Diglycerides

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  Subject Areas on Research

  • A phosphoethanolamine-modified glycosyl diradylglycerol in the polar lipids of Clostridium tetani. 
  • A retroviral-derived peptide phosphorylates protein kinase D/protein kinase Cmu involving phospholipase C and protein kinase C. 
  • A synthetic peptide homologous to retroviral transmembrane envelope proteins depresses protein kinase C mediated lymphocyte proliferation and directly inactivated protein kinase C: a potential mechanism for immunosuppression. 
  • Alpha interferon and gamma interferon stimulate transcription of a single gene through different signal transduction pathways. 
  • Analysis of calcium homeostasis in activated human polymorphonuclear leukocytes. Evidence for two distinct mechanisms for lowering cytosolic calcium. 
  • Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression. 
  • Calcium influx stimulates a second pathway for sustained diacylglycerol production in leukocytes activated by chemoattractants. 
  • Changes in bioactive lipids, alkylacylglycerol and ceramide, occur in HIV-infected cells. 
  • Comparison of alkylacylglycerol vs. diacylglycerol as activators of mitogen-activated protein kinase and cytosolic phospholipase A2 in human neutrophil priming. 
  • Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism. 
  • Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice. 
  • Diacylglycerol kinase zeta positively controls the development of iNKT-17 cells. 
  • Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses. 
  • Differential activation of human neutrophil cytosolic phospholipase A2 and secretory phospholipase A2 during priming by 1,2-diacyl- and 1-O-alkyl-2-acylglycerols. 
  • Differential stimulation of the respiratory burst and lysosomal enzyme secretion in human polymorphonuclear leukocytes by synthetic diacylglycerols. 
  • Disruption of diacylglycerol metabolism impairs the induction of T cell anergy. 
  • Evaluation of phospholipase C and D activity in stimulated human neutrophils using a phosphono analog of choline phosphoglyceride. 
  • G protein-coupled receptor kinase and beta-arrestin-mediated desensitization of the angiotensin II type 1A receptor elucidated by diacylglycerol dynamics. 
  • Graded diacylglycerol kinases α and ζ activities ensure mucosal-associated invariant T-cell development in mice. 
  • Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart. 
  • Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence. 
  • Identification, partial purification, and characterization of a novel phospholipid-dependent and fatty acid-activated protein kinase from human platelets. 
  • Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle. 
  • Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism. 
  • Leukocyte chemoattraction by 1,2-diacylglycerol. 
  • Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis. 
  • Maleylated-BSA induces hydrolysis of PIP2, fluxes of Ca2+, NF-kappaB binding, and transcription of the TNF-alpha gene in murine macrophages. 
  • Metabolomic profiling identifies complex lipid species and amino acid analogues associated with response to weight loss interventions. 
  • Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations. 
  • Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy. 
  • Negative control of diacylglycerol kinase ζ-mediated inhibition of T cell receptor signaling by nuclear sequestration in mice. 
  • Overexpression of rat long chain acyl-coa synthetase 1 alters fatty acid metabolism in rat primary hepatocytes. 
  • Pertussis toxin triggers rapid second messenger production in human T lymphocytes. 
  • Pleiotropic alterations in lipid metabolism in yeast sac1 mutants: relationship to "bypass Sec14p" and inositol auxotrophy. 
  • Protein kinase C: cellular target of the second messenger arachidonic acid? 
  • SAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling. 
  • Stereospecificity of monoacylglycerol acyltransferase activity from rat intestine and suckling rat liver. 
  • Stimulation of phosphorylcholine turnover and diacylglycerol production in human polymorphonuclear leukocytes. Novel assay for phosphorylcholine. 
  • Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance. 
  • Synthesis, structure, and thermal properties of 1,2-dipalmitoylgalloylglycerol (DPGG), a novel self-adhering lipid. 
  • Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. 
  • Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. 
  • Tight regulation of diacylglycerol-mediated signaling is critical for proper invariant NKT cell development. 
  • Transgenic mice with cardiac overexpression of alpha1B-adrenergic receptors. In vivo alpha1-adrenergic receptor-mediated regulation of beta-adrenergic signaling. 
  • Unidirectional, heterologous desensitization of the pertussis toxin receptor by the CD3/TCR complex. 
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  Keywords of People

  • Cianciolo, George James, Associate Professor Emeritus of Pathology, Pathology
  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Zhong, Xiaoping, Professor of Pediatrics, Immunology