Diazepam

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  Subject Areas on Research

  • 3-Halo-5,7-dimethylpyrazolo [1,5-a]pyrimidines, a nonbenzodiazepinoid class of antianxiety agents devoid of potentiation of central nervous system depressant effects of ethanol or barbiturates. 
  • A case of infant delirium in the neonatal intensive care unit. 
  • A pilot study assessing the bioavailability and pharmacokinetics of diazepam after intranasal and intravenous administration in healthy volunteers. 
  • A technique for investigating the intensity and duration of human psychomotor impairment after intravenous diazepam. 
  • Administration of antidepressants, diazepam and psychomotor stimulants further confirms the utility of Flinders Sensitive Line rats as an animal model of depression. 
  • An anxiety-like phenotype in mice selectively bred for aggression. 
  • Assessment of pain in sedated and mechanically ventilated patients: an observational study. 
  • Benzodiazepine receptor declines in hippocampal formation following limbic seizures. 
  • Benzodiazepines in the intensive care unit. 
  • Benzodiazepines protect hippocampal neurons from degeneration after transient cerebral ischemia: an ultrastructural study. 
  • Buspirone, chlordiazepoxide and diazepam effects in a zebrafish model of anxiety. 
  • Cajal-Retzius cells switch from expressing gamma-less to gamma-containing GABA receptors during corticogenesis. 
  • Changes in cerebral blood velocity after intravenous diazepam. 
  • Changes in intracellular chloride after oxygen-glucose deprivation of the adult hippocampal slice: effect of diazepam. 
  • Changes in sphingomyelinases, ceramide, Bax, Bcl(2), and caspase-3 during and after experimental status epilepticus. 
  • Characterization of the analgesic effects of the benzodiazepine antagonist, Ro 15-1788. 
  • Chromatographic method for the determination of diazepam, pyridostigmine bromide, and their metabolites in rat plasma and urine. 
  • Comparison of diazepam and sodium thiopental in cardioversion. 
  • Diazepam promotes ATP recovery and prevents cytochrome c release in hippocampal slices after in vitro ischemia. 
  • Diazepam, given postischemia, protects selectively vulnerable neurons in the rat hippocampus and striatum. 
  • Differential actions of diazepam and zolpidem in basolateral and central amygdala nuclei. 
  • ECT-induced status. 
  • Effect of a single dose of diazepam on balance measures in older people. 
  • Effects of continuous diazepam administration on GABAA subunit mRNA in rat brain. 
  • Effects of propranolol on cardiovascular and neuroendocrine responses to mental arithmetic in type A men. 
  • Emergence of anxiety-like behaviours in depressive-like Cpe(fat/fat) mice. 
  • Emergency management of the patient with seizures. 1. Generalized status epilepticus. 
  • Evaluation of psychopharmacological effects of Clerodendrum phlomidis Linn. extract. 
  • Evaluation of the effects of diazepam and an experimental anti-anxiety drug on regional cerebral blood flow. 
  • Fluorescence imaging of GABAA receptor-mediated intracellular [Cl-] in P19-N cells reveals unique pharmacological properties. 
  • Haploinsufficiency in peptidylglycine alpha-amidating monooxygenase leads to altered synaptic transmission in the amygdala and impaired emotional responses. 
  • In vivo evidence of the specificity of effects of GABA(A) receptor modulating medications. 
  • Intraoperative awareness and hypertensive crisis during high-dose fentanyl-diazepam-oxygen anesthesia. 
  • Intraoperative ketorolac and eye pain after vitreoretinal surgery: a prospective, randomized, placebo-controlled study. 
  • N-o-Methoxyphenylpiperazine: a simple blocker of dopaminergic receptors in the brain. 
  • Neuropeptides modulate compound postsynaptic potentials in basolateral amygdala. 
  • Novelty seeking and stereotypic activation of behavior in mice with disruption of the Dat1 gene. 
  • Population Pharmacokinetics and Exploratory Exposure-Response Relationships of Diazepam in Children Treated for Status Epilepticus. 
  • Postischemic diazepam is neuroprotective in the gerbil hippocampus. 
  • Radiation inactivation studies of the benzodiazepine/gamma-aminobutyric acid/chloride ionophore receptor complex. 
  • Reduced GABA neurotransmission underlies hyperalgesia induced by repeated forced swimming stress. 
  • Reducing long-term diazepam prescribing in office practice. A controlled trial of educational visits. 
  • Relaxant effect of diazepam on uterine muscle. 
  • Repeated seizures induce long-term increase in hippocampal benzodiazepine receptors. 
  • Selective activation of mesoamygdaloid dopamine neurons by conditioned stress: attenuation by diazepam. 
  • Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord. 
  • The correlation between the recovery rate of neurotoxic esterase activity and sensitivity to organophosphorus-induced delayed neurotoxicity. 
  • The role of diazepam loading for the treatment of alcohol withdrawal syndrome in hospitalized patients. 
  • The use of drugs in achieving successful DC cardioversion. 
  • [Benzodiazepine receptors of the mouse glioblastoma cell line: the anomalous effect of gamma-aminobutyric acid on diazepam binding]. 
  • [Endogenous inhibitors of specific benzodiazepine binding in the cerebral cortex of the bull]. 
  • [Endogenous inhibitors of the specific binding of benzodiazepines in the cerebral cortex]. 
  • [Identification and evaluation of properties of benzodiazepine receptors of glial and neuronal fractions of human cerebral cortex]. 
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  Keywords of People

  • Schwartz-Bloom, Rochelle D., Professor Emeritus of Pharmacology & Cancer Biology, Duke Science & Society