Demyelinating Diseases

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  Subject Areas on Research

  • A combinatorial network of evolutionarily conserved myelin basic protein regulatory sequences confers distinct glial-specific phenotypes. 
  • A differential diagnosis of central nervous system demyelination: beyond multiple sclerosis. 
  • A unique role for Fyn in CNS myelination. 
  • Activation of terminal components of complement in patients with Guillain-Barré syndrome and other demyelinating neuropathies. 
  • Acute inflammatory demyelinating optic neuritis: current concepts in diagnosis and management. 
  • Acute inflammatory demyelinating optic neuritis: evidence-based visual and neurological considerations. 
  • An adverse lipid profile and increased levels of adiposity significantly predict clinical course after a first demyelinating event. 
  • Anti-N-Methyl-d-Aspartate Receptor Encephalitis Presenting With Features of Kleine-Levin Syndrome and Demyelination. 
  • Applicability and limitations of MR tracking of neural stem cells with asymmetric cell division and rapid turnover: the case of the shiverer dysmyelinated mouse brain. 
  • Assignment of the gene for myelin proteolipid protein to the X chromosome: implications for X-linked myelin disorders. 
  • Association between cell-mediated demyelination and astrocyte stimulation. 
  • CT and MR imaging of Canavan disease. 
  • Chapter 31. Management of the neurogenic bladder: current status and recent developments. 
  • Chronic inflammatory demyelinating polyradiculoneuropathy of childhood: treatment with high-dose intravenous immunoglobulin. 
  • Circulating adhesion molecules and inflammatory mediators in demyelination: a review. 
  • Conduction block and continuous motor unit activity in chronic acquired demyelinating polyneuropathy. 
  • Correlation between varying levels of PMP22 expression and the degree of demyelination and reduction in nerve conduction velocity in transgenic mice. 
  • Delayed neurotoxicity of phenylphosphonothioate esters. 
  • Demyelinating radiculopathy in the Kearns-Sayre syndrome: a clinicopathological study. 
  • Diffusion tensor imaging for evaluation of the childhood brain and pediatric white matter disorders. 
  • Dynamic contrast-enhanced T2*-weighted MR imaging of tumefactive demyelinating lesions. 
  • Early-life hygiene-related factors affect risk of central nervous system demyelination and asthma differentially. 
  • Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors. 
  • Familial aggregation of multiple myeloma and central nervous system diseases. 
  • High-field (9.4 T) MRI of brain dysmyelination by quantitative mapping of magnetic susceptibility. 
  • Higher intake of omega-3 polyunsaturated fatty acids is associated with a decreased risk of a first clinical diagnosis of central nervous system demyelination: Results from the Ausimmune Study. 
  • Increased severity of experimental autoimmune encephalomyelitis, chronic macrophage/microglial reactivity, and demyelination in transgenic mice producing tumor necrosis factor-alpha in the central nervous system. 
  • Induction of anti-myelin antibodies in EAE and their possible role in demyelination. 
  • Intrathecal melphalan therapy of human neoplastic meningitis in athymic nude rats. 
  • Latitudinal variation in incidence and type of first central nervous system demyelinating events. 
  • Lhermitte's sign in cobalamin (vitamin B12) deficiency. 
  • Magnetic resonance and diffusion tensor imaging in pediatric white matter diseases. 
  • Methylphenidate in neuropsychological sequelae of radiotherapy and chemotherapy of childhood brain tumors and leukemia. 
  • Midsagittal corpus callosum area and conversion to multiple sclerosis after clinically isolated syndrome: A multicentre Australian cohort study. 
  • Model for focal demyelination of the spinal dorsal columns of transgenic MBP-LacZ mice by phototargeted ablation of oligodendrocytes. 
  • Morphological and molecular response of the MOCH-1 oligodendrocyte cell line to serum and interferon-gamma: possible implications for demyelinating disorders. 
  • Naked axons in myodystrophic mice. 
  • Neuromuscular Disease in the Neurointensive Care Unit. 
  • Neuroradiology case of the day. Multifocal inflammatory leukoencephalopathy due to treatment with 5-fluorouracil and levamisole. 
  • Occupational exposure and risk of central nervous system demyelination. 
  • Ocular toxicity following high dose chemotherapy and autologous transplant. 
  • Offspring number, pregnancy, and risk of a first clinical demyelinating event: the AusImmune Study. 
  • Preservation of motor function by inhibition of CD8+ virus peptide-specific T cells in Theiler's virus infection. 
  • Purkinje cell loss in experimental autoimmune encephalomyelitis. 
  • Recurrent acute inflammatory demyelinating polyradiculitis after allogeneic bone marrow transplantation. 
  • Schwann cell vulnerability to demyelination is associated with internodal length in tellurium neuropathy. 
  • Small lymphocytic lymphoma presenting as a paraneoplastic syndrome with acute central nervous system demyelination. 
  • Sodium channel density in hypomyelinated brain increased by myelin basic protein gene deletion. 
  • Structural brain changes revealed by MRI. 
  • Sun exposure and vitamin D are independent risk factors for CNS demyelination. 
  • Tensor diffusion imaging in B12 leukoencephalopathy. 
  • The development of Lhermitte's sign during cisplatin chemotherapy. Possible drug-induced toxicity causing spinal cord demyelination. 
  • The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination. 
  • The physical anthropometry, lifestyle habits and blood pressure of people presenting with a first clinical demyelinating event compared to controls: the Ausimmune study. 
  • The role of fractalkine (CX3CL1) in regulation of CD4(+) cell migration to the central nervous system in patients with relapsing-remitting multiple sclerosis. 
  • The sylvian aqueduct syndrome. A clinicopathologic study. 
  • Trichothiodystrophy with dysmyelination and central osteosclerosis. 
  • Very-late-onset adrenoleukodystrophy: possible precipitation of demyelination by cerebral contusion. 
  • Wernicke's encephalopathy: an experimental study in the rhesus monkey. 
  • White matter abnormalities in major depression: evidence from post-mortem, neuroimaging and genetic studies. 
  • White matter disease induced by high-dose chemotherapy: longitudinal study with MR imaging and proton spectroscopy. 
  • Widespread effects of hyperintense lesions on cerebral white matter structure. 
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  Keywords of People

  • McLendon, Roger Edwin, Professor of Pathology, Pathology