Diethylstilbestrol

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  Subject Areas on Research

  • A hypothetic mechanism of diethylstilbestrol(DES)-induced anomalies in exposed progeny. 
  • Adverse health outcomes in women exposed in utero to diethylstilbestrol. 
  • Age at natural menopause in women exposed to diethylstilbestrol in utero. 
  • Age-incidence and risk of diethylstilbestrol-related clear cell adenocarcinoma of the vagina and cervix. 
  • Amino acid sequence of the signal peptide of apoVLDL-II, a major apoprotein in avian very low density lipoproteins. 
  • Are implantation and pregnancy outcome impaired in diethylstilbestrol-exposed women after in vitro fertilization and embryo transfer? 
  • Atypical vaginal adenosis and cervical ectropion. Association with clear cell adenocarcinoma in diethylstilbestrol-exposed offspring. 
  • Autoimmune disease incidence among women prenatally exposed to diethylstilbestrol. 
  • Breast cancer screening in women exposed in utero to diethylstilbestrol. 
  • Cancer risk in men exposed in utero to diethylstilbestrol. 
  • Cancer risk in women exposed to diethylstilbestrol in utero. 
  • Cancer risk in women prenatally exposed to diethylstilbestrol. 
  • Cervical screening and general physical examination behaviors of women exposed in utero to diethylstilbestrol. 
  • Clear cell adenocarcinoma of the vagina and cervix: incidence, undetected disease, and diethylstilbestrol. 
  • Clear-cell adenocarcinoma of the vagina and cervix in girls: analysis of 170 registry cases. 
  • Clear-cell adenocarcinoma of the vagina and cervix in young females: analysis of 37 tumors that persisted or recurred after primary therapy. 
  • Comparison of histologic and colposcopic findings in DES-exposed females. 
  • Complications of prenatal therapy with diethylstilbestrol. 
  • Cytology of 575 young women with prenatal exposure to diethylstilbestrol. 
  • Cytology of clear-cell adenocarcinoma of genital tract in young females: review of 95 cases from the registry. 
  • Design and preliminary observations of National Cooperative Diethylstilbestrol Adenosis (DESAD) Project. 
  • Development of an ER action indicator mouse for the study of estrogens, selective ER modulators (SERMs), and Xenobiotics. 
  • Differential expression of p63 isoforms in female reproductive organs. 
  • Dysplasia and cytologic findings in 4,589 young women enrolled in diethylstilbestrol-adenosis (DESAD) project. 
  • Editorial: Problems in the examination of the DES-exposed female. 
  • Effect of estrogen on gene expression in the chick oviduct. Regulation of the ovomucoid gene. 
  • Effect of estrogen on the synthesis and processing of ovalbumin messenger RNA in the chick oviduct. 
  • Effect of hormones on the growth of virus-transformed hamster prostatic tissue. 
  • Effect of neonatal diethylstilbestrol exposure on luteinizing hormone secretion following ketamine anesthesia and gonadotropin-releasing hormone in castrated postpubertal rats. 
  • Effect of neonatal diethylstilbestrol exposure on volume of the sexually dimorphic nucleus of the preoptic area of the hypothalamus and pituitary responsiveness to gonadotropin-releasing hormone in female rats of known anogenital distance at birth. 
  • Effects of diethylstilbestrol on rat granulosa cell and thecal/interstitial cell transforming growth factor-beta 2 mRNA expression in vivo: analysis by reverse transcription-polymerase chain reaction. 
  • Estrogen induction of ovalbumin mRNA: evidence for transcription control. 
  • Estrogen induction of plasma vitellogenin in the cockerel: studies with a phosvitin antibody. 
  • Estrogen modulation of nuclear matrix-associated steroid hormone binding. 
  • Estrogen stimulates the transient association of calmodulin and myosin light chain kinase with the chicken liver nuclear matrix. 
  • Estrogen-induced changes in translation, and specific messenger RNA levels during oviduct differentiation. 
  • Estrogen-induced synthesis of ovalbumin messenger RNA and its translation in a cell-free system. 
  • Experience with diethylstilbestrol-exposed infertile women in a program of in vitro fertilization. 
  • Experimental study of the effect of diethylstilbestrol on the development of the human female reproductive tract. 
  • Expression of nuclear estrogen-binding sites within developing human fetal vagina and urogenital sinus. 
  • Extended field radiation therapy versus delayed hormonal therapy in node positive prostatic adenocarcinoma. 
  • Factors associated with a lack of pap smear utilization in women exposed in utero to diethylstilbestrol. 
  • Hormonal control of oviduct growth and differentiation. 
  • Hormonal regulation of a chicken oviduct messenger ribonucleic acid that shares a common domain with gizzard myosin light chain kinase. 
  • Human platelet-derived growth factor preparations contain a separate activity which potentiates follicle-stimulating hormone-mediated induction of luteinizing hormone receptor in cultured rat granulosa cells: evidence for transforming growth factor-beta. 
  • Hypospadias in sons of women exposed to diethylstilbestrol in utero. 
  • Incidence of squamous neoplasia of the cervix and vagina in women exposed prenatally to diethylstilbestrol (United States). 
  • Increased incidence of cervical and vaginal dysplasia in 3,980 diethylstilbestrol-exposed young women. Experience of the National Collaborative Diethylstilbestrol Adenosis Project. 
  • Induction of apoptosis by diethylstilbestrol in hormone-insensitive prostate cancer cells. 
  • Induction of specific translatable messenger RNA's by oestrogen and progesterone. 
  • Intrauterine diethylstilbestrol exposure and its consequences: pathologic characteristics of vaginal adenosis, clear cell adenocarcinoma, and related lesions. 
  • Isolation of protein factors from oviduct polysomes which stimulate protein synthesis. 
  • Ligand-selective interactions of ER detected in living cells by fluorescence resonance energy transfer. 
  • Liver and prostate adenocarcinoma: an "estrogen-free" environment? 
  • Mammography screening behaviors of women exposed prenatally to diethylstilbestrol. 
  • Management of metastatic prostatic cancer. 
  • Maturation of vaginal and cervical epithelium in women exposed in utero to diethylstilbestrol (DESAD Project). 
  • Microglandular hyperplasia in vaginal adenosis associated with oral contraceptives and prenatal diethylstilbestrol exposure. 
  • Morphological and biochemical studies of virus (SV40) transformed prostatic tissue. 
  • Normal development of the human female reproductive tract and alterations resulting from experimental exposure to diethylstilbestrol. 
  • Nuclear DNA study of vaginal and cervical squamous cell abnormalities in DES exposed progeny. 
  • Nuclear estrogen receptor in the avian liver: correlation with biologic response. 
  • Pathologic findings in young women enrolled in the National Cooperative Diethylstilbestrol Adenosis (DESAD) project. 
  • Pathology of colposcopic findings in 2635 diethylstilbestrol-exposed young women. 
  • Pathology of prenatal diethylstilbestrol exposure. 
  • Pathology of vaginal and cervical abnormalities associated with prenatal exposure to diethylstilbestrol (des). 
  • Platelet-derived growth factor enhances granulosa cell luteinizing hormone receptor induction by follicle-stimulating hormone and serum. 
  • Preeclampsia risk in women exposed in utero to diethylstilbestrol. 
  • Prenatal diethylstilbestrol exposure and high-grade squamous cell neoplasia of the lower genital tract. 
  • Prenatal diethylstilbestrol exposure and human genital tract abnormalities. 
  • Prenatal exposure to stilbestrol. A prospective comparison of exposed female offspring with unexposed controls. 
  • Preterm birth, fetal growth, and age at menarche among women exposed prenatally to diethylstilbestrol (DES). 
  • Protein biosynthesis on chick oviduct polyribosomes. I. Changes during estrogen-mediated tissue differentiation. 
  • Protein biosynthesis on chick oviduct polyribosomes. II. Regulation by progesterone. 
  • Radiation therapy versus delayed androgen deprivation for stage C carcinoma of the prostate. 
  • Randomized comparison of tamoxifen versus diethylstilbestrol in estrogen receptor-positive or -unknown metastatic breast cancer: a Southeastern Cancer Study Group trial. 
  • Randomized trial of cyclophosphamide, methotrexate, and 5-fluorouracil with or without estrogenic recruitment in women with metastatic breast cancer. 
  • Rat thecal/interstitial cells express transforming growth factor-beta type 1 and 2, but only type 2 is regulated by gonadotropin in vitro. 
  • Rates of induction of specific translatable messenger RNAs for ovalbumin and avidin by steroid hormones. 
  • Response of xenografts of developing human female reproductive tracts to the synthetic estrogen, diethylstilbestrol. 
  • Risk factors for cancer of the testis. 
  • Risk of benign gynecologic tumors in relation to prenatal diethylstilbestrol exposure. 
  • Role of hormones including diethylstibestrol (DES) in the pathogenesis of cervical and vaginal intraepithelial neoplasia. 
  • SV40-transformed hamster prostatic tissue: a model of human prostatic malignancy. 
  • Selected topics in the pathology of the vagina. 
  • Single-therapy androgen suppression in men with advanced prostate cancer: a systematic review and meta-analysis. 
  • Squamous cell dysplasia and carcinoma in situ of the cervix and vagina after prenatal exposure to diethylstilbestrol. 
  • Squamous cell neoplasia controversy in the female exposed to diethylstilbestrol. 
  • Structural anomalies of the cervix and vagina in women enrolled in the Diethylstilbestrol Adenosis (DESAD) Project. 
  • Synthesis of very low density lipoproteins in the cockerel. Effects of estrogen. 
  • Teratogenic effects of clomiphene, tamoxifen, and diethylstilbestrol on the developing human female genital tract. 
  • The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells. 
  • The association between in utero cigarette smoke exposure and age at menopause. 
  • The effect of neonatal exposure to DES and o,p'-DDT on pituitary responsiveness to GnRH in adult castrated rats. 
  • The effect of neonatal exposure to diethylstilbestrol, coumestrol, and beta-sitosterol on pituitary responsiveness and sexually dimorphic nucleus volume in the castrated adult rat. 
  • The effect of neonatal exposure to diethylstilbestrol, genistein, and zearalenone on pituitary responsiveness and sexually dimorphic nucleus volume in the castrated adult rat. 
  • The effect of prenatal exposure to the phytoestrogen genistein on sexual differentiation in rats. 
  • The effects of local progesterone on stilbestrol-associated vaginal adenosis. 
  • The embryologic development of the human vagina. 
  • The production of transforming growth factor-beta activity by rat granulosa cell cultures. 
  • The significance of adenosis and clear-cell adenocarcinoma of the genital tract in young females. 
  • Topographic relation of cervical ectropion and vaginal adenosis to clear cell adenocarcinoma. 
  • Ultrastructure of 16 cases of clear cell adenocarcinoma of the vagina and cervix in young women. 
  • Use of a specific probe for ovalbumin messenger RNA to quantitate estrogen-induced gene transcripts. 
  • Vaginal adenosis and other diethylstilbestrol-related abnormalities. 
  • Vaginal adenosis in women born prior to the diethylstilbestrol era. 
  • Vaginal and cervical abnormalities, including clear-cell adenocarcinoma, related to prenatal exposure to stilbestrol. 
  • Vaginal epithelial changes in young women enrolled in the National Cooperative Diethylstilbestrol Adenosis (DESAD) project. 
  • Virus-induced genitourinary malignancy. Macromolecular identity. 
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  Keywords of People

  • McDonnell, Donald Patrick, Chair, Department of Pharmacology & Cancer Biology, Duke Innovation & Entrepreneurship