Deuterium

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  Subject Areas on Research

  • (1)H, (15)N and (13)C backbone and side chain assignments of PSD-95 PDZ3 protein. 
  • 3-Hydroxyisovalerylcarnitine in 3-methylcrotonyl-CoA carboxylase deficiency. 
  • A calorimetric and monolayer investigation of the influence of ions on the thermodynamic properties of phosphatidylcholine. 
  • A comparison of in vitro acylcarnitine profiling methods for the diagnosis of classical and variant short chain acyl-CoA dehydrogenase deficiency. 
  • A standard calculation methodology for human doubly labeled water studies. 
  • Accessing long-lived disconnected spin-1/2 eigenstates through spins > 1/2. 
  • Accuracy and precision of a new H/D exchange- and mass spectrometry-based technique for measuring the thermodynamic properties of protein-peptide complexes. 
  • Analysis of glycosaminoglycans in cerebrospinal fluid from patients with mucopolysaccharidoses by isotope-dilution ultra-performance liquid chromatography-tandem mass spectrometry. 
  • Application of fast atom bombardment with tandem mass spectrometry and liquid chromatography/mass spectrometry to the analysis of acylcarnitines in human urine, blood, and tissue. 
  • Assignment of aliphatic side-chain 1HN/15N resonances in perdeuterated proteins. 
  • Base-boronated dinucleotides: synthesis and effect of N7-cyanoborane substitution on the base protons. 
  • Characterizing the use of perdeuteration in NMR studies of large proteins: 13C, 15N and 1H assignments of human carbonic anhydrase II. 
  • Concurrent assessment of hepatic and intestinal cytochrome P450 3A activities using deuterated alfentanil. 
  • Determination of l-alpha-acetylmethadol, l-alpha-noracetylmethadol and l-alpha-dinoracetylmethadol in plasma by gas chromatography-mass spectrometry. 
  • Development of a novel method for measuring in vivo breast epithelial cell proliferation in humans. 
  • Dietary energy requirements of young adult men, determined by using the doubly labeled water method. 
  • Dynamics of glutathione and ophthalmate traced with 2H-enriched body water in rats and humans. 
  • Dynamics of water transport and storage in conifers studied with deuterium and heat tracing techniques. 
  • Effect of fasting and feeding on measurement of carbon dioxide production using doubly labeled water. 
  • Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis. 
  • Hepatic sulfite oxidase. A functional role for molybdenum. 
  • High-level 2H/13C/15N labeling of proteins for NMR studies. 
  • High-throughput screening assay for the tunable selection of protein ligands. 
  • Hydraulic redistribution in a Douglas-fir forest: lessons from system manipulations. 
  • Hydrogen/deuterium exchange- and protease digestion-based screening assay for protein-ligand binding detection. 
  • Implausibility of the vibrational theory of olfaction. 
  • Isocoproporphyrin: nuclear-magnetic-resonance-and mass-spectral methods for the determination of porphyrin structure. 
  • Isotope and ion selectivity in reverse osmosis desalination: geochemical tracers for man-made freshwater. 
  • Isotope-dilution assay for urinary methylmalonic acid in the diagnosis of vitamin B12 deficiency. A prospective clinical evaluation. 
  • Measurement of methotrexate polyglutamates in human erythrocytes by ion-pair UPLC-MS/MS. 
  • Measurements of protein stability by H/D exchange and matrix-assisted laser desorption/ionization mass spectrometry using picomoles of material. 
  • Mechanistic aspects of carbon monoxide formation from volatile anesthetics. 
  • Method and rationale for recalculating dilution spaces to a single, common time point in doubly labeled water studies. 
  • Multiple mass isotopomer tracing of acetyl-CoA metabolism in Langendorff-perfused rat hearts: channeling of acetyl-CoA from pyruvate dehydrogenase to carnitine acetyltransferase. 
  • Muscle Mass Assessed by the D3-Creatine Dilution Method and Incident Self-reported Disability and Mortality in a Prospective Observational Study of Community-Dwelling Older Men. 
  • Neutron and X-ray diffraction structural analysis of phosphatidylinositol bilayers. 
  • Nuclear quantum effects on an enzyme-catalyzed reaction with reaction path potential: proton transfer in triosephosphate isomerase. 
  • Packing and viscoelasticity of polyunsaturated omega-3 and omega-6 lipid bilayers as seen by (2)H NMR and X-ray diffraction. 
  • Proteome-wide muscle protein fractional synthesis rates predict muscle mass gain in response to a selective androgen receptor modulator in rats. 
  • Pulsed EPR studies of the exchangeable proton at the molybdenum center of dimethyl sulfoxide reductase. 
  • Rapid determination of protein folds using residual dipolar couplings. 
  • Stereochemistry and mechanism of the Brønsted acid catalyzed intramolecular hydrofunctionalization of an unactivated cyclic alkene. 
  • Strong Relation Between Muscle Mass Determined by D3-creatine Dilution, Physical Performance, and Incidence of Falls and Mobility Limitations in a Prospective Cohort of Older Men. 
  • Structure of a G.T.A triplet in an intramolecular DNA triplex. 
  • The International Atomic Energy Agency International Doubly Labelled Water Database: Aims, Scope and Procedures. 
  • The doubly labeled water method produces highly reproducible longitudinal results in nutrition studies. 
  • Thermodynamic stability measurements on multimeric proteins using a new H/D exchange- and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry-based method. 
  • Throughput and efficiency of a mass spectrometry-based screening assay for protein-ligand binding detection. 
  • Use of pH and kinetic isotope effects to establish chemistry as rate-limiting in oxidation of a peptide substrate by LSD1. 
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  Keywords of People

  • Patz Jr., Edward F., James and Alice Chen Distinguished Professor of Radiology, Pathology
  • Vengosh, Avner, Nicholas Distinguished Professor of Environmental Quality, Nicholas Institute-Energy Initiative