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Subject Areas on Research
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A phosphoethanolamine-modified glycosyl diradylglycerol in the polar lipids of Clostridium tetani.
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A retroviral-derived peptide phosphorylates protein kinase D/protein kinase Cmu involving phospholipase C and protein kinase C.
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A synthetic peptide homologous to retroviral transmembrane envelope proteins depresses protein kinase C mediated lymphocyte proliferation and directly inactivated protein kinase C: a potential mechanism for immunosuppression.
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Alpha interferon and gamma interferon stimulate transcription of a single gene through different signal transduction pathways.
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Analysis of calcium homeostasis in activated human polymorphonuclear leukocytes. Evidence for two distinct mechanisms for lowering cytosolic calcium.
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Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression.
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Calcium influx stimulates a second pathway for sustained diacylglycerol production in leukocytes activated by chemoattractants.
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Changes in bioactive lipids, alkylacylglycerol and ceramide, occur in HIV-infected cells.
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Comparison of alkylacylglycerol vs. diacylglycerol as activators of mitogen-activated protein kinase and cytosolic phospholipase A2 in human neutrophil priming.
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Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism.
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Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice.
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Diacylglycerol kinase zeta positively controls the development of iNKT-17 cells.
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Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses.
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Differential activation of human neutrophil cytosolic phospholipase A2 and secretory phospholipase A2 during priming by 1,2-diacyl- and 1-O-alkyl-2-acylglycerols.
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Differential stimulation of the respiratory burst and lysosomal enzyme secretion in human polymorphonuclear leukocytes by synthetic diacylglycerols.
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Disruption of diacylglycerol metabolism impairs the induction of T cell anergy.
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Evaluation of phospholipase C and D activity in stimulated human neutrophils using a phosphono analog of choline phosphoglyceride.
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G protein-coupled receptor kinase and beta-arrestin-mediated desensitization of the angiotensin II type 1A receptor elucidated by diacylglycerol dynamics.
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Graded diacylglycerol kinases α and ζ activities ensure mucosal-associated invariant T-cell development in mice.
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Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart.
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Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence.
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Identification, partial purification, and characterization of a novel phospholipid-dependent and fatty acid-activated protein kinase from human platelets.
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Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle.
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Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism.
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Leukocyte chemoattraction by 1,2-diacylglycerol.
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Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis.
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Maleylated-BSA induces hydrolysis of PIP2, fluxes of Ca2+, NF-kappaB binding, and transcription of the TNF-alpha gene in murine macrophages.
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Metabolomic profiling identifies complex lipid species and amino acid analogues associated with response to weight loss interventions.
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Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations.
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Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy.
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Negative control of diacylglycerol kinase ζ-mediated inhibition of T cell receptor signaling by nuclear sequestration in mice.
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Overexpression of rat long chain acyl-coa synthetase 1 alters fatty acid metabolism in rat primary hepatocytes.
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Pertussis toxin triggers rapid second messenger production in human T lymphocytes.
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Pleiotropic alterations in lipid metabolism in yeast sac1 mutants: relationship to "bypass Sec14p" and inositol auxotrophy.
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Protein kinase C: cellular target of the second messenger arachidonic acid?
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SAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling.
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Stereospecificity of monoacylglycerol acyltransferase activity from rat intestine and suckling rat liver.
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Stimulation of phosphorylcholine turnover and diacylglycerol production in human polymorphonuclear leukocytes. Novel assay for phosphorylcholine.
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Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance.
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Synthesis, structure, and thermal properties of 1,2-dipalmitoylgalloylglycerol (DPGG), a novel self-adhering lipid.
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Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins.
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Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy.
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Tight regulation of diacylglycerol-mediated signaling is critical for proper invariant NKT cell development.
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Transgenic mice with cardiac overexpression of alpha1B-adrenergic receptors. In vivo alpha1-adrenergic receptor-mediated regulation of beta-adrenergic signaling.
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Unidirectional, heterologous desensitization of the pertussis toxin receptor by the CD3/TCR complex.
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Keywords of People
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Cianciolo, George James,
Associate Professor Emeritus of Pathology,
Pathology
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Milano, Carmelo Alessio,
Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery,
Surgery, Cardiovascular and Thoracic Surgery
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Zhong, Xiaoping,
Professor of Pediatrics,
Immunology