Deoxyadenine Nucleotides

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  Subject Areas on Research

  • A 9-yr evaluation of carrier erythrocyte encapsulated adenosine deaminase (ADA) therapy in a patient with adult-type ADA deficiency. 
  • Biochemical consequences of adenosine deaminase inhibition in vivo. Differential effects in acute and chronic T cell leukemia. 
  • Comparison of red cell transfusion and polyethylene glycol-modified adenosine deaminase therapy in an adenosine deaminase-deficient child: measurement of erythrocyte deoxyadenosine triphosphate as a useful tool. 
  • Discrimination between right and wrong purine dNTPs by DNA polymerase I from Bacillus stearothermophilus. 
  • Effects of mutational loss of adenosine kinase and deoxycytidine kinase on deoxyATP accumulation and deoxyadenosine toxicity in cultured CEM human T-lymphoblastoid cells. 
  • Genome mapping by fluorescent fingerprinting. 
  • Inhibition of fetal thymic caspases abrogates the consequences of adenosine deaminase deficiency. 
  • Insect crossbridges, relaxed by spin-labeled nucleotide, show well-ordered 90 degrees state by X-ray diffraction and electron microscopy, but spectra of electron paramagnetic resonance probes report disorder. 
  • Resistance of an adenosine kinase-deficient human lymphoblastoid cell line to effects of deoxyadenosine on growth, S-adenosylhomocysteine hydrolase inactivation, and dATP accumulation. 
  • Stereochemical course of nucleotidyl transfer catalyzed by bacteriophage T7 induced DNA polymerase. 
  • Surface-initiated enzymatic polymerization of DNA. 
  • The use of enzyme therapy to regulate the metabolic and phenotypic consequences of adenosine deaminase deficiency in mice. Differential impact on pulmonary and immunologic abnormalities. 
  • [Polyethylene glycol-adenosine deaminase: a new adenosine deaminase deficiency therapy. Value of deoxyadenosine triphosphate determination for therapeutic monitoring].