Disease Susceptibility

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  Subject Areas on Research

  • 2012 Young Investigator Award winner: The distribution of body mass as a significant risk factor for lumbar spinal fusion postoperative infections. 
  • 30-Year Review of Pediatric- and Adult-Onset CVID: Clinical Correlates and Prognostic Indicators. 
  • A Fungal Arrestin Protein Contributes to Cell Cycle Progression and Pathogenesis. 
  • A Genome-Wide Functional Genomics Approach Identifies Susceptibility Pathways to Fungal Bloodstream Infection in Humans. 
  • A Pseudomonas syringae type III effector suppresses cell wall-based extracellular defense in susceptible Arabidopsis plants. 
  • A comparative study of white blood cell counts and disease risk in carnivores. 
  • A correlated frailty model with long-term survivors for estimating the heritability of breast cancer. 
  • A germ-line deletion of APOBEC3B does not contribute to subtype-specific childhood acute lymphoblastic leukemia etiology. 
  • A global reference for human genetic variation. 
  • A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter. 
  • A novel murine model of inflammatory bowel disease and inflammation-associated colon cancer with ulcerative colitis-like features. 
  • A role for fetal hemoglobin and maternal immune IgG in infant resistance to Plasmodium falciparum malaria. 
  • A splicing variant of TERT identified by GWAS interacts with menopausal estrogen therapy in risk of ovarian cancer. 
  • Abnormal vertebral segmentation and the notch signaling pathway in man. 
  • Acanthosis nigricans: a practical approach to evaluation and management. 
  • Acute coronary care in the elderly, part I: Non-ST-segment-elevation acute coronary syndromes: a scientific statement for healthcare professionals from the American Heart Association Council on Clinical Cardiology: in collaboration with the Society of Geriatric Cardiology. 
  • Acute coronary care in the elderly, part II: ST-segment-elevation myocardial infarction: a scientific statement for healthcare professionals from the American Heart Association Council on Clinical Cardiology: in collaboration with the Society of Geriatric Cardiology. 
  • Adenosine deaminase deficiency in adults. 
  • Age-dependent alterations of peritoneal exudate macrophages in autoimmune-prone and autoimmune-resistant mouse strains. 
  • Aging and cancer. 
  • An examination of the association between 5-HTTLPR, combat exposure, and PTSD diagnosis among U.S. veterans. 
  • An unusual anesthetic course in a patient susceptible to malignant hyperthermia. 
  • Animal models provide insight into psychosomatic factors in diabetes. 
  • Apolipoprotein E in Creutzfeldt-Jakob disease. 
  • Apolipoprotein E-deficient mice have increased susceptibility to focal cerebral ischemia. 
  • Association between muscle fiber composition and blood pressure levels during exercise in men. 
  • Attention deficit hyperactivity disorder symptoms predict nicotine dependence and progression to regular smoking from adolescence to young adulthood. 
  • Basement membranes and autoimmune diseases. 
  • Basement membranes. 
  • Bilateral spontaneous concurrent rupture of the patellar tendon in a healthy man: case report and review of the literature. 
  • Biochemical profile of stone-forming patients with diabetes mellitus. 
  • Brain 5-HT deficiency increases stress vulnerability and impairs antidepressant responses following psychosocial stress. 
  • Brain immunology and immunotherapy in brain tumours. 
  • CASP7 variants modify susceptibility to cervical cancer in Chinese women. 
  • Catechol-O-methyltransferase genotype predicts pain severity in hospitalized burn patients. 
  • Changes in Nutritional Status Impact Immune Cell Metabolism and Function. 
  • Changes in seizure threshold over the course of electroconvulsive therapy affect therapeutic response and are detected by ictal EEG ratings. 
  • Checkpoint Blockade Strategies in the Treatment of Breast Cancer: Where We Are and Where We Are Heading. 
  • Childhood neuropsychological deficits associated with adult obsessive-compulsive disorder. 
  • Chronic alcohol exposure renders epithelial cells vulnerable to bacterial infection. 
  • Chronic pain and depression. III. Family history study of depression and alcoholism in chronic low back pain patients. 
  • Clinical and biochemical presentation of gouty diathesis: comparison of uric acid versus pure calcium stone formation. 
  • Colonization, pathogenicity, host susceptibility, and therapeutics for Staphylococcus aureus: what is the clinical relevance? 
  • Comparison of the efficacy of IGIV-C, 10% (caprylate/chromatography) and IGIV-SD, 10% as replacement therapy in primary immune deficiency. A randomized double-blind trial. 
  • Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses. 
  • Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12. 
  • Complex multilocus effects of catechol-O-methyltransferase haplotypes predict pain and pain interference 6 weeks after motor vehicle collision. 
  • Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells. 
  • DNA repair and susceptibility to basal cell carcinoma: a case-control study. 
  • Dehydration effects on the risk of severe decompression sickness in a swine model. 
  • Disease-prone and self-healing personalities. 
  • Distribution of transferrin saturations in the African-American population. 
  • Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis. 
  • Effect of pacing site on ventricular fibrillation initiation by shocks during the vulnerable period. 
  • Effects of a single dose of erythropoietin on subsequent seizure susceptibility in rats exposed to acute hypoxia at P10. 
  • Effects of kindling on subsequent learning, memory, behavior, and seizure susceptibility. 
  • Effects of quisqualic acid and glutamate on subsequent learning, emotionality, and seizure susceptibility in the immature and mature animal. 
  • Effects of reduced mitochondrial DNA content on secondary mitochondrial toxicant exposure in Caenorhabditis elegans. 
  • Elucidating the links between endocrine disruptors and neurodevelopment. 
  • Enhanced susceptibility to urinary tract infection in the spinal cord-injured host with neurogenic bladder. 
  • Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice. 
  • Ethnic differences in thromboprophylaxis for COVID-19 patients: should they be considered? 
  • Evidence for a multi-dimensional latent structural model of externalizing disorders. 
  • Evidence for genetic homogeneity in a familial platelet disorder with predisposition to acute myelogenous leukemia (FPD/AML) 
  • Explicit and implicit cognition: a preliminary test of a dual-process theory of cognitive vulnerability to depression. 
  • Expression of CCR5 increases during monocyte differentiation and directly mediates macrophage susceptibility to infection by human immunodeficiency virus type 1. 
  • Expression of the Pseudomonas syringae avirulence protein AvrB in plant cells alleviates its dependence on the hypersensitive response and pathogenicity (Hrp) secretion system in eliciting genotype-specific hypersensitive cell death. 
  • First report of involvement of Nodulisporium species in human disease. 
  • Focal increases in vascular cell adhesion molecule-1 and intimal macrophages at atherosclerosis-susceptible sites in the rabbit aorta after short-term cholesterol feeding. 
  • Functional Annotation Signatures of Disease Susceptibility Loci Improve SNP Association Analysis 
  • Functional connectivity of the amygdala in early-childhood-onset depression. 
  • Functional polymorphism in ABCA1 influences age of symptom onset in coronary artery disease patients. 
  • Future Research Directions in Pneumonia. NHLBI Working Group Report. 
  • Gamma-ray-induced mutagen sensitivity and risk of sporadic breast cancer in young women: a case-control study. 
  • Gene set analysis of survival following ovarian cancer implicates macrolide binding and intracellular signaling genes. 
  • Genetic analysis of susceptibility to Chlamydia trachomatis in mouse. 
  • Genetic basis of murine responses to hyperoxia-induced lung injury. 
  • Genetic counseling and testing for breast-ovarian cancer susceptibility: what do women want? 
  • Genetic epidemiology of the susceptibility to leprosy. 
  • Genetic predisposition to HIV-1 infection and acquired immune deficiency virus syndrome: a review of the literature examining associations with HLA [corrected]. 
  • Genetic risk factors for perinatally acquired HIV-1 infection. 
  • Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. 
  • Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32. 
  • Glipizide stimulates sympathetic outflow in diabetes-prone mice. 
  • Good prognosis or poor prognosis, dose-intensive or less intensive: who decides for adults with T-lymphoblastic lymphoma/leukemia. 
  • Guidance for the management of myasthenia gravis (MG) and Lambert-Eaton myasthenic syndrome (LEMS) during the COVID-19 pandemic. 
  • HIV-1-negative female sex workers sustain high cervical IFNɛ, low immune activation, and low expression of HIV-1-required host genes. 
  • HSV-1 retinitis and delayed hypersensitivity in DBA/2 and C57BL/6 mice. 
  • Helicobacter pylori and colorectal cancer-A bacterium going abroad? 
  • Hereditary prostate cancer in African-American families. 
  • Higher BMI, But Not Sarcopenia, Is Associated With Pembrolizumab-related Toxicity in Patients With Advanced Melanoma. 
  • Higher urine nitric oxide is associated with improved outcomes in patients with acute lung injury. 
  • Host iron status and iron supplementation mediate susceptibility to erythrocytic stage Plasmodium falciparum. 
  • Host resistance to malaria: using mouse models to explore the host response. 
  • How frailty models can be used for evaluating longevity limits: taking advantage of an interdisciplinary approach. 
  • How heritable is individual susceptibility to death? The results of an analysis of survival data on Danish, Swedish and Finnish twins. 
  • How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity. 
  • Human Gut Microbiota Predicts Susceptibility to Vibrio cholerae Infection. 
  • Human recombinant stem-cell factor induces melanocytic hyperplasia in susceptible patients. 
  • Hypercoagulable states in cardiovascular disease. 
  • Hypertension Susceptibility Loci are Associated with Anthracycline-related Cardiotoxicity in Long-term Childhood Cancer Survivors. 
  • IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. 
  • Idiopathic pain disorders--pathways of vulnerability. 
  • Immune control of tuberculosis by IFN-gamma-inducible LRG-47. 
  • Immunologic and virologic analyses of an acutely HIV type 1-infected patient with extremely rapid disease progression. 
  • Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV. 
  • Immunotherapy for Glioblastoma: Adoptive T-cell Strategies. 
  • Impact of osteoarthritis on sports careers. 
  • In vitro BPDE-induced DNA adducts in peripheral lymphocytes as a risk factor for squamous cell carcinoma of the head and neck. 
  • In vitro induction of benzo(a)pyrene diol epoxide-DNA adducts in peripheral lymphocytes as a susceptibility marker for human lung cancer. 
  • In vitro sensitivity to ultraviolet B light and skin cancer risk: a case-control analysis. 
  • Increased Susceptibility to Plasmodium falciparum in Infants is associated with Low, not High, Placental Malaria Parasitemia. 
  • Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. 
  • Individual differences in the diurnal cycle of cortisol. 
  • Infarct tissue heterogeneity by magnetic resonance imaging identifies enhanced cardiac arrhythmia susceptibility in patients with left ventricular dysfunction. 
  • Inflammatory Markers and Incidence of Hospitalization With Infection in Chronic Kidney Disease. 
  • Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. 
  • Inherited frailty and longevity. 
  • Inherited variants affecting RNA editing may contribute to ovarian cancer susceptibility: results from a large-scale collaboration. 
  • Inter-generational continuity in periodontal health: findings from the Dunedin family history study. 
  • Interplay between vesicoureteric reflux and kidney infection in the development of reflux nephropathy in mice. 
  • Inverted U-shaped relationship between vitamin D and ever-reported eczema in US adults. 
  • Invited Commentary: Cassel's "The Contribution of the Social Environment to Host Resistance"-A Modern Classic. 
  • Leveraging Nuclear Receptors as Targets for Pathological Ocular Vascular Diseases. 
  • Life-long bleeding diathesis: effect of orthotopic liver transplantation. 
  • Linkage of familial Wilms' tumor predisposition to chromosome 19 and a two-locus model for the etiology of familial tumors. 
  • Longitudinal dimensionality of adolescent psychopathology: testing the differentiation hypothesis. 
  • Loss of the perforin cytotoxic pathway predisposes mice to experimental cytomegalovirus retinitis. 
  • Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration. 
  • Mammalian iron transport: an unexpected link between metal homeostasis and host defense. 
  • Maximizing the motivational impact of feedback of lung cancer susceptibility on smokers' desire to quit. 
  • Mechanism of ventricular vulnerability to single premature stimuli in open-chest dogs. 
  • Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth. 
  • Mice immunosuppressed by murine retrovirus infection (MAIDS) are susceptible to cytomegalovirus retinitis. 
  • Molecular genetic studies of major histocompatibility complex genes in children with juvenile dermatomyositis: increased risk associated with HLA-DQA1 *0501. 
  • Molecular therapies for vascular diseases. 
  • Morbidity risks among older adults with pre-existing age-related diseases. 
  • Multilocular thymic cysts in children with human immunodeficiency virus infection: clinical and pathologic aspects. 
  • Murine cytomegalovirus retinitis during MAIDS: Susceptibility correlates with elevated intraocular levels of interleukin-4 mRNA. 
  • Murine model of pulmonary anthrax: kinetics of dissemination, histopathology, and mouse strain susceptibility. 
  • Mutagen sensitivity in upper aerodigestive tract cancer: a case-control analysis. 
  • Mutagen sensitivity to benzo(a)pyrene diol epoxide and the risk of squamous cell carcinoma of the head and neck. 
  • NADH hyperoxidation correlates with enhanced susceptibility of aged rats to hypoxia. 
  • Negative affect and chemical intolerance as risk factors for building-related symptoms: a controlled exposure study. 
  • Neuroinflammation after surgery: from mechanisms to therapeutic targets. 
  • New light on an age-old issue. 
  • Nucleotide excision repair as a marker for susceptibility to tobacco-related cancers: a review of molecular epidemiological studies. 
  • Objective but Not Subjective Short Sleep Duration Associated with Increased Risk for Hypertension in Individuals with Insomnia. 
  • Open Chromatin Profiling in Adipose Tissue Marks Genomic Regions with Functional Roles in Cardiometabolic Traits. 
  • Our cells get stressed too! Implications for human disease. 
  • PECAM-1 dampens cytokine levels during LPS-induced endotoxemia by regulating leukocyte trafficking. 
  • Pan-cancer Convergence to a Small-Cell Neuroendocrine Phenotype that Shares Susceptibilities with Hematological Malignancies. 
  • Partial uptake of varicella vaccine and the epidemiological effect on varicella disease in 11 day-care centers in North Carolina. 
  • Perceived breast cancer risk: heuristic reasoning and search for a dominance structure. 
  • Perceived susceptibility to chronic kidney disease among high-risk patients seen in primary care practices. 
  • Pharmacologic approaches to the prevention of type 2 diabetes in high risk pediatric patients. 
  • Physical and Family History Variables Associated With Neurological and Cognitive Development in Sturge-Weber Syndrome. 
  • Platelets trigger perivascular mast cell degranulation to cause inflammatory responses and tissue injury. 
  • Polymorphic repeats in the androgen receptor gene: molecular markers of prostate cancer risk. 
  • Polyteny: still a giant player in chromosome research. 
  • Post-secondary maternal education buffers against neural risk for psychological vulnerability to future life stress. 
  • Predictors of skeletal-related events and mortality in men with metastatic, castration-resistant prostate cancer: Results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database. 
  • Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood. 
  • Prior interpersonal trauma: the contribution to current PTSD symptoms in female rape victims. 
  • Prostate Cancer, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology. 
  • Pseudomonas colonization in cystic fibrosis. A study of 160 patients. 
  • Pseudomonas syringae pv. tomato DC3000: a model pathogen for probing disease susceptibility and hormone signaling in plants. 
  • Psychological and neural mechanisms of trait mindfulness in reducing depression vulnerability. 
  • Quantitative susceptibility mapping of kidney inflammation and fibrosis in type 1 angiotensin receptor-deficient mice. 
  • Racial differences in the prevalence of monoclonal gammopathy in a community-based sample of the elderly. 
  • Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromes. 
  • Recommendations for Serogroup B Meningococcal Vaccine for Persons 10 Years and Older. 
  • Reduced expression of hMLH1 and hGTBP/hMSH6: a risk factor for head and neck cancer. 
  • Resilience in sheltered battered women. 
  • Review: Collectins link innate and adaptive immunity in allergic airway disease. 
  • Risk of second primary cancers in individuals diagnosed with index smoking- and non-smoking- related cancers. 
  • Role of immune stimulation in the etiology of multiple myeloma: a case control study. 
  • Role of mast cells in inflammatory bowel disease and inflammation-associated colorectal neoplasia in IL-10-deficient mice. 
  • Role of microvolt T-wave alternans in assessment of arrhythmia vulnerability among patients with heart failure and systolic dysfunction: primary results from the T-wave alternans sudden cardiac death in heart failure trial substudy. 
  • Sarcopenia: A Time for Action. An SCWD Position Paper. 
  • Serotonin deficiency alters susceptibility to the long-term consequences of adverse early life experience. 
  • Sex differences in major bleeding with glycoprotein IIb/IIIa inhibitors: results from the CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines) initiative. 
  • Silica Exposure Differentially Modulates Autoimmunity in Lupus Strains and Autoantibody Transgenic Mice. 
  • Sociality and health: impacts of sociality on disease susceptibility and transmission in animal and human societies. 
  • Species differences in susceptibility to 1,3-dinitrobenzene-induced testicular toxicity and methemoglobinemia. 
  • Statistical methods for assessment of added usefulness of new biomarkers. 
  • Stress resistance declines with age: analysis of data from a survival experiment with Drosophila melanogaster. 
  • Susceptibility to murine cytomegalovirus retinitis during progression of MAIDS: correlation with intraocular levels of tumor necrosis factor-alpha and interferon-gamma. 
  • T cell depletion increases susceptibility to murine cytomegalovirus retinitis. 
  • TCR repertoire and CDR3 motif analyses depict the role of αβ T cells in Ankylosing spondylitis. 
  • TRPV4 channels augment macrophage activation and ventilator-induced lung injury. 
  • Targeting High Mobility Group Box-1 (HMGB1) Promotes Cell Death in Myelodysplastic Syndrome. 
  • The "disease-prone personality". A meta-analytic view of the construct. 
  • The 8.5-kb PstI allele of the stress protein gene, Hsp70-2: an independent risk factor for systemic lupus erythematosus in African Americans? 
  • The Emerging Importance of the Cerebellum in Broad Risk for Psychopathology. 
  • The Evolving Modern Management of Brain Metastasis. 
  • The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections. 
  • The antigenic properties of bacterial DNA in normal and aberrant immunity. 
  • The developmental mental-disorder histories of adults with posttraumatic stress disorder: a prospective longitudinal birth cohort study. 
  • The effect of toll-like receptors and toll-like receptor genetics in human disease. 
  • The future of perioperative therapy in advanced renal cell carcinoma: how can we PROSPER? 
  • The heritability of breast cancer: a Bayesian correlated frailty model applied to Swedish twins data. 
  • The human imprintome: regulatory mechanisms, methods of ascertainment, and roles in disease susceptibility. 
  • The impact of caspase-12 on susceptibility to candidemia. 
  • The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. 
  • The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq-3 and mediate cellular resistance in mice. 
  • The poliovirus sensitivity (PVS) gene is on chromosome 19q12----q13.2. 
  • The role of DNA repair capacity in susceptibility to lung cancer: a review. 
  • The sociality-health-fitness nexus: synthesis, conclusions and future directions. 
  • The therapeutic potential of a kallikrein inhibitor for treating hereditary angioedema. 
  • Thrombosis, thrombophilia, and thromboprophylaxis in pregnancy. 
  • Tobacco promotion and susceptibility to tobacco use among adolescents aged 12 through 17 years in a nationally representative sample. 
  • Uncovering the Role of RNA-Binding Protein hnRNP K in B-Cell Lymphomas. 
  • Update on pulmonary disease due to non-tuberculous mycobacteria. 
  • Updates in Novel Therapies for Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN). 
  • Variability of 3D arterial geometry and dynamics, and its pathologic implications. 
  • Vulnerability genes or plasticity genes? 
  • Vulnerability to depression: a moderated mediation model of the roles of child maltreatment, peer victimization, and serotonin transporter linked polymorphic region genetic variation among children from low socioeconomic status backgrounds. 
  • We are the genes we've been waiting for: rational responses to the gathering storm of personal genomics. 
  • Why is parity protective for uterine fibroids? 
  • [The Zung's autoscale for depression as predictor of sensorial and autonomic alterations to pain]. 
  • Δ(9)-Tetrahydrocannabinol treatment during human monocyte differentiation reduces macrophage susceptibility to HIV-1 infection. 
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  Keywords of People

  • Buckley, Rebecca Hatcher, James Buren Sidbury Distinguished Professor of Pediatrics, in the School of Medicine, Immunology
  • Clements III, Dennis Alfred, Professor Emeritus of Pediatrics, Pediatrics, Primary Care Pediatrics
  • Clyde, Merlise, Professor of Statistical Science, Statistical Science
  • Dodge, Kenneth A., William McDougall Distinguished Professor of Public Policy Studies, Duke Science & Society
  • Ferrari, Guido, Professor in Surgery, Molecular Genetics and Microbiology
  • Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology
  • Gottfried, Oren N, Professor of Neurosurgery, Neurosurgery
  • Johnson, G. Allan, Charles E. Putman University Distinguished Professor of Radiology, Biomedical Engineering
  • Preminger, Glenn Michael, James F. Glenn, M.D. Distinguished Professor of Urology, Surgery
  • Sparks, Matthew A., Assistant Professor of Medicine, Medicine, Nephrology
  • Taylor, Gregory Alan, Professor in Medicine, Immunology
  • Tsalik, Ephraim, Associate Professor of Medicine, Molecular Genetics and Microbiology
  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology