor of Biochemistry, Biochemistry