Disulfiram
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Subject Areas on Research
- Aldehyde dehydrogenase inhibition blocks mucosal fibrosis in human and mouse ocular scarring.
- Clinical enflurane metabolism by cytochrome P450 2E1.
- Clinical isoflurane metabolism by cytochrome P450 2E1.
- Clinical sevoflurane metabolism and disposition. II. The role of cytochrome P450 2E1 in fluoride and hexafluoroisopropanol formation.
- Concordance between trifluoroacetic acid and hepatic protein trifluoroacetylation after disulfiram inhibition of halothane metabolism in rats.
- Copper signaling axis as a target for prostate cancer therapeutics.
- Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer.
- Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage.
- Duration of cytochrome P-450 2E1 (CYP2E1) inhibition and estimation of functional CYP2E1 enzyme half-life after single-dose disulfiram administration in humans.
- Identification of the enzyme responsible for oxidative halothane metabolism: implications for prevention of halothane hepatitis.
- Inflammatory breast cancer tumor emboli express high levels of anti-apoptotic proteins: use of a quantitative high content and high-throughput 3D IBC spheroid assay to identify targeting strategies.
- Lack of single-dose disulfiram effects on cytochrome P-450 2C9, 2C19, 2D6, and 3A4 activities: evidence for specificity toward P-450 2E1.
- Metabolism of dapsone to its hydroxylamine by CYP2E1 in vitro and in vivo.
- Mitigation of pennyroyal oil hepatotoxicity in the mouse.
- Pharmacodynamic study of disulfiram in men with non-metastatic recurrent prostate cancer.
- Prospective clinical trial of disulfiram plus copper in men with metastatic castration-resistant prostate cancer.
- Single-dose disulfiram does not inhibit CYP2A6 activity.
- Single-dose disulfiram inhibition of chlorzoxazone metabolism: a clinical probe for P450 2E1.
- Site-specific retinoic acid production in the brain of adult songbirds.