Deoxyribonuclease I
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Subject Areas on Research
- A T cell-specific transcriptional enhancer within the human T cell receptor delta locus.
- A change in the structure of Vbeta chromatin associated with TCR beta allelic exclusion.
- A complex intronic enhancer regulates expression of the CFTR gene by direct interaction with the promoter.
- A connection between stress and development in the multicellular prokaryote Streptomyces coelicolor A3(2).
- A genome-wide analysis of open chromatin in human tracheal epithelial cells reveals novel candidate regulatory elements for lung function.
- Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1.
- An integrated encyclopedia of DNA elements in the human genome.
- Barriers to productive transfection of trabecular meshwork cells.
- Binding of the global response regulator protein CovR to the sag promoter of Streptococcus pyogenes reveals a new mode of CovR-DNA interaction.
- Characterization of Staphylococcus aureus Cas9: a smaller Cas9 for all-in-one adeno-associated virus delivery and paired nickase applications.
- Characterization of the DNase I hypersensitive site 3' of the human beta globin gene domain.
- Cloning and characterization of a novel endothelial promoter of the human CYP19 (aromatase P450) gene that is up-regulated in breast cancer tissue.
- Comprehensive analysis of the chromatin landscape in Drosophila melanogaster.
- Correlation of doxorubicin footprints with deletion endpoints in lacO of E. coli.
- DNase-chip: a high-resolution method to identify DNase I hypersensitive sites using tiled microarrays.
- DNase-seq predicts regions of rotational nucleosome stability across diverse human cell types.
- DNase-seq: a high-resolution technique for mapping active gene regulatory elements across the genome from mammalian cells.
- DNaseI hypersensitivity at gene-poor, FSH dystrophy-linked 4q35.2.
- DNase I sensitivity QTLs are a major determinant of human expression variation.
- Detection of mutations by cleavage of DNA heteroduplexes with bacteriophage resolvases.
- Differential staining of actin in metaphase spindles with 7-nitrobenz-2-oxa-1,3-diazole-phallacidin and fluorescent DNase: is actin involved in chromosomal movement?
- Diffusible factors are responsible for differences in nuclease sensitivity among chromatins originating from different cell types.
- Dissecting the regulatory architecture of gene expression QTLs.
- Distant conserved sequences flanking endothelial-specific promoters contain tissue-specific DNase-hypersensitive sites and over-represented motifs.
- Drosophila TFIID binds to a conserved downstream basal promoter element that is present in many TATA-box-deficient promoters.
- Enhancer-blocking activity within the DNase I hypersensitive site 2 to 6 region between the TCR alpha and Dad1 genes.
- Enzymatic nanolithography of a self-assembled oligonucleotide monolayer on gold.
- Evaluating Chromatin Accessibility Differences Across Multiple Primate Species Using a Joint Modeling Approach.
- Explicit DNase sequence bias modeling enables high-resolution transcription factor footprint detection.
- Extensive evolutionary changes in regulatory element activity during human origins are associated with altered gene expression and positive selection.
- F-Seq: a feature density estimator for high-throughput sequence tags.
- Genome accessibility is widely preserved and locally modulated during mitosis.
- Genome-wide identification of regulatory elements in Sertoli cells.
- Genome-wide mapping of DNase hypersensitive sites using massively parallel signature sequencing (MPSS).
- Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci.
- Heritable individual-specific and allele-specific chromatin signatures in humans.
- High-resolution genome-wide in vivo footprinting of diverse transcription factors in human cells.
- High-resolution mapping and characterization of open chromatin across the genome.
- High-resolution mapping of open chromatin in the rice genome.
- Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome.
- Identification of potassium-dependent and -independent components of the apoptotic machinery in mouse ovarian germ cells and granulosa cells.
- In vitro interactions of CysB protein with the cysK and cysJIH promoter regions of Salmonella typhimurium.
- Investigating and Modeling the Regulation of Extracellular Antibiotic Resistance Gene Bioavailability by Naturally Occurring Nanoparticles.
- Mapping nucleosome positions using DNase-seq.
- Mapping regulatory elements by DNaseI hypersensitivity chip (DNase-Chip).
- Method for decellularizing skeletal muscle without detergents or proteolytic enzymes.
- Mispair specificity of methyl-directed DNA mismatch correction in vitro.
- Myeloid-Specific Deletion of Peptidylarginine Deiminase 4 Mitigates Atherosclerosis.
- NMR structure of AbhN and comparison with AbrBN: FIRST insights into the DNA binding promiscuity and specificity of AbrB-like transition state regulator proteins.
- Nasally inhaled dornase alfa in the postoperative management of chronic sinusitis due to cystic fibrosis.
- Patterns of regulatory activity across diverse human cell types predict tissue identity, transcription factor binding, and long-range interactions.
- Peroxide-mediated chromatin remodelling of a nuclear factor kappa B site in the mouse inducible nitric oxide synthase promoter.
- Positive and negative elements regulate human interleukin 3 expression.
- Predicting cell-type-specific gene expression from regions of open chromatin.
- Relationship between nuclease-hypersensitive sites and meiotic recombination hot spot activity at the HIS4 locus of Saccharomyces cerevisiae.
- Retroviral DNA integration: viral and cellular determinants of target-site selection.
- Revertants and partial transformants of rat fibroblasts infected with Fujinami sarcoma virus.
- Selective loss of a DNase I hypersensitive site upstream of the tyrosine aminotransferase gene in mice homozygous for lethal albino deletions.
- Sequence-independent method for in vitro generation of nested deletions for sequencing large DNA fragments.
- Site-specific mutations alter in vitro factor binding and change promoter expression pattern in transgenic plants.
- Site-specific silencing of regulatory elements as a mechanism of X inactivation.
- Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease.
- The SV40 core sequence functions as a repressor element in yeast.
- The Use of Poly-L-Lysine as a Capture Agent to Enhance the Detection of Antinuclear Antibodies by ELISA.
- The accessible chromatin landscape of the human genome.
- The binding of SLE autoantibodies to mitochondria.
- The compact chromatin structure of a Ty repeated sequence suppresses recombination hotspot activity in Saccharomyces cerevisiae.
- The forkhead transcription factor FoxI1 remains bound to condensed mitotic chromosomes and stably remodels chromatin structure.
- Transcriptional regulation of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa: dissection of key promoter elements.
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Keywords of People
- Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Immunology
- Reddy, Timothy E, Associate Professor of Biostatistics & Bioinformatics,, Molecular Genetics and Microbiology
- Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology