Diabetes Mellitus, Experimental

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  Subject Areas on Research

  • A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes. 
  • A manganese porphyrin suppresses oxidative stress and extends the life span of streptozotocin-diabetic rats. 
  • A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone. 
  • A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat. 
  • A rodent model of rapid-onset diabetes induced by glucocorticoids and high-fat feeding. 
  • Abnormal cardiac function in the streptozotocin-induced non-insulin-dependent diabetic rat: noninvasive assessment with doppler echocardiography and contribution of the nitric oxide pathway. 
  • Abnormal muscle spindle innervation and large-fiber neuropathy in diabetic mice. 
  • Acetaminophen normalizes glucose homeostasis in mouse models for diabetes. 
  • Acetyl-L-carnitine deficiency as a cause of altered nerve myo-inositol content, Na,K-ATPase activity, and motor conduction velocity in the streptozotocin-diabetic rat. 
  • Activated protein C preserves functional islet mass after intraportal transplantation: a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death. 
  • Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease. 
  • Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration. 
  • Adrenergic desensitization in left ventricle from streptozotocin diabetic swine. 
  • Allotransplantation of insulinoma into the testis of diabetic rats. 
  • Alprazolam reduces stress hyperglycemia in ob/ob mice. 
  • Alterations in viscosity and filterability of whole blood and blood cell subpopulations in diabetic cats. 
  • Alternative immunomodulatory strategies for xenotransplantation: CD40/154 pathway-sparing regimens promote xenograft survival. 
  • Aminoguanidine inhibits reactive oxygen species formation, lipid peroxidation, and oxidant-induced apoptosis. 
  • An SOD mimic protects NADP+-dependent isocitrate dehydrogenase against oxidative inactivation. 
  • An assessment of cochlear hair-cell loss in insulin-dependent diabetes mellitus diabetic and noise-exposed rats. 
  • Apolipoprotein E4 exaggerates diabetic dyslipidemia and atherosclerosis in mice lacking the LDL receptor. 
  • Belatacept and sirolimus prolong nonhuman primate islet allograft survival: adverse consequences of concomitant alefacept therapy. 
  • Bioburden after Staphylococcus aureus inoculation in type 1 diabetic rats undergoing internal fixation. 
  • Brain death significantly reduces isolated pancreatic islet yields and functionality in vitro and in vivo after transplantation in rats. 
  • CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells. 
  • Calmodulin-induced early-onset diabetes in transgenic mice. 
  • Cardio-protective effects of carnitine in streptozotocin-induced diabetic rats. 
  • Carnitine revisited: potential use as adjunctive treatment in diabetes. 
  • Consumption of a high-galactose diet induces diabetic-like changes in the inner ear. 
  • Control of expression of insulin resistance and hyperglycemia by different genetic factors in diabetic C57BL/6J mice. 
  • Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. 
  • Corneal epithelial wound healing in normal and diabetic rabbits treated with tretinoin. 
  • Coronary blood flow in chronic insulin-dependent diabetic dogs. 
  • Cytoprotection of PEG-modified adult porcine pancreatic islets for improved xenotransplantation. 
  • Damage to the epithelial basement membrane in the corneas of diabetic rabbits. 
  • Decreased deformability of polymorphonuclear leukocytes in diabetic cats. 
  • Defective glucose-stimulated insulin release from perifused islets of C57BL/6J mice. 
  • Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia. 
  • Diabetes causes NLRP3-dependent barrier dysfunction in mice with detrusor overactivity but not underactivity. 
  • Diabetes-induced bradycardia is an intrinsic metabolic defect reversed by carnitine. 
  • Diabetic bladder dysfunction progresses from an overactive to an underactive phenotype in a type-1 diabetic mouse model (Akita female mouse) and is dependent on NLRP3. 
  • Diabetic cardiomyopathy and carnitine deficiency. 
  • Diabetic cystopathy correlates with a long-term decrease in nerve growth factor levels in the bladder and lumbosacral dorsal root Ganglia. 
  • Diabetic kidney disease in FVB/NJ Akita mice: temporal pattern of kidney injury and urinary nephrin excretion. 
  • Diabetic liver injury from streptozotocin is regulated through the caspase-8 homolog cFLIP involving activation of JNK2 and intrahepatic immunocompetent cells. 
  • Diabetic urethropathy compounds the effects of diabetic cystopathy. 
  • Diet-induced type II diabetes in C57BL/6J mice. 
  • Differential vulnerabilities of urethral afferents in diabetes and discovery of a novel urethra-to-urethra reflex. 
  • Direct antidiabetic effect of leptin through triglyceride depletion of tissues. 
  • Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines. 
  • Does ghrelin explain accelerated gastric emptying in the early stages of diabetes mellitus? 
  • Dopaminergic Control of Inflammation and Glycemia in Sepsis and Diabetes. 
  • Double genetic modification of adenovirus fiber with RGD polylysine motifs significantly enhances gene transfer to isolated human pancreatic islets. 
  • Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: diabetic milieu makes a difference. 
  • Effect of potent redox-modulating manganese porphyrin, MnTM-2-PyP, on the Na(+)/H(+) exchangers NHE-1 and NHE-3 in the diabetic rat. 
  • Effects of experimental diabetes on adrenergic and cholinergic receptors of rat myocardium. 
  • Effects of nitric oxide releasing poly(vinyl alcohol) hydrogel dressings on dermal wound healing in diabetic mice. 
  • Enhancing human islet transplantation by localized release of trophic factors from PLG scaffolds. 
  • Enzyme-Responsive Delivery of Multiple Proteins with Spatiotemporal Control 
  • Evidence that down-regulation of beta-cell glucose transporters in non-insulin-dependent diabetes may be the cause of diabetic hyperglycemia. 
  • Experimental diabetes in cats induced by partial pancreatectomy alone or combined with local injection of alloxan. 
  • Functional and morphologic changes associated with insulinoma transplantation into diabetic rats. 
  • Functional photoacoustic microscopy of diabetic vasculature. 
  • Fusion of fibroblast growth factor 21 to a thermally responsive biopolymer forms an injectable depot with sustained anti-diabetic action. 
  • Gene transfer of endothelial nitric oxide synthase improves relaxation of carotid arteries from diabetic rabbits. 
  • Generation of hydrogen peroxide and failure of antioxidative responses in pancreatic islets of male C57BL/6 mice are associated with diabetes induced by multiple low doses of streptozotocin. 
  • Genetic engineering of a suboptimal islet graft with A20 preserves beta cell mass and function. 
  • Glucose Activates Vagal Control of Hyperglycemia and Inflammation in Fasted Mice. 
  • Hepatic expression of a targeting subunit of protein phosphatase-1 in streptozotocin-diabetic rats reverses hyperglycemia and hyperphagia despite depressed glucokinase expression. 
  • High-protein feeding stimulates renal thromboxane production in rats with streptozocin-induced diabetes. 
  • High-resolution, noninvasive longitudinal live imaging of immune responses. 
  • Hyperglycemia and T Cell infiltration are associated with stromal and epithelial prostatic hyperplasia in the nonobese diabetic mouse. 
  • Hyperglycemia induces insulin resistance on angiotensinogen gene expression in diabetic rat kidney proximal tubular cells. 
  • Impact of genetic background on nephropathy in diabetic mice. 
  • Increase in liver protein phosphatase-1 in spontaneously diabetic Chinese hamsters. 
  • Increased blood-brain barrier permeability and altered tight junctions in experimental diabetes in the rat: contribution of hyperglycaemia and matrix metalloproteinases. 
  • Increased nonenzymatically glycosylated proteins in the vitreous humor of diabetic animals. 
  • Increasing Dietary Medium-Chain Fatty Acid Ratio Mitigates High-fat Diet-Induced Non-Alcoholic Steatohepatitis by Regulating Autophagy. 
  • Inhibition of Dipeptidyl Peptidase-4 Impairs Ventricular Function and Promotes Cardiac Fibrosis in High Fat-Fed Diabetic Mice. 
  • Insulin and diabetes cause reciprocal changes in the association of eIF-4E and PHAS-I in rat skeletal muscle. 
  • Insulin replacement therapy in diabetic rats using an osmotic pump normalizes expression of enzymes key to hepatic carbohydrate metabolism. 
  • Insulin-dependent diabetic microangiopathy in the inner ear. 
  • Islet xenotransplantation using gal-deficient neonatal donors improves engraftment and function. 
  • LFA-1-specific therapy prolongs allograft survival in rhesus macaques. 
  • Late administration of Mn porphyrin-based SOD mimic enhances diabetic complications. 
  • Leukocyte-capillary plugging and network resistance are increased in skeletal muscle of rats with streptozotocin-induced hyperglycemia. 
  • Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression. 
  • Long circulating genetically encoded intrinsically disordered zwitterionic polypeptides for drug delivery. 
  • Long-lived implanted silastic drum glucose sensors. 
  • Long-term type 1 diabetes influences haematopoietic stem cells by reducing vascular repair potential and increasing inflammatory monocyte generation in a murine model. 
  • Low plasma leptin in response to dietary fat in diabetes- and obesity-prone mice. 
  • Metal-Organic Framework Encapsulation Preserves the Bioactivity of Protein Therapeutics. 
  • Metallothionein alleviates cardiac dysfunction in streptozotocin-induced diabetes: role of Ca2+ cycling proteins, NADPH oxidase, poly(ADP-Ribose) polymerase and myosin heavy chain isozyme. 
  • Microangiopathic retinopathy in experimental diabetic monkeys. 
  • Modelling diabetic nephropathy in mice. 
  • Molecular biology of renal injury: emphasis on the role of the renin-angiotensin system. 
  • Molecular characterization of MHC class II antigens (beta 1 domain) in the BB diabetes-prone and -resistant rat. 
  • N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents. 
  • Naltrexone potentiates glycemic responses during stress and epinephrine challenge in genetically obese mice. 
  • Nitric oxide-releasing polymeric microspheres improve diabetes-related erectile dysfunction. 
  • OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype. 
  • Overexpression of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase in mouse liver lowers blood glucose by suppressing hepatic glucose production. 
  • Pathological endoplasmic reticulum stress mediated by the IRE1 pathway contributes to pre-insulitic beta cell apoptosis in a virus-induced rat model of type 1 diabetes. 
  • Peripheral neuropathy in mouse hereditary diabetes mellitus. II. Ultrastructural correlates of degenerative and regenerative changes. 
  • Permanent protection of PLG scaffold transplanted allogeneic islet grafts in diabetic mice treated with ECDI-fixed donor splenocyte infusions. 
  • Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone. 
  • Porous hyaluronic acid hydrogels for localized nonviral DNA delivery in a diabetic wound healing model 
  • Prevention of autoimmune islet allograft destruction by engraftment of donor T cells. 
  • Receptor tyrosine kinase MerTK suppresses an allogenic type I IFN response to promote transplant tolerance. 
  • Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis. 
  • Regulation of expression of transcobalamin II receptor in the rat. 
  • Repetitive Ozone Exposures and Evaluation of Pulmonary Inflammation and Remodeling in Diabetic Mouse Strains. 
  • Resistance of cats to the diabetogenic effect of alloxan. 
  • Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in zucker diabetic fatty rats. 
  • Retinal blood flow in normal and diabetic dogs. 
  • Retinal oxygen consumption in vitro. The effect of diabetes mellitus, oxygen and glucose. 
  • Reversal of diet-induced obesity and diabetes in C57BL/6J mice. 
  • Role of Mitochondrial Oxidative Stress in Glucose Tolerance, Insulin Resistance, and Cardiac Diastolic Dysfunction. 
  • Rpl13a small nucleolar RNAs regulate systemic glucose metabolism. 
  • Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. 
  • Stimulation of long-chain fatty acid uptake by dipyridamole in isolated myocytes. 
  • Succination of Protein Disulfide Isomerase Links Mitochondrial Stress and Endoplasmic Reticulum Stress in the Adipocyte During Diabetes. 
  • Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. 
  • Sustained release of a GLP-1 and FGF21 dual agonist from an injectable depot protects mice from obesity and hyperglycemia. 
  • Syntaxin 4 Expression in Pancreatic β-Cells Promotes Islet Function and Protects Functional β-Cell Mass. 
  • Systemic administration of HVJ viral coat-liposome complex containing human insulin vector decreases glucose level in diabetic mouse: A model of gene therapy. 
  • TCF1 links GIPR signaling to the control of beta cell function and survival. 
  • Targeted Nrf2 activation therapy with RTA 408 enhances regenerative capacity of diabetic wounds. 
  • The anterior chamber of the eye as a clinical transplantation site for the treatment of diabetes: a study in a baboon model of diabetes. 
  • The clearance of glycoproteins in diabetic mice. 
  • The effect of intraocular irrigating solutions on lens clarity in normal and diabetic rabbits. 
  • The effects of Ins2(Akita) diabetes and chronic angiotensin II infusion on cystometric properties in mice. 
  • The incretins and beta-cell health: contrasting glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 as a path to understand islet function in diabetes. 
  • The influence of genetic background on the susceptibility of mice to diabetes induced by alloxan and on recovery from alloxan diabetes. 
  • The influence of hyperglycemia on neutrophil extracellular trap formation and endothelial glycocalyx damage in a mouse model of type 2 diabetes. 
  • The role of dysregulated glucagon secretion in type 2 diabetes. 
  • Total plasmatic homocysteine and von Willebrand factor in experimental diabetes mellitus. 
  • Transplantation of feline islets of Langerhans in the subretinal space of cat eyes. 
  • Transplantation of insulinoma into the diabetic Syrian hamster. 
  • Ultrastructure of fiber cells and multilamellar inclusions in experimental diabetes. 
  • Underexpression of beta cell high Km glucose transporters in noninsulin-dependent diabetes. 
  • Urethral dysfunction in diabetic rats. 
  • Ventromedial hypothalamic glucokinase is an important mediator of the counterregulatory response to insulin-induced hypoglycemia. 
  • Voltage-dependent potassium currents of urethral afferent neurons in diabetes mellitus. 
  • Wound healing with topical BRAF inhibitor therapy in a diabetic model suggests tissue regenerative effects. 
  • β-Cell Inactivation of Gpr119 Unmasks Incretin Dependence of GPR119-Mediated Glucoregulation.