Diterpenes

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  Subject Areas on Research

  • A non-pungent resiniferatoxin analogue, phorbol 12-phenylacetate 13 acetate 20-homovanillate, reveals vanilloid receptor subtypes on rat trigeminal ganglion neurons. 
  • A pH-sensitive, neurogenic pathway mediates disease severity in a model of post-ERCP pancreatitis. 
  • Advances in drug therapy for peptic ulcer disease. 
  • Age-related alterations in vitamin A metabolism in the rat retina. 
  • Anti-HIV Macrocyclic Daphnane Orthoesters with an Unusual Macrocyclic Ring from Edgeworthia chrysantha. 
  • Anti-HIV Tigliane Diterpenoids from Wikstroemia scytophylla. 
  • Anti-HIV Tigliane-Type Diterpenoids from the Aerial Parts of Wikstroemia lichiangensis. 
  • Anti-HIV tigliane diterpenoids from Reutealis trisperma. 
  • Arachidonic acid metabolism in cultured aortic endothelial cells. Effect of cAMP and 3-isobutyl-1-methylxanthine. 
  • Bioactive ent-isopimarane diterpenoids from Euphorbia neriifolia. 
  • Conformational plasticity in the selectivity filter of the TRPV2 ion channel. 
  • Daphnepedunins A-F, Anti-HIV Macrocyclic Daphnane Orthoester Diterpenoids from Daphne pedunculata. 
  • Dietary vitamins A and E influence retinyl ester composition and content of the retinal pigment epithelium. 
  • Distinct cell-specific expression patterns of early and late gibberellin biosynthetic genes during Arabidopsis seed germination. 
  • Distinguishing effects on tumor multiplicity and growth rate in chemoprevention experiments. 
  • Distribution of vitamin A in various organs of rats in relation to the quality and the quantity of dietary proteins. 
  • Diterpenes from the stem bark of Euphorbia neriifolia and their in vitro anti-HIV activity. 
  • Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources. 
  • Divergent effects of forskolin on 3',5' cyclic adenosine monophosphate production and parathyroid hormone secretion. 
  • Effect of perillic acid, a putative isoprenylation inhibitor, on the cultured rat lens. 
  • Elucidation of the functions of genes central to diterpene metabolism in tobacco trichomes using posttranscriptional gene silencing. 
  • Enzymatic modification of proteins with a geranylgeranyl isoprenoid. 
  • G protein gamma subunits contain a 20-carbon isoprenoid. 
  • Genetic and pharmacologic analyses of the role of Icmt in Ras membrane association and function. 
  • Geranyl-geranyl acetone: a novel stimulant of secretin release in the dog. 
  • Gnidimacrin, a Potent Anti-HIV Diterpene, Can Eliminate Latent HIV-1 Ex Vivo by Activation of Protein Kinase C β. 
  • Haploidentical bone marrow transplantation in patients with relapsed or refractory severe aplastic anaemia in the USA (BMT CTN 1502): a multicentre, single-arm, phase 2 trial. 
  • Hormonal stimulation of avian embryonic cartilage growth in vitro: histologic and ultrastructural features. 
  • Identification of anti-HIV macrocyclic daphnane orthoesters from Wikstroemia ligustrina by LC-MS analysis and phytochemical investigation. 
  • Identification, structural modification, and dichotomous effects on human immunodeficiency virus type 1 (HIV-1) replication of ingenane esters from Euphorbia kansui. 
  • Immunosuppressive effects of subglutinol derivatives. 
  • Inhibition of radiation-induced up-regulation of leukocyte adhesion to endothelial cells with the platelet-activating factor inhibitor, BN52021. 
  • Interaction of ethanol and acute hypoxia (7620 m) on vitamin A distribution in rat organs. 
  • Interaction of prenylcysteine methyl esters with the multidrug resistance transporter. 
  • Intravesical ultrapotent vanilloid receptor agonists: acute effects on animal models of bladder irritation. 
  • Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora. 
  • Isolation, structure determination, and anti-HIV evaluation of tigliane-type diterpenes and biflavonoid from Stellera chamaejasme. 
  • LC-MS Identification, Isolation, and Structural Elucidation of Anti-HIV Tigliane Diterpenoids from Wikstroemia lamatsoensis. 
  • Large A-fiber activity is required for microglial proliferation and p38 MAPK activation in the spinal cord: different effects of resiniferatoxin and bupivacaine on spinal microglial changes after spared nerve injury. 
  • Machine Learning Uncovers Food- and Excipient-Drug Interactions. 
  • Mechanisms of tolerance induced by PG490-88 in a bone marrow transplantation model. 
  • Microbial hydroxylation and reduction of the diterpene psiadin. 
  • Myeloablative versus Reduced-Intensity Conditioning for Hematopoietic Cell Transplantation in Acute Myelogenous Leukemia and Myelodysplastic Syndromes-Long-Term Follow-Up of the BMT CTN 0901 Clinical Trial. 
  • New Cembranolide Analogues from the Formosan Soft Coral Sinularia flexibilis and Their Cytotoxicity 
  • Normalization of quality of life three years after temporal lobectomy: a controlled study. 
  • Pentoxifylline and other methyl xanthines inhibit interleukin-2 receptor expression in human lymphocytes. 
  • Picomolar dichotomous activity of gnidimacrin against HIV-1. 
  • Placental transfer and fetal distribution of 3H-retinoic acid in rats. 
  • Potent Anti-HIV Ingenane Diterpenoids from Euphorbia ebracteolata. 
  • Prevention of graft-versus-host disease by a novel immunosuppressant, PG490-88, through inhibition of alloreactive T cell expansion. 
  • Rapid Recognition and Targeted Isolation of Anti-HIV Daphnane Diterpenes from Daphne genkwa Guided by UPLC-MSn. 
  • Recruitment of endoplasmic reticulum-targeted and cytosolic mRNAs into membrane-associated stress granules. 
  • Relationship between dietary retinol and lipofuscin in the retinal pigment epithelium. 
  • Role of platelet activating factor in kidney transplant rejection in the rat. 
  • Role of platelet activating factor in the intestinal epithelial secretory and Chinese hamster ovary cell cytoskeletal responses to cholera toxin. 
  • Role of platelet-activating factor in Chinese hamster ovary cell responses to cholera toxin. 
  • Stelleralides A-C, novel potent anti-HIV daphnane-type diterpenoids from Stellera chamaejasme L. 
  • Stereoselective synthesis and osteogenic activity of subglutinols A and B 
  • Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines. 
  • Subglutinol A, an immunosuppressive α-pyrone diterpenoid from Fusarium subglutinans, acts as an estrogen receptor antagonist. 
  • Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes. 
  • Synthesis and Biological Evaluation of Subglutinol Analogs for Immunomodulatory Agents. 
  • Synthesis and Structure-Activity Relationship Correlations of Gnidimacrin Derivatives as Potent HIV-1 Inhibitors and HIV Latency Reversing Agents. 
  • The natural diterpene tonantzitlolone A and its synthetic enantiomer inhibit cell proliferation and kinesin-5 function. 
  • The protein synthetic surge in response to mitogen triggers high glycolytic enzyme levels in human lymphocytes and occurs prior to DNA synthesis. 
  • Total synthesis, assignment of the absolute stereochemistry, and structure-activity relationship studies of subglutinols A and B. 
  • Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F. 
  • Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. 
  • β-Cyclocitral is a conserved root growth regulator. 
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  Keywords of People

  • Chen, Jun, Professor of Medicine, Duke Cancer Institute