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Subject Areas on Research
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"Time Is Muscle" in Acute Heart Failure: Critical Concept or Fake News?
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A Contemporary Picture of Congestion in Heart Failure: from Dropsy Impression to Multifaceted Reality.
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A Systematic Review of Diuretics in the Medical Management of Ménière's Disease.
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A combined clinical and biomarker approach to predict diuretic response in acute heart failure.
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A major role for the EP4 receptor in regulation of renin.
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A systematic review of the evidence supporting post-operative diuretic use following cardiopulmonary bypass in children with Congenital Heart Disease.
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Abnormal liver function tests in acute heart failure: relationship with clinical characteristics and outcome in the PROTECT study.
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Acidic stimuli activates two distinct pathways in taste receptor cells from rat fungiform papillae.
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Acute Diuretic-Sparing Effects of Sacubitril-Valsartan: Staying in the Loop.
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Acute Responses to Diuretic Therapy in Extremely Low Gestational Age Newborns: Results from the Prematurity and Respiratory Outcomes Program Cohort Study.
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Acute decline in renal function, inflammation, and cardiovascular risk after an acute coronary syndrome.
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Acute decompensated heart failure: update on new and emerging evidence and directions for future research.
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Acute heart failure in elderly patients: worse outcomes and differential utility of standard prognostic variables. Insights from the PROTECT trial.
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Acute heart failure in the young: Clinical characteristics and biomarker profiles.
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Advanced heart failure: a call to action.
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An 8-year-old girl with headache and syncope.
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An evaluation of torsemide in patients with heart failure and renal disease.
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Apparent treatment-resistant hypertension and chronic kidney disease: another cardiovascular-renal syndrome?
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Are We Getting Any Closer to Understanding Congestion?
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Association of Changes in Heart Failure Treatment With Patients' Health Status: Real-World Evidence From CHAMP-HF.
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Back to the Future With Intravenous Diuretics: Reinvigorating an Old Treatment Through New Care Settings.
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Biomarkers in acutely decompensated heart failure with preserved or reduced ejection fraction.
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Calcium stone disease: an overview.
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Captopril-induced functional renal insufficiency in patients with bilateral renal-artery stenoses or renal-artery stenosis in a solitary kidney.
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Cardiac function and heart failure.
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Chloride transport inhibitors influence recovery from oxygen-glucose deprivation-induced cellular injury in adult hippocampus.
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Clinical Implications of Serum Albumin Levels in Acute Heart Failure: Insights From DOSE-AHF and ROSE-AHF.
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Clinical and Research Considerations for Patients With Hypertensive Acute Heart Failure: A Consensus Statement from the Society for Academic Emergency Medicine and the Heart Failure Society of America Acute Heart Failure Working Group.
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Clinical application of cardiovascular pharmacogenetics.
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Clinical features and contemporary management of patients with low and preserved ejection fraction heart failure: baseline characteristics of patients in the Candesartan in Heart failure-Assessment of Reduction in Mortality and morbidity (CHARM) programme.
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Combating Acute Heart Failure in the Arena: Lessons From the ROPA-DOP Trial.
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Combination decongestion therapy in hospitalized heart failure: loop diuretics, mineralocorticoid receptor antagonists and vasopressin antagonists.
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Combination of loop diuretics with thiazide-type diuretics in heart failure.
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Combined effect of bumetanide and metolazone in normal volunteers.
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Combining Diuretic Response and Hemoconcentration to Predict Rehospitalization After Admission for Acute Heart Failure.
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Comparative effectiveness of torsemide versus furosemide in heart failure patients: insights from the PROTECT trial.
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Concomitant use of a positive inotropic agent to create a bridge to the successful initiation of beta-blocker therapy in patients with heart failure: a proposal for a trial.
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Congestive heart failure.
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Congestive heart failure: Dx and Rx in the elderly.
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Contemporary Management of Struvite Stones Using Combined Endourologic and Medical Treatment: Predictors of Unfavorable Clinical Outcome.
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Continuous versus bolus dosing of Furosemide for patients hospitalized for heart failure.
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Correction of hypocitraturia and prevention of stone formation by combined thiazide and potassium citrate therapy in thiazide-unresponsive hypercalciuric nephrolithiasis.
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Correlation of Central Blood Pressure to Hypertensive Target Organ Damages During Antihypertensive Treatment: The J-TOP Study.
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Current and novel pharmacologic approaches in advanced heart failure.
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Current and novel pharmacologic approaches in advanced heart failure.
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Death: The Simple Clinical Trial Endpoint.
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Decongestion strategies and renin-angiotensin-aldosterone system activation in acute heart failure.
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Development and validation of the Proxy-Reported Pulmonary Outcomes Scale for premature infants.
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Diagnosis, evaluation, and treatment of hyponatremia: expert panel recommendations.
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Diagnostic and Therapeutic Challenges.
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Differential Response to Low-Dose Dopamine or Low-Dose Nesiritide in Acute Heart Failure With Reduced or Preserved Ejection Fraction: Results From the ROSE AHF Trial (Renal Optimization Strategies Evaluation in Acute Heart Failure).
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Differential regulation of renin and Cox-2 expression in the renal cortex of C57Bl/6 mice.
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Diuretic Changes, Health Care Resource Utilization, and Clinical Outcomes for Heart Failure With Reduced Ejection Fraction: From the Change the Management of Patients With Heart Failure Registry.
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Diuretic Therapy for Patients With Heart Failure: JACC State-of-the-Art Review.
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Diuretic Treatment in Heart Failure.
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Diuretic complications.
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Diuretic exposure in premature infants from 1997 to 2011.
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Diuretic management in heart failure.
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Diuretic resistance predicts mortality in patients with advanced heart failure.
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Diuretic response in acute heart failure-an analysis from ASCEND-HF.
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Diuretic response in acute heart failure: clinical characteristics and prognostic significance.
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Diuretic response in patients with acute decompensated heart failure: characteristics and clinical outcome--an analysis from RELAX-AHF.
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Diuretic strategies in patients with acute decompensated heart failure.
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Diuretics and sudden cardiac death.
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Diuretics, calciuria and secondary hyperparathyroidism in the Chronic Renal Insufficiency Cohort.
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Door-to-Furosemide Therapy in the ED: New Quality Metric or Just a Piece of the Puzzle?
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Double-blind, placebo-controlled trial of twice-daily nifedipine as a step-2 agent in mild essential hypertension.
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Dyspnoea in patients with acute heart failure: an analysis of its clinical course, determinants, and relationship to 60-day outcomes in the PROTECT pilot study.
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Early Impedance-Guided Intervention Improves Long-Term Outcome in Patients With Heart Failure.
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Early diuretic strategies and the association with In-hospital and Post-discharge outcomes in acute heart failure.
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Early intravenous heart failure therapy and outcomes among older patients hospitalized for acute decompensated heart failure: findings from the Acute Decompensated Heart Failure Registry Emergency Module (ADHERE-EM).
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Early vs. late worsening heart failure during acute heart failure hospitalization: insights from the PROTECT trial.
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Effect of Ularitide on Cardiovascular Mortality in Acute Heart Failure.
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Effect of admission oral diuretic dose on response to continuous versus bolus intravenous diuretics in acute heart failure: an analysis from diuretic optimization strategies in acute heart failure.
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Effect of medical management on recurrent stone formation following percutaneous nephrolithotomy.
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Effects of Xanthine Oxidase Inhibition in Hyperuricemic Heart Failure Patients: The Xanthine Oxidase Inhibition for Hyperuricemic Heart Failure Patients (EXACT-HF) Study.
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Effects of gender and ethnic group on blood pressure control in the elderly.
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Effects of novel ethacrynic acid derivatives on human trabecular meshwork cell shape, actin cytoskeletal organization, and transcellular fluid flow.
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Effects of the new ethacrynic acid derivative SA9000 on intraocular pressure in cats and monkeys.
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Effects of the new ethacrynic acid oxime derivative SA12590 on intraocular pressure in cats and monkeys.
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Effects of tolvaptan, a vasopressin antagonist, in patients hospitalized with worsening heart failure: a randomized controlled trial.
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Efficacy of Intravenous Furosemide Versus a Novel, pH-Neutral Furosemide Formulation Administered Subcutaneously in Outpatients With Worsening Heart Failure.
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Electromechanical associations.
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Endpoints for diuresis: are we there yet?
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Evaluation of Novel Metrics of Symptom Relief in Acute Heart Failure: The Worst Symptom Score.
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Few Disparities in Baseline Laboratory Testing After the Diuretic or Digoxin Initiation by Medicare Fee-For-Service Beneficiaries.
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Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome*.
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Fluid removal in acute heart failure: diuretics versus devices.
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Furosemide and mannitol suppression of epileptic activity in the human brain.
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Genome-wide meta-analysis of variant-by-diuretic interactions as modulators of lipid traits in persons of European and African ancestry.
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Haemodynamic effects of rolofylline in the treatment of patients with heart failure and impaired renal function.
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Heart failure drug treatment.
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Heart Failure Prevention in Older Patients Using Intensive Blood Pressure Reduction: Potential Role of Diuretics.
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Hemoconcentration-guided diuresis in heart failure.
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History of Atrial Fibrillation and Trajectory of Decongestion in Acute Heart Failure.
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Hydroxychloroquine-induced hyperpigmentation: the staining pattern.
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Hyperlipidemia and transplantation: etiologic factors and therapy.
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Hypertension.
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Hypochloremia, Diuretic Resistance, and Outcome in Patients With Acute Heart Failure.
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Identifying Ascites in Patients with Cirrhosis Using Administrative Codes and Diuretic Use: A Multicenter Study.
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Impact of Diuretic Therapy in the Treatment of Bronchopulmonary Dysplasia and Acute Kidney Injury in the Neonatal Population.
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Impact of diabetes on epidemiology, treatment, and outcomes of patients with heart failure.
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Impact of long-term potassium citrate therapy on urinary profiles and recurrent stone formation.
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Implementation of a diuretic stewardship program in a pediatric cardiovascular intensive care unit to reduce medication expenditures.
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Implications of Serum Chloride Homeostasis in Acute Heart Failure (from ROSE-AHF).
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Implications of Using Different Definitions on Outcomes in Worsening Heart Failure.
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Improving In-Hospital Diuretic Therapy for Heart Failure: The Need for High-Quality Evidence.
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Initial therapy of hypertension.
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Insights into the contemporary epidemiology and outpatient management of congestive heart failure.
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Intensification of Medication Therapy for Cardiorenal Syndrome in Acute Decompensated Heart Failure.
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Intensity and focus of heart failure disease management after hospital discharge.
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International differences in clinical characteristics, management, and outcomes in acute heart failure patients: better short-term outcomes in patients enrolled in Eastern Europe and Russia in the PROTECT trial.
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International variation in characteristics and clinical outcomes of patients with type 2 diabetes and heart failure: Insights from TECOS.
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Is Resistance Futile?: Addressing Diuretic Resistance During Hospitalization for Heart Failure.
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Is home blood pressure variability itself an interventional target beyond lowering mean home blood pressure during anti-hypertensive treatment?
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Is rhythm-control superior to rate-control in patients with atrial fibrillation and diastolic heart failure?
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Is there a need for medical evaluation and treatment of nephrolithiasis in the "age of lithotripsy"?
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Kaliuretic peptide and long acting natriuretic peptide as well as atrial natriuretic factor inhibit aldosterone secretion.
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Long-term combined treatment with thiazide and potassium citrate in nephrolithiasis does not lead to hypokalemia or hypochloremic metabolic alkalosis.
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Long-term outcomes after catheter-based renal artery denervation for resistant hypertension: final follow-up of the randomised SYMPLICITY HTN-3 Trial.
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Long-term treatment of calcium nephrolithiasis with potassium citrate.
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Lovastatin and coadministered antihypertensive/cardiovascular agents.
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Low-dose dopamine or low-dose nesiritide in acute heart failure with renal dysfunction: the ROSE acute heart failure randomized trial.
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Lower urine sodium predicts longer length of stay in acute heart failure patients: Insights from the ROSE AHF trial.
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Machine Learning Methods Improve Prognostication, Identify Clinically Distinct Phenotypes, and Detect Heterogeneity in Response to Therapy in a Large Cohort of Heart Failure Patients.
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Management of acute decompensated heart failure.
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Management of heart failure in cardiac amyloidosis using an ambulatory diuresis clinic.
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Markers of decongestion, dyspnea relief, and clinical outcomes among patients hospitalized with acute heart failure.
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Massive pulmonary pseudotumor.
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Medical advances in the treatment of congestive heart failure.
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MicroRNAs relate to early worsening of renal function in patients with acute heart failure.
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Misperceptions about beta-blockers and diuretics: a national survey of primary care physicians.
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Must I keep taking all these medicines? Optimizing diuretics in chronic heart failure.
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My hair is thinning on the top of my head. What treatments are available for hair loss in women?
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New Decongestion Strategies in an Evolving Heart Failure Landscape.
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Nondialytic management of hyperkalemia and pulmonary edema among end-stage renal disease patients: an evaluation of the evidence.
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OUTpatient intravenous LASix Trial in reducing hospitalization for acute decompensated heart failure (OUTLAST).
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Obesity and the response to intensified diuretic treatment in decompensated heart failure: a DOSE trial substudy.
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Outpatient Intravenous Diuretic Therapy for Heart Failure in the United States.
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Outpatient versus inpatient intravenous diuretic therapy for heart failure in the United States.
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Overview of current noninodilator therapies for acute heart failure syndromes.
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Oxaluria--the neglected stepchild of nephrolithiasis?
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Participation in weight-related sports is associated with higher use of unhealthful weight-control behaviors and steroid use.
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Patient Perceptions and Familiarity With Medical Therapy for Heart Failure.
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Patient journey after admission for acute heart failure: length of stay, 30-day readmission and 90-day mortality.
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Pediatric cardiovascular drug dosing in critically ill children and extracorporeal membrane oxygenation.
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Persistent high serum bicarbonate and the risk of heart failure in patients with chronic kidney disease (CKD): A report from the Chronic Renal Insufficiency Cohort (CRIC) study.
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Pharmacokinetics of Hydrochlorothiazide in Children: A Potential Surrogate for Renal Secretion Maturation.
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Pharmacologic therapy for patients with chronic heart failure and reduced systolic function: review of trials and practical considerations.
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Pharmacologic treatment of calcium calculi.
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Population Pharmacokinetics of Vericiguat in Patients With Heart Failure With Reduced Ejection Fraction: An Integrated Analysis.
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Possible protein binding displacement interaction between glibenclamide and metolazone.
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Pragmatic Design of Randomized Clinical Trials for Heart Failure: Rationale and Design of the TRANSFORM-HF Trial.
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Predischarge initiation of carvedilol in patients hospitalized for decompensated heart failure: results of the Initiation Management Predischarge: Process for Assessment of Carvedilol Therapy in Heart Failure (IMPACT-HF) trial.
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Prolonged furosemide exposure and risk of abnormal newborn hearing screen in premature infants.
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Proteomic differences among patients with heart failure taking furosemide or torsemide.
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Pulmonary hypertensive medical therapy in chronic thromboembolic pulmonary hypertension before pulmonary thromboendarterectomy.
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Quality of life among hypertensive patients with a diuretic background who are taking atenolol and enalapril.
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Racial Differences in Diuretic Efficiency, Plasma Renin, and Rehospitalization in Subjects With Acute Heart Failure.
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Randomized Evaluation of Heart Failure With Preserved Ejection Fraction Patients With Acute Heart Failure and Dopamine: The ROPA-DOP Trial.
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Rationale for and design of the TRUE-AHF trial: the effects of ularitide on the short-term clinical course and long-term mortality of patients with acute heart failure.
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Recognizing the Significance of Outpatient Worsening Heart Failure.
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Relationship between admission serum sodium concentration and clinical outcomes in patients hospitalized for heart failure: an analysis from the OPTIMIZE-HF registry.
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Relationship between heart failure treatment and development of worsening renal function among hospitalized patients.
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Relief and Recurrence of Congestion During and After Hospitalization for Acute Heart Failure: Insights From Diuretic Optimization Strategy Evaluation in Acute Decompensated Heart Failure (DOSE-AHF) and Cardiorenal Rescue Study in Acute Decompensated Heart Failure (CARESS-HF).
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Renal calculi: pathogenesis, diagnosis, and medical therapy.
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Reply: Diuretic Strategies and Renal Dysfunction in Heart Failure With Preserved Ejection Fraction.
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Reply: Efficacy of Subcutaneous vs. Intravenous Administration of Furosemide in Patients With Worsening Heart Failure: The Devil Is in the Details.
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Respiratory Medications in Infants <29 Weeks during the First Year Postdischarge: The Prematurity and Respiratory Outcomes Program (PROP) Consortium.
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Reversible pulmonary hypertension in POEMS syndrome--another etiology of triggered pulmonary vasculopathy?
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Risk of hypercalcemia in blacks taking hydrochlorothiazide and vitamin D.
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Risk-based evaluation of efficacy of rolofylline in patients hospitalized with acute heart failure - Post-hoc analysis of the PROTECT trial.
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Role of diuretics, β blockers, and statins in increasing the risk of diabetes in patients with impaired glucose tolerance: reanalysis of data from the NAVIGATOR study.
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Role of guanylate cyclase modulators in decompensated heart failure.
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Role of microsomal prostaglandin E synthase 1 in the kidney.
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Rolofylline, an adenosine A1-receptor antagonist, in acute heart failure.
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Safety of nifedipine in patients with hypertension: a meta-analysis.
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Serum Bicarbonate in Acute Heart Failure: Relationship to Treatment Strategies and Clinical Outcomes.
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Serum Potassium Levels and Outcome in Acute Heart Failure (Data from the PROTECT and COACH Trials).
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Sex-related differences in the use and adverse effects of angiotensin-converting enzyme inhibitors in heart failure: the study of patients intolerant of converting enzyme inhibitors registry.
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Sex-specific acute heart failure phenotypes and outcomes from PROTECT.
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Short-term clinical effects of tolvaptan, an oral vasopressin antagonist, in patients hospitalized for heart failure: the EVEREST Clinical Status Trials.
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Sox6 as a new modulator of renin expression in the kidney.
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Sparing a little may save a lot: lessons from the Studies of Left Ventricular Dysfunction (SOLVD).
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Specific binding sites for atrial natriuretic factor in the human kidney.
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The ABCs of managing systolic heart failure: Past, present, and future.
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The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP.
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The current role of medical treatment of nephrolithiasis: the impact of improved techniques of stone removal.
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The effect of furosemide on intravascular volume status and electrolytes in patients receiving mannitol: an intraoperative safety analysis.
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The effect of indapamide versus hydrochlorothiazide on ventricular and arterial function in patients with hypertension and diabetes: results of a randomized trial.
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The effects of adenosine A(1) receptor antagonism in patients with acute decompensated heart failure and worsening renal function: the REACH UP study.
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The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries.
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The lower is not always the better: a more comprehensive understanding of loop diuretics in heart failure.
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The pharmacokinetics of bumetanide in the newborn infant.
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Thiazide diuretic agents and the incidence of hip fracture.
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Time to diuretics in acute heart failure: the tortoise or the hare?
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Timing and Causes of Readmission After Acute Heart Failure Hospitalization-Insights From the Heart Failure Network Trials.
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Ultrafiltration in decompensated heart failure with cardiorenal syndrome.
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Ultrafiltration in heart failure with cardiorenal syndrome.
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Understanding the Pathophysiology, Implications, and Treatment Options of Patent Ductus Arteriosus in the Neonatal Population.
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Use of biomarkers to establish potential role and function of circulating microRNAs in acute heart failure.
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Usefulness of spironolactone in a specialized heart failure clinic.
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Vanilloid receptor activation by 2- and 10-microm particles induces responses leading to apoptosis in human airway epithelial cells.
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Water and sodium in heart failure: a spotlight on congestion.
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Weight perceptions and weight control practices in American Indian and Alaska Native adolescents. A national survey.
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What's new in diuretic therapy.
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When Business and Science Clash, How Can We Avoid Harming Patients?: The Case of AVOID-HF.
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When the heart runs out of heartbeats: treatment options for refractory end-stage heart failure.
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Worsening Heart Failure Following Admission for Acute Heart Failure: A Pooled Analysis of the PROTECT and RELAX-AHF Studies.
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Worsening renal function in acute heart failure in the context of diuretic response.
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Keywords of People
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O'Connor, Christopher Michael,
Richard Sean Stack, M.D. Distinguished Professor,
Medicine, Clinical Pharmacology
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Preminger, Glenn Michael,
James F. Glenn, M.D. Distinguished Professor of Urology,
Surgery, Urology